Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Showing posts with label stroke medical world. Show all posts
Showing posts with label stroke medical world. Show all posts

Wednesday, July 8, 2026

Want to live a longer, happier life? Science says work to be more successful (but not in the way you might think)

 My goal right now is to convince the stroke medical world to actively pursue 100% recovery protocols! I've laid out multiple paths but no one is listening.

Want to live a longer, happier life? Science says work to be more successful (but not in the way you might think)

A decades-long (and counting) study reveals happiness lies not necessarily in the achievement, but in the pursuit.

You want to be happier. You want to feel more fulfilled. You want to live a longer, healthier life.

Hold that thought.

Lewis Terman, a Stanford University psychologist, was a pioneer in I.Q. testing. His revisions of the Stanford-Binet test helped it become a widespread tool for measuring general intelligence.

In 1921, he identified 1,500 children who had scored 135 or higher on the test and began one of the longest longitudinal studies ever conducted. (The New York Times calls Terman and his study of “Termites,” as the kids called themselves, the “grandfather of all lifespan research.”) 

Terman’s study was guaranteed to outlive him, but that was the point: analyzing large groups of people over many decades allows researchers to uncover connections between cause and effect that short-term studies naturally miss. (It’s really hard to know if what you did in your 20s actually made you happy in your 40s and 70s unless the researchers catch you at all three stages of your life.)

Who tended to live the longest, most fulfilling lives? 

People who actively pursued, and were highly engaged in pursuing, their goals. In fact, many of those who worked the hardest turned out to live the longest.

Even if they didn’t actually accomplish their goals. According to The Longevity Project, achieving lifelong dreams doesn’t matter. According to the authors, pursuing your dreams is what counts:

We did not find that precisely living out your dreams matters much for your health. It was not the happiest or the most relaxed older participants who lived the longest. It was those who were most engaged in pursuing their goals.

Those who were the most successful were the ones least likely to die at any given age. In fact, those men who were carefree, undependable, and unambitious in childhood and very unsuccessful in their careers had a whopping increase in their mortality risk.

Of course, success means (and absolutely should mean) different things to different people.

That’s why determining what success means to you, and then actively working to achieve your definition of success, is the key. Living a laid-back, carefree, stress-free life may sound great, but as the study shows, happy-go-lucky people tend not to thrive.

Related video: Scientists can predict how well you'll age - years before it happens (TED)

Persistent, conscientious, goal-oriented people thrive — again, even if they don’t always achieve their goals.

Of course, other things matter as well. Other research shows good relationships make you happier and healthier: Terman’s study shows kids who have greater willpower and perseverance tend to be more successful as adults, regardless of relative I.Q. 

It’s not easy to change the quality of your relationships overnight, though. Nor is it easy to develop greater willpower and determination (although there are certainly ways you can increase your ability to resist temptation, stay focused and determined, and remain resolute in pursuit of your goals).

But what you can do, starting today, is actively work toward achieving one of your goals. (A great double-dip goal would be to try to improve the quality of your relationships.)

Working toward a goal will make you happier. Working hard to achieve a goal will help you live longer. Actively pursuing a goal, even if you never quite achieve it, will make your life more fulfilling, both now and when you eventually look back on a life well-lived.

Because there’s only one longitudinal study of happiness that truly matters: yours.

This post originally appeared at inc.com.

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Tuesday, June 30, 2026

Down to the Core of the Paradox: Thrombectomy in Large Stroke and Favorable Outcome — Do Time and Mismatch Matter?

 I hope this doesn't mean you're giving up! Stroke survivors have no choice but to soldier thru regardless of the incompetence of the stroke medical world in not solving stroke to 100% recovery!

Down to the Core of the Paradox: Thrombectomy in Large Stroke and Favorable Outcome — Do Time and Mismatch Matter?


Chen J, Nie X, Wang M, Zhang D, Sun D, Pan Y, Huo X, Li Z, Miao Z, for the ANGEL-ASPECT Study Group. Time-Dependent Impact of Mismatch Profiles on Outcomes Following Endovascular Thrombectomy for Large Ischemic Stroke. Stroke. 2026;57:641–649.

