Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Showing posts with label saffron. Show all posts
Showing posts with label saffron. Show all posts

Friday, May 24, 2024

Can Pink Noise Enhance Sleep and Memory? Early Research Drives a Color Noise Buzz.

 

What is your doctors sleep protocol for you? Doesn't have one! You don't have a functioning stroke doctor! Why are you there?

Is your doctor suggesting either of these? Never mind, way too soon for your doctor to read, understand and implement these interventions. Maybe 50 years from now.

Effects of saffron on sleep quality in healthy adults with self-reported poor sleep: A randomized, double-blind, placebo-controlled trial June 2020

Pink Noise Machines Improve Sleep & Fight Dementia  June 2020

 The latest here:

Can Pink Noise Enhance Sleep and Memory? Early Research Drives a Color Noise Buzz.

— "There's still a lot of work we have to do," says one researcher

A photo of Dr. Roneil Malkani showing an example of pink noise being used to enhance slow brain waves during deep sleep.
(AP Photo/Laura Bargfeld)

You may have heard of white noise used to mask background sounds. Now, it has colorful competition.

There's a growing buzz around pink noise, brown noise, green noise -- a rainbow of soothing sounds -- and their theoretical effects on sleep, concentration, and the relaxation response.

The science is new with only a few small studies behind it, but that hasn't stopped thousands of people from listening to hours of these noises on YouTube and on meditation apps that provide a palette of color noises with paid subscriptions.

What Is Pink Noise?

To understand pink noise, start with white, the most familiar of the color noises.

White noise is similar to static on a radio or TV. Sound engineers define it as having equal volume across all the frequencies audible to the human ear. It gets its name from white light, which contains all the visible color wavelengths.

But the high frequencies of white noise can sound harsh. Pink noise turns down the volume on those higher frequencies, so it sounds lower in pitch and more like the natural sound of rain or the ocean.

Brown noise sounds even lower in pitch, giving it a pleasing, soothing rumble.

Pink and brown, like white, have standard definitions to audio experts. Other color noises are more recent creations with very flexible definitions.

What's the Science Behind Color Noises?

White noise and pink noise may provide small benefits for people with attention deficit-hyperactivity disorder (ADHD), according to a recent review of limited ADHDopens in a new tab or window studiesopens in a new tab or window. In theory, it wakes up the brain, said ADHD researcher and co-author Joel Nigg, PhD, of Oregon Health & Science University in Portland.

"The noise provides stimulation to the brain without providing information, and so it doesn't distract," Nigg said.

White noise has been used to treat ringing or buzzing in the ear, called tinnitusopens in a new tab or window.

Scientists at Northwestern University are studying how short pulses of pink noise can enhance the slow brain waves of deep sleep. In small studies, these pink-noise pulses have shown promise in improving memory and the relaxation response.

Pink noise has a frequency profile "very similar to the distribution of brain wave frequencies we see in slow-wave sleep because these are large, slow waves," said Roneil Malkani, MD, associate professor of neurology at Northwestern University Feinberg School of Medicine.

If Northwestern's research pans out, it could lead to a medical device to improve sleep or memory through personalized pulses of pink noise. But many scientific questions remain unanswered, Malkani said. "There's still a lot of work we have to do."

Is There Any Harm in Trying Color Noises?

If color noises feel calming and help you drown out distractions, it makes sense to use them. Keep them at a quiet level, of course, to prevent hearing loss and take "plenty of breaks for the ears to rest," Nigg said.

Tuesday, May 7, 2024

Presence of Self-Reported Sleep Alterations After Stroke and Their Relationship With Disability: A Longitudinal Study.

What is your doctors sleep protocol for you? Doesn't have one! You don't have a functioning stroke doctor! Why are you there?

Is your doctor suggesting either of these? Never mind, way too soon for your doctor to read, understand and implement these interventions. Maybe 50 years from now.

Effects of saffron on sleep quality in healthy adults with self-reported poor sleep: A randomized, double-blind, placebo-controlled trial June 2020

Pink Noise Machines Improve Sleep & Fight Dementia  June 2020

 The latest here:

 Presence of Self-Reported Sleep Alterations After Stroke and Their Relationship With Disability: A Longitudinal Study.

