Deans' stroke musings: honokiol

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Showing posts with label honokiol. Show all posts

Saturday, November 3, 2012

Question to StrokeSmart magazine

They were asking for article ideas and this was mine. I'm sure they won't do anything about it.
Where are we in the US about hyperacute therapies like Draculin, edaravone from Japan, enzognel from New Zealand? What should doctors be giving patients in the first days? fish oil?, statins?, anti-depressants? nitric oxide? ibuprofen? ceria nanoparticles? leg compressions? music? MMP-9? minocycline? levodopa? Honokiol? amantadine? melatonin? If you don't know about all of these you are pathetic.

Dear dean,

Last week, I sent you an important survey that National Stroke Association developed to help us in preparation for our relaunch of StrokeSmart™ magazine. If you haven’t already taken it, please take a few minutes to tell us more about your needs.

Thank you for your feedback. Your information will shape the future of StrokeSmart magazine.

Sincerely,

Taryn Fort
Director, Marketing and Communications

And yes, I know I'm dammed arrogant, these are all documented in postings in my blog. Ask your countries stroke association about these or your doctor and watch them sputter.

Tuesday, March 20, 2012

Honokiol Ameliorates Cerebral Infarction from Ischemia-Reperfusion Injury in Rats

I think this is one of the TCM.
https://www.thieme-connect.com/ejournals/abstract/plantamedica/doi/10.1055/s-2003-37707

Abstract

Honokiol, a constituent extracted from Magnolia officinalis, had been shown be an antioxidant and an anti-platelet agent in biological systems with an anti-arrhythmic effect and a myocardial protective effect on ischemia-reperfusion injury. We examined the neuroprotective effect of honokiol in rats subjected to focal cerebral ischemia. Honokiol was administered intravenously either at fifteen minutes before right middle cerebral artery occlusion (pretreatment groups) or when both common carotid arteries clips were removed (treatment groups). The results showed that there was no significant hemodynamic change after intravenous infusion of honokiol at the dosages of 10^{- 8}, 10^{- 7} and 10^{- 6} g/kg in both groups. However, honokiol significantly reduced the total volume of infarction at the doses of 10^{- 7} or 10^{- 6} g/kg in both pretreatment and treatment groups. This study suggests that honokiol is a potent neuroprotective agent in focal cerebral ischemia. This beneficial effect may be related to its antioxidant effect and anti-platelet aggregation activity.

Deans' stroke musings