Patients with large-core infarctions have long been considered poor candidates for reperfusion therapy.(Why?) Although six recent randomized controlled trials evaluating endovascular therapy (EVT) versus medical management have since largely challenged this view, only 20 to 30% of these patients achieve functional independence at 90 days. In small-core infarctions, perfusion mismatch between the irreversibly damaged tissue of the core and the salvageable penumbra has become the cornerstone of EVT decision-making, particularly in the late time window. However, whether the same principle applies to large-core infarctions is uncertain. Notably, previous subgroup analyses yielded conflicting results, and it remains unknown whether perfusion mismatch can reliably inform EVT decisions in large-core infarctions across different time windows.

The authors performed a secondary, post hoc analysis of the ANGEL-ASPECT trial, a multicenter randomized controlled trial comparing EVT with medical management in adults aged 18-80 years with acute ischemic stroke and large-core infarction of the anterior circulation defined as: ASPECTS 3-5 within 24 hours, or core volume 70-100mL and either ASPECTS 0-2 within 24 hours or ASPECTS > 5 at 6-24 hours. Perfusion mismatch was defined using two criteria: (1) mismatch ratio ≥ 1.8 and mismatch volume ≥ 15mL, or (2) mismatch radio ≥ 1.2 and mismatch volume ≥ 10mL. Unadjusted logistic regression assessed the association between treatment and 90-day functional independence (mRS 0–3), including treatment-by-mismatch interaction within each time stratum (≤6 versus >6 hours) and treatment-by-time interaction in the overall cohort. Secondary outcomes included recanalization, 90-day mRS distribution, mortality, and intracranial hemorrhage.

Using the most stringent definition, 346 of the 426 participants (81%) displayed a perfusion mismatch. In the early time window (≤ 6 hours), EVT was associated with higher odds of functional independence at 90 days among patients with a perfusion mismatch compared with medical management alone (49 vs 28%; OR 2.41 [95% CI 1.28–4.55]), whereas no benefit was observed in those without a mismatch. In the late window, EVT conferred no significant advantage, aside from a non-significant trend toward benefit in the no-mismatch group. Treatment-by-mismatch and treatment-by-time interaction tests were not statistically significant for primary and secondary outcomes. Sensitivity analyses excluding wake-up stroke yielded consisted results. Any ICH occurred more frequently in the EVT group, while rates of symptomatic ICH were comparable across treatment arms.

Overall, this post hoc analysis suggests that among patients with large-core infarctions, those imaged within the early time window and exhibiting a perfusion mismatch may, as predicted by the core/penumbra model, derive the greatest benefit from EVT, whereas benefit in the late-time window appeared less dependent on mismatch status. These results contrast with subgroup analyses from SELECT-2,1 which reported EVT benefit irrespective of mismatch status, but partially align with those of TESLA,2 which did not meet its primary endpoint yet, somewhat unexpectedly, suggested a trend toward EVT benefit primarily in patients without a mismatch. Notably, some patients with no apparent mismatch still experienced favorable outcomes with EVT in extended time windows, further challenging the large-core paradox. Such findings may reflect favorable baseline characteristics; however, alternative explanations, including imaging limitations, overestimation of the core, residual tissue viability (so-called heterogeneity within the core), and reduction of vasogenic edema, cannot be excluded.3

Considering the limited subgroup sizes, potential selection bias with high prevalence of perfusion mismatch, and the unadjusted nature of the statistical analyses, these findings should be interpreted with caution. Current guidelines do not support selecting or excluding patients from EVT solely based on perfusion imaging,4 and further studies are needed to clarify how perfusion mismatch profiles and imaging timing should inform EVT decisions in large stroke.

Monday, June 29, 2026

Plasma metabolomic signatures of the no-reflow phenomenon in stroke patients following thrombectomy

 

Well shit, you're describing Capillaries that don't open due to pericytes;

 known since September 2011. The whole stroke medical world IS COMPLETELY FUCKING INCOMPENT FOR NOT SOLVING THAT PROBLEM!

