- 20,024 participants were evaluated in the REGARDS (Reasons for Geographic and Racial Differences in Stroke) study, a biracial prospective study.
- They excluded participants with stroke history(WHY?) or missing dietary data.
- They estimated flavonoid intake by using a Block98 food frequency questionnaire and the USDA’s Provisional Flavonoid Addendum and Proanthocyanidin Database.
- They assessed associations between quintiles of flavonoid intake and incident ischemic stroke by using Cox proportional hazards models, adjusting for confounders.
- 524 acute ischemic strokes happened over 6.5 y.
- As per the outcomes, flavanone intake was lower in the Southeastern United States but higher in blacks than in whites.
- Flavanone intake was inversely associated with incident ischemic stroke (HR: 0.72; 95% CI: 0.55, 0.95; P–trend = 0.03), after multivariable adjustment.
- The study observed that consumption of citrus fruits and juices was inversely associated with incident ischemic stroke (HR: 0.69; 95% CI: 0.53, 0.91; P–trend = 0.02).
- No association was found between total flavonoids and other flavonoid subclasses with incident ischemic stroke.
- The study reveal that there was no statistical interaction with sex, race, or region for any flavonoid measure.