Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Showing posts with label stroke medical 'professionals'. Show all posts
Showing posts with label stroke medical 'professionals'. Show all posts

Sunday, September 6, 2026

Counting twitches: automated mechanomyography of muscle fatigue in healthy adults

 Do your stroke medical 'professionals' have two functioning brain cells that will  be used to objectively determine your fatigue and then measure the recovery you get from their EXACT RECOVERY PROTOCOLS?

NO? So you have blithering idiots in charge! You'll never get recovered with them! GET THEM FIRED!

Counting twitches: automated mechanomyography of muscle fatigue in healthy adults

    We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final Version of Record. All legal disclaimers apply.

    Abstract

    Background

    Assessing skeletal muscle fatigue is essential for diagnosing neuromuscular impairment, but conventional methods rely on maximal or tetanic contractions that can be impractical or uncomfortable in clinical populations. Surface mechanomyography (MMG) provides a non-invasive alternative; however, current MMG-based fatigue protocols require time-consuming manual peak-to-peak analysis. This study evaluated an automated algorithm for extracting MMG-derived fatigue metrics from electrically evoked muscle twitches.

    Methods

    Eighteen healthy adults completed a standardized fatigue protocol on the wrist extensors and ankle dorsiflexors using electrical stimulation at 2, 4, and 6 Hz over 9 min. A triaxial accelerometer captured MMG signals from > 2,100 contractions per muscle (approximately 4,320 per participant across the two muscles). A custom algorithm automatically extracted peak-to-peak values and computed the endurance index; the mean contraction amplitude was derived from peak and trough points identified manually by the research team. Repeated-measures ANOVAs assessed differences across stimulation frequencies and muscle groups.

    Results

    Endurance index declined significantly across the fixed ascending 2-, 4-, and 6-Hz stimulation sequence (p < 0.001) and was lower in ankle dorsiflexors than wrist extensors (p = 0.010), averaging approximately 6% points lower across frequencies. Mean contraction amplitude was significantly lower in the dorsiflexors (p < 0.001) and greater at 6 Hz than at 2–4 Hz (p < 0.001).

    Conclusion

    This study demonstrates the feasibility of an automated peak-to-peak extraction algorithm for deriving the MMG-based endurance index, enabling rapid processing of > 2,100 contractions per muscle. The mean contraction amplitude reported here was measured manually, and extending automated extraction to that measure remains to be implemented. The combination of the endurance index and the mean contraction amplitude provides a dual-metric approach to characterizing muscle performance. As a feasibility study in healthy adults, it does not establish clinical validity. Future work should validate the algorithm against manual methods and test it in clinical populations(Like stroke), including patients with ICU-acquired weakness.

    Tuesday, August 25, 2026

    A Novel Curcumin-Based Formulation Offers Protection Against Neurodegeneration in Rat Models of AlCl3 Induced Alzheimer’s Disease

     How long will it take for your competent? doctor/hospital to get human testing going for stroke related neurodegeneration? NEVER? So your stroke medical 'professionals' are useless?

    Do you prefer your doctor, hospital and board of director's incompetence NOT KNOWING? OR NOT DOING? Your choice; let them be incompetent or demand action!

     A Novel Curcumin-Based Formulation Offers Protection Against Neurodegeneration in Rat Models of AlCl3Induced Alzheimer’s Disease

    Mohamed Arif1*, V. Gayathri2, Radhika Ravindran3,P. Kalaivani2, R. Siva2, Shonam Tamrakar2 1Gidaa Life Sciences Private Limited, 287, 9th Cross, Bapuji Layout Near Chandra Layout, Vijayanagara, Bangalore, Karnataka 560040, India. 2Centre for Toxicology and Developmental Research, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), No. 1, Ramachandra Nagar, Porur, Chennai 600116, Tamil Nadu, India. 3Tissue Engineering and Biomaterials Lab, Department of Biotechnology, IIT Madras, India. *Corresponding Author: Mohamed Arif, Gidaa Life Sciences Private Limited, 287, 9th Cross, Bapuji Layout Near Chandra Layout, Vijayanagara, Bangalore, Karnataka 560040, India. DOI: https://doi.org/10.58624/SVOANE.2026.07.030 Received: July 31, 2026 Published: August 18, 2026 Citation: Arif M, Gayathri V, Ravindran R, Kalaivani P, Siva R, Tamrakar S. A Novel Curcumin-Based Formulation Offers Protection Against Neurodegeneration in Rat Models of AlCl3-Induced Alzheimer’s Disease. SVOA Neurology 2026, 7:4, 220-238. doi.org/10.58624/SVOANE.2026.07.030 

