Common supplement linked to better everyday health in study of 16,000 older adults

 

Your competent? doctor has already prescribed multivitamins based on all this earlier research, right! Oh NO; NO KNOWLEDGE AND NO PRESCRIPTION/PROTOCOL! 

• multivitamin (15 posts to May 2015)

Call the president and ask about hiring competent persons!

Common supplement linked to better everyday health in study of 16,000 older adults

A new study suggests that a popular everyday vitamin may do more than fill nutritional gaps—it could also help older adults maintain their ability to carry out everyday tasks as they age.

Researchers at Augusta University found that adults aged 60 and older who took a daily multivitamin reported better functional health after three years compared with those who took a placebo. The findings will be presented at NUTRITION 2026, the annual meeting of the American Society for Nutrition.

Multivitamin-mineral supplements are the most commonly used dietary supplements across all age groups and may help fill nutritional gaps while supporting energy metabolism and immune function, according to the Centers for Disease Control and Prevention (CDC).

“The effects were strongest among participants with existing cardiovascular conditions, particularly carotid stenosis, where improvements reached levels considered clinically meaningful,” Bayu B. Bekele, a postdoctoral fellow at the Georgia Prevention Institute of the Medical College of Georgia at Augusta University, told Newsweek.

What the Study Found

The researchers analyzed data from more than 16,000 participants aged 60 and older who took part in the COcoa Supplement Multivitamins Outcomes Study (COSMOS).

Participants were randomly assigned to receive either a daily multivitamin, a cocoa extract supplement, both supplements, or neither. Placebos were used for the control group and for those taking only one supplement.

After three years, those taking a multivitamin had significantly better functional health scores than those taking a placebo. The biggest differences were seen in symptom burden and the clinical summary score, which combines symptom burden and physical ability measures.

 “Importantly, the multivitamin group was not suddenly able to do activities that the placebo group could not do,” Bekele told Newsweek. “The overall benefit was modest.”

He explained participants taking a daily multivitamin reported slightly fewer cardiovascular symptoms such as fatigue and shortness of breath and a modestly better overall functional health status over time compared with those taking a placebo.

Bekele said in a statement that maintaining heart health and physical function may help senior people continue performing daily activities such as dressing, bathing, walking, climbing stairs, jogging, hurrying and completing household chores.

“For older adults, these findings suggest that a daily multivitamin could be a helpful, low-risk addition to a healthy lifestyle to support physical well-being as they age, although it is not a substitute for a good diet or exercise,” Bekele said in a statement.

“These benefits may be particularly relevant for individuals experiencing fatigue, shortness of breath or swelling in the feet, which can limit daily functioning.”

Cocoa extract did not significantly improve functional health scores across the overall study population, though researchers found a significant benefit among participants with congestive heart failure.

Choosing the Right Supplements After 60

Pankti Shah, a doctor of pharmacy at U.K.-based PharmaLink Academy, shared four key tips for older adults choosing supplements:

• Pay attention to key nutrients. Senior formulas often contain higher levels of vitamins B12 and D, but little or no iron. Any additional iron supplementation should only be taken under medical supervision.
• Avoid proprietary blends. Instead, choose products that clearly list ingredient amounts and are specifically formulated for adults aged 50 and over. Shah said these formulas typically provide nutrients closer to recommended daily intakes rather than excessive doses.
• Look for independent quality verification. Certifications such as USP Verified or NSF can help confirm a product’s quality and safety. It’s also important to check whether a supplement could interact with any medications you take.
• Speak to a health professional. Scotland-based Shah recommends consulting a pharmacist or physician before starting supplements, particularly if you already take vitamins, have liver or kidney disease, or use multiple medications.

Reference

EurekAlert! (2026). A daily multivitamin may help older adults maintain functional health. [online] Available at: https://www.eurekalert.org/news-releases/1136435

Contact Newsweek editors on this story: Kara Dolman and Emma Lee-Sang

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Recognized for Results: Sutter’s Stroke Care Stands Out

 I wouldn't go there for stroke; they refer to 'care; NOT RECOVERY! Survivors want 100% recovery; this center does nothing of the sort! YOU are going to have to scream at them for not showing these three results:

There is no quality here if you don't measure the right things.

