Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, January 31, 2022

The Best Exercises for Brain Health, According to a Neuroscientist

 Your doctor is responsible for getting you recovered enough to do these exercises.

The Best Exercises for Brain Health, According to a Neuroscientist

·7 min read
Woman exercising on a designed background

Getty Images / jacoblund

An estimated 40% of people ages 65 and older experience some degree of age-related cognitive decline. In the U.S. alone, that equates to approximately 21 million people. Whether you are over 65 and concerned about age-related memory loss or are simply looking to implement measures to improve cognition, research overwhelmingly shows that exercise is one of the most important daily habits to include to prevent cognitive decline.

Here neuroscientist Ebony Glover, Ph.D., weighs in on why daily exercise may be the most important thing we can do to reduce age-related cognitive decline and improve brain function. We also take a deeper look into how exercise impacts the brain, which types of exercise to include and how much exercise we should be getting for the greatest brain-health boost.

How Exercise Improves Brain Health

We often think of exercise as something that we should do purely for our physical health and to improve our heart, muscles or bones. However, as scientists continue to learn more about the ways that exercise benefits the body, they've also uncovered overwhelming evidence that it is essential to maintain the health of the brain.

Glover explains that physical exercise can lead to improvements in cognition not only by protecting the brain, but also through a process called neurogenesis, where new neurons are formed in the brain. "Physical activity appears to lead to neurogenesis, neuroprotection and cognitive improvements, primarily through the production of chemicals called neurotrophins."

Neurotrophins are proteins that act as growth factors within our central and peripheral nervous systems to regulate cell maintenance and function. In addition to the role neurotrophins play in brain cell maintenance, Glover shares that they are also important in promoting new cell growth in the brain: "Neurotrophins are critical for the development and maintenance of new brain cells. Exercise can generate and protect new neurons, and increase the volume of brain structures, leading to overall improved cognition and health in general."

For those looking for ways to prevent or reverse age-related cognitive decline, these findings are especially exciting. Glover explains that the volume of the brain naturally decreases with age, due to the reduction in the size of individual brain cells and a decrease in the number of connections between them. These reductions lead to subtle declines in cognitive function over time.

Exercise combats this process by boosting the production of neurotrophins to help fortify brain cell structure and signaling capacity. Glover says, "The rate of age-related cognitive decline and its severity depends on a range of factors, including a person's lifestyle choices. Maintaining an active lifestyle and engaging in certain activities during one's life may help prevent age-associated cognitive decline."

The Best Exercises for Brain Health

Variety seems to be key when building an exercise regimen to reduce cognitive decline. Glover says, "The majority of studies have shown positive effects of both aerobic exercise and resistance training, either separately or combined, on cognitive performance."

In a 2017 review, researchers looked at a number of studies on exercise and cognition in order to try to determine which methods create the greatest benefit. They found that both aerobic exercise and resistance training are important. Aerobic exercise was shown to improve cognitive ability, while resistance training was most effective on enhancing executive function, memory and working memory. All this to say, getting a good mix of different activity is the way to go.

Glover suggests that individualization is key in order to accommodate individuals at different stages along their wellness journey. "Any type of physical activity that promotes balance, coordination, agility and flexibility would be beneficial, especially when done consistently over time," she says.

Glover says that the most important thing is to maintain a steady exercise routine that includes both aerobic and resistance activities: "The science shows that if this is done over the course of at least six months to a year, there should be noticeable improvements in brain health and overall cognitive functioning in all adults, but especially in older adults."

How Much Exercise Do You Need to Improve Brain Health?

To achieve the cognitive benefits of exercise, it may be helpful to think of your workouts like you might think about your diet: get a good mix of the right ingredients each day to be able to sustain long-term health benefits. The same is true for exercise.

Glover recommends that we think of exercise in portions. "A long-term exercise regimen will work best when portioned out in the right amount on a weekly basis."

The American College of Sports Medicine recommends a minimum of 150 minutes of moderate aerobic exercise per week, but you may not need that much to reap some benefits. Glover says, "Doing intermittent aerobic exercise at any intensity for 6 to 10 minutes a day could also make a big difference over time. The ACSM also recommends that older adults do some form of resistance exercise at least twice a week. The goal is to target major muscle groups in the upper and lower body, starting with lower resistance levels and adjusting to higher levels over time to promote strengthening and endurance."

When considering resistance training, many people think only of weights or dumbbells. While there is value in lifting weight to build muscle, resistance can mean any type of resistance (think: body-weight exercises such as pushups, pullups, squats, planks or using resistance bands). It is also important to remember that intensity is individualized to each person. What is considered vigorous intensity for one person may be moderate or mild intensity for another and vice versa.

One way to determine exercise intensity that is individualized for you, is to use a tool called the Rate of Perceived Exertion. To determine your RPE, simply rate on a scale of 1 to 10, with 1 being the lowest and 10 being the highest, how intense the exercise or activity feels to you.

For example, an activity like sitting on the sofa and watching TV might get an RPE of 1. Sprinting as fast as you possibly can might get an RPE of 10. Most exercise activities will fall somewhere in between these two extremes. Being mindful of where your RPE is during exercise will help you adjust your intensity to the appropriate level.

