Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Showing posts with label women. Show all posts
Showing posts with label women. Show all posts

Monday, August 31, 2026

The dried fruit that can boost your health in later life

 Mainly for the women out there.

The dried fruit that can boost your health in later life

You probably already know that strength training and calcium can help to keep your bones healthy and strong as you age. 

But some factors – like getting enough vitamin D, which helps to absorb calcium, and avoiding smoking, which raises your risk of osteoporosis and is linked to a 30-40% higher risk of broken hips – are less obvious. 

And in one study, prunes, which are high in anti-inflammatory polyphenols and calcium-balancing vitamin K, appeared to preserve bone density and strength at weight-bearing parts of the hip for post-menopausal women.

What did the research show? 

The researchers followed a group of 235 postmenopausal women, who are at greater risk of bone loss, over a year. 

They told one group to eat 50g (about five to six prunes) a day during the trial, and another group to eat 100g a day. A third group didn’t eat any prunes at all.

Though both prune levels were beneficial, the first group (50g) were more likely to stick to the habit, which meant they tended to get better results. 

Professor Mary Jane De Souza, the study’s lead author, said: “Consuming five to six prunes a day for 12 months resulted in preservation of bone at the hip, a finding that was observable at six months and persisted through month 12.” 

The same group of women were part of another study looking at how prunes seemed to affect the structure and estimated strength of their tibia. 

“This is the first randomised controlled trial to look at three-dimensional bone outcomes with respect to bone structure, geometry and estimated strength,” Professor De Souza said. 

“In our study, we saw that daily prune consumption impacted factors related to fracture risk. That’s clinically invaluable.” 

She added that prunes may help to reduce the risk of osteoporosis, but more research is needed.

Related...

Wednesday, August 19, 2026

Scientists studied 12,000 people and found this surprising link between fiber and mental health

 Your competent? doctor doesn't need this for you because they prevented depression with EXACT 100% RECOVERY PROTOCOLS, right? Sarcasm tag here! 

Scientists studied 12,000 people and found this surprising link between fiber and mental health

Depression is a complicated condition that nearly 48 million Americans grapple with. While talk therapy and antidepressants are the mainstays of treatment, a growing body of research has found that making certain lifestyle tweaks such as exercising more and doing your best to eat a healthy diet can also help to support your mental health. Now, new research suggests focusing on fiber could do your mental health a solid, too.

It’s worth noting this now: The study didn’t find that ramping up your fiber intake alone will magically cure your depression. Instead, the researchers found a link between higher fiber intake and fewer depression symptoms.

If you have depression and want to do everything you can to try to feel better, leaning into this macro a little more might help you to feel a little better—and even help your gut health along the way. Here’s why doctors say this is worth considering.

Meet the experts: Zohra Lassi, PhD, study co-author and associate professor in the School of Public Health at Adelaide University; Davide Cappon, PhD, director of neuropsychology at Tufts Medical Center; and Hillary Ammon, PsyD, a clinical psychologist at the Center for Anxiety and Women’s Emotional Wellness.

What did the study find?

The study, which was published in the journal Clinical Nutrition ESPEN, analyzed data from 12,000 people who participated in the National Health and Nutrition Examination Survey (NHANES) before and during the COVID-19 pandemic. The participants were also asked about their mental health, with researchers analyzing their symptoms based on the Patient Health Questionnaire-9 (PHQ-9), a common tool used by doctors to screen for depression and depression severity.

The researchers found some interesting links between fiber intake and mental health. Overall, the participants’ dietary fiber intake dropped from 16.52 grams a day before the pandemic to 15.95 grams a day during the pandemic. The researchers also found that eight percent of participants reported depressive symptoms before the pandemic, while 10 percent reported them during the pandemic.

But after combining the data, the researchers discovered that there was a 14 percent lower risk of having symptoms of depression for every extra five grams of fiber intake before the pandemic. This association got a little weaker for the study participants as a whole during the actual pandemic (but, to be fair, there was a lot happening during the pandemic that could’ve affected someone’s mental health). Worth noting: The protective link between eating fiber and mental health stayed true for women during the pandemic, but not for men.

What’s behind this?

The study found a link between eating more fiber and fewer symptoms of depression, making it tough to say that one led to the other. Still, doctors say there’s likely something here.