1. tPA full recovery? Better than 12%?
2. 30 day deaths? Better than competitors?
3. rehab full recovery? Better than 10%?

 

You'll want to know results so call that hospital president(whomever that is) RESULTS are; tPA efficacy, 30 day deaths, 100% recovery. Because there is no point in going to that hospital if they are not willing to publish results.

Recognized for Results: Sutter’s Stroke Care Stands Out

Stroke remains a leading cause of death in California and across the U.S. — even as new data from the American Heart Association show a slight decline in cardiovascular deaths since 2023. Too many strokes remain preventable, and too many patients aren’t getting care(NOT RECOVERY!) fast enough.

That’s the gap California-based not-for-profit Sutter Health is working to close.

Building a faster stroke system

Across the communities it serves, Sutter is scaling a stroke system built for prevention, speed and impact. As tens of thousands of Californians experience a stroke each year, the goals are simple: to help more people reduce their risk and ensure fast, coordinated care(NOT RECOVERY!) when a stroke occurs.

Sutter’s advanced neuroscience services include more than 150 neurologists and neurointerventional surgeons across 17 stroke-certified stroke centers, spanning the full continuum of care(NOT RECOVERY!): from early detection and risk management to emergency treatment, rehabilitation and recovery. The differentiator is how quickly that care(NOT RECOVERY!) activates.

Sutter pairs bedside expertise with real-time technology. This includes 24/7 telestroke consults that connect emergency teams to board-certified specialists within minutes, a Mobile Stroke Unit equipped for on-the-spot CT imaging, as well as advanced AI-enabled triage tools that accelerate diagnosis and treatment. For patients who need it, access to minimally invasive procedures that treat blood vessels from the inside like thrombectomy — which removes a blood clot from a blocked artery in the brain — can mean the difference between long-term disability and recovery.

Results that deliver for patients

Sutter’s systemwide focus on speed and coordination is translating into measurable outcomes.

Last year, the American Heart Association recognized 16 Sutter hospital campuses with the Get With The Guidelines® – Stroke Gold Plus quality achievement award — the highest level of recognition possible. Additionally, Becker’s Hospital Review named Sutter among its “100 Great Neuro and Spine Programs.”

“Improving outcomes extends far beyond the hospital walls,” said Dr. Nobl Barazangi, a vascular neurologist with Sutter West Bay Medical Group and the Sutter Advanced Neuroscience Service Line Chief of Stroke. “We’re caring for patients every step of the way — helping them lower their risk, reaching them quickly when a stroke occurs and surrounding them with the support they need to recover.”

In 2026, multiple Sutter hospitals were recognized for excellence in stroke care(NOT RECOVERY!) by Healthgrades — honors that reflect the consistency, expertise and teamwork required to deliver life-saving care(NOT RECOVERY!) on the clock.

Sutter’s Alta Bates Summit Medical Center – Alta Bates Campus

• Stroke Care(NOT RECOVERY!) Excellence Award™ for 16 consecutive years
• Top 10% in the Nation for Treatment of Stroke for 16 consecutive years
• Five-Star Recipient for Treatment of Stroke for 23 consecutive years

Sutter’s Alta Bates Summit Medical Center – Summit Campus

• Five-Star Recipient for Treatment of Stroke for 16 consecutive years

Sutter’s CPMC – Davies Campus

• Five-Star Recipient for Cranial Neurosurgery for four consecutive years

Sutter Davis Hospital

• Five-Star Recipient for Treatment of Stroke for four consecutive years

Sutter’s Eden Medical Center

• Five-Star Recipient for Treatment of Stroke for 20 consecutive years

Sutter Medical Center, Sacramento

• 2026 Stroke Care(NOT RECOVERY!) Excellence Award™
• Top 10% in the Nation for Treatment of Stroke
• Five-Star Recipient for Treatment of Stroke for two consecutive years

Sutter’s Memorial Medical Center

• Five-Star Recipient for Treatment of Stroke

Sutter’s Mills-Peninsula Medical Center

• Stroke Care(NOT RECOVERY!) Excellence Award™ for seven consecutive years
• Top 10% in the Nation for Treatment of Stroke for seven consecutive years
• Five-Star Recipient for Treatment of Stroke for seven consecutive years

Learn more about Sutter’s advanced neuroscience services.

