Smartest neurologist - Traumatic Brain Injury Quiz

Not one single question on rehab. I guess neurologists need to know nothing on TBI rehab since they need to know nothing on stroke rehab either. What the hell do neurologists do? Maybe they want to consider  post-treatment with fish oil?

Dear Smartest Neurologist Player,

We invite you to take the "Traumatic Brain Injury" Quiz >>Click Here to Play!

Injecting omega-3 fatty acid reduces brain damage in neonatal mouse model of stroke

Could our researchers correlate this research with pre and post treatment using Omega-3s? Who can take this simple task on? Or will this fall thru the cracks like every other interesting stroke study?

Looking at pretreatment with fish oil or post-treatment with fish oil

Injecting omega-3 fatty acid reduces brain damage in neonatal mouse model of stroke

Researchers from Columbia University Medical Center (CUMC) found that omega-3 fatty acids reduced brain damage in a neonatal mouse model of stroke.
Findings from the study were published recently in PLOS ONE.
The researchers treated 10-day-old mice that had incurred hypoxic-ischemic brain injury (caused by a decrease in blood flow and oxygen to the brain, as occurs during a stroke) with a fat emulsion containing either DHA or EPA--omega-3 fatty acids that are found in certain foods and in supplements. The researchers evaluated the mice's neurological function 24 hours and 8 to 9 weeks after the brain injury.
EPA and DHA are bioactive omega-3 fatty acids that are found in oils extracted from cold-water fish. The CUMC researchers and other scientists have shown that these fish-oil fatty acids protect organs and cells in numerous ways after oxygen deprivation, reducing inflammation and cell death.

At 24 hours, mice treated with DHA, but not EPA, had a significant reduction in brain injury. In the following weeks, the DHA group also had significantly better results in multiple brain functions compared to the EPA-treated mice and untreated (control) mice.
The researchers also discovered that these mice had increased concentrations of DHA in their brain mitochondria, energy-producing structures in cells that can be injured by free radicals when blood flow is restored to the brain after a stroke. This process, known as reperfusion injury, is a common cause of brain damage following the oxygen and nutrient deprivation that occurs after a stroke.
"Our findings suggest that injecting the omega-3 fatty acid DHA after a stroke-like event has the ability to protect brain mitochondria against the damaging effects of free radicals," said senior co-author, Vadim S. Ten, MD, PhD, associate professor of pediatrics at CUMC.
Interruption of blood flow and oxygen supply to the brain during or shortly after birth is a major cause of brain damage in newborns, causing life-long neurological impairments in more than 25 percent of those affected. Many of the pathways involved in this type of brain damage are similar to those in an adult stroke.
"Clinical trials are needed to determine if administering lipid emulsions containing DHA shortly after a stroke-like brain injury offers the same neuroprotective effects in babies and adults, as seen in mice. If successful, such trials could lead to the development of a novel therapy for stroke in newborns, children, and adults, addressing a major medical need," said senior co-author Richard J. Deckelbaum, MD, CM, the Robert R. Williams Professor of Nutrition (in Pediatrics) and Professor of Epidemiology and director of the Institute of Nutrition at CUMC.

Source:

Columbia University Medical Center

Our stroke leaders should be following this closely to see what can be used in stroke. Or at a minimum create a similar roundtable for stroke. But NOTHING will occur. I wonder if there will be anything on:

Looking at pretreatment with fish oil or post-treatment with fish oil

FOR IMMEDIATE RELEASEMarch 9, 2016

CONTACT: Press Office(202) 226-4972

Committee Announces Distinguished Lineup of Experts for Concussion Roundtable

 

Participants Include Representatives of Medical, Military, Athletic, and Research Communities for Discussion @ 2PM on Monday, March 14

WASHINGTON, DC – The House Energy and Commerce Committee’s broad review of concussions will commence next week with a roundtable discussion about the state of our knowledge concerning the causes, effects, and treatments of concussions and head trauma. The discussion, which will feature input from experts representing the medical, military, athletic, and research communities, is focused on building a collaborative body of knowledge to help improve the diagnosis and treatments of concussions. The roundtable, entitled, “Broad Review on Concussions: Initial Roundtable,” will take place at 2 PM on Monday, March 14. A webcast and additional information will be available HERE.