The phrase, "brisk is better for the brain," is an easy way to remember the basic intensity you need to feel to improve brain health. Use your RPE to adjust your intensity toward the range of moderate to vigorous or "brisk" to achieve the best results.

An Exercise Plan for Brain Health

There are many ways to ensure that you are getting a good mix of aerobic exercise and resistance training to meet the minimum 150-minute per week recommendation from the ACSM. This is a sample weekly schedule:

  • 2 days per week of moderate- to vigorous-intensity cardiovascular exercise (think: 20-30 minutes of walking, jogging, biking, rowing, elliptical, swimming, etc.)

  • 2 days per week of resistance training (think: 20-30 minutes of lifting weights, body-weight exercises or an at-home workout)

  • 2 days per week of moderate-intensity cardiovascular exercise (20-30 minutes)

  • 1 day per week of rest, including deep breathing exercises

To accommodate your individual needs, simply adjust the schedule as needed; modifying the days of the week to plan for your favorite class or to give yourself rest when you need it.

Why Consistency Is Key

While research shows that as little as 10 minutes of exercise can have a positive impact on brain function, long-term cognitive improvements are seen when consistent exercise is continued over time.

Glover shares that the key is to be consistent with any program you implement. "At least 6 to 12 months of exercise is necessary to detect changes in cognitive functioning. While changes in the brain have been observed after shorter durations of exercise, these changes don't necessarily translate to improved cognitive functioning right away. It takes consistency over time."

It's always a good idea to consult your medical professional before beginning any new exercise plan, especially if you're currently managing a chronic health condition. So make a plan to have that discussion, then start building up your activity levels over time.

 

Naturally Occurring Antioxidant Therapy in Alzheimer’s Disease

Interesting, but will your doctor have the same interest AND  create protocols on this for your risks of dementia?

Ebselen is referred to in the  main section.

Ebselen, an anti-inflammatory antioxidant, was originally developed by Daiichi Sankyo, in Japan, to treat patients who had suffered a stroke. But the compound was never marketed and has since come off patent. It’s also part of the National Institutes of Health Clinical Collection—several hundred small molecules that have, to some extent, gone through the gamut of human clinical trials and have been found to be safe, but never reached final FDA approval.

  • ebselen (10 posts to December 2012)

 Naturally Occurring Antioxidant Therapy in Alzheimer’s Disease

Andrila E. Collins , Tarek M. Saleh and Bettina E. Kalisch * Department of Biomedical Sciences and Collaborative Specialization in Neuroscience Program, University of Guelph, Guelph, ON N1G 2W1, Canada; andrila@uoguelph.ca (A.E.C.); tsaleh@uoguelph.ca (T.M.S.) * Correspondence: bkalisch@uoguelph.ca 

Abstract: 

It is estimated that the prevalence rate of Alzheimer’s disease (AD) will double by the year 2040. Although currently available treatments help with symptom management, they do not prevent, delay the progression of, or cure the disease. Interestingly, a shared characteristic of AD and other neurodegenerative diseases and disorders is oxidative stress. Despite profound evidence supporting the role of oxidative stress in the pathogenesis and progression of AD, none of the currently available treatment options address oxidative stress. Recently, attention has been placed on the use of antioxidants to mitigate the effects of oxidative stress in the central nervous system. In preclinical studies utilizing cellular and animal models, natural antioxidants showed therapeutic promise when administered alone or in combination with other compounds. More recently, the concept of combination antioxidant therapy has been explored as a novel approach to preventing and treating neurodegenerative conditions that present with oxidative stress as a contributing factor. In this review, the relationship between oxidative stress and AD pathology and the neuroprotective role of natural antioxidants from natural sources are discussed. Additionally, the therapeutic potential of natural antioxidants as preventatives and/or treatment for AD is examined, with special attention paid to natural antioxidant combinations and conjugates that are currently being investigated in human clinical trials. 

More at link.

The Influence of Gut Microbiota on Neurogenesis: Evidence and Hopes

How is your doctor testing your gut microbiota to make sure your neurogenesis is working properly?

The Influence of Gut Microbiota on Neurogenesis:Evidence and Hopes

Fiorella Sarubbo 1,2 , Virve Cavallucci 3,4,* and Giovambattista Pani 3,4,* 1 Faculty of Science, University of the Balearic Islands UIB, 07122 Palma, Spain; fiorella.sarubbo@uib.es 2 Research Unit, Son Llàtzer University Hospital, Health Research Institute of the Balearic Islands (IdISBa), 07198 Palma, Spain 3 Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy 4 Institute of General Pathology, Università Cattolica del Sacro Cuore, 00168 Rome, Italy * Correspondence: v.cavallucci@gmail.com (V.C.); giovambattista.pani@unicatt.it (G.P.) 