HCA HealthONE Swedish Earns National Recognition for Excellence in Stroke Care

 

 I wouldn't go there for stroke; they refer to 'care; NOT RECOVERY! Survivors want 100% recovery; this center does nothing of the sort! YOU are going to have to scream at them for not showing these three results:

There is no quality here if you don't measure the right things.

1. tPA full recovery? Better than 12%?
2. 30 day deaths? Better than competitors?
3. rehab full recovery? Better than 10%?

 

You'll want to know results so call that hospital president(whomever that is) RESULTS are; tPA efficacy, 30 day deaths, 100% recovery. Because there is no point in going to that hospital if they are not willing to publish results.

HCA HealthONE Swedish Earns National Recognition for Excellence in Stroke Care

Englewood, CO, May 03, 2026 --(PR.com)-- HCA HealthONE Swedish Earns National Recognition for Excellence in Stroke Care(NOT RECOVERY!)
American Heart Association and Healthgrades honor HCA HealthONE Swedish for advanced stroke treatment, outcomes and commitment to evidence-based Care(NOT RECOVERY!).

HCA HealthONE Swedish announced today it has received national recognition from the American Heart Association and Healthgrades for its excellence in stroke Care(NOT RECOVERY!), reinforcing its position as one of the nation's top stroke hospitals. HCA HealthONE Swedish earned the American Heart Association Get With The Guidelines®-Stroke Gold Plus quality achievement award with Target: Stroke Honor Roll Elite Plus with Advanced Therapy and Target: Type 2 Diabetes Honor Roll. HCA HealthONE Swedish also received the Healthgrades Five-Star Treatment of Stroke medallion, recognizing superior clinical performance in stroke Care(NOT RECOVERY!).

These recognitions reflect HCA HealthONE Swedish's longstanding leadership in advanced neurosciences and stroke treatment. HCA HealthONE Swedish was the first Comprehensive Stroke Center in the Rocky Mountain region recognized by The Joint Commission, helping establish a legacy of highly specialized stroke Care(NOT RECOVERY!) that continues today. Together, these distinctions highlight the hospital's ability to deliver rapid diagnosis, advanced intervention and coordinated Care(NOT RECOVERY!) for patients with complex neurological conditions.

“These awards reflect the consistency and clinical excellence of our stroke program,” said Dr. Mary Laird Warner, chief medical officer at HCA HealthONE Swedish. “Our teams are focused on delivering evidence-based Care(NOT RECOVERY!) quickly and precisely, because in stroke treatment, every minute matters. Being recognized by both the American Heart Association and Healthgrades underscores the strength of our program and the outcomes we strive to achieve for every patient.”

The American Heart Association's Get With The Guidelines® program recognizes hospitals that demonstrate a sustained commitment to following the latest, research-based guidelines for stroke Care(NOT RECOVERY!) to improve patient outcomes. Hospitals receiving these awards show they are using proven treatment protocols to support more lives saved, shorter recovery times and better long-term results for patients.

Healthgrades evaluates hospital performance based on patient outcomes, including risk-adjusted mortality and complication rates, to help patients identify high-performing hospitals for specific conditions and procedures. The Five-Star Treatment of Stroke medallion recognizes hospitals with superior outcomes in stroke Care(NOT RECOVERY!) and reflects HCA HealthONE Swedish's continued commitment to delivering high-quality treatment for one of the nation's leading causes of death and disability.

Together, these national honors strengthen HCA HealthONE Swedish's standing as a premier destination for advanced stroke Care(NOT RECOVERY!) in Colorado and beyond. As a regional referral center for complex neurological Care(NOT RECOVERY!), HCA HealthONE Swedish continues to invest in the people, processes and technology needed to Care(NOT RECOVERY!) for patients experiencing some of the most time-sensitive and serious medical emergencies.