Marcela Rangel, Leonardo Silva, Estefany Gonçalves, Andressa Silva, Luci Teixeira-Salmela, Aline Scianni

BACKGROUND: Sleep disorders have a prevalence of 30% to 70% in post-stroke individuals. The presence of sleep disorders and poor sleep quality after stroke can affect important functions and lead to worse outcomes. However, most studies are restricted to the acute post-stroke stage only.

OBJECTIVE: To investigate the frequency of self-reported sleep alterations in a sample of chronic stroke individuals and to identify which self-reported sleep alterations were associated with disability.

METHODS: Prospective exploratory study. Self-reported sleep alterations were measured by the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Epworth Sleepiness Scale, and STOP-Bang Questionnaire. The dependent variable was measured 3 years after the first contact by the Modified Rankin Scale (mRS). Step-wise multiple linear regression analysis was employed to identify which sleep alterations were associated with disability.

RESULTS: Sixty-five individuals with stroke participated. About 67.7% of participants had poor sleep quality, 52.4% reported insomnia symptoms, 33.9% reported excessive daytime sleepiness, and 80.0% were classified as intermediate or high risk for obstructive sleep apnea. Only risk for obstructive sleep apnea was significantly associated with disability and explained 5% of the variance in the mRS scores.

CONCLUSION: Self-reported sleep alterations had a considerable frequency in a sample of chronic stroke individuals. The risk of obstructive sleep apnea was associated with disability in the chronic stage of stroke. Sleep alterations must be considered and evaluated in the rehabilitation process even after a long period since the stroke onset.

Obstructive Sleep ApneaSleep ApneaStroke
Neurology

Wednesday, August 19, 2020

Sleep disruption after brain injury is associated with worse motor outcomes and slower functional recovery

Useless. Describes a problem, OFFERS NO SOLUTION.

Absolutely nothing here is going to help with 30% of survivors having sleep problems. Damn it all, solve stroke problems, don't just do useless research.

Is your doctor suggesting either of these? Never mind, way too soon for your doctor to read, understand and implement these interventions. Maybe 50 years from now.

Effects of saffron on sleep quality in healthy adults with self-reported poor sleep: A randomized, double-blind, placebo-controlled trial June 2020

Pink Noise Machines Improve Sleep & Fight Dementia  June 2020

 The latest here:

 Sleep disruption after brain injury is associated with worse motor outcomes and slower functional recovery

Neurorehabilitation and Neural Repair (NNR) , Volume 34(7) , Pgs. 661-671.

NARIC Accession Number: J84095.  What's this?
ISSN: 1545-9683.
Author(s): Fleming, Melanie K. ; Smejk, Tom ; Slater, David H.; van Gils, Veerle ; Garratt, Emma ; Kara, Ece Y.; Johansen-Berg, Heidi.
Publication Year: 2020.
Number of Pages: 9.

Abstract: 

Study investigated the relationship between sleep quality and motor recovery in 59 patients with brain injury patients receiving inpatient rehabilitation. Sleep quality was assessed (up to 3 times) objectively using actigraphy (7 nights) and subjectively using the Sleep Condition Indicator. Motor outcome assessments included Action Research Arm test (upper-limb function), Fugl-Meyer Assessment (motor impairment), and the Rivermead Mobility Index. The Functional Independence Measure (FIM) was assessed at admission and discharge by the clinical team. Fifty-five age- and gender-matched healthy controls completed one assessment. Inpatients demonstrated lower self-reported sleep quality and more fragmented sleep than controls. For inpatients, sleep fragmentation explained significant additional variance in motor outcomes, over and above that explained by admission FIM score such that more disrupted sleep was associated with poorer motor outcomes. Using stepwise linear regression, sleep fragmentation was the only variable found to explain variance in rate of change in FIM, whereby more disrupted sleep was associated with slower recovery. Results suggest that inpatients with brain injury demonstrate impaired sleep quality, and this is associated with poorer motor outcomes and slower functional recovery. Further investigation is needed to determine how sleep quality can be improved and whether this affects outcome.
Descriptor Terms: BRAIN INJURIES, LIMBS, MOBILITY IMPAIRMENTS, MOTOR SKILLS, REHABILITATION, SLEEP DISORDERS.


