Is your blood type linked to your risk of stroke before age 60?

 Since you give us nothing on how to reduce that risk, I can only conclude that all your research is devoted to getting to 100% recovery post stroke. I'm O negative and had my stroke at age 50, so half my life will be disabled because the stroke medical world is completely incompetent in solving stroke to 100% recovery.

Is your blood type linked to your risk of stroke before age 60?

MINNEAPOLIS – Gene variants associated with a person’s blood type may be linked to their risk of early stroke, according to a new meta-analysis published in the August 31, 2022, online issue of Neurology^®, the medical journal of the American Academy of Neurology. The meta-analysis included all available data from genetic studies that included young adult ischemic stroke, which is caused by a blockage of blood flow to the brain.

“Non-O blood types have previously been linked to a risk of early stroke, but the findings of our meta-analysis showed a stronger link between these blood types with early stroke compared to late stroke, and in linking risk mostly to blood type A,” said study author Braxton D. Mitchell, PhD, MPH, of University of Maryland School of Medicine in Baltimore. “Specifically, our meta-analysis suggests that gene variants tied to blood types A and O represent nearly all of those genetically linked with early stroke. People with these gene variants may be more likely to develop blood clots, which can lead to stroke.”

The meta-analysis involved a review of 48 studies on genetics and ischemic stroke from North America, Europe and Asia. The studies included 16,927 people with stroke and 576,353 people who did not have a stroke. Of those with stroke, 5,825 people had early onset stroke and 9,269 people had late onset stroke. Early onset stroke was defined as an ischemic stroke occurring before age 60 and late onset stroke was older than 60.

Researchers looked across all the chromosomes to identify genetic variants associated with stroke. They found a link between early stroke and the area of the chromosome that includes the gene that determines A, AB, B or O blood type.

They then divided participants into A, AB, B and O blood types. They compared the prevalence of those blood types in people with early stroke, late stroke and people who did not have a stroke.

Researchers found that people with early stroke were more likely to have blood type A and less likely to have blood type O compared to people with late stroke and people without stroke. Both early and late stroke were also more likely to have blood type B compared to controls.

When looking at people of European ancestry and comparing 5,825 people with early stroke to 29,320 people who did not have a stroke, the meta-analysis found that 48% of people with early stroke had blood type A compared to 45% of people with late stroke and 44% of people without stroke. They also found 35% of people with early stroke had blood type O compared to 39% of those with late stroke and 41% of people without stroke.

After adjusting for sex and other factors, researchers found those who had blood type A had an 16% higher risk of having an early stroke than people with other blood types. Those who had blood type O had a 12% lower risk of having a stroke than people with other blood types.

“This work deepens our understanding of early onset stroke development and changes,” said Jennifer Juhl Majersik, MD, MS, of the University of Utah and Fellow of the American Academy of Neurology, who wrote an editorial accompanying the study. “Future research is needed to help develop a more precise understanding of how stroke develops. This could lead to targeted preventative treatments for early onset stroke, which could result in less disability during people’s most productive years.”

A limitation of the study was the limited amount of diversity among participants, although 35% of the participants were of non-European ancestry.

The study was supported by the National Institutes of Health and Department of Veterans Affairs.

Learn more about stroke at BrainandLife.org, home of the American Academy of Neurology’s free patient and caregiver magazine focused on the intersection of neurologic disease and brain health. Follow Brain & Life^® on Facebook, Twitter and Instagram.

When posting to social media channels about this research, we encourage you to use the hashtags #Neurology and #AANscience.

The American Academy of Neurology is the world’s largest association of neurologists and neuroscience professionals, with over 38,000 members. The AAN is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimer’s disease, stroke, migraine, multiple sclerosis, concussion, Parkinson’s disease and epilepsy.

For more information about the American Academy of Neurology, visit AAN.com or find us on Facebook, Twitter, Instagram, LinkedIn and YouTube.

Your Blood Type Doesn't Affect Covid-19

 Damn, I guess this was wrong.

Study links blood type(O) to lower risk of catching coronavirus

June 2020

Your Blood Type Doesn't Affect Covid-19

August 22, 2020

 

We are at least eight months into the Covid-19 new pandemic and we are quickly learning about this virus and how it affects our bodies.  A few weeks ago there were reports that a person's blood type might protect them from getting the infection. We now know this is not true.  But first, a quick tutorial on human blood type.

