Showing posts with label muscle atrophy. Show all posts
Showing posts with label muscle atrophy. Show all posts
Sunday, August 2, 2026
Friday, July 31, 2026
Scientists may have found a clue to prevent muscles from aging, study hints
Is your doctor and hospital competent enough to get human testing going and create protocols that will prevent your muscle atrophy? NO? So, PURE FUCKING INCOMPETENCE THEN!
Which means your board of directors is completely incompetent in not recognizing incompetence in their hospital! What are YOU going to do about that?
Scientists may have found a clue to prevent muscles from aging, study hints
Scientists may have found a way to rejuvenate key cells that help rebuild muscle in the body and thus preserve muscle into old age, they report in a new mouse study.
It is "really exciting stuff," Matthew Krause, a muscle physiologist at the University of Windsor in Ontario, said of the results. It could have clinical applications down the road if shown to work in humans, as well, added Krause, who was not involved in the research.
The body loses muscle with age and with chronic conditions that compromise people's mobility. To find a potential treatment for this muscle atrophy, the scientists behind the new study looked to "satellite cells." These stem cells are located around skeletal muscle fibers and play an important role in muscle regeneration.
Muscles incur microscopic damage with use, and this damage calls satellite cells into action. They proliferate to rebuild muscle fibers, by either merging into the torn muscle cells or forming new muscle cells. With age, satellite cells activate less efficiently and muscles become weak. But the new study, published July 24 in the journal Scientific Reports, suggests that it may be possible to rescue satellite cells from dormancy.
When muscles tear during exercise, a protein called hepatocyte growth factor (HGF) gets released. This is the signal that binds to receptors on satellite cells and activates them. Previously, studies from the same team showed that HGF works less well in old lab mice because its structure is chemically altered by a compound called peroxynitrite, and this makes it harder for HGF to plug into its receptor on satellite cells. This chemical alteration is known as nitration.
As a result, satellite cells cannot be activated efficiently to trigger muscle growth, even if the amount of HGF itself does not decline. Tatsumi and colleagues showed this in a previous study in rats.
In the new study, the scientists tested two compounds to see if they could counter this effect in lab mice. They used an experimental setup in which mice couldn't use their muscles as normal, so they weakened; such muscle disuse is known to increase HGF nitration around muscle cells.
Both of the tested compounds are known to protect proteins from damage caused by highly reactive chemicals by intercepting the reaction before it can take place. In experiments, the team treated HGF with each compound before exposing it to peroxynitrite. They found that, compared with untreated HGF, HGF treated with either compound showed substantially lower levels of nitration. This preserved its ability to activate satellite cells grown in lab dishes.
At high concentrations, one of the compounds — lipoic acid trisulfide (LASSS) — not only prevented nitration but also markedly increased HGF's ability to plug into its receptor. That suggests LASSS may chemically modify HGF in a way that could boost its effects.
To see if these observations carried over to living animals, the researchers gave lab mice LASSS in their drinking water. Although these were young mice, they were prevented from bearing weight on their hind limbs for five days, so they experienced short-term muscle disuse. Compared with untreated animals, the mice given LASSS had substantially lower HGF nitration around their muscle cells.
It's "pretty remarkable" that providing LASSS by mouth was sufficient to produce this effect, Krause said. He noted, however, that the researchers did not measure muscle atrophy or try administering LASSS to old mice to see the effects on the muscle. Longer experiments would be needed to observe those changes, he told Live Science.
The compound could also be tested in other forms of muscle wasting, Krause suggested. For example, severe chronic diseases like cancer can cause cachexia, a wasting syndrome marked by dramatic weight and muscle loss.
In general, protein nitration has been linked to several age-related disorders, including Alzheimer's disease, in which nitrated proteins accumulate in the brain. Understanding how to protect proteins from this kind of chemical damage could have implications beyond muscle biology, Tatsumi said.
However, further studies are still needed to assess the effectiveness and safety of LASSS in older animals. Experiments involving aging animals are expensive and can take a lot of time, Tatsumi said, but he is optimistic that this understanding will help address a range of age-related disorders with this same underlying biology.
