Different coffee consumption patterns affect HbA1c via propionic acid-producing gut microbiota

Since I'm not worrying about HbA1c levels yet I don't have to figure out the definition of filtered on my 12 cup pot of coffee daily!

Different coffee consumption patterns affect HbA1c via propionic acid-producing gut microbiota

• Zhaoming Cao,
• Yu An,
• Yage Du,
• Guangyi Xu,
• Jingya Wang &
• Yanhui Lu 

npj Science of Food , Article number:  (2025) Cite this article

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We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply.

Abstract

This study investigates the causal relationship between coffee consumption patterns, propionic acid-producing gut microbiota, and glycated haemoglobin (HbA1c) levels using Mendelian randomisation (MR). Genome-wide association study datasets from the UK Biobank and MiBioGen consortium were analysed, identifying a significant mediating pathway: unsweetened filter coffee consumption promotes Veillonella abundance, which in turn reduces HbA1c levels. The inverse variance weighted method served as the primary analytical approach, supported by sensitivity analyses to ensure robustness. These findings highlight the potential of unsweetened filter coffee as a dietary intervention to improve glycaemic control by modulating gut microbiota. This research provides novel insights into the coffee-intestinal microbiota-metabolism axis and offers practical guidance for diabetes management, emphasising the importance of coffee preparation methods and dietary habits in harnessing its therapeutic potential.

Study: Tree nut consumption linked to improved type 2 diabetes health

You'll have to ask your doctor if the benefits from this apply to stroke survivors. Notice that peanuts are not included. But your doctor can analyze these two(when pigs fly) and come up with a diet protocol. You do expect not to have to do your doctors' work along with all your recovery rehab?

Eating peanuts may lead to supple arteries and healthy hearts  May 2017 

Study: Tree nut consumption linked to improved type 2 diabetes health May 2018

One of the largest studies to date on nuts and diabetes was published today in Diabetologia, the journal of the European Association for the Study of Diabetes (EASD). The study shows that approximately two ounces of nuts a day, as a replacement for carbohydrate foods, can improve glycemic control and blood lipids in those with type 2 diabetes.

Researchers from the University of Toronto and St. Michael's Hospital in Toronto, Canada, found that tree nuts (almonds, Brazils, cashews, hazelnuts, pecans, pine nuts, pistachios, macadamias and walnuts) and peanuts improved blood lipid levels and blood sugar levels in individuals with non-insulin dependent diabetes.

This study, which was retracted by the authors at their request, was originally published in Diabetes Care. It was a 3-month parallel design with 117 non-insulin dependent adults with diabetes (men and women with a mean age of 62 years) who were all being treated with oral hypoglycemic medications. The subjects were randomized to one of three diets for three months. The first diet included a supplement of 75g (~2½ ounces or ½ cup) of mixed nuts; the second diet included 38g (~1? ounces or ¼ cup) of mixed nuts and half portion of whole wheat muffins; and the third diet contained a full portion of whole wheat muffins.

Each supplement provided approximately 475 calories per 2,000 calorie diet. All of the diets contained roughly the same number of calories, but the nuts provided more unsaturated (i.e. healthy) fat and less carbohydrate.

The goal of the study was to determine if nuts improve glycemic control in non-insulin dependent diabetes, as assessed by HbA1c (a marker of blood sugar control over the previous three months), and also improve markers of cardiovascular health.

"The original findings revealed that the full dose nut group had a significant reduction in HbA1c compared to the other two groups," stated David Jenkins, MD, PhD, DSc, with the University of Toronto and St. Michael's Hospital. "The current study shows a reduction in HbA1c and the low-density lipoprotein (LDL)-associated cardiovascular disease (CVD) risk factor, apolipoprotein B (Apo-B), stated Dr. Jenkins. "We also found lower levels of small LDL cholesterol-- which is an emerging risk factor for CVD." He added, "The bottom line is, this study showed a modest but significant improvement in blood glucose control, despite the higher fat intake, and improvement in lipid risk factors for heart disease with increasing nut dose."

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According to Cyril Kendall, Ph.D., co-investigator of the study, "The improvements in blood glucose control and blood lipid levels that can be achieved by dietary and lifestyle changes are significant and could make a substantial contribution to the treatment of those with type 2 diabetes. Nuts are a healthy and flavorful option for individuals with diabetes that also promote healthy body weight."

A number of studies have suggested that consuming tree nuts may reduce the risk of heart disease, confirmed by the PREDIMED trial in 2013. In 2003 tree nuts received a qualified health claim from the U.S. Food and Drug Administration (FDA) which states, "Scientific evidence suggests but does not prove that eating 1.5 ounces per day of most nuts, as part of a diet low in saturated fat and cholesterol, may reduce the risk of heart disease." Interestingly, adults with diabetes are two to four times more likely to die from heart disease than adults without diabetes.

According to Maureen Ternus, M.S., R.D., Executive Director of the International Tree Nut Council Nutrition Research & Education Foundation (INC NREF), "While we've known for years that eating nuts every day can help reduce the risk for heart disease, these findings show that consuming nuts may be helpful in controlling type 2 diabetes as well."

