Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Showing posts with label Early Mobilization. Show all posts
Showing posts with label Early Mobilization. Show all posts

Tuesday, August 4, 2026

A Medicare rule finalized this week requires all rehab therapy to start within 36 hours

 Hopefully your competent? doctor believes in early mobilization and getting all your therapy going in time.

Early Mobilization (20 posts to May 2014)

A Medicare rule finalized this week requires all rehab therapy to start within 36 hours

After a stroke or a hip replacement, the difference between a good recovery and a diminished one is often measured in days rather than months. Medicare has just tightened a rule about the first day and a half, and it did it by changing one word.

The word that changed

Inpatient rehabilitation facilities — the intensive rehab hospitals patients transfer into after a stroke, a serious fall, a major orthopedic surgery, or a brain or spinal cord injury — have long operated under a federal requirement that therapy begin within 36 hours of admission. The regulation lives at 42 CFR 412.622.

In its FY2027 final rule issued July 30, 2026, CMS “finalized a revision to § 412.622(a)(3)(ii) to specify that all (not just some) therapies must be initiated within 36 hours of admission to the IRF.”

The parenthetical is the entire story. Under the looser reading, a facility could satisfy the requirement by starting one discipline promptly — physical therapy, say — while occupational therapy or speech-language pathology waited days for a therapist to become available. The clock was met on paper while a stroke patient with a swallowing impairment or a language deficit sat without the specific therapy their recovery depended on.


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Why families can use a rule written for auditors

Most Medicare regulation is invisible to patients because it governs payment mechanics they never see. This one is different, because it is checkable at the bedside by someone with no clinical training and a wristwatch.

Admission time is on the paperwork. Thirty-six hours later is simple arithmetic. Whether speech therapy has happened is a yes-or-no question a family member can ask at the nurses’ station. That combination — a specific standard, a specific deadline, and an observable event — is what turns a regulation into leverage.

The rule also sets expectations for the care planning that follows. The initial interdisciplinary team meeting must occur on or before the fourth day of admission, with subsequent meetings weekly, seven days from the initial meeting. Families who want input into a discharge plan should know that meeting exists and ask when it is scheduled, because discharge decisions made there determine where a patient goes next and who pays for it.

The money angle is downstream, and it is large

This rule carries no dollar figure for patients, which is exactly why it is easy to overlook. The financial stakes sit one step removed.

Intensive rehab is expensive, and Medicare’s coverage of it is time-limited and conditioned on the patient making measurable functional progress. A patient who loses two days of speech or occupational therapy at the start of a stay does not get those days added at the end; the stay runs on its own clock. Slower progress raises the odds of a discharge to a lower level of care before function is recovered, and the alternatives — a skilled nursing facility with daily coinsurance after day 20, outpatient therapy with travel and copays, or home care a family pays for privately — are where the household bill actually appears.Functional recovery is also the difference between returning home and needing paid help. The cost gap between an independent household and one purchasing home care is measured in thousands of dollars a month, indefinitely. That is the real financial consequence of the first 36 hours.

The rest of the FY2027 rule

The same rule sets IRF payment rates for fiscal year 2027, which begins October 1, 2026: a 2.3 percent update, an increase of roughly $340 million in aggregate. The outlier threshold was set to hold outlier payments at 3 percent of total payments, and the phase-out of rural-to-urban reclassification adjustments enters its third and final year. CMS also shortened the quality data submission window from about four and a half months to roughly 45 days, beginning in FY2029.

Those are provider-facing provisions. They matter to a household only insofar as they shape the finances of the rehab hospitals available in a given area — a real but indirect effect, and not one a patient can act on.

What to ask, and when

For anyone with a relative heading into inpatient rehab, three questions cover most of the value. Note the admission time and confirm which therapy disciplines have been ordered. At the 36-hour mark, ask whether every ordered therapy has been initiated — not whether “therapy has started.” And ask when the interdisciplinary team meeting is scheduled, then ask to be present or represented.