Abstract: 

Adult neurogenesis (i.e., the life-long generation of new neurons from undifferentiated neuronal precursors in the adult brain) may contribute to brain repair after damage, and participates in plasticity-related processes including memory, cognition, mood and sensory functions. Among the many intrinsic (oxidative stress, inflammation, and ageing), and extrinsic (environmental pollution, lifestyle, and diet) factors deemed to impact neurogenesis, significant attention has been recently attracted by the myriad of saprophytic microorganismal communities inhabiting the intestinal ecosystem and collectively referred to as the gut microbiota. A growing body of evidence, mainly from animal studies, reveal the influence of microbiota and its disease-associated imbalances on neural stem cell proliferative and differentiative activities in brain neurogenic niches. On the other hand, the long-claimed pro-neurogenic activity of natural dietary compounds endowed with antioxidants and anti-inflammatory properties (such as polyphenols, polyunsaturated fatty acids, or pro/prebiotics) may be mediated, at least in part, by their action on the intestinal microflora. The purpose of this review is to summarise the available information regarding the influence of the gut microbiota on neurogenesis, analyse the possible underlying mechanisms, and discuss the potential implications of this emerging knowledge for the fight against neurodegeneration and brain ageing.

Chroma, a company that provides musical therapy, found that the most popular song for stroke rehab was Queen’s “We Will Rock You.”

Has your stroke hospital incompetently done nothing  with music therapy for the last decade?

 

Effects of Balance Exercise Assist Robot training for patients with hemiparetic stroke: a randomized controlled trial

Sound good, but will it ever get to your stroke hospital? Do you even have a research analyst whose only job is to evaluate research and create new interventions for stroke patients? If your hospital doesn't have such a person you don't have a functioning stroke hospital.

Effects of Balance Exercise Assist Robot training for patients with hemiparetic stroke: a randomized controlled trial

Abstract

Background

Robot-assisted rehabilitation for patients with stroke is promising. However, it is unclear whether additional balance training using a balance-focused robot combined with conventional rehabilitation programs supplements the balance function in patients with stroke. The purpose of this study was to compare the effects of Balance Exercise Assist Robot (BEAR) training combined with conventional inpatient rehabilitation training to those of conventional inpatient rehabilitation only in patients with hemiparetic stroke. We also aimed to determine whether BEAR training was superior to intensive balance training.

Methods

This assessor-blinded randomized controlled trial included 60 patients with first-ever hemiparetic stroke, admitted to rehabilitation wards between December 2016 and February 2019. Patients were randomly assigned to one of three groups, robotic balance training and conventional inpatient rehabilitation (BEAR group), intensive balance training and conventional inpatient rehabilitation (IBT group), or conventional inpatient rehabilitation-only (CR group). The intervention duration was 2 weeks, with assessments conducted pre- and post-intervention, and at 2 weeks follow-up. The primary outcome measure was a change in the Mini-Balance Evaluation Systems Test (Mini-BESTest) score from baseline.

Results

In total, 57 patients completed the intervention, and 48 patients were evaluated at the follow-up. Significant improvements in Mini-BESTest score were observed in the BEAR and IBT groups compared with in the CR group post-intervention and after the 2-week follow-up period (P < 0.05).

Conclusions

The addition of balance exercises using the BEAR alongside conventional inpatient rehabilitation improved balance in patients with subacute stroke.

Trial registration

https://www.umin.ac.jp/ctr; Unique Identifier: UMIN000025129. Registered on 2 December 2016.

Background

Balance can be defined as the ability to maintain and restore the center of gravity line when the base of support continuously changes [1]. Balance control involves different underlying systems, including anticipatory postural adjustments, postural responses, sensory orientation, and balance during gait [2]. Balance issues are frequently observed in patients with stroke and are closely related to mobility [3] and an increased risk of falling [4]. Among the various types of balance rehabilitation for patients with stroke [5], robot technology has gained attention as a potentially more efficient intervention. Importantly, repetition of task-specific activities for patients with stroke is effective in improving functional ability [6]. In this context, robots are considered to have great potential because of their strength in facilitating repetitive tasks. As a form of robotic intervention, robot-assisted gait training has been widely known and reported to improve walking ability [7] and balance [8, 9]. Considering task specificity, the use of a robots specialized in balance training is desirable; however, few studies assessing the usefulness of robot-assisted training, specifically focused on balance, have been undertaken. Notably, the Balance Exercise Assist Robot (BEAR, TOYOTA Motor Corporation, Aichi, Japan) is specialized in balance training [10]. The BEAR is a stand-up robot integrated with a video game that uses information such as velocity and body gradients obtained from a sensing device to adjust the training regime, and is classified as a surface-, mobile-, or platform-type robot [11]. Studies using the BEAR for patients with central nervous system disorders [10] and older adults with frailty [12] have reported improvements in dynamic balance ability and lower extremity muscle strength after training. However, to the best of our knowledge, the effectiveness of BEAR training compared with that of conventional balance training for patients with stroke has not been investigated.

