Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, August 17, 2026

'The Good Life'; Lessons From the World's Longest Scientific Study of Happiness by Robert Waldinger, MD and Marc Schulz, PhD

 The short answer is relationships. 

I'm very good at this, My best friend from first grade on, thru high school and college is whom I bought the cabin with in northern Minnesota, second one is a college roommate from senior year(1978) The three of us get together at the cabin for boys weekend yearly. I thought I was an introvert until I realized that in order to make friends after moving to Michigan I had to interact and found I'm very good at that, now can crack jokes at my expense at the parties I'm invited to.  My stroke at 50 galvanized restoring my old college friendships after dumping the ex.

All leading to moving to Michigan and finding lots of new friendships.

When every second counts in a stroke, Norwalk Hospital is ready

 

 No, they are not! They refer to 'care'; NOT RECOVERY!

Talking about 'care' rather than recovery PROVES THEY ARE A FAILED HOSPITAL!

YOU are going to have to run it instead! 

When every second counts in a stroke, Norwalk Hospital is ready

Norwalk Hospital's nationally recognized stroke team provides lifesaving care(NOT RECOVERY!) and urges the community to know the signs of stroke.

When someone is having a stroke, every second matters. A fast, accurate response can make all the difference in saving a life and recovering well after a stroke. If you or someone you love has stroke symptoms, Northwell Health’s Norwalk Hospital is prepared — 24/7 — to provide timely, expert 

care(NOT RECOVERY!)

.

Norwalk Hospital has again earned national recognition from the American Heart Association for delivering timely, evidence-based stroke 

care(NOT RECOVERY!)

. For patients and families in Greater Norwalk, the award means you can feel confident that a highly trained team is ready to diagnose stroke quickly, provide advanced treatment and support you through recovery.

“This is our fourth consecutive year achieving Gold PLUS status with Stroke Honor Roll Elite Plus and Type 2 Diabetes Honor Roll,” says Michele Lecardo, DNP, neuroscience coordinator at Norwalk Hospital. “This is a true testament to the sustainability of our stroke program. This year, we also received the ‘advanced therapy’ recognition for our endovascular 

care(NOT RECOVERY!)

, or clot-removing through mechanical thrombectomy. This is such an amazing achievement and I’m so proud to be a part of this team.”

Norwalk Hospital also received a Commitment to Quality award from the American Heart Association for its stroke program.

“Only 222 hospitals nationwide have been given this award,” Lecardo says.

“Stroke care depends on speed, accuracy and teamwork,” says Daryl Story, MD, director of the Norwalk Hospital stroke program. “When patients arrive quickly, our team evaluates them, determines the right treatment and acts fast to help protect brain function and improve outcomes.”

Stroke care(NOT RECOVERY!)

 is a team effort. At Norwalk Hospital, that team includes emergency medical services, emergency department staff, neurologists, neurosurgeons, radiologists, nurses, pharmacists, rehabilitation specialists and many others. Each role matters, from the first 911 call to diagnosis, treatment, recovery planning and rehabilitation.

Norwalk Hospital is certified by The Joint Commission as a Thrombectomy-Capable Stroke Center, meaning the hospital has advanced technology and expertise to treat complex strokes. Specially trained endovascular neurosurgeons use a biplane angiography system to treat ischemic strokes by removing blockages in blood vessels and restoring blood flow to the brain. They also use this technology to treat conditions that can cause hemorrhagic stroke or bleeding in the brain, like an aneurysm. They perform these lifesaving procedures through tiny incisions in the wrist or thigh, helping patients recover quickly.

The American Heart Association award reflect dependable, quality 

care(NOT RECOVERY!)

 as well as stroke education. Norwalk Hospital helps people in Greater Norwalk lower their risk for stroke by maintaining healthy blood pressure and cholesterol levels, preventing or managing diabetes, smoking cessations, eating well and exercising.

If stroke does happen, it’s important for everyone to understand the signs of stroke using the acronym B.E.F.A.S.T.:

  • Balance: Sudden loss of balance or coordination
  • Eyes: Sudden vision changes in one or both eyes
  • Face: Facial drooping on one side
  • Arms: Arm weakness or numbness
  • Speech: Slurred speech or difficulty speaking
  • Time: Time to call 911 immediately. Do not drive yourself to the hospital. Emergency medical services can begin the stroke evaluation and help expedite 

    care(NOT RECOVERY!)

     at the emergency department.