"That is our big wish," he told Live Science. "I think, in the near future, we can do that."
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Thursday, July 9, 2026
Researchers Discover Biological Mechanism Behind Exercise and Healthier Aging Muscles
More reasons for your competent? doctor to have EXACT 100% RECOVERY PROTOCOLS! You don't want sarcopenia or muscle atrophy to occur.
Ask your doctor if 'Exercise-in-a-pill' (9 posts to May 2017) will also produce this benefit.
Researchers Discover Biological Mechanism Behind Exercise and Healthier Aging Muscles
And another article here:
Scientists discover why exercise reverses muscle aging
Wednesday, July 8, 2026
Pharmacological Effects of Urolithin A and Its Role in Muscle Health and Performance: Current Knowledge and Prospects
Ask your competent? doctor if this would prevent muscle atrophy post stroke. Doesn't know! You DON'T have a functioning stroke doctor if your doctor doesn't have a protocol to prevent muscle atrophy/sarcopenia!
Pharmacological Effects of Urolithin A and Its Role in Muscle Health and Performance: Current Knowledge and Prospects
Abstract
Urolithin A (UA) is a naturally occurring compound derived from the metabolism of gut microbiota, which has attracted considerable research attention due to its pharmacological effects and potential implications in muscle health and performance. Recent studies have demonstrated that Urolithin A exhibits diverse biological activities, encompassing anti-inflammatory, antioxidant, anti-tumor, and anti-aging properties. In terms of muscle health, accumulating evidence suggests that Urolithin A may promote muscle protein synthesis and muscle growth through various pathways, offering promise in mitigating muscle atrophy. Moreover, Urolithin A exhibits the potential to enhance muscle health and performance by improving mitochondrial function and regulating autophagy. Nonetheless, further comprehensive investigations are still warranted to elucidate the underlying mechanisms of Urolithin A and to assess its feasibility and safety in human subjects, thereby advancing its potential applications in the realms of muscle health and performance.
More at link.
Sunday, May 17, 2026
3 Physical Markers Beyond Blood Pressure That Can Predict Stroke Risk by mindbodygreen
Prior to my stroke I was high in all three.
3 Physical Markers Beyond Blood Pressure That Can Predict Stroke Risk
- Walking pace: Can you comfortably maintain a brisk pace (roughly 3 mph or faster) for 10 to 15 minutes? If you find yourself naturally slowing down or feeling winded quickly, it may be worth paying attention.(I can still do this)
- Grip strength: Notice if everyday tasks, like carrying groceries, opening bottles, and holding a bag, feel harder than they used to. Clinical assessments of grip strength use a special tool called a dynamometer, but functional changes in daily life are a reasonable signal.(My right hand has gotten even stronger, left hand, complete failure of my doctor and therapists to get any recovery there.)
- Muscle mass: Look for signs of sarcopenia like difficulty rising from a chair without using your arms, reduced stamina, or visible muscle loss in your legs and arms over time.(Getting out of couches and Adirondack chairs requires scooting to the edge to get my feet under me so when I push off with my right hand my weight is over my feet and I can easily stand. Stamina still pretty good, was able to keep up with a healthy tour group on the 9 days in Italy even being sick with bronchitis.)
Friday, May 15, 2026
Sleep Apnea Is Linked To A Surprising Change In Muscle Health by mindbodygreen
The one takeaway from this is your doctor doing a skeletal muscle index study so you get an objective view of your muscle atrophy/sarcopenia. Then your competent? doctor will have THE EXACT REHAB PROTOCOLS TO FIX THAT! Oh NO, you instead have an incompetent? doctor who has nothing! Fire them!
Sleep Apnea Is Linked To A Surprising Change In Muscle Health
Sunday, April 19, 2026
This Protein Is The Key To Turning Your Lifestyle Habits Into Muscle by mindbodygreen
Since your competent? doctor failed at getting you 100% recovered, you'll need this to prevent muscle atrophy. Good luck.