Each of us inherits our blood type that is carried by an antigen on our red blood cells (RBC).  The RBC is the largest quantity of blood cells in our body and is mainly designed to carry oxygen to our tissues.  Each of us is either Type A, Type B, Type AB or Type O with a protein that is either positive or negative and is called Rh factor.  We know that these types are critical in blood transfusions and receiving the wrong type of blood will cause a severe reaction.  Every time a person is administered blood they get a "type and cross" that checks the blood type and makes sure the proper transfusion is given.  People with Type O blood have no antigens so they can be given to all blood types and are called the universal donor. 

It is nice speculation that a blood type might be Covid protecting but the peer-reviewed data does not show any difference.

Harvard Mass General just reported on an observational study of 1289 Covid positive patients.  They ranked them for race, age and co-morbidities and wanted to know if blood type had any effect on the severity of the Covid illness. They looked at admit, ICU admit, intubation and death and found that there was no difference between any of these outcomes and a patient's blood type.

Because we know inflammation plays a role in severity of illness, they also looked at markers of inflammation and blood type and found no difference.

Scientists will continue to learn more about Covid and how it behaves and why certain people have worse outcomes.  For now it's not blood type.

 

Blood type O patients may have higher risk of death from severe trauma

Good thing I had an ischemic stroke rather than a bleeder. But these benefits from type O:

‘O’ blood type might be protective against dementia.

Non-O blood groups associated with higher risk of heart attack

 

 

Blood type O patients may have higher risk of death from severe trauma 

Blood type O is associated with high death rates in severe trauma patients, according to a study published in the open access journal Critical Care that involved 901 Japanese emergency care patients.

Researchers at Tokyo Medical and Dental University Hospital, Japan found that severe trauma patients (those with an injury that has the potential to cause long-term disability or death) with blood type O had a death rate of 28%, compared to a rate of 11% in patients with other blood types.

Dr. Wataru Takayama, the corresponding author said: “Recent studies suggest that blood type O could be a potential risk factor for hemorrhage (bleeding in large quantities). Loss of blood is the leading cause of death in patients with severe trauma but studies on the association between different blood types and the risk of trauma death have been scarce. We wanted to test the hypothesis that trauma survival is affected by differences in blood types.”

Patients with blood type O have been shown to have lower levels of von Willebrand factor, a blood clotting agent, than those with other blood types. Lower levels of von Willebrand factor may be linked to higher levels of haemorrhage. The authors suggest that a lower level of the factor is a possible explanation for the higher death rate in trauma patients with blood type O.

Wataru Takayama said: “Our results also raise questions about how emergency transfusion of O type red blood cells to a severe trauma patient could affect homeostasis, the process which causes bleeding to stop, and if this is different from other blood types. Further research is necessary to investigate the results of our study and develop the best treatment strategy for severe trauma patients.”

The authors used data from medical records of 901 patients with severe trauma who had been transported to either of two tertiary emergency critical care medical centers in Japan during 2013 to 2016.

The authors caution that all the patients whose data was analyzed in this study were Japanese and therefore there is a need for further research to understand if the findings apply to other ethnic groups. Additionally, there was no evaluation of the impact of the individual blood types A, AB or B on severe trauma death rates. Instead, the authors compared type O to non-O blood type which may have diluted the effect of individual blood types on patient survival.

-ENDS-

Media Contact
Hannah Lewis
Communications Assistant
BMC
T: +44 2078 4336 24
E: hannah.lewis@biomedcentral.com

Notes to editor:

1. Research article:
The impact of blood type O on mortality of severe trauma patients: A retrospective observational study
Takayama et al. Critical Care. 2018.
DOI: 10.1186/s13054-018-2022-0

The article is available at the journal website.

Why Men With This Blood Type Are More Likely to Have a Heart Attack

I guess my being type O is good.

‘O’ blood type might be protective against dementia.

http://www.menshealth.com/health/blood-type-and-heart-attack?