     Abstract 


    The exact mechanisms underlying Alzheimer’s disease (AD) pathogenesis are not fully understood, and effective disease-modifying treatments remain lacking despite decades of AD research. Therefore, alternative therapeutic approaches that may target multiple mechanisms of action underlying AD and have a better safety profile than synthetic drugs, such as phytotherapy, are being explored. We aimed to assess the neuroprotective properties of a novel curcumin formulation fortified with andrographolides and piperine (MAG XXI) in rat models of aluminium chloride–induced AD. Overall, 30 male Wistar rats were included and divided into five groups (a healthy control group, a non-treated AD group, and three AD groups treated with donepezil or 200/400 mg/kg body weight of MAG XXI). The Morris water maze, passive avoidance, and elevated plus maze tests were performed on the rats. Tissue samples from the cortex and hippocampus of the rats were then subjected to biochemical evaluation of neuronal, oxidative stress, and inflammatory markers. Compared to non-treated rats, donepezil-treated rats and high-dose (400 mg/kg body weight) MAG XXI–treated rats showed a mild but significant improvement in the Morris water maze and elevated plus maze test findings and a marked and significant improvement in the passive avoidance task results. Furthermore, oxidative stress markers, inflammatory markers, and neuronal markers improved overall in the donepezil-treated group and in both MAG XXI–treated groups. Notably, the improvement in the oxidative stress markers was more marked with MAG XXI (both doses) than with donepezil. Histopathological examination revealed lower incidence rates of neurofibrillary tangles, gliosis, and neuronal degeneration in the high-dose MAG XXI and donepezil groups. Notably, cresyl staining revealed minimal-to-mild cell dispersion in the donepezil group, whereas normal neuronal cells with well-lineated cell bodies and Nissl substance were observed in the high dose MAG XXI group. No adverse events were noted in the MAG XXI groups. MAG XXI could be a promising alternative for AD treatment because it appears to exhibit neuroprotective properties, as demonstrated by its ability to alleviate oxidative stress and neuroinflammation. However, further clinical trials involving humans are necessary to corroborate the present study’s results

    Monday, August 17, 2026

    Daily Coffee Consumption Associated With Healthier Metabolic Profile, Finnish Study Finds

     If all this earlier research didn't get you a 24 hour coffee station then your stroke medical 'professionals' ARE COMPLETELY USELESS!

    How coffee protects against Parkinson’s Aug. 2014 

    Coffee May Lower Your Risk of Dementia Feb. 2013

    Coffee drinkers rejoice! Drinking coffee could lower the risk of Alzheimer’s disease 

    And this: Coffee's Phenylindanes Fight Alzheimer's Plaque December 2018

    New research suggests drinking coffee may reduce the risk of frailty May 2025

    I think I'm in this category:  I never get the jitters or flushed skin.

    Genetics determine how much coffee you can drink before it goes wrong

    I'm doing a 12 cup pot of coffee a day with full fat milk to lessen my chances of dementia and Parkinsons. Tell me EXACTLY how much coffee to drink for that and I'll change. Yep, that is a lot more than the 400mg. suggested limit, I don't care! Preventing dementia and Parkinsons is vastly more important than whatever problems it can cause! 

    Of course, your fuckingly incompetent? doctor did nothing with this from 3+ years ago! And still hasn't created a 24 hour coffee station

    Dementia risk could drop by drinking just one shot daily of common beverage  August 2023

    This line is great: The findings indicate that even the Espresso Martini cocktail contains the espresso's beneficial compounds - and can contribute to staving off dementia.

    The latest here: 

    Daily Coffee Consumption Associated With Healthier Metabolic Profile, Finnish Study Finds

    Friday, August 14, 2026

    5 morning exercises to help adults over 60 restore muscle mass, according to a trainer

     Did your competent? doctor get you recovered enough to do all these? NO? So, PURE INCOMPETENCE THEN!

    Knowing since medical school that stroke was a complete failed shitshow and doing nothing is par for the course of your stroke medical 'professionals'!

    5 morning exercises to help adults over 60 restore muscle mass, according to a trainer

    1. Sit-to-Stands 

    I can do this from a standard kitchen chair, couches and Adirondack chairs, not!


    "I recommend these as my number one because they build strength in the quads, glutes, and core through a movement people need every day," says Kraft. "Being able to stand up from a chair with control is one of the clearest signs of functional lower-body strength. It sounds easy to do but as we age, doing this is vital to maintaining functional movement."

    1. Begin seated at the front of a sturdy chair, feet under your knees.
    2. Lean forward just a bit.
    3. Try to stand up without using your knees, hands, or additional support.
    4. Use control to slowly sit back down.

    RELATED: If You Can Do These 8 Lower-Body Moves, Your Leg Strength Is Elite

    2. Step-Ups

    My stepping is only going to get better since I bought a 4 level condo, 7 steps between levels.

    "Step-ups help rebuild lower-body strength while also training balance, coordination, and single-leg control," Kraft says. "After 60, that combination matters because people are often dealing with both muscle loss and reduced stability."

    1. Begin by standing tall, facing a low step, holding a lightweight dumbbell in each hand.
    2. Place your left foot firmly onto the surface, keeping your core engaged and chest tall.
    3. Press through your left heel to lift your body until your left leg is straight and you're standing on the surface.
    4. Use control to lower back to the start position.
    5. Repeat on the other side.

    RELATED: 5 Easy Bodyweight Tests That Show Your Real Fitness After 45

    3. Incline Pushups

    Not possible since my doctor completely failed at curing my spasticity and thus can't flatten my left hand at all.