About HCA HealthONE Swedish
HCA HealthONE, one of the largest and most comprehensive healthcare systems in the Rocky Mountain region, offers more than 170 care sites in the Denver-metro area. Offering services across the continuum of Care(NOT RECOVERY!) to meet patients’ total healthcare needs, HCA HealthONE includes seven acute care hospitals, a dedicated flagship pediatric hospital, a rehabilitation hospital, CareNow® urgent care clinics, mental health campuses, imaging and surgery centers, physician practices, home and hospice care, and AirLife Denver, which provides regional critical care air and ground transportation. Among HCA HealthONE’s acute care hospitals is Swedish, a proud member of the community for 120 years. An American College of Surgeons verified Level I Trauma Center and acute care hospital with 504 licensed beds, HCA HealthONE Swedish is a national leader in neurosciences and serves as the region’s preeminent referral center for the most advanced stroke treatment. HCA HealthONE Swedish was the first Comprehensive Stroke Center in the Rocky Mountain region recognized by The Joint Commission and remains a leader in advanced stroke Care(NOT RECOVERY!). HCA HealthONE Swedish is also home to an American Burn Association verified burn center. Consistently among the Denver Business Journals’ list of top corporate philanthropists in the Denver-metro area, HCA HealthONE was named as one of the most community-minded organizations by The Civic 50 and contributed more than $1 million through cash and in-kind donations last year alone, along with more than $400M in federal, state and local taxes.

About the American Heart Association and Healthgrades
The American Heart Association’s Get With The Guidelines® program helps ensure patient Care(NOT RECOVERY!) is aligned with the latest evidence- and research-based guidelines to improve outcomes in cardiovascular disease and stroke. Healthgrades is dedicated to empowering meaningful connections between patients, doctors and hospitals by providing objective information about hospital quality and clinical performance.

Contact

HCA HealthONE Swedish
Richard Grissom
303-788-5944
SwedishHospital.com

St. Vincent’s Joins the Nation’s Top Hospitals with Comprehensive Stroke Certification

 

 I wouldn't go there for stroke; they refer to 'care; NOT RECOVERY! Survivors want 100% recovery; this center does nothing of the sort! YOU are going to have to scream at them for not showing these three results:

There is no quality here if you don't measure the right things.

1. tPA full recovery? Better than 12%?
2. 30 day deaths? Better than competitors?
3. rehab full recovery? Better than 10%?

 

You'll want to know results so call that hospital president(whomever that is) RESULTS are; tPA efficacy, 30 day deaths, 100% recovery. Because there is no point in going to that hospital if they are not willing to publish results.

St. Vincent’s Joins the Nation’s Top Hospitals with Comprehensive Stroke Certification

 St. Vincent’s Medical Center has earned The Joint Commission’s Gold Seal of Approval® and the American Heart Association/American Stroke Association’s Heart-Check mark for Comprehensive Stroke Center Certification. St. Vincent’s underwent a rigorous, onsite review. During the visit, a team of Joint Commission reviewers evaluated compliance with program standards. The Joint Commission’s standards are developed in consultation with health care experts and providers, measurement experts and patients. They are informed by scientific literature and expert consensus to help health care organizations measure, assess and improve performance. “Comprehensive Stroke Center Certification recognizes healthcare organizations committed to striving for excellence and fostering continuous improvement in patient safety and quality of care(NOT RECOVERY!),” says Ken Grubbs, DNP, MBA, RN, executive vice president of Accreditation and Certification Operations and chief nursing officer, The Joint Commission. “We commend St. Vincent’s Medical Center for using The Joint Commission certification process to reduce variation in clinical processes and to strengthen its clinical program to drive safer, higher quality and more compassionate care(NOT RECOVERY!) for individuals served.” “We congratulate St. Vincent’s Medical Center for this outstanding achievement,” says Nancy Brown, chief executive officer, the American Stroke Association. “This certification reflects its commitment to providing the highest quality ofcare(NOT RECOVERY!) for stroke patients.” “We are proud to achieve this designation, which reflects the dedication of our multidisciplinary stroke team and our commitment to providing the highest level of care(NOT RECOVERY!) for our community,” said Stroke Director Jeremy Wells, MD, at St. Vincent’s Medical Center. “This certification affirms our ability to deliver world-class, rapid, evidence-based treatment for the most complex stroke patients.” To prepare for the certification, St. Vincent’s Medical Center strengthened its stroke program by enhancing standardized protocols, expanding advanced neuroimaging, and improving coordination across care(NOT RECOVERY!) teams. The hospital also enhanced staff training to support rapid stroke recognition and treatment, while ensuring 24/7 access to specialized services, including neurosurgery and interventional care(NOT RECOVERY!)—delivering timely, comprehensive treatment when every second counts. Comprehensive Stroke Center Certification is the highest level of stroke certification awarded by The Joint Commission and recognizes organizations with the infrastructure, staff, and training to receive and treat the most complex stroke cases. This designation positions St. Vincent’s Medical Center as a regional leader in stroke care(NOT RECOVERY!), improving access to life-saving treatment for patients across the community and statewide. This achievement is yet another example of how Hartford HealthCare’s acquisition of St. Vincent’s Medical Center has expanded access to high-quality, advanced care(NOT RECOVERY!) close to home for the community.