This Protein Is The Key To Turning Your Lifestyle Habits Into Muscle
If you've ever wondered how all of your dietary changes and exercise actually translates to muscle growth, new research offers an answer. Scientists have identified a single protein that's activated by both intermittent fasting and exercise, and it appears to be essential for healthy muscle cell development.
The protein is called PICALM (phosphatidylinositol-binding clathrin assembly protein), and according to a study published in Molecular Metabolism(\1, it may be a key molecular link between lifestyle interventions and muscle health. What is PICALM why does it matter
PICALM is what scientists call a "clathrin adaptor protein." In plain terms, it helps cells internalize and recycle proteins at their surface, a process called clathrin-mediated endocytosis. Think of it this way: Your cells need to constantly bring in nutrients, signaling molecules, and other materials from outside. PICALM helps coordinate this cellular intake process. In muscle cells specifically, this function appears critical for proper development and differentiation into mature, functional muscle fibersHow fasting exercise both boost PICALM
Researchers at the German Institute of Human Nutrition set out to identify common molecular factors that respond to both exercise and diet-based interventions for diabetes prevention. They analyzed skeletal muscle from mice subjected to three different lifestyle interventions:Time-restricted feeding (TRF): Eating only during specific hours Alternate-day fasting (ADF):Alternating between eating and fasting daysExercise training:Progressive treadmill training over four weeks. Lean muscle meets smarter metabolism.*In all three intervention groups, scientists found that PICALM was significantly up-regulated compared to controls. The researchers also examined human data. In a cohort of 25 overweight or obese participants, PICALM expression increased in skeletal muscle in every single participant after an aerobic exercise session. The fact that PICALM increased in all 25 human participants after exercise suggests these findings translate beyond mouse models.What happens when PICALM is switched off
To understand PICALM's role in muscle development, the researchers used a technique called siRNA knockdown to deplete PICALM in muscle cells. Here's what the scientists found when PICALM wasn't activated:Picalm-depleted cells couldn't properly develop into mature muscle fibers. Expression of the genes that drive muscle development was significantly reduced. The cells showed an impaired ability to form the fibers that make up functional muscle tissue.How PICALM supports muscle development
So how exactly does PICALM influence muscle cell development? The researchers found it comes down to two interconnected processes: endocytosis and actin remodeling. When PICALM was depleted, cells accumulated over 100 proteins at their surface that should have been internalized. This included proteins involved in: Vesicular trafficking – how cells move materials internally Actin remodeling – how cells reorganize their structural framework Cell adhesion – how cells attach to their surroundings If you've ever wondered how all of your dietary changes and exercise actually translates to muscle growth, new research offers an answer. Scientists have identified a single protein that's activated by both intermittent fasting and exercise, and it appears to be essential for healthy muscle cell development. The protein is called PICALM (phosphatidylinositol-binding clathrin assembly protein), and according to a study published in Molecular Metabolism, it may be a key molecular link between lifestyle interventions and muscle health.What is PICALM why does it matter
PICALM is what scientists call a "clathrin adaptor protein." In plain terms, it helps cells internalize and recycle proteins at their surface, a process called clathrin-mediated endocytosis. Think of it this way: Your cells need to constantly bring in nutrients, signaling molecules, and other materials from outside. PICALM helps coordinate this cellular intake process. In muscle cells specifically, this function appears critical for proper development and differentiation into mature, functional muscle fibers.How fasting & exercise both boost PICALM
Researchers at the German Institute of Human Nutrition set out to identify common molecular factors that respond to both exercise and diet-based interventions for diabetes prevention. They analyzed skeletal muscle from mice subjected to three different lifestyle interventions: Time-restricted feeding (TRF): Eating only during specific hours Alternate-day fasting (ADF): Alternating between eating and fasting days Exercise training: Progressive treadmill training over four weeks In all three intervention groups, scientists found that PICALM was significantly up-regulated compared to controls. The researchers also examined human data. In a cohort of 25 overweight or obese participants, PICALM expression increased in skeletal muscle in every single participant after an aerobic exercise session. The fact that PICALM increased in all 25 human participants after exercise suggests these findings translate beyond mouse models.What happens when PICALM is switched off