Reportedly, balance training, including reaching movements and weight shifting, adjustment of motor responses to changes in body movements, and strengthening of lower limb muscle strength, is an important form of exercise therapy for balance improvement in patients with stroke [13, 14]. However, importantly, it is unclear whether additional balance training in combination with conventional rehabilitation programs supplements the balance function in patients with stroke [15]. Although a recent meta-analysis that included studies with homogeneous clinical outcomes [16] found a positive effect of additional balance exercises on balance function in patients with stroke, mixed results prevent confirmation of the efficacy of additional balance training. For example, while several randomized controlled trials found that additional balance exercises had no effect on balance function [17,18,19], other randomized controlled trials [20,21,22,23] reported the positive effects of additional training on balance function in patients with stroke. Furthermore, no study has examined the effectiveness of additional balance training on balance function using a balance-focused robot.

Therefore, we aimed to determine the effect of BEAR training on balance in combination with conventional inpatient rehabilitation training compared to the effects of conventional inpatient rehabilitation alone in patients with hemiparetic stroke. Moreover, we aimed to determine whether BEAR training was superior to dose-matched supervised intensive balance training.

More at link.

 

UCLPartners Centre for Neurorehabilitation Symposium: The Neurorehabilitation of Walking

 If you are really lucky your doctor will attend and get some knowledge to apply to your walking recovery. Unless your doctor already is so knowledgeable that a 100% recovery walking protocol already exists for you.

UCLPartners Centre for Neurorehabilitation Symposium: The Neurorehabilitation of Walking

24 February 2022, 9:00 am–5:00 pm

UCLP CNR logo

Why do we as humans walk? What are the benefits of being on two feet and therefore what is the impact of walking impairment on people with neurological conditions? We have brought together experts in the field to explore these questions and advances in technologies to assess and manage walking impairment.

Event Information

Open to

All

Availability

Yes

Organiser

UCLPartners Centre for Neurorehabilitation

Location

33
378: Institute of Neurology, 33 Queen Square
33 Queen Square
London
WC1N 3BG
United Kingdom

Topics and speakers:

  • Why we walk – Shane O’Mara,  Trinity College Dublin, Ireland
  • Neuroscience physiology of gait – TBC
  • Gait assessment – gait laboratory technologies – TBC
  • Biomechanics of gait – Adam Shortland, Kings College London, UK
  • Wearable devices, self-management and monitoring – Lisa Alcock
  • Devices technologies / exoskeletons / robotics – Herman Kingma
  • Pharmacological interventions – Francois Bethoux, Cleveland Clinic Ohio USA
  • Fear of falling – Toby Elmers
  • Functional gait disorders in people with LTNCs - Glen Nielson, St Georges, University of London

Attendance: £100

  • If attending in person – Basement Lecture Theatre, 33 Queen Square, London WC1N 3BG
  • If attending virtually – Zoom link will be sent via email closer to the event.

Contact: cnr@ucl.ac.uk

 

The “cell atlas” of the cerebrovascular system connects stroke with new immune cells

You'll have to hope someone in stroke uses this to update the stroke strategy.  That will never occur, we have NO leadership and NO strategy.

The “cell atlas” of the cerebrovascular system connects stroke with new immune cells

 
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Cerebrovascular imaging. Credits: © Michel Royon / Wikimedia Commons, CC BY-SA 3.0

In a study to enhance research on diseases such as stroke and dementia, researchers at the University of California, San Francisco, cataloged all the cells that make up the blood vessels in the human brain, along with their locations and the genes transcribed in each. Did.

Atlas characterizes over 40 previously unknown cell types, including a population of immune cells whose communication with vascular cells in the brain contributes to hemorrhagic stroke bleeding. This catastrophic form of stroke accounts for 10 to 15 percent of all strokes in the United States, primarily among young people. About half of hemorrhagic strokes are fatal.

Scientists said the findings would be the basis for new research on the cerebrovascular system around the world.

Ethan Winkler, MD, a neurosurgeon and researcher at the University of California, San Francisco, said: Weill Institute for Neurosciences and one of the lead authors of this study Chemistry..

Tangles in the vascular system of the brain

The team includes Adib Abla, an associate professor of neurosurgery, MD and Daniel Lim, MD, Ph.D., a professor of neurosurgery. Led by Tomasz Nowakowski, Ph.D., both members of the UCSF Weill Institute for Neuroscience. , Arteriovenous malformations, or AVM analyzed cells, often poorly formed arterial entanglements in the brain that are responsible for hemorrhagic stroke. They compared AVM with a sample of normal cerebrovascular system from five volunteers who had already undergone epileptic brain surgery. Ranked # 1 in Neurosurgery by US News, UCSF is a leading national center for brain AVM surgery and care.

Some of the 44 samples of AVM tissue obtained during delicate surgery performed by neurosurgery chief Abla were removed intact from the patient’s brain, while others only after they began to bleed. It has been removed. Three types of tissue, normal intact AVM and bleeding AVM, gave researchers a more complete picture of the difference between how cells function normally and how they function in a variety of medical conditions.

The team, in collaboration with the Cerebrovascular Research Center, used a single-cell mRNA sequence in over 180,000 cells to identify genes expressed in different samples and align gene expression with cell location. rice field. Later, Chang Kim, a graduate student in UCSF bioinformatics and co-lead author of the study, developed a computer analysis comparing gene expression in normal and affected cells.