“There are no easy answers or simple solutions when it comes to head injuries. The goal of our roundtable is to advance the conversation beyond the attention-grabbing headlines to make a real difference for individuals across the country by bringing together experts on head trauma including the public health, military, athletic, and research communities. We’ll explore what we know and don’t know about concussions, and how the research community is working to meet these challenges. At the end of the day, we want to identify opportunities to achieve meaningful progress in our ability to diagnose and treat concussions,” said Energy and Commerce Committee Chairman Fred Upton (R-MI), and Oversight and Investigations Subcommittee Chairman Tim Murphy (R-PA). Murphy will be leading Monday’s discussion.

QUESTIONS FOR DISCUSSION
The committee has posed the following questions to help guide Monday’s roundtable discussion:

• What are the most prominent misconceptions or underappreciated facts about concussions?
• What are the critical gaps in our understanding of concussions? Why do these gaps exist? How do these knowledge gaps hinder progress in minimizing the risks of concussions?
• What are the most critical short and long-term objectives if we hope to achieve meaningful progress minimizing the risks of concussions?
• What, if any, coordination exists or is needed to ensure that independent research efforts contribute to short and long term objectives?

PARTICIPANTS
Dr. Grant Baldwin - Director of the Division of Unintentional Injury Prevention at the National Center for Injury Prevention, Centers for Disease Control and Prevention 

Dr. David Cifu - Herman J. Flax, M.D. Professor and Chairman, Department of Physical Medicine and Rehabilitation, Virginia Commonwealth University. Principal Investigator for the VA/DoD Chronic Effects of Neurotrauma Consortium (CENC) 

Dr. Michael (Micky) Collins - Director of Sports Medicine Concussion Program, University of Pittsburgh Medical Center

Capt. (Dr.) Michael Colston – Director, Defense Center of Excellence for Psychological Health and Traumatic Brain Injury, Department of Defense  

Dr. Gerald Gioia - Division Chief of Neuropsychology and Director of the Safe Concussion Outcome, Recovery & Education (SCORE) Program, Children's National Health System; and Professor at George Washington University School of Medicine 

Col. Dallas Hack (ret.) - Consultant – Directed the DoD Combat Casualty Care Research Program from 2008-2014 (currently consulting a number of organizations, including the NCAA and OneMind, to advance research in Brain Health and transition the progress to improved clinical practice) 

Dr. Brian Hainline - Chief Medical Officer, National Collegiate Athletic Association 

Dr. Walter Koroshetz - Director of National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health 

Dr. Geoff Manley - Chief of Neurosurgery at San Francisco General Hospital and Professor of Neurosurgery at University of California San Francisco (Contact Principal Investigator for large international TBI research initiative, Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI)) 

Dr. Michael McCrea - Professor of Neurosurgery and Neurology, and Director of Brain Injury Research, University of Wisconsin

Ms. Lisa McHale – Director of Family Relations, Concussion Legacy Foundation

Dr. Anne McKee – Professor of Neurology & Pathology, Director, Neuropathology Core, Alzheimer’s Disease Center, Boston University

Mr. Jeff Miller – Senior Vice President of Health and Safety Policy, National Football League

Ask A Neurologist - Traumatic Brain Injury Question

Questions wanted by:

American Brain Foundation eNewsletter: September 2015,

Yes this is the group that denied me a  board position.

Ask a Neurologist

Have a question related to traumatic brain injury? Here’s a chance to submit your question about traumatic brain injury to a leading neuroscience professional from the American Academy of Neurology. Email us with your question.

My question is below: 

Is this research on pre and post treatment with fish oil enough to create a protocol for rehabilitation? Who will do the additional research necessary? What possible negative side effects are possible?

Pretreatment, I know this is in rats.

http://www.ncbi.nlm.nih.gov/pubmed/23835930

By 14 days, the fish oil diet group performed significantly better in the Morris Water Maze.

