Deans' stroke musings: Topographical measures of functional connectivity as biomarkers for post-stroke motor recovery

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, July 11, 2017

Topographical measures of functional connectivity as biomarkers for post-stroke motor recovery

No clue what possible use this could be for getting you to 100% recovery.
https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-017-0277-3

Gavin R. PhilipsEmail author View ORCID ID profile,
Janis J. Daly and
José C. Príncipe

Journal of NeuroEngineering and Rehabilitation201714:67

DOI: 10.1186/s12984-017-0277-3

Received: 24 February 2017

Accepted: 20 June 2017

Published: 6 July 2017

Abstract

Background

Biomarkers derived from neural activity of the brain present a vital tool for the prediction and evaluation of post-stroke motor recovery, as well as for real-time biofeedback opportunities.

Methods

In order to encapsulate recovery-related reorganization of brain networks into such biomarkers, we have utilized the generalized measure of association (GMA) and graph analyses, which include global and local efficiency, as well as hemispheric interdensity and intradensity. These methods were applied to electroencephalogram (EEG) data recorded during a study of 30 stroke survivors (21 male, mean age 57.9 years, mean stroke duration 22.4 months) undergoing 12 weeks of intensive therapeutic intervention.

Results

We observed that decreases of the intradensity of the unaffected hemisphere are correlated (r _s=−0.46;p<0.05) with functional recovery, as measured by the upper-extremity portion of the Fugl-Meyer Assessment (FMUE). In addition, high initial values of local efficiency predict greater improvement in FMUE (R ²=0.16;p<0.05). In a subset of 17 subjects possessing lesions of the cerebral cortex, reductions of global and local efficiency, as well as the intradensity of the unaffected hemisphere are found to be associated with functional improvement (r _s=−0.60,−0.66,−0.75;p<0.05). Within the same subgroup, high initial values of global and local efficiency, are predictive of improved recovery (R ²=0.24,0.25;p<0.05). All significant findings were specific to the 12.5–25 Hz band.

Conclusions

These topological measures show promise for prognosis and evaluation of therapeutic outcomes, as well as potential application to BCI-enabled biofeedback.