Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Showing posts with label arginine. Show all posts
Showing posts with label arginine. Show all posts

Wednesday, March 13, 2024

Fenugreek seeds: A superfood for health and wellness, says new review

Ask your doctor if this needs to be added to your diet protocol. If you don't have a diet protocol containing EXACT amounts your doctor is massively incompetent!

Fenugreek seeds: A superfood for health and wellness, says new review

The growing interest in adopting a healthier lifestyle has been accompanied by an increased use of healthy food ingredients, which refers to naturally occurring bioactive compounds that have functions in the human body related to human health. These foods are often referred to as functional foods and are crucial for preventing disease, managing chronic conditions, and providing nutritional value.

A recent study published in the Journal of Food Science discusses the dietary importance and possible applications of fenugreek seeds in foods and beverages.

Study: Current perspectives on fenugreek bioactive compounds and their potential impact on human health: A review of recent insights into functional foods and other high value applications. Image Credit: kostrez / Shutterstock.com

Nutritional composition of fenugreek seeds

Each 100 grams (g) of fenugreek seeds comprises 60% carbohydrates, 25% dietary fiber, 23 g protein, 6 g lipids, and 9 g water. Fenugreek is particularly rich in potassium, phosphorus, magnesium, and calcium. Fresh fenugreek leaves contain about 86% water, 6% carbohydrates, 4% protein, and about 1% each of fiber and fat.

Fenugreek seed carbohydrates have a high glycemic index (GI), thus demonstrating their potential to reduce blood sugar levels, as well as total and low-density lipoprotein (LDL) cholesterol levels. The equimolar galactose:mannose ratio is responsible for a distinctive type of gum that is high in molecular weight and water solubility compared to other plant gums.

Extruded snack foods fortified with fenugreek have a lower GI, better nutritional and functional profile, as well as a long shelf life. For example, the addition of GM to a chickpea-rice blend reduced the GI of this product from 68% to 43%.

Germination increases, and roasting reduces dietary fiber, respectively. Roasted fenugreek seed has lower carbohydrate content but higher protein content.

Between 13-39% of fenugreek seed is protein, which is similar to other legumes used as food, though it differs with the variety. As compared to the husk, the endosperm contains six-fold the protein content.

Fenugreek seed contains proteins that are resistant to heat denaturation, are very stable, water-soluble, and form stable foams and films. In curries, soups, sauces, bread, meat dishes, cheeses, and desserts, fenugreek seeds provide taste, texture, and thickening, in addition to their non-nutritional benefits.

Soaking, germinating, and roasting fenugreek seeds increases protein digestibility by 10-15%. Comparatively, certain processes like brief blanching can increase the vitamin content of fenugreek seeds.

Glutamic acid, aspartic acid, and arginine are the primary amino acids in fenugreek seeds. The main volatile compound is 4-hydroxyisoleucine (4-HIL), which is converted to sotolone, the principal taste-producing molecule. Importantly, 4-HIL, an amino acid not involved in protein synthesis, mediates many of the metabolic actions of fenugreek.

Fenugreek seed lipids include phospholipids and glycolipids, mostly unsaturated triacylglycerols in the form of polyunsaturated fatty acids (PUFA). The high omega-6:omega-3 ratio of fenugreek seeds is nearly 3:1, which is similar to that of hemp, promotes health, and reduces diet-related chronic disease risk. Phytosterols like campesterol and β-Sitosterol comprise 56% to 72% of the total sterols in fenugreek seeds, respectively.

Nutraceuticals in fenugreek include saponins like dioscin and diosgenin, alkaloids, phenolics, and volatile essential oils (Eos). Other nutraceutical compounds present in fenugreek include flavonoids like quercetin and ellagic acid, eugenol and linalool, as well as trigonelline.

Diosgenin is used to synthesize various steroidal drugs, including progesterone and cortisone. Saponin hydrolysis to sapogenins is also capable of producing many compounds that are more bioactive than the parent compounds.

Trigonelline is the most abundant alkaloid present in fenugreek and is potentially protective against type 2 diabetes and neurodegenerative diseases. Triogenelline has been shown to reduce blood lipids, support kidney and liver function, and prevent cancerous changes. Trigonelline may also prevent bacterial and viral infections and appears to act synergistically with other compounds.

Health benefits of fenugreek seeds

Some benefits associated with fenugreek include blood sugar control, lower blood lipids, anticancerous activity, immunomodulation, and pain relief, thereby offering protective effects for the heart and vascular system, gastrointestinal tract, liver, brain, and endocrine system. Fenugreek is also used for preserving reproductive function and relieving skin inflammatory conditions.