Multivitamins may slow biological aging in older adults, study finds

 

Your competent? doctor has already prescribed multivitamins based on all this earlier research, right! Oh NO; NO KNOWLEDGE AND NO PRESCRIPTION/PROTOCOL! 

• multivitamin (13 posts to May 2015)

Call the president and ask about hiring competent persons!

Multivitamins may slow biological aging in older adults, study finds

The research focused on biological aging, which reflects wear and tear on the body at the cellular level.

Regular Multivitamin Use Associated With Slower Aging in Older Adults: Study

 You competent? doctor has already prescribed multivitamins based on all this earlier resesarch, right! Oh NO; NO KNOWLEDGE AND NO PRESCRIPTION! 

• multivitamin (11 posts to May 2015)

Call the president and ask about hiring competent persons!

Regular Multivitamin Use Associated With Slower Aging in Older Adults: Study

Iron metabolism dysregulation and post-stroke cognitive impairment: mechanisms and therapeutic perspectives

 

Your doctor, if competent at all, should have already known about ferroptosis from this research from September 2017.  And should have initiated stroke treatment interventions from it. But I bet incompetence prevailed! No excuses are allowed, call that president and have these incompetent doctors fired!

 Dementia research leads to potential new stroke treatment September 2017

Ferroptosis (12 posts to July 2012) All this earlier research that your doctor knows about, right!

Iron metabolism dysregulation and post-stroke cognitive impairment: mechanisms and therapeutic perspectives

• 

  Zi-Ming Guo 1,2†

• Y

  Ying-Tong Lu 1,2†

• J

  Jia-Qi Li 2,3

• H

  Hao-Qi Wu 1,2

• X

  Xi-Chen Zhu 1,2,3*

• T

  Tao Ma 1,2,3*

• 1. Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, China

• 2. Department of Neurology, The Wuxi No. 2 People’s Hospital, Jiangnan University Medical Center, Wuxi, Jiangsu, China

Abstract

Post-stroke cognitive impairment (PSCI) is a frequent neurological consequence of acute stroke. It manifests as persistent deficits in cognitive function for at least 6 months following cerebral infarction and substantially diminishes patients’ quality of life. Currently, its specific pathogenesis remains unclear. In recent years, increasing attention has been directed toward the contribution of disrupted iron metabolism to the development of PSCI. Acute stroke can cause iron metabolism disorder in the central nervous system and result in iron deposition, which causes damage to nerve cells through mechanisms such as ferroptosis, thereby leading to cognitive decline. Therefore, studies on the treatment of PSCI by regulating this mechanism have emerged. This review summarizes recent advances in the mechanisms linking iron metabolism dysregulation to PSCI and highlights emerging therapeutic strategies, offering new insights for improving its diagnosis and management.

Introduction

Post-stroke cognitive impairment (PSCI) is a prevalent complications of acute cerebral infarction, involving cognitive deficits that persist for at least 6 months after the initial event (1). PSCI is generally regarded as a clinical subtype within the broader spectrum of vascular cognitive impairment (VCI), specifically referring to cognitive deficits occurring after a clinically overt stroke event. Although PSCI markedly reduces patients’ quality of life, its underlying mechanisms remain incompletely understood, and epidemiological data indicate that more than one-third of stroke survivors are affected (2). In addition to impairing daily functioning, PSCI increases the risk of long-term disability and mortality. The dynamic balance of iron content maintains the normal operation of neurological function, and the occurrence of stroke can break this balance. Therefore, disturbances in iron metabolism are closely linked to stroke. Abnormal iron metabolism is mainly manifested as iron deposition in the brain, and may promote ferroptosis, which leads to nerve cell damage and dysfunction (3). Consequently, the interplay between iron metabolism disorders and PSCI has gained considerable research interest in recent years. This article first clarifies the physiological mechanisms of brain iron metabolism and the alterations that occur following stroke, then reviews the related research on iron deposition, ferroptosis and PSCI, and finally summarizes the regulatory effects of iron chelators, diet therapy and traditional Chinese medicine (TCM) on PSCI related to iron metabolism disorders, we propose that iron metabolism dysregulation promotes PSCI primarily through iron deposition-induced ferroptosis, and that targeting this axis represents a promising therapeutic strategy.