To understand PICALM's role in muscle development, the researchers used a technique called siRNA knockdown to deplete PICALM in muscle cells. Here's what the scientists found when PICALM wasn't activated: Picalm-depleted cells couldn't properly develop into mature muscle fibers. Expression of the genes that drive muscle development was significantly reduced. The cells showed an impaired ability to form the fibers that make up functional muscle tissue.How PICALM supports muscle development
So how exactly does PICALM influence muscle cell development? The researchers found it comes down to two interconnected processes: endocytosis and actin remodeling. When PICALM was depleted, cells accumulated over 100 proteins at their surface that should have been internalized. This included proteins involved in:Vesicular trafficking – how cells move materials internally Actin remodeling – how cells reorganize their structural framework Cell adhesion – how cells attach to their surroundings The actin connection proved particularly important. When researchers treated PICALM-depleted cells with a compound that stabilizes actin filaments, the cells' ability to develop into muscle fibers was restored.What this means for your fasting & fitness routine
This research provides molecular evidence for something many in the wellness world have long suspected: both intermittent fasting and exercise support muscle health. But, there are some important things to think about when it comes to fasting and your fitness routine. Fasting doesn't necessarily mean muscle loss. The finding that intermittent fastingmupregulates a protein essential for muscle development challenges the notion that fasting is inherently bad for muscle tissue. Exercise and fasting may be complementary. Since both interventions activate PICALM, combining time-restricted eating with regular exercise could potentially amplify benefits for muscle health. Fasting shouldn't interfere with getting your macronutrients. While fasting does have it's benefits, it's important that you are eating enough hours of the day that you can get in all the protein, fiber and other important nutrients you need. One caveat to mention here: intermittent fasting isn't always the best for women. Women’s bodies rely on a fine-tuned system of hormones that work together to maintain a regular menstrual cycle. This system is highly responsive to stress signals, and intense exercise combined with prolonged fasting can be read by your body as a stress event, which can mess with your hormones. This doesn't mean intermittent fasting is inherently bad, just that it's important to pay attention to any major changes that happen in your body if you begin fasting. And if you notice concerning symptoms, like fatigue, irritability, brain fog, and changes to your menstrual cycle, that might mean intermittent fasting isn't the right choice for you.The takeaway
It's worth noting that this research focused on the molecular and cellular level. The researchers didn't measure actual muscle mass or strength outcomes in humans. But it does provide a compelling biological rationale for why these lifestyle interventions may support muscle health. So if you're looking to build up your muscle, this study shows us that exercise and some form of fasting are a good place to start.Thursday, February 26, 2026
Daily Peanut Butter Intake Linked to Improved Muscle Strength in Older Adults: Study
You're already at an elevated risk for sarcopenia. Will your competent? doctor determine if plain peanuts are better? The "bad" components in many commercial peanut butters include added sugars (like corn syrup), hydrogenated vegetable oils (trans fats), palm oil, and high sodium levels.
Daily Peanut Butter Intake Linked to Improved Muscle Strength in Older Adults: Study
Wednesday, December 10, 2025
Scientists Reveal Exactly How Long You Need to Lift Weights to Gain Muscle
Have your competent? doctor objectively measure your muscle atrophy so you can use the EXACT PROTOCOLS TO BUILD THAT MUSCLE BACK. Oh, your doctor has nothing and will do nothing! Too bad, your doctor gets paid regardless of them not getting you recovered!
Scientists Reveal Exactly How Long You Need to Lift Weights to Gain Muscle
Korin Miller
5 min read
Scientists Reveal Exactly How Long You Need to Lift Weights to Gain Muscle"Hearst Magazines and Yahoo may earn commission or revenue on some items through these links."
New research suggests you can get noticeable muscle gains from shorter strength training sessions.
Researchers found that lifting for just 30 minutes, twice a week, helped people increase their muscle mass.
The lifting routine is not overly complicated, either.
A
wave of research over the past few years has made it clear that a
strength training habit is really important for your health. New
research suggests that you don’t need to spend every day grinding it out
at the gym to see results. In fact, researchers found that you can gain
muscle in as little as 30 minutes of weight training.