One possibility is the gut-brain axis. “Fiber is fermented by bacteria in the gut, producing compounds called short-chain fatty acids,” explains Zohra Lassi, PhD, a study co-author and associate professor in the School of Public Health at Adelaide University. “These compounds are involved in processes including inflammation, immune function, and communication between the gut and the brain.”

Hillary Ammon, PsyD, a clinical psychologist at the Center for Anxiety and Women’s Emotional Wellness, agrees that this is likely at the heart of the link. “Fiber can act as prebiotics that fuel microbes in the digestive tract,” she says. Ammon points out that recent research suggests that people with depression may have lower levels of short-chain fatty acids in their guts.

“What this research may be suggesting is that people [who] consume more fermentable fiber may have healthier gut microbes, which in turn, produces more short-chain fatty acids, which ultimately can reduce inflammation, impact brain functioning, and improve mood,” she says.

But it’s also possible that the reverse is true. “People experiencing fewer depressive symptoms may also eat healthier,” says Davide Cappon, PhD, director of neuropsychology at Tufts Medical Center. “Future studies should follow people over time and include biomarkers of inflammation and gut health to better understand whether fiber itself is driving the association and through what mechanisms.”

Does the type of fiber matter?

There are two main types of fiber: soluble and insoluble. Soluble fiber dissolves in water to create a gel-like substance in your gut, while insoluble fiber passes through your gut mostly unchanged.

It’s not clear if the type of fiber matters, Lassi says. “We measured total dietary fiber intake and did not have information that allowed us to distinguish between different types of fiber,” she says. “Different types and sources of fiber can have different physiological effects, so this is an important question for future research.”

How much fiber do people need to get the perks?

Overall, the study participants didn’t have as much fiber intake as dietary guidelines recommend. (It’s generally recommended that adults consume 25 to 38 grams of fiber a day, or about 14 grams of fiber for every 1,000 calories you take in.) But the researchers found that ramping up that intake a little and at least nearing the recommended amounts each day was linked to better mental health.

“The main message is that diet may be one part of the mental health picture, and fiber appears to be part of that conversation,” Lassi says. But she cautions against loading up on fiber supplements in an effort to prevent or manage depression.

“A practical approach is to include more naturally fiber-rich foods such as vegetables, fruit, whole grains, beans, lentils, and nuts as part of a healthy diet,” she says. Overall, Lassi emphasizes that depression is complicated. “Depression is influenced by many biological, psychological, and social factors, and diet is only one part of that much bigger picture,” she says. But if you want to add more fiber to your plate, go ahead. It may do your mind—and your gut—a solid.

Saturday, August 8, 2026

The Simple Squat You Should Do Every Day to Protect Your Body as You Age

 Did your competent? doctor get you recovered enough to do this? NO?

So, incompetence prevailed, yet your doctor still has a job! I'm sure this applies to men also.

The Simple Squat You Should Do Every Day to Protect Your Body as You Age


    It’s normal and natural for bodies to change as they age. Even healthy bodies experience a gradual decline in muscle mass and bone density as they get older—it’s part of life. However, there are ways to support your body through aging to help you maintain strength and mobility—namely, by moving it.

    Walking, for instance, is widely considered a powerful anti-aging intervention that research suggests can reduce the risk of chronic age-related diseases such as cardiovascular disease, type 2 diabetes, and some cancers. Another activity acclaimed for its ability to slow aging? Strength training.

    Research published in the journal Biology found that 90 minutes of strength training a week was associated with a lower biological age—a reduction of nearly four years. There’s one exercise in particular, however, that personal trainer and former orthopedic surgeon Dr Kate Ella does every single day to delay aging and protect her body as she gets older—and it’s so simple, she does it in her pajamas while brushing her teeth.


    “By doing this exercise consistently I feel stronger and fitter so that everyday life is easier (and more fun),” she says. “It allows me to take the opportunities that come my way, whether that’s climbing a hill or a climbing wall, and swimming in the sea or the waterpark.”

    Introducing: the high-heeled squat.

    What is the high-heeled squat?

    Picture your standard bodyweight squat—feet are hip-width apart, you bend at the knees and lower until your thighs are roughly parallel to the floor, only you don’t drive back up through your whole foot. Instead, you shift your weight to your toes and rise on the balls of your feet. This is a high-heeled squat.