Can this document be ordered through NARIC's document delivery service*?: Y.
Get this Document: https://journals.sagepub.com/doi/full/10.1177/1545968320929669.

Citation: Fleming, Melanie K. , Smejk, Tom , Slater, David H., van Gils, Veerle , Garratt, Emma , Kara, Ece Y., Johansen-Berg, Heidi. (2020). Sleep disruption after brain injury is associated with worse motor outcomes and slower functional recovery.  Neurorehabilitation and Neural Repair (NNR) , 34(7), Pgs. 661-671. Retrieved 8/19/2020, from REHABDATA database.
 

Thursday, August 6, 2020

Sleep Problems Adversely Impact Recovery Following Stroke

Useless. Describes a problem, OFFERS NO SOLUTION.

Absolutely nothing here is going to help with 30% of survivors having sleep problems. Damn it all, solve stroke problems, don't just do useless research.

 

Is your doctor suggesting either of these? Never mind, way too soon for your doctor to read, understand and implement these interventions. Maybe 50 years from now.

Effects of saffron on sleep quality in healthy adults with self-reported poor sleep: A randomized, double-blind, placebo-controlled trial June 2020

Pink Noise Machines Improve Sleep & Fight Dementia  June 2020

 

The latest here:

Sleep Problems Adversely Impact Recovery Following Stroke

Amit Akirov, MD

Sleep problems may adversely impact health-related quality of life, function, and participation during the first 12 months of stroke rehabilitation, according to study results published in Clinical Rehabilitation.

Previous studies reported that sleep has a major role in the acquisition of motor skills after stroke and that poor sleep quality is associated with worse outcomes. The goal of the current study was to assess the impact of self-reported sleep problems on recovery following stroke.

The researchers performed a secondary analysis of sleep-related data collected at 2, 6, and 12 months post-stroke from the Locomotor Experience Applied Post-Stroke (ClinicalTrials.gov Identifier: NCT00243919)  study. This was a phase III, single blind, randomized-controlled clinical trial of adult patients during the first year following stroke.

The participants reported sleep problems at each point and the impact of sleep on their function. In addition, they completed the Stroke Impact Scale to assess health-related quality of life after stroke.

Today’s Top Picks for You on Neurology Advisor


Data collected from 408 subjects (mean age 62.0 years; 55% men) was used for the study, including 327 (80%) patients with a history of ischemic stroke and 76 (19%) patients with that of a hemorrhagic stroke. Data was available from 380 participants at 6 months and from 360 subjects at 12 months.

A total of 98 participants (24%) reported the presence of sleep problems at 2 months, and this rate remained steady at 6 months (94 subjects, 25%) and at 12 months (83 subjects, 23%). Additionally, 10% of participants with sleep problems reported a moderate-to-quite-a-bit-of-impact on function at 2, 6 and 12 months.

Participants who reported having a “sleep problem such as insomnia” that impacted their function had worse function in limb strength, memory and thinking, mood and ability to control emotions, communication, activities of daily living ability, mobility, hand function, and participation during the first year after stroke. However, there was no difference in full recovery.

The study had several limitations, including those associated with the use of self-reported data and lack of objective evidence for sleep disorder. Researchers had not determined whether patients who reported sleep problems were subsequently assessed, diagnosed, or if they received treatment during the study. Other limitations included the study’s cross-sectional design and missing data on sleep disorder diagnoses preceding stroke.

“Our findings here,” concluded the researchers, “indicate that sleep problems may degrade health-related quality of life, function, and participation during the subacute and chronic stages of post stroke recovery.”

Reference

Fulk G, Duncan P, Klingman KJ. Sleep problems worsen health-related quality of life and participation during the first 12 months of stroke rehabilitation [published online, June 30, 2020]. Clin Rehabil. doi:10.1177/0269215520935940

Saturday, June 27, 2020

Effects of saffron on sleep quality in healthy adults with self-reported poor sleep: A randomized, double-blind, placebo-controlled trial

Not to be done on your own because your doctor already has an effective sleep protocol, hopefully it is not sleeping pills. 