    "One of my favorite ways to train upper-body pushing strength safely. It works the chest, shoulders, arms, and core without requiring someone to get down on the floor, and it's easy to scale based on ability," Kraft tells us.

    1. Use a stable surface like a wall, countertop, plyometric box, or workout bench, and place your hands on it, shoulder-width apart.
    2. Walk your legs back so you're at a straight incline from your head to your heels.
    3. Keep your legs together and rise onto the balls of your feet. Engage your core and keep your gaze forward.
    4. Bend your elbows to lower your body until your chest lines up with your elbows.
    5. Return back to straight arms.

    RELATED: These 5 Daily Moves Reverse Muscle Loss Faster Than Gym Workouts After 45

    4. Farmer's Carry

    "Farmer carries are one of the most practical strength exercises I use. They challenge grip, posture, core stability, and full-body tension in a way that translates directly to real life, like carrying groceries, laundry, or bags," Kraft explains. "So many folks I meet past 60 really start losing grip strength and posture while walking quickly. This keeps those muscles firing and you mobile."

    1. Hold a dumbbell in each hand at your sides.
    2. Start walking forward, keeping your torso still and maintaining a tall posture.

    RELATED: 5 No-Equipment Exercises That Strengthen Your Core Faster Than Planks After 40

    5. Glute Bridges

    "The glutes are the largest muscle in the body and the first to weaken after 60," Siwicki tells us.

    1. Lie flat on your back with bent knees and feet hip-width apart on the floor, arms at your sides with palms pressing into the ground.
    2. Press through your heels to lift your hips until your body forms a straight line from head to heels.
    3. Squeeze your buttocks, holding at the top for 2 seconds.
    4. Lower your hips back to the start position.

    Read the original article on Eat This Not That.

    Thursday, August 13, 2026

    Experts share 14 anti-aging secrets that could add years to your life

     I'm good.

    Experts share 14 anti-aging secrets that could add years to your life

     

    Cut back on added sugar

    Sugar is a major dietary driver of premature aging, says plastic surgeon Anthony Youn, MD, an anti-aging expert and author of The Age Fix: A Leading Plastic Surgeon Reveals How to Really Look 10 Years Younger. “One study attributed 184,000 deaths each year to sugary drinks like soda pop and punch,” he says. “Not only do they increase your risk of [type 2] diabetes and being overweight, but the sugar in the drinks also can make you look older.”

    Alongside added sugar, aim to moderate your intake of saturated fat, trans fats, syrups, and refined carbs, advises Michael Roizen, MD, Cleveland Clinic’s chief wellness officer and author of several books, including Real Age: Are You as Young as You Can Be? “By avoiding these five food categories, you can significantly lower your chances of disease and premature aging.”

    Eat the rainbow

    Colorful fruits and vegetables are packed with anti-aging antioxidants—you can actually see these nutritious compounds in the pigments that give these foods their vibrant colors, Dr. Youn says. “Eat a wide array of colors to improve your health and slow down the aging process.”

    Stanford nutrition experts call “the best diet to prevent chronic illness”: the Mediterranean diet. Rich in colorful fruits and vegetables, whole grains, legumes, heart-healthy fats, and lean meat, it’s been consistently shown to support long-term health down to the cellular level. 

    Go easy on red meat

    The Mediterranean diet emphasizes lean protein sources, like poultry, fish, and legumes. While red meat does provide important nutrients, including iron, zinc, and vitamin B12, it’s also high in saturated fat. That’s why even moderate intake—about two servings of red meat per week—is associated with a greater risk of type 2 diabetes, according to 2023 research in The American Journal of Clinical Nutrition

    Stay on top of your dental health

    Flossing daily helps decrease inflammation in your gums, Dr. Roizen says. “Inflammation is one of the greatest causes of aging; it’s linked to heart disease and stroke and impedes the immune system, which increases the risk of infection, cancer, and brain dysfunction,” he says. “Gum disease is one of the biggest causes of inflammation that we have, but we can prevent it by flossing and seeing a dentist twice a year.”

    Move more throughout the day

    Long stretches of sitting raise the risk for all sorts of diseases and conditions that can shorten lives, Dr. Roizen says. “Don’t sit for more than two hours in a row, and walk at least two minutes every two hours,” he says. Even short, regular movement breaks improve cardiovascular, metabolic, and cognitive health.

    While you’re at it, a bit of playful movement can help build stronger bones. Dr. Roizen recommends jumping in place about 40 times to strengthen your spine and decrease your risk of fractures. According to the Centers for Disease Control (CDC), more than 38,000 adults over age 65 die from falls each year, which means strong bones are an important anti-aging key to keep you healthy.

    Quit smoking (and vaping)

    Good on this.

    Smoking tobacco is linked to a laundry list of diseases that will shorten your life, including cancer, heart disease, and stroke. It’s not just cigarettes, either: Vaping or spending time in hookah parlors is also dangerous, Dr. Roizen says. 

    Know your health numbers

    Preventive healthcare is one of the most powerful tools for long-term health. A 2023 paper in the American Journal of Preventive Medicine and Public Health notes that tracking your key metrics helps reduce the risk of age-related illness by giving you time to make lifestyle changes, treat issues early, and take proactive control of your health. 

