Neuroplasticity, Neuroregeneration, and Brain Repair

Your doctor should be able to get some takeaways from this conference to update your stroke recovery protocol to 100% recovery. If 100% recovery is not your doctors goal for you then you have a fucking incompetent asshole for a doctor.
http://www.nyas.org/Events/Detail.aspx?cid=f42ad038-6416-4c56-a12a-9782725d3f57
June 13 - 14, 2017
The New York Academy of Sciences
Presented by Eli Lilly and Company and the New York Academy of Sciences

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  May 01, 2017
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  April 17, 2017
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  April 17, 2017
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Strategies to stimulate neuroregeneration and neurorestoration hold promise to vastly improve the treatment of a range of neurological diseases and injuries, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), spinal cord injury, and multiple sclerosis (MS). While progress has been made in understanding the cellular mechanisms of these processes, more research is needed in order to translate this knowledge into more effective treatments that restore function to the central nervous system.
This 2-day convening will bring together leading researchers, clinicians, industry, and governmental stakeholders from around the world to explore neuroregenerative processes and identify strategies for translating knowledge into treatments for neurodegenerative diseases and nervous system injuries. Plenary sessions will be designed to present emerging basic and clinical research in the following areas: neurodegenerative disease-modifying therapies that slow progression; mechanisms of neuroplasticity, including the role of dendritic spines, axonal growth, synaptic plasticity, inflammation, oxidative stress, mitochondrial function, and autophagy; glial function in the central nervous system; cutting-edge strategies to promote and modify neurogenesis; and biomarker and imaging modalities for neuroregeneration. The conference will conclude with an interactive panel discussion exploring future directions, critical open questions, and promising therapies in the field of neuroregeneration and neurorestoration.

Clinical cell therapy guidelines for neurorestoration (China version 2016)

What will your doctor take from this to get you closer to 100% recovery? You and your doctors' goal is 100% recovery? Isn't it?  If not you need your doctor to be fired.
https://www.dovepress.com/articles.php?article_id=31288

Authors Huang H, Chen L, Zou Q, Han F, Sun T, Mao G, He X
Received 25 June 2016
Accepted for publication 24 August 2016
Published 13 February 2017 Volume 2017:5 Pages 39—46
DOI https://doi.org/10.2147/JN.S115756
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Amy Norman
Peer reviewer comments 3
Editor who approved publication: Prof. Dr. Hari Shanker Sharma

Hongyun Huang,¹ Lin Chen,² Qingyan Zou,³ Fabin Han,⁴ Tiansheng Sun,⁵ Gengsheng Mao,¹ Xijing He<sup>6

1</sup>Institute of Neurorestoratology, General Hospital of Armed Police Forces, ²Department of Neurosurgery, Yuquan Hospital, Tsinghua University, Beijing, ³Guangdong 999 Brain Hospital, Guangzhou, ⁴Centre for Stem Cells and Regenerative Medicine, Affiliated Hospital of Taishan Medical University, Liaocheng, Shandong, ⁵Department of Orthopedics, Beijing Army General Hospital, Beijing, ⁶Second Department of Orthopedics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China

On behalf of the Chinese Association of Neurorestoratology and Chinese Branch of the International Association of Neurorestoratology


Abstract: Cell therapy has been shown to be a key clinical therapeutic option for central ­nervous system disease or damage, and >30 types of cells have been identified through preclinical studies as having the capacity for neurorestoration. To standardize the clinical procedures of cell therapy as one of the strategies for treating neurological disorders, the first set of guidelines governing the clinical application of neurorestoration was completed in 2011 by the Chinese Branch of the International Association of Neurorestoratology. Given the rapidly advancing state of the field, the Neurorestoratology Professional Committee of Chinese Medical Doctor Association (Chinese Association of Neurorestoratology) and the Chinese Branch of the International Association of Neurorestoratology have approved the current version known as the “Clinical Cell Therapy Guidelines for Neurorestoration (China Version 2016)”. We hope this guideline will reflect the most recent results demonstrated in preclinical research, transnational studies, and evidence-based clinical studies, as well as guide clinical practice in applying cell therapy for neurorestoration.

Keywords: cell therapy, neurorestoration, China, clinical application

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

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Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke

This would seem to be useful for our recovery, so DEMAND your doctor create a stroke protocol to help this out. Your doctor should be doing something useful to help your recovery, instead of just sitting on their ass. 

Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke

• Zhongwu Liu^{a, ,} ,
• Michael Chopp^{a, b}

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doi:10.1016/j.pneurobio.2015.09.008

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Highlights

•

Astrocytes play essential roles in maintaining normal brain function.

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Astrocytes perform multiple functions both detrimental and beneficial on neurological recovery after stroke.

•

These detrimental and beneficial effects of astrocytes designate astrocytes as a promising therapeutic target for neuroprotection and neurorestoration.