If a therapy has not begun on time, the escalation path runs through the facility’s case manager or patient advocate first. Every Medicare beneficiary also has access to a Beneficiary and Family Centered Care Quality Improvement Organization for their state, which handles quality-of-care complaints and expedited discharge appeals. The revised regulation gives that complaint a specific standard to point at, which is more than families had a week ago.

This article was produced with AI assistance and reviewed by a human editor. Figures are linked to their primary sources; where a claim could not be verified from the public record, we say so.

Friday, July 25, 2025

Modern approaches to the management of early rehabilitation period after ischemic stroke

 Early mobilization has been discussed forever; WHERE IS THE PROTOCOL LOCATED? And you incompetently DIDN'T CREATE A PROTOCOL?

  • Early Mobilization (20 posts to May 2014)
  • Modern approaches to the management of early rehabilitation period after ischemic stroke

    Authors: Galimov A.R.1, Stenkina N.V.1, Gaikina E.A.2, Shafikova E.S.1, Bashirova A.R.1, Yapparov A.R.1, Amirkhanyan A.V.3, Rozhkov M.I.3, Morozov N.P.1, Davletbaeva N.R.1, Gimranova N.M.1, Yamgurova R.R.1, Shagiakhmetova D.R.1, Sultanmuratov I.R.1, Reshetnikova A.A.1

    Affiliations:
    1.Bashkir State Medical University, Ufa, Russia 
    2. Ulyanovsk State University, Ulyanovsk, Russia
    3. Voronezh State Medical University named after N.N. Burdenko, Voronezh, Russia

    Abstract

    Ischemic stroke (IS) is a form of acute cerebral circulatory failure (ACBF), the pathogenesis of which is based on occlusion of the head or neck arteries supplying blood to the brain, which leads to ischemia and, as a consequence, to the death of cortical areas of the brain and the development of focal neurological disorders. This disease remains one of the leading causes of death and disability in the world. According to the latest statistical data, about 16.9 million cases of IS are registered annually and this figure is steadily increasing, especially in connection with the increase in life expectancy of the population. The present review is devoted to the analysis of modern approaches to the management of early rehabilitation period after IS, which remains one of the leading causes of disability and mortality in the world. The authors analyze the pathophysiological basis of the early rehabilitation period, including the role of neuroplasticity, neuroinflammation, and interhemispheric cortical reorganization. Special attention is paid to innovative rehabilitation methods such as robotic technology, transcranial magnetic stimulation, virtual reality and cell therapy. The efficacy of these techniques is reviewed based on data from randomized controlled trials and meta-analyses. The results demonstrate significant improvement in functional outcomes with early initiation of rehabilitation programs and combined use of traditional and innovative techniques.

    Saturday, April 19, 2025

    Does Vessel Occlusion Drive the Harmful Effect of Very Early Mobilization in Patients With Ischemic Stroke? A Post Hoc Analysis of AVERT

     You really don't understand the neuronal cascade of death at all, do you? Since you haven't stopped this cascade of death, the first week hundreds of millions to billions of neurons die because of incompetence in not solving this! And you don't understand why you are completely wrong on early mobilization, get out of stroke and find something easier!

    Does Vessel Occlusion Drive the Harmful Effect of Very Early Mobilization in Patients With Ischemic Stroke? A Post Hoc Analysis of AVERT

  • Abstract

    BACKGROUND:

    The international trial AVERT (A Very Early Rehabilitation Trial) found that very early mobilization (VEM; commenced <24 hours after stroke) negatively affected functional outcome (modified Rankin Scale [mRS]). The drivers of this effect remain unclear. One plausible mechanism is that high-dose upright activity worsens cerebral perfusion in patients with cerebral large vessel occlusion (LVO). For this retrospective AVERT substudy, we collected brain imaging from participants from 8 AVERT sites (n=910) to explore the potential relationship between LVO, VEM, and mRS in ischemic stroke. We hypothesized that patients with evidence of LVO would be adversely affected by VEM compared with non-LVO patients.