    I track and know none of these, not important to me.

    Even if you’re feeling well, make sure you know your:

    • Daily calorie needs
    • Waist size (circumference)
    • Blood pressure
    • Resting heart rate
    • Triglyceride levels
    • Blood sugar

    Screening tests are another cornerstone of disease prevention, as they allow doctors to detect and catch problems early—when they’re easiest to treat. 

    Most adults should have their blood pressure checked annually and cholesterol levels screened at least every five years, according to the National Institutes of Health (NIH). Depending on your sex, age, and personal risk factors, you’ll also want to talk to your doctor about screenings for different cancers and conditions like diabetes and osteoporosis. 

    Stay up-to-date on vaccines

    According to the CDC, most U.S. adults have not received age-appropriate vaccinations, leaving them vulnerable to preventable diseases. Even if you’re first in line to get your annual flu shot, make sure you’re up-to-date on the main vaccinations doctors want you to know about. 

    Check your vitamin D levels

    No clue.

    Dr. Roizen recommends asking your doctor to check your vitamin D status and to consider taking a supplement if your levels are low. Vitamin D deficiency has been linked to a wide range of age-related diseases, many of which can shorten your lifespan, according to research published in Aging and Disease. And as we get older, our skin gets less efficient at producing vitamin D from sunlight, which raises the risk of deficiency. 

    Manage daily stress

    Now retired, no stress at all.

    While it’s tough to eliminate stress from your life, shifting the way you react can reap some anti-aging benefits. That’s key because not coping well with stress can take its toll on health and longevity, Dr. Roizen says. 

    “Learning how to manage stress with guided imagery, meditation, deep breathing, or another practice can add years to your life,” he says. One of his own tricks: placing a finger on his belly button to feel it moving in and out—confirmation he’s taking deep breaths—when he needs to combat the effects of stress.

    Sleep like it’s medicine

    Now retired, sleep is decent.

    Getting quality sleep is another way to reduce stress—and to lower your risk of developing chronic health conditions associated with stress, says Los Angeles sleep expert Michael J. Breus, PhD, a board-certified clinical psychologist and clinical sleep specialist.

    Poor sleep, on the other hand, sets us up for a greater risk of obesity and other diseases that can shorten our lives.

    Live with purpose

    My purpose is to get stroke solved to 100% recovery! There seems to be NO stroke medical 'professionals' or fucking failures of stroke associations doing anything towards 100% recovery!

    .

    A growing body of research links a strong sense of meaning and purpose with a lower risk of chronic disease and early mortality. A 2021 study published in the American Journal of Health Promotion looked specifically at how purpose impacts health outcomes. 

    Analyzing data from nearly 13,000 adults over age 50, the researchers found that those who feel a strong sense of purpose had a:

    • 46% reduced risk of mortality
    • 33% lower risk of sleep problems
    • 22% lower likelihood of developing an unhealthy BMI
    • Stay positive

    Look on the bright side: not all anti-aging secrets mean a trip to the doctor! Of 100,000 women in the Women’s Health Initiative study, those with an optimistic outlook on life were 14% less likely than pessimists to die during the study’s first eight years, according to research published in the Journal of the Academy of Nutrition and Dietetics.

    Give back

    Not for me.

    Research shows that caring for others is strongly associated with longevity. A 2025 study published in Social Science & Medicine found that volunteering—even as little as one hour a week—can actually slow biological aging, especially in retired adults. This slower aging is linked with the delayed onset of age-related diseases, stronger cognitive and physical functioning, and a more resilient immune system. 

    Even donating blood may be a life-lengthening form of giving back. A study published in Transfusion found that frequent blood donors live longer than those who don’t donate. 

    For daily wellness updates, subscribe to The Healthy newsletter and follow The Healthy on Facebook and Instagram. Keep reading:

    The post Experts Share 14 Anti-Aging Secrets That Could Add Years to Your Life appeared first on The Healthy.

    Tuesday, August 11, 2026

    Regenerative Astrocytes Repair Brain Damage

     How long will it take for your competent? doctor/hospital to get human testing going for stroke? NEVER?

    Do you prefer your doctor, hospital and board of director's incompetence NOT KNOWING? OR NOT DOING? Your choice; let them be incompetent or demand action!

    Your stroke medical 'professionals' have been creating protocols on astrocytes for over a decade, right!

    Regenerative Astrocytes Repair Brain Damage

    Summary: Researchers discovered a previously unknown mechanism through which the adult mammalian brain repairs itself following focal injuries or autoimmune damage. Using two-photon microscopy and longitudinal gene mapping in living mouse models, researchers identified a specialized population of “regenerative” astrocytes capable of repopulating damaged brain regions.

    Rather than relying solely on classical cell body division at the site of injury, these specialized astrocytes situated along the lesion perimeter send newly formed daughter cell nuclei gliding long distances through their star-shaped cellular extensions. These migrating cell nuclei repopulate the depleted lesion zone, re-establishing functional astrocyte networks.