    What are the benefits of doing high-heeled squats?

    There are a number of reasons Dr Kate Ella incorporates the high-heeled squat into her daily routine:

    • It helps to improve balance by strengthening the ankles and feet, and teaching the body how to move safely when it has less stability (in this case, because the weight is in the balls of the feet). “Balance is something I’m particularly aware of as a former orthopedic surgeon who’s treated 100s of broken hips,” she says.

    • It builds thigh and glute strength. “This is key to making sure you can get off the floor in your 80s,” Dr Kate Ella says. That said, progressive overload is important for building strength and muscle so, if you are able to, consider including additional strength training exercises in your routine, such as deadlifts and weighted squats, and gradually increasing the difficulty over time.

    • It builds vastus medialis strength. “This is an important muscle to stabilize your knees and help with knee pain, which affects so many of us as we get older,” says Dr Kate Ella.

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    • It builds calf strength. This, Dr Kate Ella says, is crucial for walking mechanics “so that you can push off when taking a step and it doesn’t feel like you’re walking through mud.”

    • It improves ankle stability and mobility. “This is essential for getting around and getting down to the ground, and something I'm very aware of having spent a year researching broken ankles for my MD.”

    • It improves core strength. Shifting your weight into the balls of your feet while at the bottom of the movement, and then returning to standing without lowering your heels to the ground, requires core engagement.

    “Because it helps with balance, leg and core strength, and ankle mobility, I've recommended this exercise to so many clients—even my mother, who's a great example of how movement can help give us back the confidence that's easy to lose as we get older,” says Dr Kate Ella.

    How to do the high-heeled squat exercise

    a) Start with a controlled squat like you’re about to sit down on an invisible chair.

    b) Then, lift your heels off the ground like you’re wearing high heels.

    c) Staying on tiptoes, push back up to standing.

    d) Finish by lowering your heels back down to the ground, then repeat.

    Dr Kate Ella recommends performing the high-heeled squat exercise for one minute at a time, whenever you can fit it in throughout the day—while brushing your teeth, waiting for the kettle to boil, or watching TV.

    High-heeled squat modifications

    If you’re new to the exercise and are struggling to maintain balance, Dr Kate Ella advises keeping your heels planted to begin with. “Then, when you feel ready to progress to lifting your heels, you can hold on to a stable surface for balance.”

    You could also incorporate a chair if you need a little more support with your squat—simply lower onto the chair, then return to standing.

    Once you feel confident performing the high-heeled squat, Dr Kate Ella suggests trying it in reverse. “From standing, rise up onto your tiptoes then, remaining on your tiptoes, squat down, before releasing your heels and returning to standing.”

    Monday, August 3, 2026

    New research reshapes approach to muscle, strength and protein

     Will this change your doctor's protocols on these? OH sorry, your incompetent? doctor has no protocols for you at all! You're supposed to recover by focusing on energy from the ether!

    New research reshapes approach to muscle, strength and protein

    New research reshapes approach to muscle, strength and protein

    Size isn’t everything: Studies show technique, leverage, and neural adaptation can let smaller athletes outperform bigger ones in strength tests.

    Protein myths busted: Experts say most healthy people need less protein than popular advice suggests, and timing is less critical than total daily intake.

    Over 50 strength: A new Women’s Health plan offers a science-based, sustainable path for women in midlife to build muscle, improve health, and maintain mobility.

    1. Role of Skill, Leverage, and Neural Efficiency in Strength

    Strength performance is heavily influenced by factors such as technical skill, biomechanical leverage, and neural efficiency. These factors can enable individuals with smaller muscles to outperform larger counterparts in certain lifts.
    2. Training Recommendations for Size Versus Strength Goals

    For muscle size, higher training volume is recommended, while for strength, heavier loads are more effective. A combination of both approaches can be used to target both size and strength simultaneously.
    3. Complete protein needs can be met through varied diet over time

    Dietitians emphasize that it is not necessary to consume all essential amino acids in a single meal. A varied diet over the course of a day can provide complete protein for healthy adults.
    4. Muscle building potential for women over 50

    Women over the age of 50 are capable of building muscle. This challenges assumptions that significant muscle growth is not possible in this demographic. The statement emphasizes that age alone does not prevent strength and muscle development.
    5. Prevalence of ineffective training methods among women over 50

    Many women over 50 are engaging in training methods that are not optimal for building muscle. This suggests a gap between current exercise practices and the most effective, evidence-based approaches for this age group.
    6. Launch of WH+ Strong After 50 Program

    Women's Health has introduced the WH+ Strong After 50 program, a four-week sustainable strength training plan aimed at women over 50. The program is designed to address age-related muscle and bone loss through structured exercise and lifestyle guidance.