    METHODS:

    In this post hoc analysis of a randomized controlled trial, 2 neurologists independently classified patients with ischemic stroke as having LVO via direct (vessel truncation on computed tomography/magnetic resonance imaging angiography) or indirect evidence (hyperdense artery sign or established infarction of >2/3 of an arterial territory) from brain imaging obtained ≤7 days poststroke. The association between LVO, VEM, and 3- and 12-month mRS was tested using logistic regression, adjusted for age, treatment with thrombolysis, and baseline National Institutes of Health Stroke Scale.

    RESULTS:

    Interrater reliability for LVO signs was high (weighted κ, 0.842 [95% CI, 0.631–0.969]). Of 689 participants (37.2% female; median age, 74.5 [interquartile range, 65.0–81.2] years) included in the primary analysis, 192 (28%) showed direct or indirect evidence of LVO. Computed tomography/magnetic resonance imaging angiography were available in 179 (26%) of those 689 participants. While LVO was associated with poor mRS (>2) at 3 months (adjusted odds ratio, 2.15 [95% CI, 1.29–3.64]) and 12 months (adjusted odds ratio, 1.76 [95% CI, 1.1–2.84]; P=0.02), there was no significant interaction between VEM, LVO, and mRS (P=0.16).

    CONCLUSIONS:

    We found no evidence that VEM was specifically harmful in patients with LVO. However, as arterial imaging was not consistently obtained before first mobilization, larger prospective studies with standardized measures of LVO are needed to fully address this question.

    REGISTRATION:

    URL: xxx; Unique identifier: ACTRN12606000185561.

    Graphical Abstract

    Get full access to this article

    Monday, March 10, 2025

    Efficacy and Safety of Early Mobilization and Factors Associated with Rehabilitation After Stroke—Review

     Why the fuck was this review needed? You're so out-of-date you don't constantly follow stroke research?

  • Early Mobilization (18 posts to May 2014)
  • Efficacy and Safety of Early Mobilization and Factors Associated with Rehabilitation After Stroke—Review

                                     by 1,*, 2 and 1
    1
    Neurological and Neurosurgical Nursing Department, Faculty of Health Science, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 85-821 Bydgoszcz, Poland
    2
    Department of Neurological Nursing, Faculty of Health Science, Poznań University of Medical Sciences, 60-806 Poznań, Poland
    *
    Author to whom correspondence should be addressed.
    J. Clin. Med. 2025, 14(5), 1585; https://doi.org/10.3390/jcm14051585
    Submission received: 29 January 2025 / Revised: 18 February 2025 / Accepted: 25 February 2025 / Published: 26 February 2025
    (This article belongs to the Special Issue Clinical Perspectives in Stroke Rehabilitation)

    Abstract

    Background/Objectives: Knowledge about the safety and effectiveness of early post-stroke mobilization and its correlation with various factors is necessary to select an appropriate rehabilitation program and reduce the time of convalescence. Understanding the above processes will help to effectively lower the economic burden. Thus, we conducted a review to assess the safety and effectiveness of early post-stroke rehabilitation and the impact of various factors on the course of therapy. 

    Methods: The analysis included publications meeting the inclusion criteria published in the years 2015–2024 in Web of Science, Scopus, Embase, and PubMed. Finally, 12 studies were qualified for the review. The study group ranged from 37 to 2325 people. 

    Results: The results of studies on early stroke mobilization indicate possible benefits, including reduced time of hospitalization and faster achievement of higher functional scores. It has been shown that the important factors correlating with the effectiveness of therapy include: rehabilitation intensity, age, functional status before the stroke, depression, social support, lesion location, lower extremity deep vein thrombosis, cognitive disorder, dysphagia, and lower limb spasticity. 

    Conclusions: There is a strong need for research into post-stroke rehabilitation to speed up recovery times and reduce the economic burden on the country. Current research findings on the efficacy and safety of early rehabilitation are inconsistent. There is a strong need for international guidelines.