    This discovery overturns long-held assumptions regarding the limited regenerative capacity of adult glial networks, revealing molecular signaling pathways that could serve as therapeutic targets for traumatic brain injury and autoimmune conditions such as neuromyelitis optica spectrum disorder (NMOSD).

    Key Facts

    • Overturning Dogma on Glial Regeneration: Demonstrates that the adult central nervous system possesses a previously unrecognized capability to replace lost astrocytes and restore damaged tissue architecture.
    • Mechanism of Long-Distance Nuclear Migration: Specialized regenerative astrocytes remain at the lesion boundary and send newly generated cell nuclei gliding across long astrocytic extensions into the depleted injury core.
    • Rebuilding Functional Glial Networks: Astrocytes perform vital homeostatic functions, including nutrient supply to neurons, blood flow regulation via end-feet, and extracellular ion balance, making their network reconstruction essential for neuronal survival.
    • Targeted Clinical Applications: Holds therapeutic relevance for neurotraumatic brain injuries and rare autoimmune conditions like neuromyelitis optica spectrum disorder (NMOSD), where autoantibodies selectively destroy astrocytes.
    • Molecular Targets for Therapeutics: The team identified specific genes and signaling pathways temporarily activated during nuclear migration, providing potential targets for pharmacological interventions to accelerate brain repair.

    Source: University of Zurich

    The brain evidently can regenerate itself better than previously assumed after injuries or certain autoimmune diseases. Using a mouse model, researchers at the University of Zurich have demonstrated that special supporting and nourishing cells repopulate damaged areas of the brain by initially sending only newly formed cell nuclei there.

    Glial cells are supporting and nourishing cells in the brain. Star-shaped glial cells called astrocytes are vital to the functioning of neurons. They supply the nerve cells with nutrients, help to regulate blood flow and keep brain tissue healthy.

    It had long been assumed that when astrocytes are lost – as happens, for instance, in brain injuries or autoimmune diseases such as rare neuromyelitis optica spectrum disorder, in which the body’s own antibodies destroy these cells – the adult brain cannot fully replace them.This shows the astrocytes repairing damaged tissue in the brain.

    The image on the left shows a brain lesion (diameter: just under 0.5 mm). Around the perimeter of the lesion, the newly discovered “regenerative” astrocytes begin to seal the defect by forming long cellular extensions (shown in red). Newly formed cell nuclei (shown in blue) migrate along the cellular extensions toward the damaged area. Unaltered astrocytes (shown in green) surround the lesion area. The image on the right shows an enlargement of the marked area in the left image. Credit: Institute of Pharmacology and Toxicology, University of Zurich

    Regenerative astrocytes repair damaged tissue

    A new study by co-lead authors Marina Herwerth and Matthias Wyss from the Institute of Pharmacology and Toxicology at the University of Zurich (UZH) has now overturned that assumption: their research team headed by Bruno Weber discovered a specialized group of “regenerative” astrocytes in the brains of living mice that step in on the perimeter of the damaged area of the brain to rebuild the cells.

    “The findings of our study reveal a previously unknown ability of the adult brain to repair itself. They point toward new ways of supporting recovery from ailments involving the loss of astrocytes,” Weber says.

    Only cell nuclei migrate

    The researchers used two-photon microscopy to observe the brains of living mice in real time over a period of several weeks and mapped which genes switch on in which areas of the brain. This way they were able to identify the special astrocytes that take care of rebuilding injured tissue. But those cells don’t just divide, they also perform a remarkable feat: “they send the newly formed nuclei of their daughter cells gliding across long distances to repopulate the damaged area of the brain and knit the astrocyte network back together,” Weber explains.

    Starting points for targeted regeneration

    The discovery of how adult brain cell nuclei migrate through the long star-shaped extensions of astrocytes to injured tissue expands comprehension of how the brain organizes and regenerates itself after certain injuries. If those mechanisms can be selectively activated, that could help to more effectively repair damaged brain tissue, restore astrocyte networks and thus improve recovery after certain brain disorders.

    “We were able to identify numerous genes and signaling pathways that are temporarily activated during repair. They could serve as starting points in the future for influencing post-disease and -injury regeneration processes,” Weber stresses.

    Key Questions Answered:

    Q: How do “regenerative” astrocytes differ from standard cell division during tissue repair?

    A: Instead of whole cells migrating or simply dividing locally, these specialized astrocytes remain at the perimeter of the damaged area. They divide and send the newly formed nuclei of their daughter cells gliding long distances through their extended cellular processes directly into the injured zone to rebuild the network.

    Q: What conditions cause the loss of astrocytes in the adult brain?

    A: Astrocytes are lost during traumatic brain injuries, strokes, and specific neuroinflammatory or autoimmune conditions, most notably Neuromyelitis Optica Spectrum Disorder (NMOSD), where the body’s immune system produces autoantibodies that target and destroy astrocytes.

    Q: How was this nuclear migration observed in real time?

    A: Researchers at the University of Zurich used in vivo two-photon microscopy in living mouse models over several weeks. This allowed them to track living cells, observe nuclear movement through astrocytic branches, and map corresponding gene expression changes as the tissue repaired itself.