Surprise of immune cells

The results revealed a population of immune cells that appear to cause stroke by communicating with the smooth muscle cells of the affected artery and weakening them, as well as various new cell types. Scientists suspect that the immune system may be activated by malformations such as AVM. However, Nowakowski says, “Without this study, we cannot identify this very specific cell population in the blood that can be a major contributor to the progression of the disease.”

Identifying these specific immune cells will completely change the way researchers think about treating this type of vascular disease, he added. If cells circulate in the blood, regulating the immune system may reduce the risk of stroke.

“This opens up great therapeutic potential,” said Nowakowski.

The possibilities extend beyond stroke. This map is useful for investigating neurovascular diseases, including one of the most common dementias.

“Many forms of dementia, including Alzheimer’s disease, appear to support blood vessels,” Lim said. “We need such an atlas to better understand how changes in the vascular system contribute to cognitive and memory loss.”

“This study is a truly beautiful collaboration between surgeon scientists and molecular biologists, where there is incredible access to clinical specimens,” Lim said. “That’s why the Weil Neuroscience Institute at the University of California, San Francisco is so special.”

Although not many institutions have access to all of these critical resources, Lim added that they have access to the dataset for this study. Nowakowski believes that this information will enable researchers around the world to perform much cheaper analyzes on large numbers of patients. This is the only way to get a complete picture of how vascular disease works.

“Understanding cells and cerebrovascular disease in cells Molecular level It will take the work of many researchers in a new direction. ”

Cell “Periodic Table”

The team’s research contributes to Human CellAtlas, an international effort to create whole-body cell reference maps.

Nowakowski has described these atlases as “Periodic table The Human Cell Atlas is the location of cells in the body and theirs so that the Periodic Table of Chemistry organizes elements into structures and chemists can draw relationships between them based on where they appear in the table. Reveals the resulting interactions between.

Much work has been done around the world to generate these atlases of different organs and tissues, many of which only map the geographic location of cells. The comparison of normal and abnormal cells in this study takes it to a higher level and provides very sophisticated guidance for drug development.

“Our research really shows how cell atlas can be used,” says Nowakowski. “You can refer to our” Periodic Table “to start asking which cells do not work with the disease and target them very accurately. cell For treatment. ”


Cholesterol accumulation in the brain presents new goals for reducing the risk of dementia due to stroke


For more information:
Ethan A. Winkler et al, a single-cell atlas of the normal and malformed human cerebrovascular system, Chemistry (2022). DOI: 10.1126 / science.abi7377.. www.science.org/doi/10.1126/science.abi7377

Quote: The “cell atlas” of the cerebrovascular system connects cerebrovascular and new immune cells (January 27, 2022).

This document is subject to copyright. No part may be reproduced without written permission, except for fair transactions for personal investigation or research purposes. Content is provided for informational purposes only.



The “cell atlas” of the cerebrovascular system connects stroke with new immune cells

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Mixing and Matching BP Meds? Consider the Implications for Dementia

 You'll have to ask your doctor if what you are taking is contributing to your already high dementia risk. With all this description I still don't know anything. But since they excluded people with stroke none of this may apply to us, your doctor better know the answer.

For your edification:

10 Drugs Commonly Prescribed for High Blood Pressure

I had to look up mine separately; nifediprine, is in a class of medications called calcium-channel blockers

Mixing and Matching BP Meds? Consider the Implications for Dementia

 

SPRINT analysis favors certain classes of antihypertensives

A blood pressure cuff, a stethoscope and a spilled prescription bottle of green pills.

The theory that certain antihypertensives can be tied to less dementia was supported by a secondary analysis of the hypertension trial SPRINT.

Between study participants with high blood pressure (BP) who only used medications that stimulate type 2 and 4 angiotensin II receptors and those who only used receptor-inhibiting drugs, the former tended to have a lower risk of cognitive impairment nearly 5 years later:

  • Amnestic mild cognitive impairment or probable dementia: 45 vs 59 cases per 1,000 person-years (HR 0.76, 95% CI 0.66-0.87)
  • Amnestic MCI alone: 40 vs 54 cases per 1,000 person-years (HR 0.74, 95% CI 0.64-0.87)
  • Probable dementia alone: 8 vs 10 cases per 1,000 person-years (HR 0.80, 95% CI 0.57-1.14)

"On a population level, shifting antihypertensive prescribing from inhibiting to stimulating regimens, while adhering to current hypertension guideline recommendations, could be a promising strategy to reduce the burden of dementia," according to study authors led by Zachary Marcum, PharmD, PhD, of the University of Washington in Seattle, writing in JAMA Network Open.

"This strategy would mean shifting the treatment paradigm from ACE [angiotensin-converting enzyme] inhibitors to angiotensin II receptor type 1 blockers and reducing the amount of inappropriate β-blocker use in the absence of coronary heart disease or heart failure with reduced ejection fraction," the researchers continued.

Dementia is a growing public health problem with no good preventive measures to date.

"For now, we cannot recommend in the clinical setting that antihypertensives be prescribed for mild cognitive impairment or dementia. Yet, this study lays a solid foundation for future research on specific types of antihypertensives for the prevention of cognitive decline in aging," according to memory specialist Zoe Arvanitakis, MD, MS, of Rush University Medical Center in Chicago.

