Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Showing posts with label grant. Show all posts
Showing posts with label grant. Show all posts

Monday, October 22, 2018

Sainburg receives grant renewal for stroke rehabilitation research

This grant will likely be wasted money since there seems to be NO requirement to write a protocol on using this for stroke recovery.  This would seem to conflict with constraint induced therapy.

Sainburg receives grant renewal for stroke rehabilitation research

UNIVERSITY PARK, Pa. — The National Institutes of Health recently renewed funding for Penn State researcher Robert Sainburg, which will allow him to begin testing his rehabilitation intervention in treating the “unaffected” hand in stroke patients. The first cycle of this grant funded a series of basic science experiments to determine how each brain hemisphere contributes unique processes to the control of each arm, while the renewal is a large, 2-site, clinical intervention study that seeks to improve the lives of stroke survivors.
Sainburg, professor of kinesiology and neurology, in collaboration with Carolee Winstein, University of Southern California professor of biokinesiology and physical therapy, will expand on the findings of the previous grant period which found that stroke-induced brain lesions can substantially limit non-paretic arm function, the arm that was previous thought to be unaffected by stroke.
“We hypothesize that the deficits in the brain’s ability to control the patient’s ‘good’ hand interfere with doing everyday tasks. These deficits make it much harder for those who rely on this hand for function to be independent,” said Sainburg.
While it is known that each hand is controlled by one side of the brain, this is only true for very basic aspects of motor control. Sainburg explained that both sides of the brain contribute to control of each hand. Therefore, a lesion to one side of the brain will cause motor deficits in both hands.
Handedness results from specialization of each side of the brain to coordinate different aspects of a task, such as planning the direction and speed of a reaching movement, or correcting the movement due to unexpected events in the environment.
Severe stroke damage to specific areas in the brain can produce severe paresis in one hand, while the other arm, in comparison, seems to remain functional, yet its movement is often impaired.  
“We have specifically developed this intervention to focus on treating the problems in the ‘good’ hand since most current rehabilitation interventions tend to ignore this hand and put all their effort into the paretic hand. Since these patients really only have the one 'good' hand to carry out their daily tasks, if we get it better, they’ll be much more efficient in performing their activities of daily living, which is the main goal of rehabilitation,” said Sainburg.
The intervention utilizes virtual reality technology; patients practice different tasks with their non-paretic arm in a virtual setting that they can later translate into movements that allow them to live more independently.
The study will rely on the integration of Sainburg’s and Winstein’s laboratories, bringing together their experience in studying brain hemisphere specific motor deficits in stroke survivors and Winstein’s research in stroke clinical trial interventions.
“I look forward to starting our study and seeing the results from our intervention because it has the potential to have a big impact on the future of stroke rehab,” said Sainburg.

Friday, August 25, 2017

Kessler Foundation receives Wallerstein Foundation grant to advance stroke rehabilitation research

It seems there might be a protocol for spatial neglect, ask your doctor to find the publicly available location for it. If it is not public it doesn't exist. We need public protocols so we as survivors can take them to our stroke medical professionals and have them implement them with us. The other way where our stroke medical professionals know about and bring those protocols to us has completely failed. Proof by your 'professional' using the statement; 'All strokes are different, all stroke recoveries are different'. This grant is worthless if it didn't contain publishing protocols and results in a publicly available database.
https://www.news-medical.net/news/20170822/Kessler-Foundationc2a0receives-Wallerstein-Foundation-grantc2a0to-advance-stroke-rehabilitation-research.aspx
Kessler Foundation was awarded a $250,000 grant by the Wallerstein Foundation for Geriatric Life Improvement. The three-year grant will advance the Foundation's stroke rehabilitation research in the diagnosis and treatment of spatial neglect, a hidden disability that complicates recovery after right brain stroke.
In this project, Kessler Foundation creates a national, practice-based network for spatial neglect treatment and research. Network partners are trained to implement Kessler Foundation's spatial neglect assessment and treatment protocols -- the Kessler Foundation Neglect Assessment Process (KF-NAP™), and the Kessler Foundation Prism Adaptation Treatment (KF-PAT™) -- at 12 rehabilitation centers across the U.S. Therapy teams at each center will report on the use of these tools. The practice-based network will be a key resource to examine outcomes of spatial neglect assessment, and prism adaptation treatment, to assess whether these care processes enhance functional recovery and overall quality of life.
"This grant enables us to bring our bench-to-bedside treatment program to larger numbers of people recovering from right brain stroke, and produce systematic information supporting its impact" said A.M. Barrett, MD, director of Stroke Rehabilitation Research at Kessler Foundation. "The severity of spatial neglect, which can be measured with KF-NAP, can affect rates of home discharge, an important benchmark for stroke rehabilitative care," noted Dr. Barrett. "We feel that value-based, patient-centered care is advanced when professionals incorporate KF-NAP and KF-PAT in their rehabilitation protocols. This will be obvious when more stroke survivors attain optimal functional recovery and greater independence, which is the pathway to successfully returning to home, the community and the workplace."
The Wallerstein Foundation, a nonprofit organization based in West Orange, NJ, is dedicated to supporting quality of life for the elderly. "The Foundation recognizes the importance of research in helping seniors stay engaged in family life and the community," said Michele Pignatello, chief development officer of Kessler Foundation. "By providing more than half a million dollars for our research since 2000, The Wallerstein Foundation has substantially extended its influence, contributing to the improvement in rehabilitative care for the greater population of stroke survivors."

