Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, December 3, 2014

Dextromethorphan/Quinidine: A Review of Its Use in Adults with Pseudobulbar Affect

So maybe there is something for emotional lability Ask your doctor about this.
http://www.ncbi.nlm.nih.gov/pubmed/25420446
Yang LP1, Deeks ED.

Author information

Abstract

Fixed-dose dextromethorphan/quinidine capsules (Nuedexta®) utilize quinidine to inhibit the metabolism of dextromethorphan, enabling high plasma dextromethorphan concentrations to be reached without using a larger dose of the drug. The drug combination is the first treatment to be approved for pseudobulbar affect (PBA), a condition of contextually inappropriate/exaggerated emotional expression that often occurs in adults with neurological damage conditions, such as amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), stroke, traumatic brain injury, Alzheimer's disease or Parkinson's disease. Dextromethorphan/quinidine at the recommended dosages of 20/10 or 30/10 mg twice daily reduced the rate of PBA episodes and improved PBA severity in a 12-week, double-blind, placebo-controlled trial in adults with ALS or MS (STAR), with further improvements in the severity of the condition observed in a 12-week open-label extension phase. Dextromethorphan/quinidine 20/10 mg twice daily also improved PBA secondary to dementia in a cohort of a 12-week noncomparative trial (PRISM II). The drug combination was generally well tolerated in these studies, with no particular safety or tolerability concerns. Although longer-term efficacy and tolerability data for dextromethorphan/quinidine 20/10 or 30/10 mg twice daily would be beneficial, current evidence indicates that it is a useful option in the treatment of adults with PBA.
Posted by at
Labels: , , , ,

1 comment:

  1. momcaregiverJanuary 6, 2015 at 9:21 PM

    Well I just wanted to add that in an anoxic brain injury(whole brain stroke if we`re not getting technical) regular OTC DM had the best effect I`ve seen since ambien worked backwards and woke him up and freed up his movements. Sadly the DM wow effect has dwindled too, but was so good to see. I`ve been reading all kinds of stuff on it since and yes it all started with an article for neudexta in a magazine called quest. It had the study and how some ALS patients reported better speech and swallowing. A few other anoxic peps have tried it and had some results too. All so interesting and I`m hooked on finding out why. Wish I was a lot smarter though reading all the technical stuff :) Ruth

    ReplyDelete

Subscribe to: Post Comments (Atom)