"While the results are based on secondary analyses from data collected for another research question, the findings that a certain group of BP medications are associated with a lower risk of developing cognitive impairment are very exciting," she commented.

SPRINT included over 9,000 people ages 50 and older at higher risk of cardiovascular disease. Participants were randomized to an intensive treatment strategy (targeting systolic BP <120 mm Hg) or a standard treatment strategy (targeting systolic BP <140 mm Hg).

It was on the basis of this trial that American guidelines started recommending 130/80 mm Hg as the new BP target for most people in 2017.

For the present analysis, Marcum's group analyzed the 8,685 people on BP-lowering medications at 6 months (mean age 67.7 years, 64.3% men). This cohort was split into three:

  • 30.4% were users of only antihypertensives that stimulate type 2 and 4 angiotensin II receptors (e.g., angiotensin II receptor type 1 blockers, dihydropyridine calcium channel blockers, and thiazide diuretics)
  • 17.7% were users of only inhibitors of type 2 and 4 angiotensin II receptors (e.g., ACE inhibitors, β-blockers, and nondihydropyridine calcium channel blockers)
  • 51.9% were users of both types of BP-lowering medication

Dementia screening was conducted at 24 and 48 months after randomization, as well as at the closeout visit and an extended follow-up visit.

The investigators said the cognitive findings were consistent when incorporating the competing risk of death and were independent of systolic BP, cardiovascular risk factors, sociodemographic characteristics, and baseline cognitive function.

Yet negative control analyses suggested the presence of unmeasured confounding.

It was already known that before weighted propensity score matching, people only on stimulating antihypertensives were more likely to be women, Black participants, and randomized to intensive treatment; and less likely to have a history of cardiovascular disease, coronary revascularization, atrial fibrillation, and statin use, compared with users of inhibiting regimens.

"Both underadjustment caused by unmeasured confounding and overadjustment caused by inclusion of covariates measured after treatment initiation, which may be intermediate on the causal pathway between treatment and outcome, are possible," Marcum's group acknowledged.

For now, more research is merited, even in persons with no high BP. The next step may include randomized trials specifically testing whether antihypertensives prevent mild cognitive impairment or dementia, according to Arvanitakis.

"A clinical trial to test the hypothesis assessed in our study for primary prevention would take years to complete. Alternatively, observational studies in larger samples, using a new-user design, with validated cognitive outcomes could provide a useful replication," the researchers suggested.

They also cautioned that SPRINT had excluded people with diabetes, advanced kidney disease, symptomatic heart failure, or a history of stroke -- limiting the study's generalizability.

  • author['full_name']

    Nicole Lou is a reporter for MedPage Today, where she covers cardiology news and other developments in medicine. Follow

Disclosures

The study was supported by grants from the National Institute on Aging.

Marcum reported no relevant conflicts of interest.

 

Friday, January 28, 2022

Ischemic stroke incidence, severity heightens risk for dementia

Regardless, your doctor IS RESPONSIBLE FOR PREVENTING YOUR DEMENTIA.

Ischemic stroke incidence, severity heightens risk for dementia

Among participants in a decades-long prospective cohort study, risk for dementia significantly increased after ischemic stroke, according to results published in JAMA Neurology.

“Risk of dementia increases after stroke and may be especially high in patients with larger and more severe strokes,” Silvia Koton, PhD, RN, professor of nursing in the Stanley Steyer School of Health Professions at Tel Aviv University, and colleagues wrote. “Reliable estimates for the risk of dementia after stroke (especially ischemic stroke, which is the most common type) are needed to inform clinicians, researchers and policymakers.”

Ischemic Stroke
Source: Adobe Stock

Researchers, seeking to examine the risk for dementia following ischemic stroke (IS) and assess the impact of stroke severity and recurrence, monitored 15,379 individuals who were free from stroke and dementia from 1987 to 1989. Participants, aged 45 to 64 years, were part of a cohort in the Atherosclerosis Risk in Communities study, which spans Mississippi, Maryland, Minnesota and North Carolina. Koton and colleagues evaluated participants and studied associations between diagnosis of dementia and IS incidence, frequency and severity at baseline and at six additional visits, at 1- to 2-year intervals, through 2019.

Investigators reviewed hospital records to classify initial and recurrent IS and measured severity with the NIH Stroke Scale (minor, 5; mild, 6-10; moderate, 11-15; and severe, 16). They determined dementia cases by reviewing in-person evaluations, telephone-based assessments, hospitalization codes and death certificates.

According to study results, 1,378 (1,155 incident) IS and 2,860 dementia cases were diagnosed 1 year or more after incident stroke in participants with stroke, or at any point after baseline in participants without stroke. Of the dementia cases, 269 had a preceding IS, and the median time between ischemic stroke and dementia was 7.2 years. Compared with participants with no stroke, the risk for dementia was highest for those who suffered two or more moderate to severe strokes, followed by those with two or more mild strokes and those who had one moderate to severe stroke. The risk was lowest for those with one minor to mild stroke.