Plasma metabolomic signatures of the no-reflow phenomenon in stroke patients following thrombectomy


  • 1. Department of Neurology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China

  • 2. Guilin Municipal People's Hospital, Guangxi Zhuang Autonomous Region, Guilin, China

Abstract

Background: 

Although successful recanalization of the occluded artery is achieved, no-reflow phenomenon (NRP) becomes a main contributor to poor prognosis in patients with acute ischemic stroke. There are some laboratory results to represent biomarkers of the no-reflow phenomenon. However, few studies have characterized the metabolomic signature of NRP. Using high-performance liquid chromatography–tandem mass spectrometry (LC–MS)-based method, this study aims to characterize the plasma metabolites associated with NRP.

Methods: 

A total of 34 patients with acute large vessel occlusion in anterior circulation who underwent successful thrombectomy with final angiographic expanded Treatment in Cerebral Infarction score of 2c-3 score were enrolled (19 without NRP and 15 with NRP). Fasting venous blood collected 24 h after the procedure was centrifuged and subjected to metabolomic analysis.

Results: 

We identified 29 differentially expressed plasma metabolites, the majority of which were phosphatidylcholine (PC) species. Among them, PC(20:4(5Z,8Z,11Z,14Z)/P-16:0) showed the most significant alteration and exhibited robust predictive performance (AUC = 0.846). The most prominently disrupted metabolic pathway was glycerophospholipid metabolism, particularly PC-mediated pathways, which appeared to play a central role in the association with of NRP.

Conclusion: 

This study depict the plasma metabolic profile of NRP patients following stroke thrombectomy, and discover that phosphatidylcholine-dominated metabolites and related pathways may play a potential role in the occurrence of NRP. These metabolic biomarkers demonstrate promising discriminative ability and may help identify high-risk patients at an early stage, providing new targets for mechanism research and therapeutic intervention.


More at link.

Monday, June 8, 2026

A 15-Year Study Found This Trait Could Delay Cognitive Decline by mindbodygreen

 My purpose in life is to get stroke 100% recovered! 16 years of trying and nothing has been accomplished. In my next 40 years- til age 110 - nothing will occur either, the stroke medical establishment is too inbred with stupidity to ever recover sanity!

A 15-Year Study Found This Trait Could Delay Cognitive Decline

Tuesday, May 5, 2026

Retired executive shares powerful stroke survival story for American Stroke Month

 This just proves the COMPLETE FUCKING FAILURE OF THE STROKE WORLD! 100% recovery should be normal and mapped out WITH EXACT PROTOCOLS! Not having those protocols means the ASA is a COMPLETE FUCKING FAILURE!

Send me personal hate mail on this: oc1dean@gmail.com. I'll print your complete statement with your name and title(If you can't stand by your name don't bother replying anonymously) and my response in my blog. Or are you afraid to engage with my stroke-addled mind? No excuses are allowed! You're medically trained; it should be simple to precisely state EXACTLY WHERE I'M WRONG. I want to hear your excuses for failure(not getting to 100% recovery IS FAILURE!) so I can demolish them! You aren't solving to 100% recovery protocols with NO EXCUSES! I've never received any communications from any stroke association. You'd think they would want to talk to their fiercest critic, but no, they are hiding under a rock someplace, probably don't even know I exist! Swearing at me is allowed, I'll return the favor. Don't even attempt to use the excuse that brain research is hard.

I'm looking directly at you; Nancy Brown; care to reply? The AHA/ASA chief executive officer is Nancy Brown

Retired executive shares powerful stroke survival story for American Stroke Month

American Stroke Association highlights survivor’s journey to underscore the importance of B.E. F.A.S.T. action in emergencies

ROGERS, Ark., May 4, 2026 —When 59‑year‑old Rogers resident Earvin Young woke up on Jan. 2, 2025, he had no idea his life would change within hours. An avid cyclist, corporate executive and father of four, Young describes himself as healthy, active and “the last person who thought a stroke could happen to me.”

