Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, April 1, 2025

Tracking Spasticity Dynamics in Hemiparetic Stroke Survivors Following Cyproheptadine Administration: A Pilot Study Using Controlled Varying Tendon Indentation Depths

 WHY? Aren't you following the incorrect opinions of  Dr. William F. Landau. 

Of course the infamous Dr. William M. Landau thinks spasticity is not worth treating. 

Do you believe in the do nothingism of Dr. William M. Landau on spasticity?  

His statement from here:

Spasticity After Stroke: Why Bother? Aug. 2004

Wonder if he will be singing the same tune after he becomes the 1 in 4 per WHO that has a stroke, will he be satisfied with not getting recovered?

The latest here:

Tracking Spasticity Dynamics in Hemiparetic Stroke Survivors Following Cyproheptadine Administration: A Pilot Study Using Controlled Varying Tendon Indentation Depths

Sungjin Bae Sungjin Bae 1Matthieu Chardon Matthieu Chardon 1Elliot J Roth Elliot J Roth 1,2William Zev Rymer William Zev Rymer 1,2Nina L Suresh Nina L Suresh 1,2*
  • 1 Northwestern University, Evanston, Illinois, United States
  • 2 Shirley Ryan AbilityLab, Chicago, Illinois, United States

The final, formatted version of the article will be published soon.

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    This study evaluates the potential of the Linmot® tapper as a precise tool for tracking spasticity changes in hemiparetic stroke survivors following cyproheptadine HCl administration. Spasticity, a significant health concern among stroke survivors, is characterized by increased muscle tone due to upper motor neuron dysfunction. Conventional clinical assessments, such as the Modified Ashworth Scale (MAS), often lack the sensitivity to accurately monitor treatment. In this study, we utilized the Linmot® tapper to assess the stretch reflex threshold (SRT) in three stroke survivors and one control subject by progressively altering tendon indentation to change muscle length.(Measuring spasticity DOES ABSOLUTELY NOTHING TO GET SURVIVORS RECOVERED! I'd have you all fired for incompetency!) The SRT was defined as the indentation depth at which consistent reflex responses of the biceps brachii were observed, as indicated by reflex force or rectified integrated EMG (RIEMG) signals. Measurements were taken at baseline and at 2, 4, and 6 hours after drug administration. Results showed significant increases in SRT following cyproheptadine administration, indicating reduced motor neuron excitability and highlighting the drug's effect on spasticity. Both reflex force and RIEMG data consistently captured these changes, while MAS grades remained unchanged. The high correlation between SRTs derived from force and EMG further supports the tool's accuracy in detecting subtle neuromuscular changes. These findings highlight that the Linmot® tapper offers a precise, quantitative method for monitoring spasticity dynamics, providing a more accurate alternative to conventional clinical assessments and demonstrating potential for enhancing stroke rehabilitation strategies.

    Keywords: Stretch reflex threshold, Deep tendon reflex, stroke rehabilitation, Spasticity, Cyproheptadine HCl

    Received: 27 Nov 2024; Accepted: 31 Mar 2025.

    Copyright: © 2025 Bae, Chardon, Roth, Rymer and Suresh. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Nina L Suresh, Northwestern University, Evanston, 60208, Illinois, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.     

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