Fenugreek compounds act by restoring beta cell function in the pancreas, reducing hepatic neogluconeogenesis, as well as upregulating antioxidant and hepatoprotective enzymes. Improved insulin signaling and antioxidant activity is also associated with trigonelline. Fenugreek can also restore gut microbiota composition, thereby improving metabolic function and glucose tolerance with secondary beneficial effects on other organ systems.

Fenugreek seeds may also regulate appetite, prevent cognitive decline, promote wound healing, treat asthma, reduce dysmenorrhea and muscle pain, and modulate menopausal symptoms.

How is fenugreek used?

Fenugreek (Trigonella foenum-graecum L.) is an herb bearing small brown seeds with a unique taste and nutritional value. Fenugreek seeds, leaves, and stems are often used for culinary and medicinal purposes.

Fenugreek seeds provide soups, spice blends, desserts, and teas with a somewhat bittersweet taste. Additionally, biopolymers synthesized from fenugreek are used to stabilize and texturize a wide range of foods.

Fenugreek is a promising ingredient for functional foods and is a ‘generally recognized as safe (GRAS)’ flavoring agent in the United States and other countries. Multiple forms of fenugreek are available, including seed powder, leaf flour, seed gum, seed husk, Eos, and extracts, as well as edible film.

Specialty foods like pasta, bread, milk analogs, low-fat dairy cheese, or flavor-enhanced cheeses have been produced using fenugreek. Meat products can also be made more functional by incorporating fenugreek without noticeably altering the taste. Fenugreek leaves have high antioxidant and antimicrobial content, thus preventing the spoiling and rancidity of meat when used in a marinade.

Fenugreek is tolerable in humans when used at therapeutic doses, except for rare or transient minor side effects like nausea, abdominal pain, or dizziness. In diabetics, fenugreek overuse may lead to hypoglycemia and, if used with drugs that induce low potassium levels, may cause hypokalemia. Fenugreek may also interact with oral anticoagulants to increase bleeding risk and interfere with the absorption of oral drugs.

Journal reference:
  • Alu’datt, M. H., Rababah, T., Al-ali, S., et al. (2024). Current perspectives on fenugreek bioactive compounds and their potential impact on human health: A review of recent insights into functional foods and other high value applications. Journal of Food Science. doi:10.1111/1750-3841.16970.

Wednesday, December 14, 2016

Researchers to study effect of watermelon juice in reducing heart disease

Were these two earlier research efforts not enough to prove the benefits? This waste of resources is directly a result of NO fucking stroke strategy.  I eat a pound of watermelon a day whenever possible, can't find juice.

Watermelon Could Lower Blood Pressure April 2014 

Watermelon juice reverses hardening of the arteries Nov. 2011

 

 Researchers to study effect of watermelon juice in reducing heart disease

University of Alabama researchers soon will launch a study that looks at watermelon juice as a way to reduce heart disease.
Dr. Kristi Crowe-White and Dr. Amy Ellis, researchers in the College of Human Environmental Sciences' department of human nutrition and hospitality management, are recruiting subjects for a 10-week study to see how watermelon impacts blood vessel function.
The researchers believe that several natural ingredients in watermelon — lycopene, citrulline, arginine, glutamine and ascorbic acid — will act in synergy to decrease arterial stiffness and oxidative stress.
Arterial stiffness is an early independent risk factor for cardiovascular disease and cardiovascular events like heart attack and stroke. As people get older, the arteries get stiffer, more rigid and less able to dilate, Ellis said.
Oxidative stress also increases with age because the body is not able to compensate, and people's diet typically is lacking in needed antioxidants. Oxidative stress is one of the underlying causes of all chronic disease, so when the level is high, if a person has a genetic predisposition for a chronic disease, that's when the manifestation will occur, Crowe-White said.
"Our goal is to reduce the risks of these future cardiovascular events, but since we are both dietitians, we're interested in doing this through a food-first approach versus just another pill or medication," Ellis said. "If there are natural ingredients in this food that could be beneficial, why not try that first."
Study participants need to be postmenopausal African-American or European-American women ages 55 to 69 who do not smoke or have high blood pressure, diabetes, liver disease or kidney disease. The first four weeks will involve study participants drinking either 100 percent watermelon juice or a placebo twice a day.
At the end of the four weeks, there will be a two-week washout period where neither beverage is consumed. In the next four weeks, participants will drink the opposite of what they had in the beginning of the study. Vascular and blood measures will be assessed at the beginning and end of each four-week period. Participants are eligible for compensation up to $100.
Source:
University of Alabama