Meet the experts: Albert Matheny, R.D., C.S.C.S., co-founder of SoHo Strength Lab; Brad Schoenfeld, Ph.D., study co-author and a professor in exercise science at Lehman College in the Bronx, NY; Luke Pryor, Ph.D., C.S.C.S., clinical associate professor in the Department of Exercise and Nutrition Sciences at University at Buffalo
But it’ll take more than one quick dumbbell lifting session to see results. Here’s what the study found, plus how to maximize your results when you lift weights.
What did the study find?
The small study, which was published in Medicine & Science in Sports & Exercise, had 42 healthy men and women follow a lifting program with one set of eight to 10 reps for each exercise that was either train to failure (pushing yourself until you can’t do more reps with the right form) or leaving reps in reserve (pushing themselves but still having energy to do more).
The participants cycled through nine exercises that targeted major muscle groups twice a week for eight weeks. Each session was done in 30 minutes. Afterward, the researchers analyzed them for changes in muscle thickness in select areas of the body, as well as measures of muscle strength, power, and endurance.
The
researchers discovered that all of the participants had muscles that
were bigger and stronger than they were at the beginning of the program.
But the changes were similar in men and women who pushed themselves
until they couldn’t do more reps (train to failure) with the right form
or those who still had energy to do more (reps in reserve).
Why might just 30 minutes of weightlifting help?
The Centers for Disease Control and Prevention (CDC) currently recommends that people do two days of “muscle-strengthening activity” a week, along with at least 150 minutes of moderate-intensity physical activity. But the CDC also notes that just over 24% of adults actually hit both of those goals.
The idea of squeezing in two 30-minute lifting sessions a week seems doable, and it is, according to Albert Matheny, R.D., CSCS, co-founder of SoHo Strength Lab. “I repeat this often: It doesn’t have to be the most to have a benefit,” he says. “There is a law of diminishing returns.”
But the study participants also didn’t slack off on their workouts. “In our study, the workouts were sufficiently hard to challenge the participants’ muscles beyond their present capacity,” says Brad Schoenfeld, Ph.D., study co-author and a professor in exercise science at Lehman College in the Bronx, NY. “This is key to making continued muscular gains.”
There’s a lot that happens in your body when you lift, including the release of hormones, metabolic stress (which disrupts the muscle’s usual state and can cause it to grow), muscle strain, and molecular signaling in the muscle, explains Luke Pryor, Ph.D., C.S.C.S., clinical associate professor in the Department of Exercise and Nutrition Sciences at University at Buffalo. Even shorter sessions will tap into all of these.
Pryor says these shorter sessions have less recovery time, like one to two minutes. “By shortening the recovery time, it drives up metabolic stress,” he says. Cue the muscle growth.
Pryor notes that the study was done on people who already did resistance training, which suggests that even people who are already fit can gain muscle from this approach. “These shorter sessions are really effective for those who are sedentary, but this shows that even in folks who have been exercising for a number of nears, you can still maintain or even grow skeletal muscle in these shorter sessions,” he says.
Why does this matter?
There are a lot of perks to strength training beyond looking fit. Not only will it make you physically stronger, but research also suggests that a lifting habit will help increase bone density, an important area of health to focus on as you age.
“There are also links to longevity and hormonal improvements,” Matheny says. Strength training can even increase your metabolism, he points out.
“Resistance training has a plethora of benefits for almost all organ systems,” Schoenfeld says. “This includes improved ability to carry out tasks of everyday living, enhanced metabolic function, better cardiovascular health, better mental health, and greater injury resistance, among others.”
How to maximize your weightlifting time
If you’re interested in starting a lifting routine, Matheny suggests giving yourself a little extra time at first to figure out what you’re doing. “You have to work a bit to figure out the right weight to get the most out of each exercise,” he says.
The study specifically had participants cycle through these exercises:
Front lat pull-down
Seated cable row
Shoulder press
Chest press
Cable triceps pushdown
Supinated dumbbell biceps curl
Smith machine squats
Leg press
Leg extension
But Matheny recommends focusing on major muscle groups for your lifting routine. “A lot of times these studies incorporate tricep-related things because they’re easier to measure, but larger, multi-joint muscle exercises are best,” he says. Pryor agrees. “You want to do exercises that recruit a lot of muscle,” he says.