Effects of saffron on sleep quality in healthy adults with self-reported poor sleep: A randomized, double-blind, placebo-controlled trial

Lopresti AL, Smith SJ, Metse AP, et al
Journal of Clinical Sleep Medicine|June 18, 2020
This 28-day, parallel-group, double-blind, randomized controlled trial with healthy adults (aged 18–70) with self-reported sleep problems was conducted to determine the sleep-enhancing impacts of a standardized saffron extract (affron). The participants were randomly assigned to receive either saffron extract (affron; 14 mg twice daily) or a placebo. The primary outcome measure was the Insomnia Severity Index. The Restorative Sleep Questionnaire and the Pittsburgh Sleep Diary were also used. Findings revealed improvements in sleep quality in correlation with saffron intake in adults with self-reported sleep complaints. Read the full article on Journal of Clinical Sleep Medicine.

Monday, January 15, 2018

Saffron in the treatment of patients with mild to moderate Alzheimer’s disease: a 16-week, randomized and placebo-controlled trial

Notice that this is for treating those already having Alzheimers, not a preventative yet. Don't do this on your own.
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2710.2009.01133.x/full

Authors

Shahin Akhondzadeh, PhD, Psychiatric Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, South Kargar Street, Tehran 13337, Iran. Tel.: +98 21 88281866; fax: + 98 21 55419113; e-mail: s.akhond@neda.net

Abstract

What is known:  Herbal medicines have been used in the treatment of behavioural and psychological symptoms of dementia but with variable response. Crocus sativus (saffron) may inhibit the aggregation and deposition of amyloid β in the human brain and may therefore be useful in Alzheimer’s disease (AD).
Objective:  The goal of this study was to assess the efficacy of saffron in the treatment of mild to moderate AD.
Methods:  Forty-six patients with probable AD were screened for a 16-week, double-blind study of parallel groups of patients with mild to moderate AD. The psychometric measures, which included AD assessment scale-cognitive subscale (ADAS-cog), and clinical dementia rating scale-sums of boxes, were performed to monitor the global cognitive and clinical profiles of the patients. Patients were randomly assigned to receive capsule saffron 30 mg/day (15 mg twice per day) (Group A) or capsule placebo (two capsules per day) for a 16-week study.
Results:  After 16 weeks, saffron produced a significantly better outcome on cognitive function than placebo (ADAS-cog: F = 4·12, d.f. = 1, P = 0·04; CDR: F = 4·12, d.f. = 1, P = 0·04). There were no significant differences in the two groups in terms of observed adverse events.
What is new and conclusion:  This double-blind, placebo-controlled study suggests that at least in the short-term, saffron is both safe and effective in mild to moderate AD. Larger confirmatory randomized controlled trials are called for.

Sunday, May 21, 2017

Top 10 Spices for a Healthy Brain

Will your doctor and stroke hospital do one fucking thing with this information? Or is it time once again to bury their brains/heads up their asses? Up to you how to respond, take it lying down or agitate. Nothing will get better for your children and grandchildren unless lots of people step forward and call out their stroke medical 'professionals' for doing nothing for future survivor recovery.  With no research references for this you will have to depend on your doctor for advice.
https://psychcentral.com/blog/archives/2017/02/24/top-10-spices-for-a-healthy-brain/