    Doctor: This is the No. 1 thing women should do to live a long, healthy life–but 'it's not a free pass'

     Did your competent? doctor give you this talk? Oh, told you nothing and did nothing, like mine!

    Doctor: This is the No. 1 thing women should do to live a long, healthy life–but 'it's not a free pass'

    Orthopedic sport surgeon Dr. Vonda Wright is looking to change the way women age in America.

    "I am acutely aware that even though we're living longer, we're suffering longer, and that most of the conversation around longevity in this country so far has been directed at men, or using the science of men," Wright tells CNBC Make It.

    As a clinician who has studied longevity for two decades, Wright equips her patients with the tools they need for healthy aging. She recently published a guide to longevity, with a focus on women, called "Unbreakable."

    Her book explores four core pillars for longevity: nutrition, exercise, lifestyle and supplements. But the No. 1 thing she says women should do to age well would surprise you.

    "If you ask me, what the number one [thing] when someone's closing the book that I want them to walk away with is I want them to walk away with mindset mobilization," Wright says.

    "The number one thing that we can do is to pivot our mindset from worshiping our youth to understanding that now and in the future, if we invest in ourselves every day, because we're worth it, that we can be healthy, vital, active, joyful. But it's not a free pass. It takes work."

    Developing mental resilience is what Wright believes women need to be consistent with the practices that lead to optimal health and wellness. Mental resilience is the ability to adapt well when faced with challenges, according to the American Psychological Association.

    Wright has three C's for building emotional resilience:

    1. Control: When you're feeling stressed, only focus on your response, which is what you can control.
    2. Commitment: "Being committed actually teaches your brain resilience, and it tells your brain that you're worth it."
    3. Challenge: Pushing yourself to take the next step when met with challenges teaches your brain that you're stronger than you realize.

    Boosting your ability to be mentally resilient can help you to implement the top two habits Wright suggests to women for a healthy body: "We are going to impact our bones and we're going to lift weights."

    Weight lifting, and intentional jumping — hopscotch or jump rope — are the essentials of the fitness plan that she recommends to her female patients. To really build muscle, you'll need to increase the weight you're lifting over time, she notes.

    "Here's the cool part in contracting skeletal muscle and jumping up and down, our muscle and our bone sends hormones to our brain to build a better brain," Wright says.

    Want to stand out, grow your network, and get more job opportunities? Sign up for Smarter by CNBC Make It's new online course, How to Build a Standout Personal Brand: Online, In Person, and At Work. Learn from three expert instructors how to showcase your skills, build a stellar reputation, and create a digital presence that AI can't replicate. Sign up today with coupon code EARLYBIRD for an introductory discount of 30% off the regular course price of $67 (plus tax). Offer valid July 22, 2025, through September 2, 2025.

    Plus, sign up for CNBC Make It's newsletter to get tips and tricks for success at work, with money and in life, and request to join our exclusive community on LinkedIn to connect with experts and peers.

    Thursday, July 30, 2026

    Daily eating change linked to sharper thinking in older women, study finds

     Do your really think your doctor has enough competence and clout to get this diet protocol implemented in the hospital?

    Daily eating change linked to sharper thinking in older women, study finds

    Eating all meals within an eight-to-nine-hour window each day may offer benefits for brain health beyond weight loss alone, according to new research presented at a major nutrition conference. 

    The research was presented at NUTRITION 2026, the annual meeting of the American Society for Nutrition in National Harbor, Maryland. 

    Researchers found that participants who restricted their daily eating window showed improvements in certain cognitive abilities after six months, even though they lost a similar amount of weight as those who followed a more typical eating schedule. 

