http://www.nature.com/nrneurol/journal/vaop/ncurrent/full/nrneurol.2013.226.html
Abstract
An
oral therapy that targets the unfolded protein response (UPR) has been
shown to prevent neurodegeneration in a mouse model of prion disease.
The treatment abrogated the behavioural, clinical and pathological
characteristics associated with accumulation of misfolded prion protein.
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