Post treatment, yes this is only a single case.

http://www.cnn.com/2012/10/19/health/fish-oil-brain-injuries/index.html?hpt=hp_c2

Stroke survivor Dean Reinke

Bombard them with questions, they need to understand the total lack of public information on this.

League of Denial: The NFL’s Concussion Crisis

I know I'm just a stroke-addled non-medical person but it seems incredibly stupid that no one in football is talking about possible interventions.
A repeat of the Frontline show on PBS, Tuesday, September 30.

UC to Study New Drug in Patients with Traumatic Brain Injury

Looking at pretreatment with fish oil or post-treatment with fish oil

After the fact here;
Aspirin plus fish oil for a hyperacute treatment 

What the hell is the downside? Fish breath?

Brain Trauma to Affect One in Three Players, N.F.L. Agrees

Does no one ever read any research at all? Or even think a little bit?
Maybe by rubbing two functioning neurons together they might look at these.  What's the downside? Fish breath?
Looking at pretreatment with fish oil or post-treatment with fish oil

After the fact here;
Aspirin plus fish oil for a hyperacute treatment
or interventions after the concussions.

Dietary Strategy to Repair Plasma Membrane After Brain Trauma Implications for Plasticity and Cognition

 

 

http://www.nytimes.com/2014/09/13/sports/football/actuarial-reports-in-nfl-concussion-deal-are-released.html?

The White House Healthy Kids and Safe Sports Concussion Summit

This is so seemingly f*cking simple. Doesn't anyone read research or think at all?
Maybe by rubbing two functioning neurons together they might look at these.  What's the downside? Fish breath?
Looking at pretreatment with fish oil or post-treatment with fish oil

After the fact here;
Aspirin plus fish oil for a hyperacute treatment

http://abcnews.go.com/Health/wireStory/obama-plans-conference-youth-sports-concussions-23737565 

Comprehensive Management of Mild Traumatic Brain Injury-Brain Injury Association of America Webinar Program

I'm sure your hospital is attending.

The Brain Injury Association of America (BIAA) will be sponsoring a webinar examining the questions,  What is the current scientific perspective surrounding mild traumatic brain injury (MTBI)? What are the necessary elements to a comprehensive approach to concussion management?
The webinar will take place on Thursday, May 8, 2014 from 3:00 p.m. Eastern, 12:00 p.m. (noon) Pacific
The scheduled speakers are Kevin Crutchfield, M.D., Vascular Neurologist and Director of the Comprehensive Sports Concussion Program at LifeBridge Health, and Jessica McWhorter, Ph.D., ABPP/RP  Rehabilitation Neuropsychologist at The Sandra and Malcolm Berman Brain & Spine Institute, will discuss current controversies in the treatment of concussion and diagnostic dilemmas in working with patients who experience persistent symptoms. They will also present a comprehensive model of care. Register by 5:00 p.m. (ET) May 6, 2014.
Click here to register.

I bet not a single report in here will talk about fish oil. Proving once again that medical persons don't read research, or can't even be bothered to hire someone to summarize research for them.

Maybe by rubbing two functioning neurons together they might look at these.  What's the downside? Fish breath?
Looking at pretreatment with fish oil or post-treatment with fish oil

After the fact here;
Aspirin plus fish oil for a hyperacute treatment

ARGHHH!!!

The Sports Concussion Conference

I bet not a single report in here will talk about fish oil. Proving once again that medical persons don't read research, or can't even be bothered to hire someone to summarize research for them.

Maybe by rubbing two functioning neurons together they might look at these.  What's the downside? Fish breath?
Looking at pretreatment with fish oil or post-treatment with fish oil

After the fact here;
Aspirin plus fish oil for a hyperacute treatment

ARGHHH!!!

https://www.aan.com/conferences/sports-concussion-conference/
July 11-13, 2014, in Chicago.

Neurology Now article - Ben Utecht, concussions in the NFL

Once again medical personell are not reading research and possibly applying it to the current conditions. 

High Note: After leaving the NFL because of repeated concussion, Ben Utecht has found a new sense of purpose in music and advocacy

This line from the article is appalling.
On average, the symptoms of a concussion last for approximately 10 to 14 days, although the underlying brain injury may last longer. The only treatment for concussion is rest.