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Abstract

Astrocytes are the most abundant cell type within the central nervous system. They play essential roles in maintaining normal brain function, as they are a critical structural and functional part of the tripartite synapses and the neurovascular unit, and communicate with neurons, oligodendrocytes and endothelial cells. After an ischemic stroke, astrocytes perform multiple functions both detrimental and beneficial, for neuronal survival during the acute phase. Aspects of the astrocytic inflammatory response to stroke may aggravate the ischemic lesion, but astrocytes also provide benefit for neuroprotection, by limiting lesion extension via anti-excitotoxicity effects and releasing neurotrophins. Similarly, during the late recovery phase after stroke, the glial scar may obstruct axonal regeneration and subsequently reduce the functional outcome; however, astrocytes also contribute to angiogenesis, neurogenesis, synaptogenesis, and axonal remodeling, and thereby promote neurological recovery. Thus, the pivotal involvement of astrocytes in normal brain function and responses to an ischemic lesion designates them as excellent therapeutic targets to improve functional outcome following stroke. In this review, we will focus on functions of astrocytes and astrocyte-mediated events during stroke and recovery. We will provide an overview of approaches on how to reduce the detrimental effects and amplify the beneficial effects of astrocytes on neuroprotection and on neurorestoration post stroke, which may lead to novel and clinically relevant therapies for stroke.

Clinical neurorestorative progress in traumatic brain injury

Which of these therapies mentioned can also be used in stroke? Does your doctor know anything about this?
http://www.dovepress.com/articles.php?article_id=20957

Authors Huang H, Chen L, Huang H
Published Date March 2015 Volume 2015:3 Pages 57—62
DOI http://dx.doi.org/10.2147/JN.S74486
Received 30 September 2014, Accepted 26 November 2014, Published 20 March 2015
Approved for publication by Prof. Dr. Hari Shanker Sharma

Huiling Huang,¹ Lin Chen,^2,3 Hongyun Huang<sup>4–6

1</sup>Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, Tianjin Neurosurgical Institute, Tianjin, People's Republic of China; ²Medical Center, Tsinghua University, Beijing, People's Republic of China; ³Tsinghua University Yuquan Hospital, Beijing, People's Republic of China; ⁴General Hospital of Chinese people's Armed Police Forces, ⁵Beijing Rehabilitation Hospital of Capital Medical University, Beijing, People's Republic of China; ⁶Beijing Hongtianji Neuroscience Academy, Beijing, People's Republic of China

Abstract: Traumatic brain injury (TBI) is a leading cause of death and disability from trauma to the central nervous system. Besides the surgical interventions and symptomatic management, the conventional therapies for TBI and its sequelae are still limited. Recently emerging evidence suggests that some neurorestorative treatments appear to have a potential therapeutic role for TBI and improving the patient's quality of life. The current clinical neurorestorative strategies available in TBI include pharmacological treatments (recombinant human interleukin-1 receptor antagonist, amantadine, lithium, and valproate), the neuromodulation treatments (repetitive transcranial magnetic stimulation, transcranial direct current stimulation, and low-level laser therapy), cell transplantation (bone marrow stromal cells and umbilical cord stromal cells), and combined neurorehabilitation. In this review, we summarize the recent clinical neurorestorative progress in the management of neurodegeneration as well as cognitive and motor deficits after TBI; indeed further clinical trials are required to provide more robust evidence.

NEURORESTORATIVE process law and mechanisms

This 8 page paper attempts to pull together all the various mechanisms of brain repair. It failed miserably and just became word salad. The idea was good but the execution didn't work.
http://www.dovepress.com/getfile.php?fileID=23541
Hongyun Huang,^1–3 Lin Chen<sup>3–5

1</sup>General Hospital of Armed Police Forces, ²Beijing Rehabilitation Hospital of Capital Medical University, ³Beijing Hongtianji Neuroscience Academy, ⁴Tsinghua University Yuquan Hospital, ⁵Medical Center, Tsinghua University, Beijing, People's Republic of China

Abstract: Neurorestoration, or restoration of neurological function, can be achieved by different strategies through a series of neurorestorative mechanisms, including neuroprotection, neuromodulation, neuroplasticity, immunomodulation, axonal regeneration and sprouting, remyelination or neurorepair, neuroregeneration or neurogenesis, and neuroreplacement. Unfortunately, these mechanisms have been studied and viewed in isolation. The aim of this review is to generalize all attacking insults and restoring mechanisms as a complete neurorestorative process, then analyze the changing process of dynamic interaction between neural insults and restorative mechanisms, and highlight neurorestorative law, ie, “smaller or larger self-restoration always occurs by nature while facing insults, active and appropriate medical intervention is able to better restore functions and/or structures”. This review also briefly describes several important neurorestorative mechanisms.