Matheny recommends focusing on moves like these that target several muscle groups at once to get the biggest results:
Pushups
Squats
Lunges
Deadlifts
Pullups
Schoenfeld also suggests keeping the time between sets to under two minutes to really maximize your time. But he recommends choosing exercises that will help you reach your goals. “Ultimately, personal choice should dictate which exercises you select,” he says.
Of course, doing any strength training is better than none, and you may not even need to set aside 30 minutes. “You can even get results with 20-minute sessions,” says Pryor.
Wednesday, November 26, 2025
The relationship between stroke-related sarcopenia and 3-month neurological outcome in stroke patients: a prospective cohort study
Your doctor is completely incompetent if sarcopenia prevention protocols don't exist!
The relationship between stroke-related sarcopenia and 3-month neurological outcome in stroke patients: a prospective cohort study
Abstract
Background
Sarcopenia was initially defined as an age-related decline in muscle mass and function. As sarcopenia has been observed at any age and secondary to many diseases, extending the classical meaning of sarcopenia beyond the age-related phenomenon to the ‘disease-related’ sarcopenia has been debated recently. Stroke-related sarcopenia occurs secondary to the brain injury and is age-independent, potentially worsening patients’ neurological outcomes. We aimed to explore the relationship between stroke-related sarcopenia and 3-month neurological outcome in stroke patients, as well as to evaluate the predictive value of the two main indicators of stroke-related sarcopenia—muscle mass and muscle strength—for adverse neurological outcomes.
Methods
A single-centre prospective cohort study of 228 individuals with ischaemic stroke who were admitted for routine rehabilitation treatment, followed up for neurological outcome for 3 months following the onset of the stroke. The muscle mass was expressed by the ratio of appendicular skeletal muscle mass (ASM) to height (Ht) (ASM/Ht2), and the muscle strength was assessed by the grip strength. The neurological outcome was assessed using modified Rankin Scale (mRS) scores three months after the stroke. Statistical analyses, including correlation coefficient tests, multivariate regression analyses, and receiver operating characteristic (ROC) analyses, were applied in this study.
Results
The prevalence of sarcopenia was 28.9% in all included patients. Compared with the good outcome group, the poor outcome group showed a significantly lower level of ASM/Ht2, grip strength, and a higher level of mRS scores (all P < 0.05). Both ASM/Ht2 and grip strength were associated with mRS scores (r = -0.549 and − 0.592, respectively; both P < 0.01). Both ASM/Ht2 and grip strength were independent protective factors for the neurological outcome (OR = 0.525 [0.399–0.690] and 0.684 [0.605–0.773], respectively; both P < 0.01). The AUCs of grip strength and ASM/Ht2 were 0.884 and 0.833, respectively. The optimal cutoff values for grip strength to predict neurological outcome in the total patients, the male patients, and the female patients were 18.66, 26.69, and 18.66, respectively, with sensitivities of 79.10%, 90.48%, and 95.65% and specificities of 90.68%, 72.04%, and 77.94%, respectively. The optimal cutoff values for ASM/Ht2 to predict neurological outcome in the total population, the male patients, and the female patients were 6.01, 6.19, and 6.01, respectively, with sensitivities of 85.07%, 71.43%, and 93.48% and specificities of 73.91%, 86.02%, and 54.41%, respectively.
Conclusions
Stroke-related sarcopenia is closely related to worse neurological function at the convalescence stage. Higher ASM/Ht2 and grip strength at baseline were independent protective factors for neurological outcomes. ASM/Ht2 and grip strength could be of superior predictive value for neurological outcomes, with different weights and gender differences in their predictive efficacy.
Sunday, November 23, 2025
Effect of Neuromuscular Electrical Stimulation on Muscle Atrophy in Patients with Acute Stroke: A Randomized Controlled Trial
Of course, your competent? doctor put together EXACT PROTOCOLS ON NMES USE YEARS AGO, RIGHT? Too bad, your doctor is incompetent and still gets paid for not getting you fully recovered! Let's check on how long your doctor and hospital have been incompetent!
