Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html

Saturday, October 8, 2016

Cocoa flavanol intake and biomarkers for cardiometabolic health: A systematic review and meta-analysis of randomized controlled trials

Totally unable to understand anything about this. Unreadable for any layperson. The senior person on this should have deep sixed this writeup.
http://www.mdlinx.com/internal-medicine/medical-news-article/2016/10/06/cocoa-flavanols-cardiometabolic-health-randomized-controlled/6878573/?
The Journal of Nutrition, 10/06/2016
Lin X, et al. – A systematic review and meta–analysis of randomized clinical trials (RCTs) were performed to evaluate the impact of cocoa flavanol intake on cardiometabolic biomarkers. The results demonstrate that cocoa flavanol intake has favorable effects on select cardiometabolic biomarkers among adults. These discoveries support the requirement for large long–term RCTs to survey whether cocoa flavanol intake diminishes the risk of diabetes and cardiovascular events.

Methods

  • In this study, the researchers looked PubMed, Web of Science, and the Cochrane Library for RCTs that assessed the impacts of cocoa flavanols on biomarkers relevant to vascular disease pathways among adults.
  • Information were extracted following a standardized protocol.  
  • They utilized DerSimonian and Laird random-effect models to compute the weighted mean differences (WMDs) and 95% CIs.
  • They additionally inspected potential modification by intervention duration, design, age, sex, comorbidities, and the form and amount of cocoa flavanol intake.  

Results

  • 19 RCTs that involved 1131 members were included, and the number of studies for a specific biomarker varied.
  • The amount of cocoa flavanols ranged from 166 to 2110 mg/d, and intervention duration ranged from 2 to 52 wk.
  • Cocoa flavanol intake significantly enhanced insulin sensitivity and lipid profile.  
  • The WMDs between treatment and placebo were -0.10 mmol/L (95% CI: -0.16, -0.04 mmol/L) for total triglycerides, 0.06 mmol/L (95% CI: 0.02, 0.09 mmol/L) for HDL cholesterol, -2.33 μIU/mL (95% CI: -3.47, -1.19 μIU/mL) for fasting insulin, -0.93 (95% CI: -1.31, -0.55) for the homeostatic model assessment of insulin resistance, 0.03 (95% CI: 0.01, 0.05) for the quantitative insulin sensitivity check index, 2.54 (95% CI: 0.63, 4.44) for the insulin sensitivity index, -0.83 mg/dL (95% CI: -0.88, -0.77 mg/dL) for C-reactive protein, and 85.6 ng/mL (95% CI: 16.0, 155 ng/mL) for vascular cell adhesion molecule 1.  
  • No significant affiliations were found for other biomarkers.
  • None of the modifiers appeared to qualitatively modify the effects of cocoa flavanol intake.   
Go to PubMed Go to Abstract Print Article Summary Cat 2 CME Report

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