    Editorial Notes:

    • This article was edited by a Neuroscience News editor.
    • Journal paper reviewed in full.
    • Additional context added by our staff.

    About this neuroscience research news

    Author: Kurt Bodenmueller
    Source: University of Zurich
    Contact: Kurt Bodenmueller – University of Zurich
    Image: The image is credited to Institute of Pharmacology and Toxicology, University of ZurichOriginal Research: Open access.

    Focal astrocyte loss reveals nuclear translocation during lesion repopulation” by Marina Herwerth, Matthias T. Wyss, Nicola B. Schmid, Anna Lasne, Jacqueline Condrau, Luca Ravotto, José María Mateos Melero, Andres Kaech, Gustav Bredell, Carolina Thomas, Rachel Kim, Petra Kukanja, Vladyslav L. Korobeynyk, Christine Stadelmann, Thomas Misgeld, Jeffrey L. Bennett, Sebastian Jessberger, Aiman S. Saab, Shane A. Liddelow & Bruno Weber. Nature Neuroscience
    DOI:10.1038/s41593-026-02354-5

    Monday, August 10, 2026

    Regenerative Astrocytes Repair Brain Damage

     A competent? doctor and hospital WOULD INSURE HUMAN TESTING OCCURS! Do you have competence among in your stroke medical 'professionals'?

    Do you prefer your doctor, hospital and board of director's incompetence NOT KNOWING? OR NOT DOING? Your choice; let them be incompetent or demand action!

    Regenerative Astrocytes Repair Brain Damage

    Summary: Researchers discovered a previously unknown mechanism through which the adult mammalian brain repairs itself following focal injuries or autoimmune damage. Using two-photon microscopy and longitudinal gene mapping in living mouse models, researchers identified a specialized population of “regenerative” astrocytes capable of repopulating damaged brain regions.

    Rather than relying solely on classical cell body division at the site of injury, these specialized astrocytes situated along the lesion perimeter send newly formed daughter cell nuclei gliding long distances through their star-shaped cellular extensions. These migrating cell nuclei repopulate the depleted lesion zone, re-establishing functional astrocyte networks.

    This discovery overturns long-held assumptions regarding the limited regenerative capacity of adult glial networks, revealing molecular signaling pathways that could serve as therapeutic targets for traumatic brain injury and autoimmune conditions such as neuromyelitis optica spectrum disorder (NMOSD).

    Key Facts

    • Overturning Dogma on Glial Regeneration: Demonstrates that the adult central nervous system possesses a previously unrecognized capability to replace lost astrocytes and restore damaged tissue architecture.
    • Mechanism of Long-Distance Nuclear Migration: Specialized regenerative astrocytes remain at the lesion boundary and send newly generated cell nuclei gliding across long astrocytic extensions into the depleted injury core.
    • Rebuilding Functional Glial Networks: Astrocytes perform vital homeostatic functions, including nutrient supply to neurons, blood flow regulation via end-feet, and extracellular ion balance, making their network reconstruction essential for neuronal survival.
    • Targeted Clinical Applications: Holds therapeutic relevance for neurotraumatic brain injuries and rare autoimmune conditions like neuromyelitis optica spectrum disorder (NMOSD), where autoantibodies selectively destroy astrocytes.
    • Molecular Targets for Therapeutics: The team identified specific genes and signaling pathways temporarily activated during nuclear migration, providing potential targets for pharmacological interventions to accelerate brain repair.

    Source: University of Zurich

    The brain evidently can regenerate itself better than previously assumed after injuries or certain autoimmune diseases. Using a mouse model, researchers at the University of Zurich have demonstrated that special supporting and nourishing cells repopulate damaged areas of the brain by initially sending only newly formed cell nuclei there.

    Glial cells are supporting and nourishing cells in the brain. Star-shaped glial cells called astrocytes are vital to the functioning of neurons. They supply the nerve cells with nutrients, help to regulate blood flow and keep brain tissue healthy.

    It had long been assumed that when astrocytes are lost – as happens, for instance, in brain injuries or autoimmune diseases such as rare neuromyelitis optica spectrum disorder, in which the body’s own antibodies destroy these cells – the adult brain cannot fully replace them.

    Regenerative astrocytes repair damaged tissue

    A new study by co-lead authors Marina Herwerth and Matthias Wyss from the Institute of Pharmacology and Toxicology at the University of Zurich (UZH) has now overturned that assumption: their research team headed by Bruno Weber discovered a specialized group of “regenerative” astrocytes in the brains of living mice that step in on the perimeter of the damaged area of the brain to rebuild the cells.

    “The findings of our study reveal a previously unknown ability of the adult brain to repair itself. They point toward new ways of supporting recovery from ailments involving the loss of astrocytes,” Weber says.

    Only cell nuclei migrate

    The researchers used two-photon microscopy to observe the brains of living mice in real time over a period of several weeks and mapped which genes switch on in which areas of the brain. This way they were able to identify the special astrocytes that take care of rebuilding injured tissue. But those cells don’t just divide, they also perform a remarkable feat: “they send the newly formed nuclei of their daughter cells gliding across long distances to repopulate the damaged area of the brain and knit the astrocyte network back together,” Weber explains.

