- The authors retrospectively compared clinical and radiological outcomes in 167 bridging patients with 255 patients receiving direct MT because of large artery anterior circulation stroke.
- They matched all patients from the direct MT group who would have qualified for intravenous tissue–type plasminogen activator with controls from the bridging group, using multivariate and propensity score analyses.
- Functional independence was defined as modified Rankin Scale score of 0 to 2.
- From February 2009 to August 2014, 40 patients from the direct MT group would have qualified for bridging thrombolysis but were treated with MT only.
- Clinical and radiological characteristics did not differ from the bridging cohort, except for higher rates of hypercholesterolemia (P=0.019), coronary heart disease (P=0.039), and shorter intervals from symptom onset to endovascular intervention (P=0.01) in the direct MT group.
- Functional independence, mortality, and intracerebral hemorrhage rates did not differ (P>0.1).
- After multivariate matching analysis outcome in both groups did not differ, except for lower rates of asymptomatic intracerebral hemorrhage (P=0.023) and lower mortality (P=0.007) in the direct MT group.