Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 14612 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke.DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER, BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Deans' stroke musings
Changing stroke rehab and research worldwide now.Time is Brain!Just think of all thetrillions and trillions of neuronsthateach daybecause there areeffective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
What this blog is for:
Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group. My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html
Monday, September 5, 2016
Correlates of Post-Stroke Brain Plasticity, Relationship to Pathophysiological Settings and Implications for Human Proof-of-Concept Studies
Department of Neurology, University Hospital Essen, Essen, Germany
The promotion of neurological recovery by enhancing neuroplasticity
has recently obtained strong attention in the stroke field. Experimental
studies support the hypothesis that stroke recovery can be improved by
therapeutic interventions that augment neuronal sprouting. However
plasticity responses of neurons are highly complex, involving the growth
and differentiation of axons, dendrites, dendritic spines and synapses,
which depend on the pathophysiological setting and are tightly
controlled by extracellular and intracellular signals. Thorough
mechanistic insights are needed into how neuronal plasticity is
influenced by plasticity-promoting therapies in order not to risk the
success of future clinical proof-of-concept studies.
The intrinsic capacity of brain repair can be
efficiently stimulated by exogenous therapeutic interventions, e.g., by
physical exercise, delivery of growth factors, cell-based biologicals or
pharmacological compounds, which in rodent and primate models of stroke
were shown to enhance neurological recovery (Bacigaluppi et al., 2009; Reitmeir et al., 2011, 2012; Jaeger et al., 2015; Wang et al., 2016).
Neurological recovery in the experimental setting can be defined as
regain of lost function of the paretic limb as compared to a baseline
defined previous to the stroke, which should not be confused with
neurological compensation (Murphy and Corbett, 2009),
in which other parts of the limbs (e.g., shoulder or the non-paretic
limb) are recruited to complete a task. Neurological recovery and
compensation can be discriminated by specific tests that allow the study
of the paretic limb in isolation, e.g., pellet withdrawal in rodents or
digit testing in primates that measure fine motor skills (Nudo and Milliken, 1996; Biernaskie et al., 2004), and tests measuring overall motor function, such as the rotarod, tight rope or hand grip tests (Doeppner et al., 2014a).
There seems to be a critical time window after stroke in which various
interventions, such as voluntary motor stimulation, pharmacological
treatment or transcranial brain stimulation, can improve neurological
recovery (Nudo et al., 1996; Biernaskie et al., 2004; Hummel et al., 2005; Sawaki et al., 2014; Wahl et al., 2014).
In contrast to acute neuroprotective therapies, plasticity-promoting
therapies have proven efficacy over weeks or even months post-stroke in
animal and human studies.
Within this perspective article, we would like to briefly
integrate some findings regarding brain remodeling and plasticity after
stroke, elucidating: (a) structural surrogates of successful
neurological recovery depending on the localization of ischemic lesions;
(b) reorganization and plasticity processes of the cellular,
subcellular and network level; (c) critical time windows for various
therapeutic interventions; and (d) modes for the delivery of biologicals
or drugs. We will shortly present (e) selected molecular signals that
are likely mediators of plasticity processes, since we believe that
understanding these signals is a major hallmark to prevent the failure
of treatments in future clinical studies.