    Starting points for targeted regeneration

    The discovery of how adult brain cell nuclei migrate through the long star-shaped extensions of astrocytes to injured tissue expands comprehension of how the brain organizes and regenerates itself after certain injuries. If those mechanisms can be selectively activated, that could help to more effectively repair damaged brain tissue, restore astrocyte networks and thus improve recovery after certain brain disorders.

    “We were able to identify numerous genes and signaling pathways that are temporarily activated during repair. They could serve as starting points in the future for influencing post-disease and -injury regeneration processes,” Weber stresses.

    Key Questions Answered:

    Q: How do “regenerative” astrocytes differ from standard cell division during tissue repair?

    A: Instead of whole cells migrating or simply dividing locally, these specialized astrocytes remain at the perimeter of the damaged area. They divide and send the newly formed nuclei of their daughter cells gliding long distances through their extended cellular processes directly into the injured zone to rebuild the network.

    Q: What conditions cause the loss of astrocytes in the adult brain?

    A: Astrocytes are lost during traumatic brain injuries, strokes, and specific neuroinflammatory or autoimmune conditions, most notably Neuromyelitis Optica Spectrum Disorder (NMOSD), where the body’s immune system produces autoantibodies that target and destroy astrocytes.

    Q: How was this nuclear migration observed in real time?

    A: Researchers at the University of Zurich used in vivo two-photon microscopy in living mouse models over several weeks. This allowed them to track living cells, observe nuclear movement through astrocytic branches, and map corresponding gene expression changes as the tissue repaired itself.

    Editorial Notes:

    • This article was edited by a Neuroscience News editor.
    • Journal paper reviewed in full.
    • Additional context added by our staff.

    About this neuroscience research news

    Author: Kurt Bodenmueller
    Source: University of Zurich
    Contact: Kurt Bodenmueller – University of Zurich
    Image: The image is credited to Institute of Pharmacology and Toxicology, University of Zurich

    Original Research: Open access.
    Focal astrocyte loss reveals nuclear translocation during lesion repopulation” by Marina Herwerth, Matthias T. Wyss, Nicola B. Schmid, Anna Lasne, Jacqueline Condrau, Luca Ravotto, José María Mateos Melero, Andres Kaech, Gustav Bredell, Carolina Thomas, Rachel Kim, Petra Kukanja, Vladyslav L. Korobeynyk, Christine Stadelmann, Thomas Misgeld, Jeffrey L. Bennett, Sebastian Jessberger, Aiman S. Saab, Shane A. Liddelow & Bruno Weber. Nature Neuroscience
    DOI:10.1038/s41593-026-02354-5

    Thursday, July 30, 2026

    13 million views of this blog

     

    I must still be interesting to some people. I have never received any direct communications from any stroke medical 'professionals'. Are they scared to talk to me?

    First million took from Aug. 2010  to Sept. 2014

    Second million from Sept. 2014 to May 2016

    Third million from May 2016 to March 2017

    Fourth million from March 2017 to November 2018

    Fifth million from November 2018 to September 2021

    Sixth million from September 2021 to June 2024

    Seventh million was from June 2024 to January 2025. 

    Eigth million was from January 2025 to June 2025

    Ninth million was from June 2025 to September 2025;

    Tenth million was from September 2025 to January 2026

    Eleventh million was from January 2026 to April 2026

    Twelfth million from April 2026 to June 2026

    Thieteen million from June 2026 to July 2026

    The first post was:



    What my doctor should have told me about stroke recovery

    Still has the same relevance today. And I'm still as arrogant and opinionated as ever. Arrogance is only true if you don't know what you're talking about! I do know what I'm talking about! 

    Your doctor really knows nothing SPECIFIC AND EXACT to get you recovered. Ask him/her; you'll get dissembling rather than specifics! Or you'll get the craptastic saying: 'All strokes are different, all stroke recoveries are different'. In my opinion, that is the comment of a totally incompetent doctor!

    Friday, July 24, 2026

    New procedure helps restore independence after stroke

     If it's new to your hospital; THAT IS PURE INCOMPETENCE! 

    There is nothing new about vagus nerve treatment for stroke. The only thing new is your stroke medical 'professionals' incompetence in acknowledging they are incompetent.

    vagus nerve (56 posts to July 2012)

    And why the surgical option? Need the revenue?

    New procedure helps restore independence after stroke

    For many stroke survivors, weakness or limited movement in their hands and arms can persist long after the initial event, making routine tasks a daily challenge. Baptist Health is bringing renewed hope to those affected by stroke by offering a new outpatient procedure that, when paired with rehabilitative therapy, may help patients regain function in their upper extremities months or even years after an ischemic stroke.

    “This first-of-its-kind treatment represents a promising new advancement in stroke recovery,” said neurosurgeon Eric Sauvageau, M.D., co-medical director of Baptist Stroke & Cerebrovascular Center. “Because it helps create new neural connections, improvements in movement can continue even after rehabilitative therapy ends. I’ve seen patients who couldn’t open their hands following a stroke five, seven or even 10 years ago now using their hands to eat.”