Every day, Norwalk Hospital’s stroke team sees the importance of recognizing stroke symptoms quickly and getting patients to the right 

care(NOT RECOVERY!)

 without delay. Fast treatment can lead to better outcomes: It can help save a life — and preserve the quality of that life.

“Our goal is to help people in Greater Norwalk understand that stroke is an emergency, and that experienced, compassionate and advanced 

care(NOT RECOVERY!)

 is available close to home,” says Lecardo.

Adults lose muscle with age—researchers found an unexpected health risk

 More reasons for your doctor to get you 100% recovered! 

DOES YOUR DOCTOR HAVE THE EXACT PROTOCOLS TO DO THAT?

Adults lose muscle with age—researchers found an unexpected health risk

The gradual loss of muscle that often comes with aging may do more than make everyday tasks harder.  

Known as sarcopenia, the condition is already linked to frailty and a higher risk of death. 

Now, a new study suggests it could also leave people more vulnerable to serious infections. 

people with sarcopenia faced a significantly higher long-term risk of infections than those with healthy muscle function. 

The elevated risk extended to respiratory infections, urinary tract infections, skin and soft tissue infections, and sepsis.  

The study, published in MedScience, followed participants for a median of more than 12 years, making it one of the largest investigations yet into the relationship between muscle health and infection risk.  

Researchers found a graded pattern: people with low muscle mass were at increased risk of infection, while those with more advanced sarcopenia faced an even greater risk. 

Professor Arshad Rather, a consultant geriatrician at Medical Express Clinic who was not involved in the research, said many people mistakenly assume significant muscle loss is simply an unavoidable part of getting older. 

Losing some muscle with age is common, but becoming weak enough to affect daily life is not inevitable,” Rather told Newsweek

He said the earliest warning signs are often subtle. 

“Getting out of a chair without using your arms becomes harder,” Rather said. “Stairs take longer. You struggle with jars, luggage or heavy shopping bags. You may walk more slowly, feel more tired, or notice clothes fitting differently even though your weight has not changed much.” 

According to Rather, sarcopenia can affect people who appear to have a healthy weight, as muscle tissue can gradually be replaced by fat. 

The study’s findings add weight to a growing body of evidence suggesting that muscle plays an important role in immune health.  

While muscles are best known for movement, they also function as an endocrine organ, releasing signaling molecules called myokines that help regulate immune responses and inflammation.  

Muscle also acts as a reserve of amino acids that the body can draw upon during periods of illness or physiological stress. 

Researchers proposed several mechanisms that might explain the association.  

Reduced muscle mass could impair the production of immune-regulating myokines, limit the availability of amino acids needed by immune cells, and contribute to chronic low-grade inflammation that weakens the body’s defenses. 

Rather said the biological explanation is plausible.  

“Muscle is not just for movement,” he said. “It helps regulate inflammation and acts as a reserve of amino acids the body uses when fighting infection. When muscle mass and strength fall, that reserve shrinks.” 

He noted that the new findings showed people with sarcopenia faced a substantially higher risk of infections over time, including respiratory infections and sepsis. 

However, he cautioned that the research demonstrates an association rather than proving that muscle loss directly causes infections. 

Still, experts said there are good reasons to protect muscle health as people age.  

Rather pointed to resistance training and adequate protein intake as the most effective evidence-based strategies. 

“The best evidence for slowing it is still practical: regular resistance exercise two to three times a week, using weights, bands or supervised strength training, plus enough protein spread across the day,” he said. 

He added that maintaining strength earlier in life may provide a valuable buffer against future illness. 

“The key message is to start before a crisis,” Rather said. “Maintaining strength in your 50s and 60s gives you more reserve for illness, surgery, and recovery later in life.” 

Reference  

Meng Gao, Bolong Liu, Hequn Chen, Zewu Zhu, Juliet Matsika, Minghui Liu, Jiao Hu, Xiaogen Kuang, Jinbo Chen. Association of sarcopenia with the long-term risk of overall infections and infectious diseases: a prospective cohort study of 458 332 participants. MedScience, 2026, 20 (2) : 345-357 DOI:10.1007/s11684-026-1224-0. 