Maybe by rubbing two functioning neurons together they might look at these.  What's the downside? Fish breath?
Looking at pretreatment with fish oil or post-treatment with fish oil

After the fact here;
Aspirin plus fish oil for a hyperacute treatment

Health Resources Services Administration (HRSA) Traumatic Brain Injury Webinar: The Unique Needs of Veterans and Returning Service Members with TBI

And if they were any good at all they would be providing solutions for TBI.
Maybe these post-treatment options with fish oil.
http://www.veteransfocus.org/ai1ec_event/hrsa-traumatic-brain-injury-webinar/?instance_id=589

When:

April 7, 2014 @ 3:00 pm – 4:30 pm

Add to Calendar Add to Google

Webinar & Training

Health Resources Services Administration (HRSA) Traumatic Brain Injury Webinar:

The Unique Needs of Veterans and Returning Service Members with TBI

Military personnel are at an increased risk for sustaining a traumatic brain injury but many with a TBI may not come forward because they are unaware of their injury, unsure if help is available, or fear stigma of asking for help. Being part of military culture presents unique challenges that are not always understood by professionals delivering their care in a civilian community. This webinar provides an overview of how states identifying military service members who have a TBI, how states are building cultural competence among health professionals and others who interact with this population, the supports and services offered by the Department of Veterans Affairs (VA) to individuals with a TBI and their families that could complement state efforts.
RSVP to: HRSA-TBITAC@norc.org

Invisible Cure For TBI: Good News For NFL And US Army?

Is everyone in the NFL and the war machine f#cking stupid? Are these research items on fish oil not enough for implementation? What's the downside of this type of treatment? Fish breath? In exchange for relief from the effects of brain trauma?  I don't think these people have two functioning neurons to rub together.
Looking at pretreatment with fish oil or post-treatment with fish oil

After the fact here;
Aspirin plus fish oil for a hyperacute treatment

And the latest news here:
http://www.united-academics.org/magazine/mind-brain/good-news-for-nfl-and-us-army-the-invisible-cure-for-tbi/

Drug treatment may be a stroke breakthrough

Aspirin plus fish oil for a hyperacute treatment.  This was written about almost 2 years ago and if we had anything other than craptastic stroke associations clinical trials would be completed. You'll have to challenge your doctor if you have an ischemic stroke as to what is the downside to providing this treatment. I'm sure Dr. Bazan can be found by your doctor with a minute amount of google research.
http://www.nola.com/health/index.ssf/2012/02/drug_treatment_may_be_a_stroke.html

Thursday, February 02, 2012

Led by Louisiana State University neurologist Dr. Nicolas Bazan, a team of researchers from several institutions has claimed a potential breakthrough in drug treatment to prevent long-term brain damage in those who suffer certain strokes. Bazan directed a study that, using laboratory rats, administered aspirin and an omega-3 essential fatty acid to yield a new protective molecule that can mitigate damage to cells around the area of an ischemic stroke. Ischemic stroke occurs when an arterial blockage denies oxygenated blood to parts of the brain, as opposed to hemorrhagic stroke, which occurs when a vessel bursts inside the brain.

Daniel ErathLouisiana State University neurologist Dr. Nicolas Bazan

The results, Bazan said, portend a “novel approach for pharmaceutical intervention.”
Stroke is the fourth-leading cause of death in the United States and the leading cause of newly acquired disability in adulthood. Bazan presented his findings Thursday at the International Stroke Conference, which concludes Friday at the Ernest N. Morial Convention Center in New Orleans.
The study, which was financed by a National Institutes of Health grant, was designed to analyze benefits of neuroprotective agents — long a focus of Bazan’s career — that can help prevent irreversible damage in the stroke-affected area. There is considerable research interest internationally in neuroprotectors as an additional therapy beyond the more developed, widely used thrombolytic therapy or drugs that break up and dissolve the clot itself.
Bazan’s study relied in part on his previous research on the role of omega-3 essential fatty acids in neuroprotection. In the latest discovery, Bazan said the team discovered that aspirin and the omega-3 acid DHA (docosahexaenoic acid) yield in the brain a neuroprotective molecule. Bazan said the synthesis results from how aspirin, a common anti-inflammatory agent, acts on a certain enzyme protein that he described as “evil and angel” in brain chemistry.
In the study with rats, Bazan’s team chemically generated that new molecule outside of the brain. Then, the animal subjects were anesthetized and induced with a middle cerebral artery blockage for two hours. In humans, the middle cerebral artery is the largest artery in the brain and the most commonly affected by stroke. Because it affects such a large portion of the brain, MCA stroke can affect many physical abilities and cognitive functions.