But that morning, when his son came home from his night shift to check on him, he found his father on the bathroom floor, unable to feel his legs or stand.

Young had suffered the first of what would be two strokes within ten days.

As the American Stroke Association recognizes American Stroke Month in May, Young is sharing his experience to urge Northwest Arkansans to learn and recognize the B.E. F.A.S.T. warning signs of stroke, when every minute can mean the difference between recovery and lifelong disability.

Before his stroke, Young rode 40–50 miles every weekend, spent 35 years building a career in human resources and was deeply involved in community volunteer work. He said nothing in his life suggested he was at risk.

“I knew what a stroke was, but like most people, I thought it would never happen to me,” Young said.

In the early morning hours after his first stroke, he was transported from hospital to hospital as medical teams searched for answers. Ten days later, while undergoing rehabilitation, Young suffered a second, more severe stroke, one that left him unable to speak or move.

Doctors warned his wife, Rosalind, that his chances of survival were uncertain.

What Young remembers from that experience is not fear, but frustration.

“I could hear everything,” he said. “I just couldn’t move or respond. People were talking around me, deciding things about me. I kept thinking, talk to me like I’m still here.”

That moment became part of Young’s new mission: advocating for stroke awareness, survivor dignity and better communication between patients and care teams.

He spent nearly three months in three different hospitals and rehab facilities, working to regain his ability to walk, speak and manage daily life. Today, he continues therapy for challenges with balance, hand mobility and vocal fatigue, all lingering effects of his strokes.

But his outlook remains hopeful.

“With every ending, there’s a new beginning,” Young said. “This is my life after stroke. I don’t want the old life back. I want to build something new.”

That “something new” includes advocacy. Young has launched a blog, begun connecting with survivor networks and is working with local barbershops, churches and community groups in Northwest Arkansas to create spaces where men — especially Black men, who are at higher risk for stroke — can talk openly about health.

“Nobody in the barbershop or church was talking about stroke until I had mine,” he said. “Awareness starts where people gather.”

Arkansas sits squarely in the nation’s “stroke belt,” where stroke mortality rates are significantly higher than the U.S. average, according to CDC data. Yet awareness of stroke symptoms remains low across the state. This reality hit home for Young, who says neither he nor his son recognized the warning signs during his medical emergency

“If we had known B.E. F.A.S.T., we would have called 911 immediately,” he said. “Time lost is brain lost.”

B.E. F.A.S.T. helps people recognize the most common stroke warning signs: Balance loss, Eye or vision changes, Face drooping, Arm weakness, Speech difficulty and Time to call 911. Calling emergency services immediately allows first responders to begin care and alert the hospital’s stroke team before arrival.

Arkansas sits in the nation’s “stroke belt,” where stroke death rates are significantly higher than the national average. Men and African Americans face particularly high risk, and awareness gaps remain widespread.

Young now uses his voice to advocate for stroke awareness, survivor dignity and earlier action. He is working with barbershops, churches and community groups across Northwest Arkansas to spark honest conversations about stroke risk and prevention, especially among men.

“Nobody was talking about stroke where we gather until it happened to me,” Young said. “Awareness starts with conversation.”

As American Stroke Month continues, the American Stroke Association encourages Arkansans to learn B.E. F.A.S.T., know their risk factors and act quickly if stroke symptoms appear.

“If sharing my story helps even one family recognize the signs and call for help sooner,” Young said, “then it’s worth it.”

Additional resources: 

###

About the American Heart Association

The American Heart Association is a relentless force for a world of longer, healthier lives. Dedicated to ensuring equitable health in all communities, the organization has been a leading source of health information for more than one hundred years. Supported by more than 35 million volunteers globally, we fund groundbreaking research, advocate for the public’s health, and provide critical resources to save and improve lives affected by cardiovascular disease and stroke. By driving breakthroughs and implementing proven solutions in science, policy, and care, we work tirelessly to advance health and transform lives every day. Connect with us on heart.org, Facebook or X by calling 1-800-AHA-USA1.   