Contact Newsweek editors on this story: Kara Dolman and Emma Lee-Sang

Related Articles

Start your unlimited Newsweek trial

What Is the Association Between Music-Related Leisure Activities and Dementia Risk? A Cohort Study

 I bet your incompetent? doctor never created a music protocol for your stroke recovery either! How long before s/he is fired for incompetence?

music (94 posts back to March 2011)

music therapy (85 posts back to October 2014)

musical training (13 posts back to June 2014)

singing (12 posts to July 2013)

What Is the Association Between Music-Related Leisure Activities and Dementia Risk? A Cohort Study

Sex-Specific Associations Between Blood Pressure and Cognitive Decline

 Have your competent? doctor determine what this means for your cognitive ability.

Sex-Specific Associations Between Blood Pressure and Cognitive Decline

Faster declines in systolic blood pressure were associated with simultaneous declines in global and domain-specific cognition among older women, but not older men.Faster declines in systolic blood pressure are associated with faster simultaneous declines in cognition among older women, but not men, according to a study published in the Although changes in blood pressure (BP) and cognition are common with aging, the relationship between longitudinal changes in BP and cognitive function, particularly by sex, remains poorly understood.  Researchers therefore evaluated whether simultaneous changes in BP and cognition differed between older women and men using data from 5 ongoing longitudinal, community-based cohorts: Religious Orders Study (ROS)Rush University’s Memory and Aging Project (MAP) Minority Aging Research Study (MARS) Rush University’s Alzheimer’s Disease Center Clinical Core (ClinCore) Latino Core (LATC) Adults (N=4719) who underwent annual BP and cognitive assessments were evaluated for longitudinal changes in both. The women (n=3502) and men (n=1217) had a mean (SD) age of 76.7 (7.8) and 76.8 (7.5) years, respectively. Among women and men, 62.9% and 70.3% were White, respectively; mean (SD) BMI was 28.3 (5.9) and 27.93 (4.3) kg/m2, and 58.1% and 50.1% had a history of hypertension, respectively.Understanding these sex-specific associations may help advance the understanding of drivers behind sex differences in cognitive decline. Over a mean (SD) 8.7 (5.7)-year follow-up, systolic BP, diastolic BP, global cognition, working memory, semantic memory, episodic memory, perceptual speed, and visuospatial ability all declined significantly (all P <.01). Men experienced a greater decline in diastolic BP than women (adjusted estimate, −0.031 vs −0.011; P <.001), whereas no sex differences were observed in rates of decline for systolic BP or cognitive measures. Among women, higher systolic BP at baseline was significantly correlated with lower semantic memory, perceptual speed, and visuospatial ability scores (r range, −0.07 to −0.05; all P ≤.04). Faster declines in systolic BP over time were correlated with faster declines in global cognition and all 5 cognitive domains (r range, 0.20-0.32; all P <.001).

Diastolic BP was correlated with global cognition, working memory, and visuospatial ability among women (r range, -0.06 to -0.05; all P ≤.03), whereas changes in diastolic BP were not correlated with changes in any cognitive outcomes (all P ≥.35).

Among men, higher systolic BP at baseline was significantly correlated with lower global cognition, perceptual speed, and visuospatial ability (all r, −0.08; all P ≤.04). Changes in systolic BP were not correlated with changes in any cognitive outcomes (all P ≥.23).

Diastolic BP was correlated with global cognition, episodic memory, and perceptual speed among men (r range, -0.11 to -0.10; all P <.01), while increasing diastolic BP was correlated with faster declines in working memory (r, −0.18; P =.03).

Sensitivity analyses showed that the associations between changes in BP and cognition were robust after adjustment for BMI, race/ethnicity, apolipoprotein E (APOE) ε4 status, study cohort, and number of follow-up visits. Excluding participants who developed dementia within 3 years of baseline and adjusting for death during follow-up also did not alter the findings.

In age-stratified analyses, the relationships between changes in BP and cognition were primarily observed later in life. Among participants older than 70 years, associations between declining systolic BP and global and domain-specific cognition were comparable to or larger than those in the primary analyses. Among participants aged 70 years and younger, these relationships were attenuated.

Study limitations included the predominantly White study population, the inability to determine whether declining BP precedes cognitive decline or vice versa, the lack of data on hypertension control, and the possibility that a floor effect in cognitive scores among men contributed to the observed sex differences.

“As women experience a disproportionate burden of both hypertension and cognitive decline in late-life, declining systolic BP, a routine clinical measure, may serve as an important indicator of concurrent cognitive decline in older women,” the researchers concluded. They continued, “Understanding these sex-specific associations may help advance the understanding of drivers behind sex differences in cognitive decline.”