Sunday, May 1, 2016

Elusive brain receptor may play vital role in death of neurons from neurological diseases

Whom is going to follow this up, write up a grant proposal and research the hell out of it?  Certainly not any of our fucking failures of stroke associations. Sounds like the precursor to glutamate poisoning.  One of the 5 causes of the neuronal cascade of death.
http://www.news-medical.net/news/20160430/Elusive-brain-receptor-may-play-vital-role-in-death-of-neurons-from-neurological-diseases.aspx

Strokes, seizures, traumatic brain injury and schizophrenia: these conditions can cause persistent, widespread acidity around neurons in the brain. But exactly how that acidity affects brain function isn't well understood.
In a paper published in March in Scientific Reports, University at Buffalo researchers have begun to unravel some of the puzzle. They found that an elusive brain receptor may play an important role in the death of neurons from neurological diseases.
The UB researchers study a family of brain receptors that are critical to learning and memory, called NMDA (N-methyl-D-aspartate) receptors. They found that one of these receptors called N3A functions through a different mechanism than all other NMDA receptors.
"We found that in contrast to all other NMDA receptors, acidity can reactivate dormant N3A receptors," said Gabriela K. Popescu, PhD, senior author and professor in the Department of Biochemistry in the Jacobs School of Medicine and Biomedical Sciences at UB. "This insight led us to hypothesize that N3A receptors are silent in normal conditions, which may explain why other researchers have failed to observe them previously."
Popescu and Kirstie A. Cummings, lead author and doctoral candidate in the UB Department of Biochemistry, found that when the N3A receptors were exposed to acidic conditions, as occurs in brain disorders such as stroke or epilepsy, they reactivate, causing neurons to become more sensitive to the neurotransmitter glutamate, which can, under certain circumstances, kill them.
The research was done in cell culture with recombinant receptors.
"Given that acidity increases after a stroke or an epileptic seizure, reactivation of N3A receptors may be one reason why neurons die after these neurologic events," said Popescu. "So finding ways to prevent acidification or the reactivation of N3A receptors may prevent brain damage from strokes or seizures, for example."
She added that N3A proteins appear to be more abundant in brains of people with schizophrenia. "This is in line with our findings, since schizophrenia, a disease associated with high acidity in the brain, causes brains to shrink," she said.
Popescu noted that the finding also sheds much needed light on the N3A receptors. "Since their discovery more than 20 years ago, attempts to understand the roles of N3A receptors in the brain have been unsuccessful," she said. "Because many labs have failed to record N3A activity from neurons, some researchers even began to doubt their relevance to brain activity."
The new paper reveals that electrical currents passed by N3A receptors can excite cells in response to acidity, which makes them different from all other NMDA receptors.
The researchers have identified the site on the receptor where acidity acts to reactivate these receptors, a different location from the site where acidity acts to inhibit all other NMDA receptors.
"This site is new and unique and thus can be used to make drugs that are very specific to the N3A receptor," said Popescu.
Source:
University at Buffalo

Tuesday, October 6, 2015

Soon we'll cure diseases with a cell, not a pill

This switch in thought processes can't come too soon for stroke. But I bet not a single stroke leader will think of putting this into practice for solving all the problems in stroke. Our current stroke leadership is non-existent. We should be growing all the different types of neurons along with a blood supply to nourish them. There is the request for proposal to researchers. Send it out to find out what the cost would be to find answers and then go grant writing to get foundations to pay for that research. It's so fucking simple to accomplish stroke solutions. You describe the problem in specific terms that researchers will be able to create clinical trials on. None of this pie-in-sky research. 