Effect of Neuromuscular Electrical Stimulation on Muscle Atrophy in Patients with Acute Stroke: A Randomized Controlled Trial
ABSTRACT
Objectives:
This study aimed to assess the effectiveness of neuromuscular electrical stimulation (NMES) in reducing muscle atrophy in patients with acute stroke.
Methods:
In acute stroke patients with hemiparesis, NMES or control treatment was applied to the quadriceps muscles for 2 weeks. The change of the quadriceps muscle thickness was assessed using ultrasound after 2 weeks.
Results:
Sixty-three patients were randomized to control treatment or NMES treatment. On the paretic side, muscle thickness changed by −2.65 ± 4.24 mm in the NMES group and −4.64 ± 4.58 mm in the control group (P=0.119). On the non-paretic side, the respective changes were −0.42 ± 5.19 mm and −1.93 ± 3.36 mm (P=0.223). In an exploratory subgroup analysis, no significant effect was observed in severely affected patients, whereas patients with mild-to-moderate stroke (National Institute of Health Stroke Scale score <12, n=23) showed a smaller reduction in quadriceps thickness on the paretic side in the NMES group compared with controls (0.00 ± 3.21 mm vs. −3.88 ± 5.11 mm, P=0.043). These exploratory subgroup findings should be regarded as hypothesis-generating.
Conclusions:
This underpowered trial did not demonstrate a significant preventive effect of 2 weeks of NMES on quadriceps atrophy in patients with acute stroke. Exploratory subgroup findings suggest a potential benefit in patients with less severe stroke, but these results should be considered hypothesis-generating and require confirmation in future adequately powered trials.
Thursday, October 30, 2025
A Simple Way to Prevent Muscle Loss, According to New Study
You are at high risk for muscle loss/sarcopenia post stroke. What is your doctor's EXACT PROTOCOL TO PREVENT THAT? Doesn't have a protocol, COMPLETE FUCKING INCOMPETENCE!
Here's let's prove that incompetence with research just below!
The latest here for your doctor to ignore also:
A Simple Way to Prevent Muscle Loss, According to New Study
New science shows your gut [mahy-kroh-bahy-ohm]nounThe community of microorganisms (bacteria, viruses, fungi) living in a particular environment, especially the gut.Learn More[mahy-kroh-bahy-ohm]nounThe community of microorganisms (bacteria, viruses, fungi) living in a particular environment, especially the gut.Learn More directly influences muscle strength, power, and long-term vitality, making nutrition and training inseparable.
We say it all the time: you have more power than you realize to shape your future. And when it comes to [lon-jev-i-tee]nounLiving a long life; influenced by genetics, environment, and lifestyle.LEARN MORE, strength is non-negotiable.
A new editorial in Frontiers in Sports and Active Living echoes this truth, arguing that building and maintaining muscle during midlife is one of the most important investments you can make for your long-term [helth-span]nounThe number of years you live in good health, free from chronic illness or disability.LEARN MORE.
The editorial, authored by UK researchers, focuses on the rising threat of [sar-koh-pee-nee-uh]nounAge-related loss of muscle mass and strength.LEARN MORE, which is the gradual loss of [muh-suhl mas]nounThe total weight of muscle in your body, critical for longevity.LEARN MORE, strength, and function with age. While many associate sarcopenia with the elderly, the authors argue that its roots are planted much earlier and that proactive strategies in middle age can dramatically change the trajectory of healthspan.
“The physiological decline in skeletal muscle mass, strength, and quality is not exclusively a phenomenon of older age,” the authors write. “In fact, changes in muscle function and metabolism can begin as early as the fourth decade of life.”
In other words, if you’re in your 40s or 50s, you are in a critical phase that can either set you up for decades of vitality or begin a silent decline that will only become obvious years later.
Why Building Muscle Now Protects Your Health for Decades
Skeletal muscle is a metabolic powerhouse, playing a major role in glucose regulation, fat storage, and energy regulation. Loss of muscle mass is strongly associated with chronic diseases like type 2 diabetes, cardiovascular disease, osteoporosis, and cognitive decline.