References:

Baumgartner NW, Capuano AW, Barnes LL, Bennett DA, Arvanitakis Z. Sex differences in the association of simultaneous decline in blood pressure and decline in cognition during aging. Ann Neurol. Published online July 7, 2026. doi:10.1002/ana.78280

Daily Coffee Consumption Associated With Healthier Metabolic Profile, Finnish Study Finds

 If all this earlier research didn't get you a 24 hour coffee station then your stroke medical 'professionals' ARE COMPLETELY USELESS!

How coffee protects against Parkinson’s Aug. 2014 

Coffee May Lower Your Risk of Dementia Feb. 2013

Coffee drinkers rejoice! Drinking coffee could lower the risk of Alzheimer’s disease 

And this: Coffee's Phenylindanes Fight Alzheimer's Plaque December 2018

New research suggests drinking coffee may reduce the risk of frailty May 2025

I think I'm in this category:  I never get the jitters or flushed skin.

Genetics determine how much coffee you can drink before it goes wrong

I'm doing a 12 cup pot of coffee a day with full fat milk to lessen my chances of dementia and Parkinsons. Tell me EXACTLY how much coffee to drink for that and I'll change. Yep, that is a lot more than the 400mg. suggested limit, I don't care! Preventing dementia and Parkinsons is vastly more important than whatever problems it can cause! 

Of course, your fuckingly incompetent? doctor did nothing with this from 3+ years ago! And still hasn't created a 24 hour coffee station

Dementia risk could drop by drinking just one shot daily of common beverage  August 2023

This line is great: The findings indicate that even the Espresso Martini cocktail contains the espresso's beneficial compounds - and can contribute to staving off dementia.

The latest here: 

Daily Coffee Consumption Associated With Healthier Metabolic Profile, Finnish Study Finds

Experts link hip stretches and fitness tests to healthy aging

 Did your competent? doctor get you recovered enough to do these? NO? So, PURE FUCKING INCOMPETENCE!

Experts link hip stretches and fitness tests to healthy aging

Experts link hip stretches and fitness tests to healthy aging

Hips and longevity: Hip flexibility supports posture, stride, and joint health, while mobility loss can accelerate decline.

Testing your fitness: Simple tests such as sitting-rising, balance stances, and timed walking can reveal functional capacity.

Daily movement plan: Stretching, strength work, and periodic self-assessments can help preserve independence as you age.

References

Tight hips? 6 seriously underrated stretches. | Outside
This is 1 stretch you should be doing more of as you age | HuffPost
Simple fitness test could offer clue about life expectancy in older adults | Daily Voice Westchester County, NY
Can you pass these 5 mobility tests every man should master? | Mens Fitness
I’m a personal trainer who works with seniors—these three moves can help protect your hips and spine | Fit&Well
Prolonged sitting causes hip flexor tightness

Extended periods of sitting can lead to tightness in the hip flexor muscles. This tightness is identified as a common physical issue linked to sedentary behavior.

References

Tight hips? 6 seriously underrated stretches. | Outside
This is 1 stretch you should be doing more of as you age | HuffPost
Hip flexor stretching counters tightness from prolonged sitting

Stretching the hip flexors helps to alleviate tightness that develops from extended periods of sitting. This tightness can negatively affect mobility and contribute to discomfort in the lower body. Regular stretching can mitigate these effects and support better movement patterns.

References

This is 1 stretch you should be doing more of as you age | HuffPost
Flexibility improves balance and joint health through better circulation

According to Gavin Hamer, maintaining flexibility enhances balance and supports joint health by promoting improved blood circulation.

References

Tight hips? 6 seriously underrated stretches. | Outside
This is 1 stretch you should be doing more of as you age | HuffPost
Flexibility routines support active lifestyle despite age-related changes

Regular flexibility exercises can help individuals maintain an active lifestyle even as they experience age-related physical changes.

References

Tight hips? 6 seriously underrated stretches. | Outside
This is 1 stretch you should be doing more of as you age | HuffPost

15 Biomarkers That May Predict SuperAger Brains by Super Age

 I don't care about any of these, I'm just going to get there. This just causes worry, which is useless!

15 Biomarkers That May Predict SuperAger Brains


Researchers Have Discovered 2 New Dementia Risk Factors. Here's What They Are

 Until we get EXACT PROTOCOLS this is almost useless, but great for conscience laundering for our medical 'professionals'!