More at link.

Perampanel Regulates Neuroinflammation and Ferroptosis via Activating FSP1 Following Brain Ischemia

 Your competent? doctor is already quite familiar with this, right? And is completely ready to ensure human testing gets done, right!

Perampanel (2 posts to June 2022)

Ferroptosis (10 posts to July 2012)

Your doctor, if competent at all, should have already known about ferroptosis from this research from September 2017.  And should have initiated stroke treatment interventions from it. But I bet incompetence prevailed! No excuses are allowed, call that president and have these incompetent doctors fired!

 Dementia research leads to potential new stroke treatment 

The latest here:

Perampanel Regulates Neuroinflammation and Ferroptosis via Activating FSP1 Following Brain Ischemia

Authors Lv JM, Pan YJ, Wang X, Zhang MM, Li W, Liu J, Wang T

Received 4 June 2025

Accepted for publication 3 October 2025

Published 17 October 2025 Volume 2025:18 Pages 14423—14437

DOI https://doi.org/10.2147/JIR.S544785

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Editor who approved publication: Prof. Dr. Dharmappa Krishnappa

Jian-Meng Lv, Ya-Juan Pan, Xuan Wang, Mei-Mei Zhang, Wei Li, Juan Liu, Tao Wang

Department of Neurology, Shaanxi Provincial People’s Hospital, Xi’an, Shaanxi, 710068, People’s Republic of China

Correspondence: Tao Wang, Department of Neurology, Shaanxi Provincial People’s Hospital, 256 Youyi West Road, Xi’an, Shaanxi, 710068, People’s Republic of China, Email wangtao_sxrm@163.com

Purpose: Ischemic stroke remains a leading cause of global disability and mortality, with neuroinflammation and ferroptosis emerging as critical contributors to secondary neuronal damage. Perampanel, a non-competitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist, exhibits neuroprotective properties in neurological disorders, yet its mechanisms in ischemic stroke remain incompletely understood. This study investigated the therapeutic potential of post-injury perampanel administration in both in vivo and in vitro models, focusing on neuroinflammation, ferroptosis, and the role of ferroptosis suppressor protein 1 (FSP1).
Methods: Rats received intraperitoneal perampanel (1.5 mg/kg) 10– 15 minutes post-reperfusion for 3 days and exposed to middle cerebral artery occlusion (MCAO) for 60 minutes. Neurological function, neuronal survival, and markers of neuroinflammation and ferroptosis were assessed via immunostaining, Western blot, and behavioral tests. The in vitro ischemia model was mimicked by oxygen glucose deprivation (OGD) in primary cultured cortical neurons.
Results: Perampanel significantly attenuated MCAO-induced neuronal loss (NeuN⁺ cells) and improved motor coordination in rotating pole tests. It suppressed microglial (Iba-1⁺) and astrocytic (GFAP⁺) activation, indicating its anti-inflammatory effects. Mechanistically, perampanel reversed the MCAO-driven downregulation of ferroptosis markers FTH-1 and GPX-4, while enhancing neuronal FSP1 expression. Crucially, the FSP1 inhibitor icFSP1 abolished perampanel-mediated neuroprotection, neuronal preservation, and ferroptosis suppression, supporting the FSP1-dependent mechanisms. In in vitro conditions, perampanel exerted protective effects in a dose- and time-dependent manner. The results of immunostaining and Western blot showed that perampanel attenuated neuronal ferroptosis via activation of FSP1.
Conclusion: These findings demonstrate that perampanel mitigates post-ischemic brain injury by inhibiting neuroinflammation and neuronal ferroptosis via FSP1 activation. This study highlights FSP1 as a novel therapeutic target and positions perampanel as a promising candidate for ischemic stroke treatment, leveraging its established safety profile and clinical availability.