Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html

Tuesday, April 11, 2017

The relationship between intracranial pressure and neurocognitive function before and after the repair of a skull injury

You probably want to know about this if you had a skull flap removed to reduce pressure.
http://www.europeanreview.org/wp/wp-content/uploads/1285-1289-Expression-of-IGF-1-and-Abeta-in-patients-with-repaired-skull-injury.pdf
J. HE
1
, L.-L. CHEN
2
, D.-K. SUN
1
, H.-T. WANG
1
, J.-J. WANG
1
, X. ZHAI
3
1
Neurosurgery Ward 2, Linyi City Yishui Central Hospital, Linyi, Shandong, P.R. China
2
Clinical Laboratory, Linyi City Yishui Central Hospital, Linyi, Shandong, P.R. China
3
Department of Neurological Surgery Unit 1, the First Affiliated Hospital of Liaoning Medical
University, Jinzhou, Liaoning, P.R. China
Abstract.
OBJECTIVE:
This study examines the relationship between intracranial pressure (ICP) changes after skull injury repair and neurocognitive function before and after the repair.
PATIENTS AND METHODS:
Sixty patients undergoing skull injury repair participated in the study. A non-invasive detection analyzer was used to detect the ICP 2 days before operation, 10 days after the operation and one month after the operation in all patients. Additionally, the mean cerebral blood flow velocities (MV) in the internal carotid and the medial cerebral arteries were detected using a transcranial Doppler ultrasound (TCD). The neurological and cognitive functions were assessed using the NIHSS and the MMSE scales, respectively. And finally, an ELISA assay was used to detect the plasma insulin-like growth factor (IGF)-1 and β-amyloid peptide (Aβ
) levels.
RESULTS :
The results showed that all parameters studied improved significantly and continuously after surgery.
CONCLUSIONS:
We suggest that the improvement in the ICP values and the neurocognitive functions are related to the resulting decreased expression levels of IGF-1 and Aβ after the repair.
 

No comments:

Post a Comment