    1. Introduction

    According to the American Stroke Association: “A stroke occurs when a blood vessel that carries oxygen and nutrients to the brain is either blocked by a clot or bursts (or ruptures). When that happens, part of the brain cannot get the blood (and oxygen) it needs, so it and brain cells die” [1]. Stroke is a disease with a high risk of death. The World Health Organization estimates that 15 million people worldwide suffer a stroke each year, and 5 million of them die. Another five million people struggle with many permanent consequences of stroke, such as paresis, paralysis, cognitive impairment, epilepsy, and aphasia. The permanent disability of patients significantly burdens the community and family [2,3]. It is recognized that the direct clinical consequences of stroke are associated with many more or less known medical, psychosocial, and musculoskeletal problems [4]. The goal of post-stroke therapy is primarily to enhance the functional and structural reorganization of the brain. Therefore, healthcare workers and scientists are still looking for effective methods to stimulate the natural healing process, which is influenced by many factors, e.g., the area of damage and its location in the brain, the patient’s condition before the stroke, genetic factors, and comorbidities. Currently, rehabilitation is the only form of treatment that is considered an effective way to enhance the healing process both in the subacute and chronic period after vascular incidents [5,6].
    Stroke remains the leading cause of death and disability worldwide. The economic costs of caring for stroke patients are high. Nearly 34% of global health expenditure is spent on stroke [7,8]. Nevertheless, implementing early rehabilitation after stroke contributes to reducing the costs of care for neurological patients. Early mobilization is defined as out-of-bed activities in the acute stroke phase [9]. In many countries, patients are qualified for rehabilitation after 24 h from the moment of stroke. In general, it is worth noting that the optimal time to start physiotherapy is still elusive and is subject to many trials and studies. Both early and long-term and intensive rehabilitation play a significant role [10]. One study conducted in Washington among 72 patients showed that the respondents in the group of therapy initiated 2–3 months after the stroke were characterized by the greatest improvement one year after the stroke. The authors of the study emphasize the need to provide patients with more intensive physical rehabilitation in the period from 60 to 90 days after the stroke [11]. In turn, the primary justification for early rehabilitation is to prevent or reduce the risk of complications (falls, infections and deep vein thromboembolism, loss of cardiovascular fitness, muscle atrophy), promoting brain recovery. Furthermore, there are a number of doubts regarding early mobilization due to, among others, its possible impact on blood pressure. These concerns apply mainly to patients with hemorrhagic stroke and patients treated with recombinant tissue-type plasminogen activator (r-tPA). Many of the previously published research results on the efficacy and safety of early mobilization after acute stroke are inconsistent [12]. The A Very Early Rehabilitation Trial (AVERT) [13] series of studies highlighted that very early rehabilitation after stroke is not always beneficial. These studies also included patients who had received rt-PA. The authors of the study pointed out that, as usual, care in a stroke unit varies depending on the location. Therefore, it would be an oversimplification to simply advise usual care. However, another multicenter study, the Early Sitting in Ischemic Stroke Patients (SEVEL) [14], showed that sitting exercises over 24 h can reduce neurological deficit both at discharge and within 3 months after stroke. Due to the large discrepancies in the results of the studies conducted, the most reasonable solution would be to introduce the required safety criteria taking into account the patient’s condition, type of stroke, treatment applied, blood pressure measurement, and others. Due to the fact that the current discussion lacks a common understanding regarding the definition of early rehabilitation, evidence regarding patient qualifications, benefits, and risks of its implementation, we decided to conduct a general review of currently published studies. The aim of this review of studies was to assess the impact of the start time of rehabilitation, its effectiveness, and the correlation of multiple factors in terms of physiotherapy on the overall improvement in the functioning of patients after stroke.

    More at link.

    Thursday, December 19, 2024

    Assessing the benefits of early intervention in post-stroke care

     Early mobilization has been suggested for a long time. is your competent? hospital doing it?

  • Early Mobilization (17 posts to May 2014)
  • Assessing the benefits of early intervention in post-stroke care

    With over 12 million people a year experiencing a stroke globally and over 100 million living with the effects and consequences of stroke, the burden of stroke is high and set to increase.

    Thankfully with advancements in acute stroke care, more and more people are surviving strokes, but the range of potential complications they face – including spasticity speech & language difficulties, and cognitive problems – can be life-changing and result in socio-economic consequences for patients, their families, healthcare systems and wider society. 