    “We are confident it is due to meal timing itself, because this was a randomized controlled trial and both groups lost weight (about 8 percent) but there was a greater cognitive benefit only in the group that also was restricting their eating window to 8 hours compared to the control group eating 12 hours,” Sue Shapses, a professor at Rutgers University and Rutgers-RWJ Medical Center and the study’s principal investigator, told Newsweek.  

    However, she cautioned that the findings were limited to women with overweight or obesity who were actively losing weight.  

    “We did not study leaner women or those who are not losing weight during the time-restricted eating,” Shapses said. “As a result, we cannot confidently state that it applies to other women, or to men.” 

    Alzheimer’s disease and other forms of dementia are becoming increasingly common as populations age.  

    Previous research has linked diet and lifestyle habits to dementia risk, but relatively few studies have explored whether changing those habits can help reduce that risk. 

    To investigate, researchers enrolled 47 women between the ages of 50 and 79 who were overweight or obese.  

    All participants were advised to cut 500 calories from their daily diets as part of a weight-loss program. 

     Twenty-six women were assigned to a time-restricted eating plan, limiting food consumption to fewer than nine hours per day.  

    Most ate between 10 a.m. and 6 p.m., resulting in an average eating window of 8.2 hours. 

    The remaining participants maintained a more conventional schedule, eating over roughly 12 hours per day on average. 

    After six months, women in both groups had lost about 15 pounds on average, suggesting that the amount of weight lost was not the key factor separating the groups. 

    Instead, differences emerged in cognitive performance. 

    Compared with women who maintained a 12-hour eating window, those who restricted eating to eight or nine hours a day performed significantly better on tests measuring spatial planning and problem-solving abilities.  

    Researchers also observed a trend toward fewer mistakes on memory and learning tasks, although those improvements did not reach statistical significance. 

    The findings suggest participants may have become better at remembering information during everyday activities while making fewer mistakes linked to memory, attention and problem-solving.  

    The researchers also found that greater reductions in the eating window were associated with larger cognitive improvements. 

    Shapses said the approach may also be practical for people who cannot follow a strict schedule every day. 

    “If they can’t do this every day—due to weekend events or weekday business dinners—it is OK to have occasional aberrations,” she said, noting that participants in the study also occasionally deviated from the eating schedule. 

    The team cautioned that the study was small and that the findings remain preliminary.  

    “At this point, we will continue our analysis and submit the full length manuscript for peer-review for publication,” Shapses said.

    Reference

    American Society for Nutrition. “Eating within 8 hours may help keep the aging brain sharp.” ScienceDaily. ScienceDaily, 27 July 2026. www.sciencedaily.com/releases/2026/07/260727012125.htm

    Contact Newsweek editors on this story: Kara Dolman and Emma Lee-Sang

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    Thursday, June 4, 2026

    Metabolite Score Improves Ischemic Stroke Risk Prediction Among Women

     So what?  What is needed is EXACT  PROTOCOLS THAT PREVENT THIS! Are you really that blitheringly stupid? 

    Oops, I'm not playing by the polite rules of Dale Carnegie,  'How to Win Friends and Influence People'. 

    Telling your supposedly smart stroke medical 'professionals' they know nothing about stroke is a no-no even if it is true. 

    Politeness will never solve anything in stroke. Yes, I'm a bomb thrower and proud of it. Someday a stroke 'leader' will try to ream me out for making them look bad by being truthful, I look forward to that day.

    Metabolite Score Improves Ischemic Stroke Risk Prediction Among Women

    A 4-metabolite stroke score independently predicted incident ischemic stroke and improved risk prediction beyond traditional risk factors, suggesting potential utility for earlier identification of women at elevated stroke risk.

    A stroke metabolite score comprising 4 validated metabolites is associated with incident stroke and improves ischemic stroke risk prediction beyond traditional risk factors, according to a study published in Neurology.Women have a higher lifetime risk for stroke than men, and metabolic factors appear to be more strongly associated with stroke risk among women. Although key stroke risk factors in women are well established, a gap remains between identified risk factors and the biological processes that mediate this risk.

    To discover and validate metabolomic profiles associated with incident ischemic stroke risk after adjustment for traditional stroke risk factors, researchers applied liquid chromatography-tandem mass spectrometry (LC-MS) to measure 519 plasma metabolites in a discovery set of women from the Nurses’ Health Study, including 454 women who developed incident ischemic stroke and 454 control individuals. Validation was performed in 2 independent prospective cohorts: Prevención con Dieta Mediterránea (PREDIMED), which included 118 participants who developed stroke and 791 participants who did not, and Nurses’ Health Study 2, which included 49 women who developed incident ischemic stroke and 49 control individuals.