The original study was published in 2011 but retracted as the statistical model used did not control for repeated measures in the same individual. The current study fixed the previous statistical error and added new data of interest including LDL particle size and clotting factors.

Source:

https://www.easd.org/

Anti-hyperglycemic use tied to reduced risk of intracranial aneurysm rupture

Go ask your doctor if this applies to you. You do expect her to know about this study since she should have been aware of the setup and establishment of the research?
https://www.mdlinx.com/internal-medicine/top-medical-news/article/2017/12/20/7498233/?

Reuters Health News

The use of anti-hyperglycemic agents is associated with a reduced risk of intracranial aneurysm rupture, according to a medical records study.
"This study suggests that anti-hyperglycemic medications may be potential therapeutic agents for the prevention of aneurysm rupture,” Dr. Rose Du from Brigham and Women's Hospital, Harvard Medical School, Boston, told Reuters Health by email. “However, future studies will be required to understand the mechanism behind this association, and prospective clinical studies will be required to confirm the protective effects.”
Some reports have suggested that diabetes could be a protective factor for rupture of intracranial aneurysms, but the findings are inconsistent.
Dr. Du’s team investigated the possible association of hemoglobin A1c (HbA1c) values and the use of anti-hyperglycemic agents with the risk of intracranial aneurysm rupture in a study of medical records from 4,701 patients with 6,411 aneurysms, of which 1,302 (28%) were ruptured.
The findings were published online December 4 in Stroke.
Anti-hyperglycemic use was associated with a 43% lower risk of intracranial aneurysm rupture in multivariate analysis. Also independently associated with a lower rupture risk were female sex and a family history of aneurysm.
Factors independently associated with a significantly higher risk of rupture included black, Hispanic, Asian, or "other" race, as well as current alcohol and tobacco use.
HbA1c values were not significantly associated with the risk of aneurysm rupture.
“We were surprised to find that it was the use of anti-hyperglycemic agents rather than the hyperglycemia itself that is inversely associated with aneurysm rupture,” Dr. Du said.
She cautioned, “We would like to point out that while the results of this study showed an association between anti-hyperglycemic agents and decreased risk of aneurysm rupture, it would be important not to assume causation without additional studies.”
—Will Boggs, MD

5 New Heart Tests That Could Save Your Life

We should probably consider asking our doctors about these.  Full descriptions at the caring.com link. 

5 New Heart Tests That Could Save Your Life

1. Coronary artery calcium scan (CAC)

Calcium is one of the main components in the plaque that builds up inside coronary arteries, narrowing and stiffening them and obstructing blood flow to and through the heart. A CAC score of zero is considered ideal; a score over 400 indicates severe atherosclerosis. Although CAC scanning is still one of the lesser-known heart tests, a study in the New England Journal of Medicine a few years ago determined that the CAC test was a "strong predictor" of heart attack and fatal heart disease. The researchers followed close to 7,000 people, testing them for CAC, then followed them for more than three years, correlating the data with the number of fatal or life-threatening coronary events. Those whose scores ranged from 100 to 300 were seven times more likely to die of a heart attack or other heart ailment than those with low CAC scores, and those with scores over 300 were even more at risk.

2. Corus CAD

A genetic test, as opposed to a physical measurement, Corus CAD looks for evidence of narrowing or blockage in the coronary arteries at the molecular level. Blood samples are screened for the activity of 23 genes that exhibit changes when there's an obstruction in the arteries. It's gender specific, taking into account differences in how men and women respond to obstructive coronary artery disease.

3. High-sensitivity C-reactive protein assay

Levels of C-reactive protein in the blood rise when there's widespread inflammation somewhere in the body. This can be due to bacterial or viral infection, but inflammation can also occur when plaque buildup irritates and inflames artery walls. Research shows that elevated levels of CRP correlate with increased risk of heart attack and fatal heart disease, possibly because inflammation damages and fragments arterial plaque, causing tiny portions of plaque to break off and be released into the bloodstream, leading to heart attack or stroke.

4. Carotid artery IMT ultrasound (C-IMT)

One of the newest heart health tests to reach doctor's offices is a specialized, high-resolution ultrasound of the carotid artery called C-IMT. C-IMT uses sophisticated computer software to calculate the thickness of the intima and media, two layers of the lining of the carotid artery. Studies have found a strong correlation between the health of carotid arteries in the neck and the coronary arteries in the heart.

5. Hemoglobin A1c test

The newest and least-known of the heart tests listed here is actually an extremely common test for diabetes, but it's only recently been used to detect heart disease. Also called glycated hemoglobin or glycosylated hemoglobin, the hemoglobin A1c test (HbA1c) is considered a measure of average blood sugar levels over time. More specifically, it measures the percentage of hemoglobin -- a protein in red blood cells that carries oxygen -- that's coated with sugar (glycated). The higher the A1C level, the poorer your blood sugar control.