BDNF is good for our recovery. What the hell is your doctors' protocol to ensure your levels are good and you are getting enough?
- Neuronal cell injury is the primary pathological mechanism responsible for most types of brain injury.
- Brain-derived neurotrophic factor (BDNF) may facilitate protective and regenerative effects following injury.
- BDNF is involved in several pathological conditions, including hypoxic brain injury, stroke, Alzheimer’s disease and Parkinson’s disease.
- Targeting BDNF can be applied in clinical settings and can serve as a new therapeutic strategy against neuronal injury.
- PKA, protein kinase A;
- cAMP, cyclic AMP;
- CREB, cAMP response element binding;
- AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor;
- NMDA, N-methyl-D-aspartate receptor;
- CAMK, Ca2+-calmodulin-dependent protein kinase;
- BDNF, brain derived neurotrophic factor. MAPK, mitogen-activated protein kinase;
- MEK, MAPK/ERK kinase;
- ERK, extracellular signal-regulated kinase;
- GAB1, GRB-associated binder 1;
- Ins(1,4,5)P3, inositol-1,4,5-trisphosphate;
- DAG, diacylglycerol;
- PKC, protein kinase C;
- Ca2+/CaM, Ca2+/calmodulin;
- CaMK, Ca2+/calmodulin-dependent protein kinases
- Brain-derived neurotrophic factor;
- Brain injury