This is exactly what I was talking about in May, 2011 And the neurohospitalists could use this instead of their impossible 10 point plan.
http://www.dovepress.com/articles.php?article_id=11159
Abstract: Low-toxicity magnetic nanocarriers (MNCs) composed of a shell of poly [aniline-co-N-(1-one-butyric acid) aniline] over a Fe3O4
magnetic nanoparticle core were developed to carry recombinant tissue
plasminogen activator (rtPA) in MNC-rtPA for targeted thrombolysis. With
an average diameter of 14.8 nm, the MNCs exerted superparamagnetic
properties. Up to 276 µg of active rtPA was immobilized per mg of MNCs,
and the stability of the immobilized rtPA was greatly improved during
storage at 4°C and 25°C. In vitro thrombolysis testing with a tubing
system demonstrated that magnet-guided MNC-rtPA showed significantly
improved thrombolysis compared with free rtPA and reduced the clot lysis
time from 39.2 ± 3.2 minutes to 10.8 ± 4.2 minutes. In addition,
magnet-guided MNC-rtPA at 20% of the regular rtPA dose restored blood
flow within 15–25 minutes of treatment in a rat embolism model without
triggering hematological toxicity. In conclusion, this improved system
is based on magnetic targeting accelerated thrombolysis and is
potentially amenable to therapeutic applications in thromboembolic
diseases.
Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 28,972 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke.DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER, BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
What this blog is for:
My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.
Monday, October 1, 2012
Bioconjugation of recombinant tissue plasminogen activator to magnetic nanocarriers for targeted thrombolysis
Labels:
magnetic,
nanocarriers,
rats,
tPA
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