Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 13643 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke.DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER, BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Deans' stroke musings
Changing stroke rehab and research worldwide now.Time is Brain!Just think of all thetrillions and trillions of neuronsthateach daybecause there areeffective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
What this blog is for:
Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group. My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html
Wednesday, April 12, 2017
Picroside II protects the blood-brain barrier by inhibiting the oxidative signaling pathway in cerebral ischemia-reperfusion injury
is used to improve cerebral circulation; at the same time,
neuroprotective drugs such as antioxidants should also be used. The aim
of these experiments was to explore the protective mechanism of an
antioxidant, picroside II, on the blood-brain barrier (BBB) after
cerebral ischemia-reperfusion (CI/R) injury.
observe the antagonistic effect of picroside II on CI/R damage, the
neurological deficit score and the infarct volume were measured. To
detect the protective effect of picroside II on nerve cells and the BBB,
the morphology and structure of cortical brain tissue were observed,
respectively. To investigate the antioxidant effect and mechanism of
picroside II, reactive oxygen species (ROS) content, the activity of
Nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase), and
the protein levels of Nox2 and Rac-1 were detected. To investigate the
protective mechanism of picroside II on the BBB, the levels of ROCK,
MLCK, MMP-2 and claudin-5 were tested.
higher neurological score, bigger cortex infarction, more damaged
neuron structure and injured BBB, increased content of ROS and activity
of NADPH oxidase, higher protein levels of Nox2, Rac-1, ROCK, MLCK and
MMP-2 and lower levels of claudin-5 were observed in the model group. In
the picroside group, the neurological score, neuronal damage, BBB
injury, ROS content and NADPH oxidase activity were reduced (P<0.05), and the protein levels of Rac-1, Nox2, ROCK, MLCK and MMP-2 were down-regulated (P<0.05), while the expression of claudin-5 was up-regulated (P<0.05).
II could protect the nervous system possibly through reducing the
content of ROS by down-regulating the expression of Rac-1 and Nox2 and
could protect the BBB through reducing the expression of ROCK, MLCK, and
MMP-2, while enhancing the expression of claudin-5.