    Globally, the indirect costs of stroke – resulting from lost productivity, early retirement, and the burden of informal care upon caregivers – are substantial, for both high- or low-income countries. Improvements in early intervention and rehabilitation are essential to support better patient outcomes. Studies show that early rehabilitation improves physical function, reduces longer-term complications, and enhances stroke survivors’ daily living. 

    Early intervention and treatment can be particularly effective in preventing long-term movement complications. Achieving improved outcomes such as these enhances stroke survivors’ quality of life and reduces the long-term strain on healthcare resources. Conversely, delayed treatment can lead to increased pain, reduced mobility, and greater long-term care needs – ultimately driving up costs. In particular, evidence demonstrates that prompt spasticity treatment and physiotherapy can significantly reduce overall costs compared to standard care, resulting in fewer hospital readmissions and lower outpatient expenses.

    A key goal of public healthcare systems is to reduce the burden of care following a stroke. This includes minimizing hospital readmissions, freeing up essential resources, and providing respite for family caregivers. Caregivers often shoulder a significant burden, impacting their own well-being and finances, with an often substantial emotional and physical toll that can lead to issues such as chronic fatigue, sleep disturbances and mental health challenges. This can lead to reduced work hours, lost productivity, and increased financial strain for both families and healthcare systems. Investing in early post-stroke care can improve patient outcomes and significantly alleviate this caregiver burden. 


    As a community, we need to advocate for, and adhere to, policies and guidelines that prioritize timely and comprehensive post-stroke care and rehabilitation to reduce costs, improve patient outcomes and support caregivers. To demonstrate Ipsen’s commitment to this, we’re launching Neuro Connections, a new vodcast series developed in collaboration with the World Stroke Organization, that explores the consequences of sub-optimal post-stroke care and identifies potential solutions to improve patient outcomes.

    Investing in effective post-stroke care is a societal investment with significant returns in improved health, economic stability, and overall well-being, ensuring a brighter future for stroke survivors and their families. 

    Tuesday, October 29, 2024

    Efficacy and safety of very early rehabilitation for acute ischemic stroke: a systematic review and meta-analysis

     

    My god, the ABSOLUTE FUCKING STUPIDITY DISPLAYED HERE! Very early rehabilitation does nothing towards the mortality risk! You are totally missing not stopping the 5 causes of the neuronal cascade of death in the first week thus not saving millions to billions of neurons.  Those extra dead neurons are likely the reason for the increased mortality.  Do you not understand cause and effect?

    Efficacy and safety of very early rehabilitation for acute ischemic stroke: a systematic review and meta-analysis

    Ying Lou,Ying Lou1,2Zhongshuo Liu,Zhongshuo Liu1,2Yingxiao Ji,,Yingxiao Ji1,2,3Jinming Cheng,,Jinming Cheng1,2,3Congying Zhao,,Congying Zhao1,2,3Litao Li,,Litao Li1,2,3*
    • 1Department of Neurology, Hebei General Hospital, Shijiazhuang, Hebei, China
    • 2Graduate School of Hebei Medical University, Shijiazhuang, Hebei, China
    • 3Hebei Provincial Key Laboratory of Cerebral Networks and Cognitive Disorders, Shijiazhuang, Hebei, China

    Background: Early rehabilitation after acute ischemic stroke (AIS) contributes to functional recovery. However, the optimal time for starting rehabilitation remains a topic of ongoing investigation. This article aims to shed light on the safety and efficacy of very early rehabilitation (VER) initiated within 48 h of stroke onset.

    Methods: A systematic search in PubMed, Embase, Cochrane Library, and Web of Science databases was conducted from inception to January 20, 2024. Relevant literature on VER in patients with AIS was reviewed and the data related to favorable and adverse clinical outcomes were collected for meta-analysis. Subgroup analysis was conducted at different time points, namely at discharge and at three and 12 months. Statistical analyses were performed with the help of the Meta Package in STATA Version 15.0.

