Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html

Monday, October 3, 2016

Nobel Prize in medicine awarded to Japan’s Yoshinori Ohsumi for work on ‘cell recycling’

Our stroke doctors should be able to figure out how to apply this to stroke to help our recovery. Which will never occur.
https://www.washingtonpost.com/news/to-your-health/wp/2016/10/03/nobel-prize-in-medicine-awarded-to-japans-yoshinori-ohsumi/
Japanese biologist Yoshinori Ohsumi was awarded the 2016 Nobel Prize in medicine on Monday for discovering and elucidating a key mechanism in our body’s defense system that involves degrading and recycling parts of cells. Known as autophagy, this process plays an important role in cancer, Alzheimer’s, Type 2 diabetes, birth defects from Zika virus and numerous other devastating diseases.
In making the announcement, the prize committee in Stockholm said the work involves a series of “brilliant experiments” in the 1990s involving baker’s yeast that have helped explain how a cell, the smallest unit of life, adapts in response to stresses such as starvation and infection. In studying thousands of yeast mutants, Ohsumi identified 15 genes essential for autophagy. It turned out that virtually identical mechanisms exist in human cells as well.
“His discoveries opened the path to understanding the fundamental importance of autophagy in many physiological processes, such as in the adaptation to starvation or response to infection,” the Nobel committee wrote. “Mutations in autophagy genes can cause disease, and the autophagic process is involved in several conditions including cancer and neurological disease.”
Autophagy, which literally means “self-eating” in Greek, is a process of cell renewal that removes damaged proteins and organelles. When this process fails, it can speed up cell aging and causes diseases associated with aging. On the flip side, “too much” autophagy can promote growth of tumor cells in cancer and resistance to treatments.
Ohsumi, who is 71 and now serves as a professor emeritus at the Tokyo Institute of Technology, called the prize the “greatest source of joy and pride” for a scientist.
“Looking into bodily processes, I found that we have an ongoing renewal process without which living organisms can’t survive,” Ohsumi told NHK, the Japanese public broadcaster, shortly after the announcement. “This recycling process did not receive as much attention as it deserved, but I discovered that we should be paying more attention to this autophagy process,” he said, adding that he was “lucky” to make the discovery early on in his career.
The Nobel committee noted that “autophagy has been known for over 50 years.” However, its fundamental importance in physiology and medicine “was only recognized after Yoshinori Ohsumi’s paradigm-shifting research.” This amazing graph, which was displayed on a screen when the award was announced, shows just how much other work has been built on the discovery:

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