The research team treated two groups of rats with the synthetic molecules one hour after the stroke period ended. One group got a sodium salt form of the treatment, the second a methyl-ester form. A third control group received saline.
The rats who received the neuroprotector treatment displayed significantly less damage than the saline group, ranging from 44 percent to 81 percent fewer lesions in various parts of the brain. They also demonstrated lower water volume, a sign of less damage following ischemic stroke. In both measures, the methyl-ether results outpaced sodium salt results.

Fish Oil Injection to Stroke Victims: Remedy for Brain Damage

For this TBI case the fish oil was administered thru a feeding tube.  This is why I'm going to chow down on fish oil for my next stroke. You may have to beat your doctor over the head with these reports to get it. I however won't listen to my doctor, I'll tell him/her what I want done. I guess you shouldn't listen to me, I know nothing.
http://www.medicaldaily.com/articles/14129/20130222/fish-oil-injection-stroke-remedy-brain-damage.htm

A new fish oil remedy may be the key to preventing brain damage after patients suffer from stroke.

• nShare

Researchers from Columbia University and Louisiana State University in New York conducted experiments on mice showing that a fish-oil-based drug given within hours of a stroke can help damaged cells stay alive.

Follow us

The existing drug used to prevent brain damage in stroke patients has to be given within four hours of a stroke. It breaks up blood clots that block oxygen flow to the brain, but does not keep suffocating cells from dying - which doesn't help patients who need several hours just to get to a hospital from recovering brain functions in the damaged areas.
If it works in humans in the same way, the fish oil drug might be given much later to keep damaged cells alive, which can help patients who don't get to a hospital quickly enough to prevent permanent brain damage.
The drug, a fluid rich in the omega-3 fatty acid docosahexanoic acid (DHA), uses several methods of keeping damaged cells alive, like turning on gene switches that produce protective proteins.
The researcher's work was published in PLOS One earlier this week, entitled "N-3 Fatty Acid Rich Triglyceride Emulsions Are Neuroprotective after Cerebral Hypoxic-Ischemic Injury in Neonatal Mice."
Omega-3 fatty acids are vital for proper brain function, and necessary for nervous system developments. Mostly found in cold water fatty fish like salmon, tuna, and mackerel, omega-3 fatty acids are necessary for a healthy diet and have strong anti-inflammatory effects.
DHA treatment has been shown to be beneficial in the treatment of many inflammatory chronic diseases, like coronary heart disease, asthma, arthritis, and macular degeneration. This study showcases its potential benefit in stroke treatment.
"Stroke is a brain attack that each year kills 130,000 Americans," notes Dr. Nicolas Bazan of Louisiana State University, one of the authors of the study.
"Strokes can occur at any age, including in newborns, with long-term and devastating consequences. DHA is already widely consumed as a dietary supplement in the US, and from a therapeutic point of view, we can now see a light at the end of the tunnel."
According to the Centers for Disease Control and Prevention (CDC), 795,000 Americans have a stroke each year, and stroke causes 1 in every 18 deaths. Stroke is also the single most common cause of long-term disability, and the costs of stroke in the United States were estimated to total nearly $74 billion in 2010.
The researchers hope to develop a drug testable on humans very soon, which would be delivered through an injection in the arm.

Read more at http://www.medicaldaily.com/articles/14129/20130222/fish-oil-injection-stroke-remedy-brain-damage.htm#ACzBA0dF8V8Fgtf6.99