    Results: A total of 14 randomized controlled trial (RCT) studies and 3,039 participants were included in the analysis. VER demonstrated a significant association with mortality [risk ratio (RR) = 1.27, 95% confidence interval (CI) (1.00, 1.61)], ability of daily living [weighted mean difference (WMD) = 6.90, 95% CI (0.22, 13.57)], and limb motor function [WMD = 5.02, 95% CI (1.63, 8.40)]. However, no significant difference was observed between the VER group and the control group in adverse events [RR = 0.89, 95% CI (0.79, 1.01)], severity of stroke [WMD = 0.52, 95% CI (−0.04, 1.08)], degree of disability [RR = 1.06, 95% CI (0.93, 1.20)], or recovery of walking [RR = 0.98, 95% CI (0.94, 1.03)] after stroke. Subgroup analysis revealed that VER reduced the risk of adverse events in the late stage (at three and 12 months) [RR = 0.86, 95% CI (0.74, 0.99)] and degree of disability at 12 months [RR = 1.28, 95% CI (1.03, 1.60)], and improved daily living ability at 3 months [WMD = 4.26, 95% CI (0.17, 8.35)], while increasing severity of stroke during hospitalization [WMD = 0.81, 95% CI (0.01, 1.61)].

    Conclusion: VER improves activities of daily living (ADLs) and lowers the incidence of long-term complications in stroke survivors. However, premature or overly intense rehabilitation may increase mortality in patients with AIS during the acute phase. PROSPERO registration number: CRD42024508180.

    Systematic review registration: This systematic review was registered with PROSPERO (https://www.crd.york.ac.uk/PROSPERO/). PROSPERO registration number: CRD42024508180.

    1 Introduction

    Acute ischemic stroke (AIS) refers to the abrupt onset of focal neurological dysfunction resulting from insufficient blood supply to the brain or determined according to objective evidence of vascular origin observed through imaging or pathological examination (1). It features high incidence, recurrence, disability, and mortality worldwide (2), and represents approximately 80% of all stroke cases (3). In the Trial of Org 10,172 in Acute Stroke Treatment (TOAST) classification system, large-artery atherosclerosis and cardioembolism are the main etiologies of stroke, with contributing risk factors including cardiovascular, endocrine, and others. Stroke, as the second leading cause of death and disability worldwide according to the Global Burden of Disease Study in 2016 (4), imposes substantial health and economic burdens in both developed and developing nations. Moreover, there has been a gradual increase in stroke incidence among young populations (5, 6). The progression of ischemic stroke is commonly categorized into acute, subacute, and chronic phases; however, the temporal boundaries of these stages are inconsistently defined. In the present study, acute stroke was defined as a stroke that occurs within 7 days after the onset, subacute stroke was a stroke occurring more than 7 days and less than 3 months after the onset, and chronic stroke generally referred to a non-recurrent stroke that lasts 3 months. Despite advancements in stroke unit management and early revascularization which promote timely recovery of brain blood flow in recent years, 50% of patients became chronically disabled with low life quality (7), because neural restoration was constrained by a narrow therapeutic window and irreversible damage to neuron. Some stroke survivors experience lingering complications and sequelae, particularly motor impairment and cognitive decline (8). In a recent study, it was demonstrated that acute or subacute stroke patients with Clostridium difficile infection exhibited significant improvement in basic living ability at discharge after 3 h of daily neurorehabilitation, but no significant difference was found in comparison to non-infected patients (9). Therefore, in addition to standard care, systematic, regular and intensive rehabilitation is of great importance in the early period of stroke even in the presence of other complications such as infections, unless patients have malaise or worse symptoms.