Researchers Have Discovered 2 New Dementia Risk Factors. Here's What They Are

Strides have been made in the world of dementia research compared with even just a few years ago. There’s now a blood test that can diagnose Alzheimer’s accurately 90% of the time, and more is understood about the factors (many of which are lifestyle habits) that can put you at higher risk for the condition.

In a new dementia report published in The Lancet journal by researchers who are part of The Lancet Commission, two new modifiable risk factors have been identified: high cholesterol after 40 and untreated vision loss.

In 2020, these same researchers determined 12 modifiable risk factors that are known to put folks at higher risk of developing dementia. These are:

  1. Physical inactivity
  2. Smoking
  3. Excessive alcohol consumption
  4. Air pollution
  5. Head injury
  6. Infrequent social contact
  7. Less education
  8. Obesity
  9. Hypertension
  10. Diabetes
  11. Depression
  12. Hearing impairment

According to the report, these 12 factors, along with the two new ones, account for 49% of dementia cases across the world. Researchers determined these two new risk factors by looking at recent meta-analyses and studies on the topics; they looked at 14 papers on vision loss and 27 on high cholesterol. 

“It makes a lot of mechanistic sense,” said Dr. Arman Fesharaki-Zadeh, a behavioral neurologist and neuropsychiatrist at Yale Medicine in Connecticut. “A lot of these factors are very much interrelated.” (Fesharaki-Zadeh is not affiliated with the report.)

“There are many sources of vision loss, of course, but it tends to be a lot more common in folks who have metabolic risk factors such as high blood pressure, such as poorly controlled diabetes, such as high cholesterol, which is the other risk factor [identified in the report],” he said.

Health: This 1 Activity Is Great For Your Brain — And It's Extremely Simple To Do

Moreover, vision is our primary sensory organ — it’s how we process the world around us — and when you can’t see clearly, you’re less likely to spend time doing brain-boosting activities like puzzles, reading or even spending time with other people, said Fesharaki-Zadeh. And these activities are known to help prevent dementia.

When it comes to high LDL cholesterol (the so-called bad cholesterol), it can lead to the hardening of the blood vessels in the heart and brain, Fesharaki-Zadeh said, adding that high blood pressure and uncontrolled diabetes also affect the blood vessels.

This can make it more difficult for oxygen to get to the brain, which over time can lead to neuron damage — “and dementia is essentially an end product of the neurons dying out, so it’s a neurodegenerative process,” Fesharaki-Zadeh explained.

“I can’t tell you how often I see in our patient populations, especially folks above the age of 60, there are certain parts of the brain that are more vulnerable to damage ... and these are the areas that are especially vulnerable to hardening of blood vessels. Someone who has ... high cholesterol, the correlation between that and hardening of blood vessels is quite high, and we see it in our clinical setting very frequently as well.”

“The saying that I like to use with patients quite often is what affects your heart will affect your brain, and we see that time and time again,” the doctor said..

You can lower your risk. First, have a good medical team and primary care doctor.

“I cannot highlight the importance of a collaborative model between primary care physicians and specialties,” said Fesharaki-Zadeh. Having a primary care doctor who understands your health and is willing to share pertinent information with specialists, like cardiologists and neurologists, will help you stay on top of any issues putting your well-being at stake.

Your primary care doctor should also be proactively working to help you control the risk factors — like high cholesterol and high blood pressure — whether that’s through medication, diet or exercise.

Health: Research Suggests This 1 Annoying Illness Might Actually Help Protect You From COVID

Fesharaki-Zadeh said you and your doctor should focus on these lifestyle changes as early as possible, at least in midlife, not when you’re at the point when dementia starts to show up.

“The front line of medical care are primary care physicians. These are the folks that, by having early discussions ... can go a long distance to prevent the onset of dementia,” he explained.

There are also tests that can detect early signs of neurodegeneration and genetic markers of the disease. A primary care doctor can help you learn about these options.

“Up to 40% of dementias are potentially preventable,” he added, but it’s worth noting that dementia can also be genetic, which makes prevention trickier. But someone who is diagnosed with dementia or mild cognitive impairment can benefit from managing these risk factors, too.

Health: 'Rucking' Is The Walking Trend You Need To Try. Here's Why.