Consider adding these 10 spices below to your current diet, or better yet cook with them to improve overall brain health, and help prevent, or at the very least stave off future cognitive decline. These top spices have been studied extensively by world renowned psychiatrist Dr. Daniel Amen, and is widely discussed in many of his journal publications and books, including one of his latest Change Your Brain, Change Your Life. He recommends the 10 spices below to be incorporated into your every diet to have a happier and healthier brain.
Turmeric
Found in curry, turmeric contains a chemical that has been shown to decrease plaques and tangles in the brain thought to be responsible for the onset of Alzheimer’s disease.
Saffron
In 3 specific studies that Dr. Amen conducted, a saffron extract was found to be as effective as antidepressant medication in treating people with major depression, and various anxiety disorders.
Sage
There is strong scientific evidence that sage helps to improve and strengthen the hippocampus of our brains, which is responsible for memory.
Cinnamon has been shown to help regulate attention, and focus. Additionally, it helps to regulate blood sugar, which decreases the hunger hormone Ghrelin, while boosting Leptin, the satiety hormone responsible for fullness.
Basil, a common antioxidant pizza topper is responsible for improving blood flow to the heart and brain, and has additional anti inflammatory properties that offer protection from Alzheimer’s disease, and other forms of dementia.
Thyme is responsible for increasing the amount of DHA, an essential fatty acid in the brain. DHA is responsible for playing a central role in brain health. In fact, an optimal intake of DHA is especially essential for pregnant and nursing mothers to endure adequate brain development in their children.
Oreganoespecially dried oregano has between 30-40 times the brain healing antioxidant power of raw blueberries, 46 times more than Quercetin that’s found in the skin of apples, and 56 times as much as strawberries, making it one of the most powerful brain cell protectors on the planet.
Garlic promotes better blood flow to the brain, and actually works by stopping/killing brain cancer cells in a 2007 study.
Ginger can potentially make you smarter. A study that combined ginger with ginkgo biloba suggests that it does, and further studies aiming to replicate those earlier findings are currently underway. Ginger root extract may also be beneficial in the treatment of Parkinson’s disease, and for those who suffer from migraine/ tension/cluster headaches.
Rosemary
A recent study highlighted the beneficial effects of rosemary in diminishing cognitive decline in people with dementia. Fresh or dried will do the trick.
Despite our genetic blueprint, a lot of things regarding our overall health are really in our hands, and specifically found in nature. Take advantage of the power you personally have by incorporating these healing spices into your diet and you will be rewarded with a happier and healthier brain in the long run.

Wednesday, January 4, 2017

This Wonderful Spice Is Superior To Antidepressants

But does it have the same recovery benefits as these anti-depressants? We'll never know.

Common antidepressant can help stroke patients improve movement and coordination Sept. 2015 

 

Antidepressants may help people recover from stroke even if they are not depressed Jan. 2013 

 

 This Wonderful Spice Is Superior To Antidepressants

Spice extract has fewer side effects than pharmaceutical antidepressants (includes suggested supplements and dosage).
Extract of saffron, the exotic spice, is a safer alternative to pharmaceutical antidepressants in mild to moderate depression, recent studies find.
Saffron has fewer side effects and is just as effective in some cases.
The conclusions come from a review of six separate studies that included 230 clinically depressed patients.
Using saffron as an antidepressant was compared with both Prozac and Tofranil (generically known as fluoxetine and imipramine).
All the studies were high-quality randomised controlled trials — although they were small.
Dr Adrian Lopresti, the study’s first author, said:
“So far the literature shows saffron is as effective as pharmaceuticals.
Saffron has had a number of really well designed, robust studies investigating its antidepressant properties and pretty much all the studies have been positive.”
Pharmaceuticals can cause a wide range of side effects.
Some of the most common side effects of pharmaceuticals are:
  • sleepiness,
  • constipation,
  • and sexual problems.
Saffron, though, was not linked to such severe or wide-ranging side effects, Dr Lopresti said:
“Saffron certainly had less severe side effects than pharmaceutical medication.
The most common side effect, which is really only minor, was digestive issues.”
It’s not yet known exactly why saffron works, but it is probably at least partly down to its antioxidant effect.
Saffron contains crocin, which is an anti-inflammatory and crocetin, which is an antioxidant.
Dr Lopresti said:
“What’s been found in the literature over the last ten years is that people with depression have high levels of inflammation and free radical damage associated with oxidative stress.
That led to interesting work looking into antioxidants and anti-inflammatories as antidepressants.”
Dr Lopresti hopes to carry out further studies with more people and over longer periods, he said:
“We need thousands of samples to get a good idea of the side effects, but so far it looks like there is a better safety profile for saffron.”

Supplements and dosage


  The doses used in the studies were 15mg taken twice daily.
They should be taken for 6-8 weeks before making a decision about whether it is helping.
The study was published in the journal Human Psychopharmacology: Clinical and Experimental (Lopresti & Drummond et al., 2014).