    Post-stroke rehabilitation, as a long and relatively safe intervention, is conducive to restoring limb motivation, improving walking and balancing abilities, and reducing the incidence of disability, falls and cardiorespiratory diseases (10). Initiating rehabilitation promptly after the stabilization of vital signs would help to accelerate the recovery of central nervous system and prevent potential complications (11). Sun et al. suggested that early rehabilitation could influence the expression of serum inflammatory factors, such as vascular endothelial growth factor (VEGF), tumor necrosis factor-α (TNF-α), interleukin-10, and stromal cell-derived factor-1α, and motivate endothelial progenitor cells (12), thereby promoting endothelial formation and vascular regeneration in AIS (13). However, the optimal timing for commencing early rehabilitation after stroke remains controversial, with uncertainty regarding the safety and efficacy of very early rehabilitation (VER) in patients with AIS. Firstly, for patients with post-stroke paralysis, very early out-of-bed activities may precipitate falls due to weak limb strength or poor balancing ability. Moreover, significant head position change after stroke would decrease cerebral blood flow (14), which could aggravate ischemia in the infarct area and lead to deterioration of the disease, while maintaining a supine position could increase cerebral perfusion pressure and boost collateral circulation to support the ischemic penumbra (15, 16). Despite the absence of definitive evidence and a lack of consensus regarding the optimal rehabilitation strategy, which involves starting time, frequency and intensity (17, 18), VER has been advocated within some published stroke guidelines (19, 20), and merits further exploration. Notably, a recent meta-analysis of randomized controlled trials (RCTs) conducted in 2021 revealed positive efficacy of early rehabilitation at 3 months. No statistical difference in adverse events and disability rate was noted between the VER group and control group, but the study did not assess outcomes in different endpoints (21).

    This meta-analysis included RCTs to evaluate the effects of initiating VER within 48 h of stroke onset on short- and long-term recovery. Additionally, a subgroup analysis at different time points (at discharge, 3 months and 12 months) was performed to observe the dynamic changes of the efficacy and safety of VER, which could serve as a reference for clinical practice.

    More at link.

    Thursday, October 10, 2024

    Efficacy and safety of very early rehabilitation for acute ischemic stroke: a systematic review and meta-analysis

     My god, the ABSOLUTE FUCKING STUPIDITY DISPLAYED HERE! Very early rehabilitation does nothing towards the mortality risk! You are totally missing not stopping the 5 causes of the neuronal cascade of death in the first week thus not saving millions to billions of neurons.  Those dead neurons are likely the reason for the increased mortality.  Do you not understand cause and effect?

    Efficacy and safety of very early rehabilitation for acute ischemic stroke: a systematic review and meta-analysis

    Provisionally accepted
    Ying Lou Ying Lou Zhongshuo Liu Zhongshuo Liu Yingxiao Ji Yingxiao Ji Jinming Cheng Jinming Cheng Congying Zhao Congying Zhao Litao Li Litao Li *
    • Hebei General Hospital, Shijiazhuang, China

    The final, formatted version of the article will be published soon.

      Background: 

      Early rehabilitation after acute ischemic stroke (AIS) contributes to functional recovery. However, the optimal time for starting rehabilitation remains a topic of ongoing investigation. This article aims to shed light on the safety and efficacy of very early rehabilitation (VER) initiated within 48 hours of stroke onset. 

      Methods: 

      A systematic search in PubMed, Embase, Cochrane Library, and Web of Science databases was conducted from inception to January 20, 2024. Relevant literature on VER in patients with AIS was reviewed and the data related to favorable and adverse clinical outcomes were collected for meta-analysis. Subgroup analysis was conducted at different time points, namely at discharge and at three and 12 months. Statistical analyses were performed with the help of the Meta Package in STATA Version 15.0. 

      Results: 

      A total of 14 randomized controlled trial (RCT) studies and 3,039 participants were included in the analysis. VER demonstrated a significant association with mortality [risk ratio (RR) = 1.27, 95% confidence interval (CI) (1.00, 1.61)], ability of daily living [weighted mean difference (WMD) = 6.90, 95% CI (0.22, 13.57)], and limb motor function [WMD = 5.02, 95% CI (1.63, 8.40)]. However, no significant difference was observed between the VER group and the control group in adverse events [RR = 0.89, 95% CI (0.79, 1.01)], severity of stroke [WMD = 0.52, 95% CI (-0.04, 1.08)], degree of disability [RR = 1.06, 95% CI (0.93, 1.20)], or recovery of walking [RR = 0.98, 95% CI (0.94, 1.03)] after stroke. Subgroup analysis revealed that VER reduced the risk of adverse events in the late stage (at three and 12 months) [RR = 0.86, 95% CI (0.74, 0.99)] and degree of disability at 12 months [RR = 1.28, 95% CI (1.03, 1.60)], and improved daily living ability at three months [WMD=4.26, 95% CI (0.17,8.35)], while increasing severity of stroke during hospitalization [WMD=0.81, 95% CI (0.01, 1.61)]. Conclusion: VER improves activities of daily living (ADLs) and lowers the incidence of long-term complications in stroke survivors. However, premature or overly intense rehabilitation may increase mortality in patients with AIS during the acute phase. PROSPERO registration number: CRD42024508180.

