Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:

Tuesday, April 11, 2017

CardioBrief: Pendulum Swings Further Away From Vitamin D Supplements

You'll have to have your doctor read my 31 posts on vitamin D to see what other benefits it has.
Like these:

Effects of vitamin D supplementation on neuroplasticity in older adults: a double-blinded, placebo-controlled randomised trial


More Evidence That Vitamin D Protects Against Alzheimer’s - 


Vitamin D Blog: A Bedroom Boost


The Vitamin Which May Reduce Risk of Alzheimer’s and Dementia


Vitamin D, Omega-3 May Help Clear Amyloid Plaques Found in Alzheimer's


Low-Dose Vitamin D Prevents Muscular Atrophy and Reduces Falls and Hip Fractures in Women after Stroke


More Evidence That Vitamin D Protects Against Alzheimer’s - 

The negative article here:

Pendulum Swings Further Away From Vitamin D Supplements

A new randomized controlled trial offers no support for the use of increasingly popular vitamin D supplements to prevent cardiovascular disease or reduce mortality.
But the trial, published in JAMA Cardiology, is also not the last word on the subject and leaves open the possibility that vitamin D may be found beneficial in the future for cardiovascular disease or other indications.
Family physician doctors in New Zealand randomized more than 5,100 adults between 50 and 84 years of age to vitamin D or placebo. Vitamin D was administered as an initial dose of 200,000 IU, followed by monthly doses of 100,000 IU. There was no hint of any effect on the primary outcome between the groups.
After 3.3 years of follow-up, cardiovascular disease occurred in 11.8% of participants in the vitamin D group and in 11.5% in the placebo group. The results were similar in the important subgroups of participants with vitamin D deficiency at baseline and in those with previous cardiovascular disease.
The study used higher overall doses than used in many previous studies, which had been criticized for this potential weakness. A random sample of 438 participants in the study showed that 25(OH)D levels were 20 ng/mL higher in the treatment group, reaching optimal levels as suggested by observational studies. The authors acknowledged that there are questions whether the monthly dosing of vitamin D results in persistent increases in vitamin D levels.
It is well-established that people with low vitamin D levels are at increased risk for cardiovascular disease but unknown whether this is a cause-and-effect relationship or, if so, whether supplements would be effective. “Our results do not support the findings from observational studies that report an inverse association between 25 (OH)D and CVD, which could be explained by residual confounding from other lifestyle risk factors,” the authors concluded. “It is possible that 25 (OH)D concentrations are a surrogate marker of sun exposure, which may have other health effects entirely separate from vitamin D.”
Erin Michos (Johns Hopkins) commented that “the evidence supports that generally healthy people should not take vitamin and mineral supplementation for CVD prevention, and that includes Vitamin D.” She said the large on-going VITAL study, with more than 25,000 participants, will provide much more clarity on the effects of vitamin D supplements on heart disease, cancer, and other endpoints. But Michos said she suspects that VITAL will also be a negative trial, “especially since vitamin D deficiency was not an enrollment criteria. That likely will be the end of the era of enthusiasm for use of vitamin D for preventing all chronic ills.”
“I am a strong believer that IF supplementation might help anyone (and that is a big if), it likely would be only among individuals with deficiency,” said Michos. “MORE IS NOT BETTER, and people with adequate vitamin D stores do not need supplementation.” She pointed out that, although there was no signal of benefit in the group with low vitamin D levels at baseline, the trial was not powered to detect differences. She speculated that supplements might also be found helpful in people with severe vitamin D deficiencies, such as below 15 ng/mL.

No comments:

Post a Comment