     

    Further research to identify the mechanisms responsible for these findings, as well as to replicate other metabolites, is needed.

    In the Nurses’ Health Study, 23 metabolites were significantly associated with incident ischemic stroke after adjustment for traditional risk factors (q<0.05). Of these, 14 metabolites were available in PREDIMED, and 3 were significantly associated with incident stroke: methionine sulfoxide, N6-acetyllysine, and sucrose/lactose/trehalose (q<0.05). In Nurses’ Health Study 2, glucuronate was significantly associated with incident ischemic stroke (q<0.05).

    Higher levels of all 4 metabolites were associated with increased risk, and the metabolites were used to create a stroke metabolite score. Per 1-standard deviation increase in the stroke metabolite score, the odds ratio for incident stroke was 4.12 (95% CI 2.26-7.51) in PREDIMED after adjustment for traditional risk factors.

    In PREDIMED, the area under the receiver operating characteristic curve increased from 0.65 to 0.70 when the stroke metabolite score was added to traditional risk factors, corresponding to a 5% improvement in risk prediction (P <.005).

    Study limitations include that metabolomics profiling was obtained at a single point in time, imaging was available for only 69% of participants who developed stroke in Nurses’ Health Study 2, and the discovery dataset in the Nurses’ Health Study was predominantly composed of postmenopausal White women.“We identified 23 metabolites associated with incident ischemic stroke in women, and validated 4 of these in independent cohorts. A score comprising the 4 validated metabolites resulted in significant improvement in stroke risk prediction,” noted the authors. “Further research to identify the mechanisms responsible for these findings, as well as to replicate other metabolites, is needed.”

    Saturday, April 18, 2026

    Building muscle strength may help prevent depression, especially in women

     This method of preventing depression would require 100% recovery protocols from your competent? doctor! And since your doctor isn't competent enough to have created them, you're screwed!

    My left hand grip is appalling and my occupational therapist had nothing to fix that. First I would have to pry all my fingers open before even trying to grip. My right hand is extremely strong. Curing spasticity is required first.

    Building muscle strength may help prevent depression, especially in women

    A recent study published in the Journal of Affective Disorders suggests that greater muscle strength, particularly in women, might play a direct role in reducing the risk of depression and its specific symptoms. Scientists at University College London found no evidence that aerobic fitness influences depression, but their findings indicate that building muscle strength could help prevent and treat the condition. This provides evidence that strength training could be an effective, targeted strategy for improving mental health.Physical activity is known to help protect against depression, but the exact biological reasons for this connection remain unclear. Scientists wanted to understand the specific ways exercise influences mental health so they can develop better treatment plans.

    Two possible ways exercise might improve mood are through better cardiorespiratory fitness and increased muscle strength. Cardiorespiratory fitness refers to the ability of the heart and lungs to supply oxygen to the body during sustained physical activity. Previous studies have linked both of these fitness types to lower rates of depression.

    Traditional observational studies, which simply watch people’s habits over time, struggle to prove cause and effect because other lifestyle choices might influence the results. It is also possible that being depressed causes people to exercise less, rather than a lack of fitness causing the depression.

    “Although physical activity is known to help prevent and treat depression, the underlying mechanisms through which this occurs remain poorly understood. In this study, we examined the effects of two specific physiological aspects of physical activity (cardiorespiratory fitness and muscle strength) on depression,” said study authors Snehal M. Pinto Pereira, John Vincent, and Amy E. Taylor — a professor, research fellow, and senior research fellow, respectively — in a joint statement to PsyPost.“Depression is well documented as being a highly heterogeneous disorder, with symptoms varying widely across individuals. Therefore, we examined whether cardiorespiratory fitness and muscle strength might be causally linked to individual symptoms of depression as well as depression as a single disorder.”