For Media Inquiries

Cyd King: cyd.king@heart.org

For Public Inquiries: 1-800-AHA-USA1 (242-8721)

heart.org and stroke.org

 

Friday, April 17, 2026

Researchers are near a breakthrough drug for brain recovery after stroke

 

I can almost guarantee your doctor and hospital will KNOW NOTHING AND DO NOTHING! 

No human research will occur; nothing will be done! That is how fucking incompetent the whole stroke medical world is. Hopefully comeuppance will hit them all.

Let's see how long incompetence has existed!

  • DDL-920 (5 posts to March 2025)
  • Parvalbumin neurons (8 posts to June 2013)
  • Researchers are near a breakthrough drug for brain recovery after stroke

    Doctor holding a patient's MRI result with the senior patient sitting upright on the hospital bed in the background, next to a relative and the nurseSource: Shutterstock For millions of stroke survivors, recovery doesn’t end when they leave the hospital. While emergency treatments can save lives, the long road afterward often involves months or years of physical therapy, with no guarantee of regaining lost movement or coordination. Stroke remains the leading cause of long-term disability in adults, and many patients never fully recover.In the United States alone, nearly 800,000 people suffer a stroke each year, and an estimated 7.8 million adults are living as stroke survivors, many coping with lasting mobility or speech impairments. Despite the scale of the problem, treatment options focused specifically on repairing brain function after stroke remain limited.

    That may be starting to change. New research suggests scientists are closer than ever to developing a medication that could help the brain rewire itself after stroke, potentially reducing reliance on grueling rehabilitation alone.

    What the New Research Has Found

    study published in Nature Communications, researchers at UCLA identified a drug candidate that restored movement in mice after stroke by mimicking the effects of physical rehabilitation. The compound, known as DDL-920, was able to repair disrupted neural connections that typically limit recovery.The research builds on years of work examining how the brain heals after stroke. Scientists found that damage isn’t limited to the area where the stroke occurs. Instead, stroke disrupts communication among brain cells located far from the injury site, particularly a type called parvalbumin neurons.

    These neurons play a critical role in generating gamma oscillations, which are rhythmic brain signals that help coordinate movement. Physical therapy was shown to restore these rhythms in both humans and mice. The breakthrough came when researchers discovered that DDL-920 could activate the same recovery pathway without physical rehabilitation in mouse models.

    Why This Approach is Different

    Most past stroke treatments have focused on preventing additional damage rather than repairing what’s already been lost. The UCLA findings mark a shift toward treating recovery itself as a biological process that can be targeted with medicine, a single pill.

    According to the researchers, DDL-920 works by re-exciting parvalbumin neurons and restoring synchronized brain activity necessary for movement control. In mice, the drug produced improvements nearly equivalent to those seen with intensive physical therapy.This matters because many stroke patients are unable to participate fully in rehabilitation due to mobility limitations or lack of access. A medication that enhances or replicates the effects of rehab could dramatically expand recovery options, especially for older adults and those in underserved communities.

    Still, researchers emphasize that the work is in early stages. The drug has only been tested in animals, and extensive safety and efficacy studies are required before human trials can begin. No clinical trials in people are currently underway.

    What Comes Next for Stroke Recovery

    If future research confirms the drug’s safety and effectiveness in humans, it could fundamentally reshape how stroke recovery is treated. Instead of relying solely on physical therapy, doctors may one day prescribe medications that help the brain rebuild its own neural networks

    Researchers caution that the drug is not intended to replace rehabilitation entirely, but to complement it — potentially making therapy more effective or accessible. The ultimate goal is to move stroke recovery into what scientists call an era of molecular medicine, where biology and rehabilitation work together.

    For now, the findings represent a significant step forward rather than a finished solution. But for a field that has gone decades without a single recovery-focused drug, the possibility of a pill that helps the brain heal offers something long missing from stroke care: cautious optimism.