Four 8-ounce cups of coffee or six shots of espresso for 400 milligrams of caffeine per day.
Reduction by coffee consumption of prostate cancer risk: Evidence from the Moli-sani cohort and cellular models
Systematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children
- Under a Creative Commons license
- Conducted systematic review of the potential adverse effects of caffeine consumption in healthy populations.
- Included evaluation of cardiovascular, behavioral, reproductive & developmental, bone & calcium, and acute effects.
- Evidence supported consumption of ≤400 mg/day in adults is not associated with overt, adverse effects.
- Intakes of ≤300 mg/day in pregnant women and ≤2.5 mg/kg-day in children and adolescents remain acceptable.
- Findings support shift in future research to unhealthy populations, sensitive populations and interindividual variability.