      Keywords: Rehabilitation, Early Ambulation, ischemic stroke, prognosis, Meta-analysis

      Received: 03 May 2024; Accepted: 09 Oct 2024.

      Copyright: © 2024 Lou, Liu, Ji, Cheng, Zhao and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

      * Correspondence: Litao Li, Hebei General Hospital, Shijiazhuang, China 

      Friday, May 3, 2024

      Early mobility in acute ischemic stroke linked to better outcomes at 90 days

       And EXACTLY HOW does this bland statement get any survivor recovered?

      Early mobility in acute ischemic stroke linked to better outcomes at 90 days

      Key takeaways:

      •     Early mobility was considered as an evaluation from physical and occupational therapy during the first 24 hours of stroke symptoms.
      •     Patients with stroke given early mobility had fewer days hospitalized compared with those not given the intervention.

      DENVER — Patients with acute ischemic stroke who received IV thrombolysis and were allowed mobility within the first 24 hours of onset saw better functional outcomes in 90 days, according to a poster presentation.

      “The early mobility time period is anywhere from 24 hours to 72 hours,” Gunjanpreet Kaur, MD, a neurology resident at Saint Louis University School of Medicine, told Healio at the American Academy of Neurology annual meeting. “What we did with our retrospective study is we started ordering early mobility, it’s a specific order set at our institute where we see patients within their 24-hour window.”

      Source: Adobe Stock.
      Recent research found that those with ischemic stroke given IV thrombolysis and who were mobile within 24 hours had better outcomes at 90 days. Image: Adobe Stock

      Early mobilization for individuals with acute ischemic stroke (AIS) after receiving IV thrombolysis may benefit the patient; however, the body of knowledge is limited, Kaur and colleagues wrote.

      Kaur and colleagues aimed to assess whether mobility within 24 hours of hospital admission for those with AIS is associated with better functional outcomes defined as a modified Rankin Scale (mRS) score of less than 2.(All this proves is that those with less damage recover better. Nothing to do with getting them moving early! Do you people have any functioning brain cells at all?)

      Their retrospective chart review yielded 168 persons with AIS given IV thrombolysis (median age 67.5 years) between January 2020 and April 2023. Early mobility was considered as an evaluation from physical and occupational therapy during the first 24 hours of stroke symptoms.

      The primary outcome was mRS score at 90 days and the secondary endpoint was National Institutes of Health Stroke Scale (NIHSS) score at discharge and total days of hospitalization. A total of 55 individuals (median age 65 years; 54.5% male) were subject to early mobility protocol.

      Results showed that individuals with early mobility orders recorded higher odds of having an excellent mRS (0 to 1) at 90 days (OR = 2.96; 95% CI: 1.38-6.37) and at discharge (OR = 5.47; 95% CI: 2.49-12.04).

      Data further showed the number of hospitalized days were fewer for those in the early mobility group (median days 4 vs. 6); however, no significant difference was found in NIHSS change between baseline and discharge among early mobility and non-protocol individuals.

      “The earlier we get (patients) moving, the better they do at discharge and at 90 days,” Kaur said. “I think it’s time we should standardize (IV thrombolysis to within 24 hours).”(Way too slow, you need to get it done in three minutes in research in mice. THINK YOU CAN DO THAT?)

      Sources/Disclosures

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      Source:

      Kaur G, et al. Effects of early mobilization on functional outcomes in patients with acute ischemic stroke who received intravenous thrombolysis. Presented at: American Academy of Neurology annual meeting; April 13-18, 2024; Denver.

      Disclosures: Kaur reports no relevant financial disclosures.