“Despite decreases in stroke incidence rates over time, dementia remains a major concern

for individuals with a prior stroke,” Koton and colleagues wrote. “Because both stroke severity and recurrent stroke are associated with an elevated risk of dementia, this emphasizes the importance of not only prevention of stroke incidence but also secondary prevention to reduce stroke recurrence.”

 

Current status of robotic stroke rehabilitation and opportunities for a cyber-physically assisted upper limb stroke rehabilitation

 Somehow you think there is a chance that stroke hospitals will buy expensive rehab like this?

Current status of robotic stroke rehabilitation and opportunities for a cyber-physically assisted upper limb stroke rehabilitation

 Proceedings
 of TMCE 2014,
May 19-23, 2014, Budapest, Hungary, Edited by I. Horváth, Z. Rusák

 Organizing Committee of TMCE 2014, ISBN 978-94-6186-177-1
 Chong Li
Faculty of Industrial Design Engineering Delft University of Technology & The State Key Laboratory of Tribology Tsinghua University C.Li-1@tudelft.nl
Zoltán Rusák Imre Horváth
Faculty of Industrial Design Engineering Delft University of Technology { Z.Rusak, I.Horvath }@tudelft.nl
Linhong Ji Yuemin Hou
The State Key Laboratory of Tribology Tsinghua University  jilh@tsinghua.edu.cn, hym01@mails.tsinghua.edu.cn
 ABSTRACT
In the last two decades, robotics-assisted stroke reha-bilitation has been wide-spread, in particular for movement rehabilitation of upper limbs. Several studies have reported on the clinical effectiveness of this kind of therapy. The results of these studies show that robot assisted therapy can be more effective in recovering motor control abilities than conventional therapy. On the other hand, studies found no signifi-cant improvement on motor function abilities of pa-tients. These contradictory results stimulated our re-search to survey current status of robotics-assisted rehabilitation and to look for advancement opportuni-ties. We developed a reasoning model that help us conduct the study systematically and to consider the four most important aspects, namely (i) the post-stroke pathophysiological status of patients, (ii) the nature of the rehabilitation therapies, (iii) the versatil-ity of the robotic rehabilitation instruments, and (iv) the kind of stimulation provided for patients. Our major finding is that there are strong evidences that the efficacy of robotics-assisted rehabilitation can be increased by motivation and engagement. We con-cluded that by exploiting the opportunities offered by cyber-physical systems and gamification, a signifi-cant improvement of context sensitive engagement can be realized. Our follow-up research will study various implementation opportunities, the affordabilities of various cyber-physical solutions, and influence on patients.
KEYWORDS
Stroke rehabilitation, robotic rehabilitation, rehabili-tation program, motivation and engagement, cyber physical system
1. INTRODUCTION TO THE PROBLEM
Stroke is a serious disabling health-care problem ob-servable all round the world [1]. Approximately 16 million people experience a stroke worldwide per year, of which about two-thirds survive [2]. Some 85 percent of stroke survivors recover partially [3], and about 35 percent of them suffer from a major disabil-ity [4] [5]. The most common impairment caused by stroke is motor impairment, which can be regarded as a loss of muscle function control, or limitations in limb movements or mobility [6]. Therefore, problem of stroke rehabilitation has got to the focus of both academic research and practical therapy. In their practical work of physiotherapists and occupational therapists are concentrating on the recovery of im-paired movement capabilities and the associated functions, especially in the case of patients with the impaired upper extremity. The simple reason is that the lack or limitation of arm-movement heavily in-fluences the activities of daily activities of post-stroke patients, their abilities to take care of them- selves, and thus their well-being and social inde-pendence [7] [8]. In the context of treatment and rehabilitation, robot-ic-assisted rehabilitation represents the state of the art in the practice. It was introduced twenty years ago in the developed countries and has been proliferating all over the world, in particular for movement rehabilita-tion of upper limbs [9]. Numerous rehabilitation ro-bots have been developed and applied in rehabilita-tion processes. By now, a lot of knowledge and expe-rience has been aggregated concerning their clinical effectiveness [9] [10]. Certain studies argue that less improvement of the functional abilities was achieved after lengthy train-ing processes than expected [9]. This entails that only limited improvements were achieved in the activities of daily living (ADL) of patients. For example, the results obtained by applying the Fugl-Meyer assess-ment model show that robot assisted therapy is much more effective in recovering motor control abilities, such as motor power, than conventional therapy [9]. On the other hand, studies that used function inde-pendence measurement and the Wolf functional abil-ity test found no significant improvement on motor function abilities of patients [11] [12] [13]. In some cases conventional therapy even had greater gains in motor function abilities than robot assisted therapy [11]. These contradictory results can partially be ex-plained by the limitations of movement patterns in the motor exercises offered by the robotic systems compared to exercises involving daily activities. Fur-thermore, recent findings suggest that maintaining attention and engagement during the learning of new motor skills or the re-learning of forgotten skills are important for inducing cerebral plasticity after neuro-logical impairments [14] [15]. Current robotics-assisted therapies do not place the patients in an im-mersive training environment, which would be able
to motivate the patients’ initiative so that their
 poten-tials to recover could be developed to their fullest. Though movement rehabilitation of upper limbs has been in the center of developments and applications, the results achieved so far are only sub-optimal. The objective of this paper is to cast light on the af-fordances and the limitations of the current rehabili-tation instrumentation and approaches, to propose a more effective version of robotics-assisted rehabilita-tion as a possible solution for eliminating a number of limitations and offering new opportunities for in-volving patients in the facilitation of their own reha-bilitation processes. Section 2 introduces our reason-ing model that was applied in the survey of the cur-rent state of the art. Both a patient-centered and a rehabilitation-centered classification have been con-sidered in order to be able to end up with a compre-hensive and consistent analysis. Four categories of rehabilitation robotics have been identified and used in the analysis of the advantages and the limitations in the context of various stroke patient categories. Section 3, 4, 5 and 6 present the results of the anal-yses of the identified four categories of rehabilitation robotics and applications. Section 7 and 8 summarize the limitations of the current rehabilitation approach-es and identify the opportunities of the cyber-physical solution for rehabilitation, respectively.
 