Damn it all: stroke is easy; 5 steps.
1.  Describe the problems exactly. There are tens of thousands of pieces of research already hinting at solutions, just need followup.
2.  Write thousands of RFPs to researchers/MIT grads to solve those problems.
3.  Fund them with foundation grants.
4.  Write stroke rehab protocols based on the research.
5.  Get the Nobel prize in medicine.  

Soon we'll cure diseases with a cell, not a pill 


Current medical treatment boils down to six words: Have disease, take pill, kill something. But physician Siddhartha Mukherjee points to a future of medicine that will transform the way we heal.

Wednesday, May 13, 2015

UTHealth professor awarded $1 million grant from Stryker Neurovascular for stroke research

This researcher is going down the wrong route. You don't need to select the right patients, you need to figure out why all the patients don't recover better. There is a simple answer. The neuronal cascade of death has not been addressed at all. Fix that and your therapy will work much better. This is what happens when you don't have a stroke strategy that is being followed. The scattershot approach rarely works. The mentors for this guy do not know enough to be mentors. This is why stroke survivors need to be in charge.
http://www.news-medical.net/news/20150506/UTHealth-professor-awarded-241-million-grant-from-Stryker-Neurovascular-for-stroke-research.aspx
A $1 million grant for stroke research has been awarded from Stryker Neurovascular to Amrou Sarraj, M.D., assistant professor of neurology at The University of Texas Health Science Center at Houston (UTHealth).
Sarraj completed his residency and fellowship at UTHealth, where he began investigating which patients would do best with intra-arterial therapy - the mechanical removal of a blood clot that has stopped blood flow in an artery in the brain, during which a catheter is deployed through an artery in the groin up to the site of the clot.
While still a fellow, Sarraj devised a new scoring method to help physicians determine if a patient is a candidate for intra-arterial therapy. Called the Houston Intra-Arterial Therapy 2 "HIAT2" score, the new method earned him the Mordecai Y.T. Globus New Investigator Award in Stroke from the American Stroke Association (ASA) in 2012.
The dilemma for neurologists is that while intra-arterial therapy re-opens a clogged artery in 80 percent of patients, ONLY 30 PERCENT have an improved outcome.
"Even if you open the vessel, there can be too much damage that has already occurred,"(Wrong. You haven't stopped the damage that continues to occur in the death cascade) said Sarraj, who is an attending physician at Memorial Hermann-Texas Medical Center and Mischer Neuroscience Institute at Memorial Hermann. "We need to be able to select the right patients."(Wrong, wrong, wrong. Determine why your patients don't all recover, your assumption is wrong.)
At the recent ASA International Stroke Conference, Sarraj presented new study findings that revealed blood circulation flow, the extent of damage and patient age may be more important than arrival time when physicians are predicting which patients would benefit the most from intra-arterial therapy.
The new grant will fund a multi-institutional study that will evaluate different selection methods currently being used to see which one has the greatest probability of selecting the patients most likely to benefit from intra-arterial therapy. There are potential health care cost savings, he said, by avoiding an unnecessary procedure. The new study is called Optimizing Patient's Selection for Endovascular Treatment in Acute Ischemic Stroke (SELECT).
"This project has become all the more important as new published studies are beginning to show benefit of endovascular therapy for acute stroke," said Sean I. Savitz, M.D., professor of neurology and director of the UTHealth Stroke Program and Memorial Hermann-Texas Medical Center Stroke Center. "This grant represents the culmination of several years of research that Amrou has been doing. We are very proud of him."
"Now that endovascular therapy is a proven treatment, future trials should assess strategies to enhance clinical outcomes and optimization of patient selection and SELECT will take the lead," Sarraj said. "Informing stroke patients' families on their chances of having good outcomes after intra-arterial therapy is crucial; we hope the study will bring an answer to that".
Sarraj credits mentors including Savitz; Andrew Barreto, M.D., associate professor of neurology; Jon E. Tyson, M.D., M.P.H., professor of pediatrics and director of the Center for Clinical Research and Evidence-Based Medicine; Kathleen A. Kennedy, M.D., M.P.H., the Richard W. Mithoff Professor of Pediatrics and director of the MS Clinical Research Degree Program; and Charles Green, Ph.D., associate professor at the Center for Clinical Research and Evidence-Based Medicine. Sarraj is a graduate of the masters' degree research program.
"I would also like to thank Mark Paul and Mark O'Brien for their vision," Sarraj said. Paul is the president of the Neurovascular Division of Stryker Neurovascular while O'Brien is vice-president of Customer Excellence.
Source:
University of Texas Health Science Center at Houston