Deans' stroke musings: Mechanisms of ageing: growth hormone, dietary restriction, and metformin

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, February 27, 2023

Mechanisms of ageing: growth hormone, dietary restriction, and metformin

Just talked to my doctor today about metformin, she said it's too early to tell, no clinical studies have been run on it yet. And since I'm not even pre-diabetic, I can't wheedle my way onto the drug.

You'll have to read about dietary restriction in this book: '

Ageless:The New Science of Getting Older Without getting Old'

Your doctor should have already gotten you protocols for IGF-1 with all the benefits already proven for stroke. So ask about those protocols.

IGF-1 (10 posts to March 2014)

Mechanisms of ageing: growth hormone, dietary restriction, and metformin

Published:February 24, 2023DOI:https://doi.org/10.1016/S2213-8587(23)00001-3

Summary

Tackling the mechanisms underlying ageing is desirable to help to extend the duration and improve the quality of life. Life extension has been achieved in animal models by suppressing the growth hormone–insulin-like growth factor 1 (IGF-1) axis and also via dietary restriction. Metformin has become the focus of increased interest as a possible anti-ageing drug. There is some overlap in the postulated mechanisms of how these three approaches could produce anti-ageing effects, with convergence on common downstream pathways. In this Review, we draw on evidence from both animal models and human studies to assess the effects of suppression of the growth hormone–IGF-1 axis, dietary restriction, and metformin on ageing.