“The research is also showing that if you have two groups of individuals, someone who has comorbid metabolic diseases such as hypertension, high cholesterol, diabetes, versus somebody who doesn’t, and both of these individuals have dementia, the rates of progression of dementia in somebody who doesn’t have metabolic risk factors tend to be slower,” explained Fesharaki-Zadeh.

It’s never too late to make changes and corrections, he noted, whether you’re a young, seemingly healthy person, in your 80s or 90s, or someone who has already been diagnosed with dementia.

Our brains are highly malleable, Fesharaki-Zadeh said. So if you decide to make healthy lifestyle changes at any point, your brain will respond and be healthier for it.

This Coping Behavior Is Super Common Right Now — And It Says So Much About Where We Are As A Country

Read the original on HuffPost

Sunday, August 16, 2026

Novel LSD Formulation Significantly Improves Anxiety Symptoms

 

Anxiety EXISTS DIRECTLY BECAUSE OF THE FUCKING FAILURE OF YOUR DOCTOR TO NOT HAVE 100% RECOVERY PROTOCOLS!

Post stroke anxiety(20% chance).  

Novel LSD Formulation Significantly Improves Anxiety Symptoms

 Single-dose DT120 ODT achieved significant, sustained reductions in HAM-A anxiety scores vs placebo at week 12, with clinical efficacy observed as early as day 2.Positive topline data were announced from a phase 3 trial evaluating DT120 (lysergide) orally disintegrating tablets (ODT) in adults with generalized anxiety disorder (GAD).  DT120 ODT is a proprietary tartrate salt form of lysergide, a semi-synthetic psychedelic that acts as a partial agonist at serotonin-2A receptors. The randomized, double-blind, placebo-controlled, phase 3 Voyage trial (ClinicalTrials.gov Identifier: NCT06741228) evaluated the safety and efficacy of DT120 ODT in adults with GAD and a baseline Hamilton Anxiety Rating Scale (HAM-A) total score of 20 or greater.  Study participants (N=214) were randomly assigned to receive a single 100µg dose of DT120 ODT (n=107) or placebo (n=107) during a 12-week double-blind treatment period (Part A). Eligible participants were then allowed to transition into a 40-week open-label extension phase (Part B), during which up to 4 additional doses of the semi-synthetic psychedelic could be administered based on symptom severity.   The primary endpoint was the change from baseline in HAM-A total score at week 12. The total score ranges from 0 to 56, with higher scores indicating more severe symptoms.  Findings showed treatment with DT120 ODT significantly improved HAM-A total score from baseline compared with placebo at week 12 (least squares [LS] mean change, -11.6 vs -6.2; placebo-adjusted difference, -5.4; P <.0001; effect size, d =.81). Clinical improvement was seen starting from day 2 and was sustained throughout the double-blind treatment period.  Notably, at week 1, the LS mean change from baseline in HAM-A total score (key secondary endpoint) was -11.9 in the psychedelic treatment arm vs -4.2 in the placebo arm (placebo-adjusted difference, -7.7; P <.0001).  Patients treated with D120 ODT also demonstrated significantly greater improvements in Clinical Global Impression–Severity (CGI-S) Scale scores compared with placebo as early as day 2 (LS mean change, -1.0 vs -0.2; placebo-adjusted difference, -0.8; P <.0001) and maintained through week 12 (LS mean change, -1.0 vs -0.4; placebo-adjusted difference, -0.6; P <.0001). DT120 ODT was well tolerated, with no new safety signals observed. No suicidality signal or suicidal behavior was reported in Part A of the trial. “The unprecedented efficacy demonstrated in Voyage should raise the bar for what patients and clinicians expect from GAD treatments and reinforces our belief that DT120 has the potential to redefine care for the millions of patients in need,” said Rob Barrow, Chief Executive Officer of Definium Therapeutics. “Importantly, the consistent, large effect size we’ve now observed across three studies underscores the potential of DT120 to transform psychiatry and usher in a new era of mental health care.” DT120 ODT is also being evaluated in adults with GAD in the ongoing, 3-arm, phase 3 Panorama trial (ClinicalTrials.gov Identifier: NCT06809595).

References:

Definium Therapeutics announces positive topline results from phase 3 Voyage study of DT120 ODT in generalized anxiety disorder. News release. Definium. August 12, 2026. https://www.businesswire.com/news/home/20260812579720/en/Definium-Therapeutics-Announces-Positive-Topline-Results-from-Phase-3-Voyage-Study-of-DT120-ODT-in-Generalized-Anxiety-Disorder