    The minimally invasive procedure, performed at Baptist Medical Center Jacksonville, involves implanting a medical device no bigger than the palm of a hand into a patient’s chest. A wire connects the device to the vagus nerve in the neck, which carries signals between the brain and body. The FDA-approved Vivistim Paired VNS System delivers gentle, repeated stimulation to help support recovery.

    Vagus nerve stimulation (VNS), when delivered alongside physical and occupational therapy, boosts the brain’s ability to relearn movement by strengthening existing neural pathways and creating new ones that bypass areas damaged by the stroke. Research has shown that pairing VNS with rehabilitation may help people recover hand and arm function better than rehabilitation alone, with some studies finding improvements that were two to three times greater. While VNS is a newer approach for stroke recovery, it has been used at Baptist Health for years to treat other conditions such as epilepsy. 

    Regaining movement and independence

    The VNS treatment for stroke is suitable for those who have experienced moderate to severe upper extremity impairment for at least six months or more following an ischemic stroke. Outpatient rehabilitation therapy begins two to three weeks after implantation, with sessions focused on everyday activities such as brushing one’s hair or cutting food. The device delivers stimulation as patients perform these movements, and patients can continue therapy at home by activating the device while practicing exercises or performing daily tasks.

    “This innovative therapy is part of our ongoing effort to bring leading-edge stroke treatments to the communities we are privileged to serve,” said Nicole B. Thomas, president of Baptist Jacksonville. “As the regional leader in comprehensive stroke care, our specialist teams excel at delivering compassionate care that restores independence and quality of life to our patients and their families.”

    Baptist Health is a regional leader in neurology and neurosurgery and is recognized nationally for minimally invasive, innovative treatments and groundbreaking research.

    At the forefront of this work is Baptist Stroke & Cerebrovascular Center. Located at Baptist Jacksonville, it is a leader for advanced diagnostics and treatments for strokes, brain aneurysms and other cerebrovascular conditions. The center’s reach extends to more than two dozen hospitals and satellite EDs via the Telestroke Program, which virtually connects physicians and health care professionals in the greater Jacksonville area and South Georgia with Baptist Health’s stroke experts.

    Accessible 24/7, the program promotes quicker diagnosis and treatment, reduces potential disability and saves lives.

    For more information on Baptist Health’s stroke program and the Baptist Stroke & Cerebrovascular Center, go to baptistjax.com/services/brain-and-spine/stroke-and-cerebrovascular-care.

    Friday, July 10, 2026

    From Literature to Lived Experiences: Architectural determinants of Subjective Well-Being in Post-Stroke Rehabilitation

    Actual well-being is the better measurement! Ask the survivor; 'Are you 100% recovered?' That is the only question needed, didn't get there; FAILURE OF YOUR STROKE MEDICAL 'PROFESSIONALS'!

     From Literature to Lived Experiences: Architectural determinants of Subjective Well-Being in Post-Stroke Rehabilitation

    Louise MASCIARELLIa, b , Ann PETERMANS b, Clémentine SCHELINGS a, Jan VANRIE b and Catherine ELSEN a aUniversity of Liège, Belgium bUniversity of Hasselt, Belgium ORCiD ID: Louise MASCIARELLI https://orcid.org/0000-0003-2051-7632 Ann PETERMANS https://orcid.org/0000-0001-7023-4628 Clémentine SCHELINGS https://orcid.org/0000-0001-7718-4539 Jan VANRIE https://orcid.org/0000-0003-2633-5194 Catherine ELSEN https://orcid.org/0000-0003-1433-3298 

    Abstract. 


    Post-stroke rehabilitation environments involve multiple user profiles. While the influence of architecture on well-being is increasingly acknowledged in healthcare settings, a comprehensive understanding of how architectural determinants relate to the subjective well-being of these users in post-stroke rehabilitation remains limited. Based on a previous systematic literature review, twenty-one architectural themes impacting subjective well-being in post-stroke rehabilitation contexts were identified. These themes reflect a wide range of spatial, environmental, and experiential aspects discussed in existing research. Building on this review synthesis, this article explores how these themes are perceived and experienced by different user profiles in a real-life post-stroke rehabilitation setting within a Belgian context: not only long-term inpatients, but also healthcare professionals, informal caregivers, and visitors (family members). To do so, the study adopts a qualitative methodology combining walking interviews in the rehabilitation service with semi-structured interviews relying on photo-elicitation (n=10). Participants are invited to discuss photographs of rehabilitation environments to support their reflection on experiences, perceptions, and priorities related to architectural space and subjective well-being. This methodology aims to facilitate expression in a sensitive clinical context and to capture nuanced, subjective perspectives that may not emerge through verbal or self-administered questioning alone. The article brings into dialogue the insights from the systematic literature and the empirical material. It also examines whether engagement with various users' profiles in a real rehabilitation context reveals additional architectural themes related to subjective well-being beyond those identified in the literature. By articulating insights from the literature with situated user experiences, this research seeks to refine and extend current knowledge on the relationship between architecture and subjective well-being in post-stroke rehabilitation contexts.