Preserving muscle isn’t just about building mass; it’s also about supporting muscle quality. Muscle becomes infiltrated with fat and connective tissue over time, decreasing its functional capacity even if mass is preserved. That’s why focusing on both strength and power, meaning the ability to generate force quickly, is essential.
Preserving muscle isn’t just about building mass; it’s also about supporting muscle quality.”
The authors emphasize that resistance training, also known as [strength tray-ning]nounResistance-based exercise to build muscle and support healthy aging.LEARN MORE, is an essential component of sarcopenia prevention. Not cardio alone. Not yoga alone. “The inclusion of high-velocity resistance training (power training) has been proposed to counteract the rapid decline in muscle power with age,” they note.
The Gut-Muscle Axis: How Your Gut Health Shapes Strength
One of the most exciting insights discussed in the editorial is the emerging understanding of the gut-muscle axis. Your gut microbiome, those trillions of bacteria living in your digestive system, plays a direct role in muscle health.
In fact, your muscles and your gut are in constant conversation. Strong muscles help support a healthy, diverse gut microbiome, and in return, a healthy gut helps your body build and maintain muscle.
“Gut microbiota composition influences systemic [in-fluh-mey-shuhn]nounYour body’s response to an illness, injury or something that doesn’t belong in your body (like germs or toxic chemicals).LEARN MORE, [in-suh-lin sen-si-tiv-i-tee]nounHow effectively your body uses insulin, which regulates blood sugar levelsLEARN MORE, and nutrient metabolism, all of which are critical for muscle maintenance,” the authors note.
A healthy, diverse microbiome supports better protein absorption, reduces muscle-degrading inflammation, and even promotes mitochondrial function inside muscle cells. Disruptions to the microbiome (through poor diet, stress, or antibiotics) can worsen muscle decline.
New research continues to strengthen this connection. A 2025 study published in Frontiers in Nutrition analyzed data from nearly 9,500 adults and found a clear link between gut-friendly diets and muscle preservation.
Researchers used a framework called the Dietary Index for Gut Microbiota (DI-GM), which evaluates how much a person’s diet supports a healthy gut microbiome. The DI-GM scores specific foods and nutrients based on how whether they support gut health or not (See: The 10 Foods That Strengthen Your Microbiome and Help You Age Slower).
How Your Microbiome Supports Muscle Health
- Miscrobiome-Supporting foods Decrease Muscle Loss: Each one-point increase in DI-GM score was associated with a 15% lower risk of sarcopenia. Those with the highest DI-GM scores had a 51% lower prevalence of sarcopenia compared to the group with the lowest scores.
- Inflammation-Causing Foods Increase Muscle Loss: Conversely, diets higher in inflammation-causing foods, measured by the Dietary Inflammatory Index (DII) ,were linked to a 28% higher risk of sarcopenia.
Even more compelling, the researchers found that over half of the protective effect of a gut-friendly diet on muscle strength could be explained by reducing systemic inflammation.
In short: Eating to support your gut microbiome is a powerful way to protect your muscles as you age.
The Best Way to Eat Protein for Muscle Growth
While diet plays a critical role in muscle maintenance, nutrition alone isn’t enough.
Muscle protein synthesis declines with age, meaning you’ll need higher protein intake in order to induce an anabolic (muscle-building) state. However, simply eating more protein without pairing it with resistance training “produces minimal impact,” says the researchers.
Protein supplementation without strength training won’t prevent sarcopenia.”In fact, a recent study found that high-protein diets alone had limited effects on muscle mass and strength in physically active middle-aged adults. The message is clear: Protein supplementation without strength training won’t prevent sarcopenia. The true formula for midlife muscle health is integrated.
The Formula For Building (and Keeping) Quality Muscle
This approach creates a continuous, low-grade anabolic environment, supporting stronger, more resilient muscles over time. Incorporate progressive resistance training at least 2–3 times per weekThrough smart strength training, conscious nutrition, and care for your gut health, you can rebuild and future-proof your body for the decades ahead.
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