2. THE REASONING MODEL USED IN THE SURVEY
To frame our explorative research, we considered a reasoning model that interconnects four main fields of interest. The first one is pathophysiological status of the patients, which focuses on introducing stages of recovery process of the patients and which kind of therapy should be used in each stage. The second one is the nature of rehabilitation therapies, which is from a therapy-centered view introducing different kinds of therapies being used in current clinical rehabilita-tion process. The third one is versatility of robotic instruments which focuses on the robotic instruments and their programs. Last but not least, there is an as-pect focusing on the kind of stimulation provided for the patients , which is an influencing factor of stroke rehabilitation that have not been fully addressed by current robotic rehabilitation. This model is graph-ically represented in Figure 1. Each of the indicated
Figure 1
 
The reasoning model used in this study
 

Stroke imaging prior to thrombectomy in the late window results from a pooled multicentre analysis

I don't know what stroke researchers are doing but they most assuredly are not solving stroke to get survivors 100% recovered. And that is all because we have NO leadership and NO strategy since survivors are not in charge. Researchers should be following the strategy for 100% recovery(that needs to be created yet.).

Stroke imaging prior to thrombectomy in the late window results from a pooled multicentre analysis

  1. Mohammed A Almekhlafi1,
  2. John Thornton2,
  3. Ilaria Casetta3,
  4. Mayank Goyal4,
  5. Stefania Nannoni5,
  6. Darragh Herlihy6,
  7. Enrico Fainardi7,
  8. Sarah Power8,
  9. Valentina Saia9,
  10. Aidan Hegarty6,
  11. Giovanni Pracucci10,
  12. Andrew Demchuk4,
  13. Salvatore Mangiafico11,
  14. Karl Boyle6,
  15. Patrik Michel5,
  16. Fouzi Bala4,
  17. Rubina Gill4,
  18. Andrea Kuczynski12,
  19. Ayolla Ademola4,
  20. Michael D Hill13,
  21. Danilo Toni14,
  22. Sean Murphy15,
  23. Beom Joon Kim16,
  24. Bijoy K Menon17
  25. for the Selection Of Late-window Stroke for Thrombectomy by Imaging Collateral Extent (SOLSTICE) Consortium
  1. Correspondence to Dr Mohammed A Almekhlafi, Foothills Medical Centre, Calgary, Canada; mohammed.almekhlafi1@ucalgary.ca

Abstract

Background and purpose Collateral assessment using CT angiography is a promising modality for selecting patients for endovascular thrombectomy (EVT) in the late window (6–24 hours). The outcome of these patients compared with those selected using perfusion imaging is not clear.

Methods We pooled data from seven trials and registries of EVT-treated patients in the late-time window. Patients were classified according to the baseline imaging into collateral imaging alone (collateral cohort) and perfusion plus collateral imaging (perfusion cohort). The primary outcome was the proportion of patients achieving independent 90-day functional outcome (modified Rankin Scale ‘mRS’ 0–2). We used the propensity score–weighting method to balance important predictors between the cohorts.

Results In 608 patients, the median onset/last-known-well to emergency arrival time was 8.8 hours and 53.2% had wake-up strokes. Both cohorts had collateral imaging and 379 (62.3%) had perfusion imaging. Independent functional outcome was achieved in 43.1% overall: 168/379 patients (45.5%) in the perfusion cohort versus 94/214 (43.9%) in the collateral cohort (p=0.71). A logistic regression model adjusting for inverse-probability-weighting showed no difference in 90-day mRS score of 0–2 among the perfusion versus collateral cohorts (adjusted OR 1.05, 95% CI 0.69 to 1.59, p=0.83) or in a favourable shift in 90-day mRS (common adjusted OR 1.01, 95% CI 0.69 to 1.47, p=0.97).

Conclusion This pooled analysis of late window EVT showed comparable functional outcomes in patients selected for EVT using collateral imaging alone compared with patients selected using perfusion and collateral imaging.

PROSPERO registration number CRD42020222003.

Data availability statement

All data relevant to the study are included in the article or uploaded as supplementary information.

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Data availability statement

All data relevant to the study are included in the article or uploaded as supplementary information.

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