Useless piece of crap. Nothing here will help survivors recover. You should all be fired.
Sleep as a model to understand neuroplasticity and recovery after stroke: Observational, perturbational and interventional approaches
Mensen A1, Pigorini A2, Facchin L3, Schöne C3, D'Ambrosio S2, Jendoubi J3, Jaramillo V4, Chiffi K3, Eberhard-Moscicka AK3, Sarasso S2, Adamantidis A3, Müri RM3, Huber R4, Massimini M2, Bassetti C3.
Erratum in
Abstract
Our
own experiences with disturbances to sleep demonstrate its crucial role
in the recovery of cognitive functions. This importance is likely
enhanced in the recovery from stroke; both in terms of its physiology
and cognitive abilities. Decades of experimental research have
highlighted which aspects and mechanisms of sleep are likely to underlie
these forms of recovery. Conversely, damage to certain areas of the
brain, as well as the indirect effects of stroke, may disrupt sleep.
However, only limited research has been conducted which seeks to
directly explore this bidirectional link between both the macro and
micro-architecture of sleep and stroke. Here we describe a series of
semi-independent approaches that aim to establish this link through
observational, perturbational, and interventional experiments. Our
primary aim is to describe the methodology for future clinical and
translational research needed(So you want someone else to do the actual hard work of solving this? Too hard for you? Not your job?) to delineate competing accounts of the
current data. At the observational level we suggest the use of
high-density EEG recording, combined analysis of macro and
micro-architecture of sleep, detailed analysis of the stroke lesion, and
sensitive measures of functional recovery. The perturbational approach
attempts to find the causal links between sleep and stroke. We promote
the use of transcranial magnetic stimulation combined with EEG to
examine the cortical dynamics of the peri-infarct stroke area.
Translational research should take this a step further using optogenetic
techniques targeting more specific cell populations. The interventional
approach focuses on how the same clinical and translational
perturbational techniques can be adapted to influence long-term recovery
of function.
Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.
KEYWORDS:
Brain damage; EEG; Functional recovery; Sleep; Slow waves; Stroke; Translational- PMID:
- 30571989
- DOI:
- 10.1016/j.jneumeth.2018.12.011
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