If you don’t know your blood type, you might want to pick up the phone and ask your mom. That’s because it may tell you more about your health than you think—in fact, back in March, we reported that blood types can predict which men get better erections.
Now, it may point to something more deadly, too: Your blood type may help determine if you’re at risk of a heart attack, new research presented at Heart Failure 2017—4th World Congress on Acute Heart Failure suggests.

Researchers analyzed data on more than 1,300,000 people from nine previous studies, and concluded that those with type A, type B, or type AB blood were 9 percent more likely to have a cardiovascular event—like a heart attack—than those with type O blood.
The exact mechanism behind the increased heart risk isn’t exactly clear. But one possibility may be because people with non type-O blood have greater concentrations of a blood clotting protein called von Willebrand factor, which can make the development of a blockage that causes a heart attack more likely, the researchers say in a press release. (That also may be why guys with non type-O blood are more likely to develop erectile dysfunction, too.)
People with non-O blood also tend to have higher cholesterol and higher levels of inflammation.
More research is needed to clarify the links between blood type and heart risks—and to look at each blood type separately—but the researchers believe that blood type may eventually play a role in risk assessment for heart disease, along with traditional factors like cholesterol, age, and blood pressure.

Researchers analyzed data on more than 1,300,000 people from nine previous studies, and concluded that those with type A, type B, or type AB blood were 9 percent more likely to have a cardiovascular event—like a heart attack—than those with type O blood.
The exact mechanism behind the increased heart risk isn’t exactly clear. But one possibility may be because people with non type-O blood have greater concentrations of a blood clotting protein called von Willebrand factor, which can make the development of a blockage that causes a heart attack more likely, the researchers say in a press release. (That also may be why guys with non type-O blood are more likely to develop erectile dysfunction, too.)
People with non-O blood also tend to have higher cholesterol and higher levels of inflammation.
More research is needed to clarify the links between blood type and heart risks—and to look at each blood type separately—but the researchers believe that blood type may eventually play a role in risk assessment for heart disease, along with traditional factors like cholesterol, age, and blood pressure.

Non-O blood groups associated with higher risk of heart attack

Since I'm O negative this might help me.
And this might help me also;

‘O’ blood type might be protective against dementia.

Non-O blood groups associated with higher risk of heart attack

28 April 2017 European Society of Cardiology (ESC)

• Under embargo until 30 April 2017 08:00 GMT

Having a non-O blood group is associated with a higher risk of heart attack, according to research presented today at Heart Failure 2017 and the 4th World Congress on Acute Heart Failure.1
Lead author Tessa Kole, a Master’s degree student at the University Medical Centre Groningen, the Netherlands, said: “It has been suggested that people with non-O blood groups (A, B, AB) are at higher risk for heart attacks and overall cardiovascular mortality, but this suggestion comes from case-control studies which have a low level of evidence. If this was confirmed it could have important implications for personalised medicine.”
The current study was a meta-analysis of prospective studies reporting on O and non-O blood groups, and incident cardiovascular events including myocardial infarction (heart attack), coronary artery disease, ischaemic heart disease, heart failure, cardiovascular events and cardiovascular mortality.
The study included 1 362 569 subjects from 11 prospective cohorts, described in nine articles. There were a total of 23 154 cardiovascular events. The researchers analysed the association between blood group and all coronary events, combined cardiovascular events, and fatal coronary events.
The analysis of all coronary events included 771 113 people with a non-O blood group and 519 743 people with an O blood group, of whom 11 437(1.5%) and 7 220 (1.4%) suffered a coronary event, respectively. The odds ratio (OR) for all coronary events was significantly higher in carriers of a non-O blood group, at 1.09 (95% confidence interval [CI] of 1.06–1.13).
The analysis of combined cardiovascular events included 708 276 people with a non-O blood group and 476 868 people with an O blood group, of whom 17 449 (2.5%) and 10 916 (2.3%) had an event, respectively. The OR for combined cardiovascular events was significantly higher in non-O blood group carriers, at 1.09 (95% CI 1.06–1.11).
The analysis of fatal coronary events did not show a significant difference between people with O and non-O blood groups.
“We demonstrate that having a non-O blood group is associated with a 9% increased risk of coronary events and a 9% increased risk of cardiovascular events, especially myocardial infarction,” said Ms Kole.
The mechanisms that might explain this risk are under study. The higher risk for cardiovascular events in non-O blood group carriers may be due to having greater concentrations of von Willebrand factor, a blood clotting protein which has been associated with thrombotic events. Further, non-O blood group carriers, specifically those with an A blood group, are known to have higher cholesterol. And galectin-3, which is linked to inflammation and worse outcomes in heart failure patients, is also higher in those with a non-O blood group.
Ms Kole said: “More research is needed to identify the cause of the apparent increased cardiovascular risk in people with a non-O blood group. Obtaining more information about risk in each non-O blood group (A, B, and AB) might provide further explanations of the causes.”
She concluded: “In future, blood group should be considered in risk assessment for cardiovascular prevention, together with cholesterol, age, sex and systolic blood pressure. It could be that people with an A blood group should have a lower treatment threshold for dyslipidaemia or hypertension, for example. We need further studies to validate if the excess cardiovascular risk in non-O blood group carriers may be amenable to treatment.”
https://www.escardio.org/The-ESC/Press-Office/Press-releases/non-o-blood-groups-associated-with-higher-risk-of-heart-attack?hit=wireag