    The researchers examined data from up to 341,326 adults between the ages of 37 and 73. All participants were of European descent and were part of the UK Biobank, a large database of genetic and health information.To determine cause and effect, the scientists used a technique called Mendelian randomization. This method looks at tiny genetic variations that people are born with, which are known to be linked to specific physical traits. Because these genetic markers are assigned randomly at conception, they act like a natural experiment.The scientists looked at genetic variants associated with cardiorespiratory fitness and genetic variants associated with grip strength. Grip strength was adjusted for body weight and used as a practical substitute for overall muscle strength.

    For the mental health outcomes, the researchers looked at general depression based on self-reported history and hospital records. They also evaluated nine specific symptoms of depression to get a more detailed picture of a person’s mental state.

    These symptoms included depressed mood, appetite changes, concentration problems, and anhedonia, which is a core symptom of depression defined as the loss of pleasure or interest in previously enjoyable activities. They also looked at psychomotor changes, which involve either a noticeable slowing down of physical movements or extreme restlessness and fidgeting.

    The individual symptoms were measured using a standard questionnaire given to a subset of 108,622 participants. People who reported experiencing a symptom for several days or more over the past two weeks were considered to have that symptom.

    The researchers found no evidence that genetic markers for cardiorespiratory fitness were linked to overall depression or any of its individual symptoms. This was an unexpected outcome for the scientists, as aerobic exercise is often recommended to improve mental health.On the other hand, the data showed a clear link between greater grip strength and lower rates of depression. A 0.1 kilogram increase in grip strength per kilogram of body weight was associated with a 14 percent lower likelihood of experiencing general depression.

    Higher grip strength was also linked to a lower likelihood of several specific symptoms. For example, it was associated with a 21 percent reduction in the likelihood of experiencing anhedonia. Stronger grip strength was also tied to a 44 percent lower chance of experiencing appetite changes. The scientists also found evidence that greater strength is associated with depressed mood, physical slowness, extreme fatigue, and concentration problems.

    “Whilst muscle strength is clearly only one of many factors that influence depression, these findings suggest that improving muscle strength could make meaningful contribution to reducing depression as well as several of its symptoms,” the researchers said. “Importantly, the results were consistent across several analyses, which increases confidence in the robustness of the findings.”

    When the scientists analyzed the data by sex, they found that these effects were generally stronger in women than in men. The protective effects against loss of pleasure, depressed mood, and concentration problems were observed in females but not in males.

    The link between grip strength and appetite changes was present in both men and women. There was no clear evidence that grip strength affected sleep problems or suicidal thoughts in either sex.

    “The key takeaway from our findings is that muscle strength (particularly in females) likely plays a causal role in depression and several of its symptoms in middle to older aged adults,” the researchers explained. “Our findings suggest that increasing muscle strength could help reduce depressed mood and the loss of pleasure or interest in previously pleasurable activities (anhedonia), which represent the core symptoms of depression, as well as secondary symptoms such as appetite change, concentration problems and low self-esteem. However, it is important that future research replicates these effects in other samples and populations to improve generalizability.”

    There are several possible reasons why muscle strength might help protect against depression. Lower muscle strength can lead to a loss of independence and greater difficulty completing daily tasks. Struggling with everyday activities is known to increase the likelihood of experiencing depressive symptoms.

    Another possibility involves biology at the cellular level. When muscles contract during exercise, they release specific proteins into the body. Some scientists suspect these proteins might help protect the brain against depression, though more research is needed to confirm this.

    The scientists noted a few potential misinterpretations and limitations. The people in the UK Biobank tend to be healthier and more educated than the average population, which might skew the results. The study also only included individuals of white European ancestry.

    The scientists also used hand grip strength as a substitute for total body muscle strength. This is a common scientific practice, but there is an ongoing debate about how accurately hand strength reflects overall muscle power.

    “We remain very interested in pursuing this line of research,” the researchers told PsyPost. “Our next steps will include examining both environmental and genetic factors related to depression and anxiety, as well as how the interplay between these factors can influence mental health.

    “One important way in which our study moves the field forward is by examining individual depressive symptoms (in addition to depression as a single disorder). This approach may help researchers better understand the different pathways that contribute to depression and inform more targeted prevention strategies.”

    The study, “Cardiorespiratory fitness, grip strength and depression symptoms: A Mendelian Randomization study,” was authored by John Vincent, Snehal M. Pinto Pereira, Jane Maddock, Dylan M. Williams, Mark Hamer, Jonathan P. Roiser, and Amy E. Taylor.