• Full bibliographic informationThe abstract ‘ABO blood group and cardiovascular outcomes in the general population: a meta-analysis’ will be presented during Moderated Poster session 2 – The global problem of heart failure which takes place on 30 April from 10:00 to 11:00 in the Moderated Poster Area.

‘O’ blood type is associated with larger grey-matter volumes in the cerebellum

I'm sure there is no one in the world that I can ask whether my blood type of O negative is enough to offset my 33% dementia chance post-stroke from an Australian study.
This is what is so bad with stroke knowledge today, there is no one in the world any survivor can ask ANY SIMPLE QUESTION and expect any answer other than the f*ckingly stupid response of
'All strokes are different, all stroke recoveries are different' .
http://www.sciencedirect.com/science/article/pii/S0361923015000805

• Matteo De Marco^a,
• Annalena Venneri^{a, b, ,}

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doi:10.1016/j.brainresbull.2015.05.005

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Highlights

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‘O’ blood type adults have increased volumes in the posterior cerebellum.

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‘O’ blood type might be protective against dementia.

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Biological explanations include possible fostering of endothelial dysfunction.

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Abstract

Recent evidence indicated higher incidence of cognitive deficits in ABO blood-type system ‘AB’ individuals. Since this statistical difference might originate from the lack of protective effects exerted by ‘O’ alleles on the brain via vascular or non-vascular routes, this study investigated volumetric differences in grey matter between ‘O’ and non-‘O’ adults to explore the possibility of a structural endophenotype visible in ‘O’ adults without cognitive impairment or neurodegeneration.

A large sample of cognitively healthy adults who had previously undergone structural MRI for research purposes were contacted telephonically and enquired about their ABO blood type. Out of the 189 individuals who were able to retrieve and communicate this information, ‘O’ (n = 76) and ‘A’ adults (n = 65) were included in Model 1. In Model 2, all non-‘O’ (n = 113) were instead collapsed in a single group. Voxel-Based Morphometry analyses were carried out on three-dimensional T1-weighted scans, and between-sample t tests were run to compare the maps of grey-matter volumes of the subgroups of interest, controlling for major nuisance variables.

In Model 1, ‘O’ adults had larger grey-matter volumes in two symmetrical clusters within the posterior ventral portion of the cerebellum. This was confirmed in Model 2. Additionally, non-‘O’ adults showed lower volume values in temporal and limbic regions, including the left hippocampus.

The cerebellar clusters were located in regions previously found to be part of a network responsible for sensorimotor integration. It is speculated that the structural reductions seen in non-‘O’ adults might result in a susceptibility to down-regulation of this network. This occurrence is likely to intensify along the ageing process and may contribute to foster cognitive decline. Although Model 2 seems to suggest that having a ‘O’ blood type might play a role in protection against those conditions in which temporal and mediotemporal volumetric loss is observed (Alzheimer's disease), additional supporting evidence is needed.

A number of potential biological processes might sustain these between-group differences, including sensorimotor ontogenesis, hormonal function, and a regional impact of cerebral amyloid angiopathy. These findings identify the cerebellar tissue as a candidate for further studying ABO function, and support a general association between ABO blood type and variance in the development of the nervous system.

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Graphical abstract