Impact of Short‐Term Exposure to Ozone on Hospital Admissions for Multiple Cardiovascular Diseases: A Systematic Review and Meta‐Analysis

My God, even the AHA doesn't know that stroke has been called neurological disease by the WHO since 2006 not cardiovascular, once again proving the stroke medical world doesn't keep up to date in their field!

But what about these uses for ozone?

A case of vertebrobasilar stroke during oxygen-ozone therapy

 

Selective ozone concentrations may reduce the ischemic damage after a stroke

 

Application of ozone therapy in interventional medicine

 

Efficacy and safety of ozone therapy administered by autologous blood transfusion for acute ischemic stroke: study protocol for a multi-center open-label large-sample… 

Safety of Ozone Therapy Applied by Different Routes in Patients with Ischemic Stroke

The latest here:

Impact of Short‐Term Exposure to Ozone on Hospital Admissions for Multiple Cardiovascular Diseases: A Systematic Review and Meta‐Analysis

Yu You MM,  Juan Chen PhD,  Kai Wang MM, Tong Wu MM, Lijun Bai MM, Ge Li MM https://orcid.org/0000-0001-6659-0291, and Shaowei Wu PhD https://orcid.org/0000-0003-2680-6064 shaowei_wu@xjtu.edu.cnAuthor Info & Affiliations Journal of the American Heart Association New online https://doi.org/10.1161/JAHA.124.037205>

Abstract

Background

The associations between short‐term exposure to ambient ozone (O3) pollution and the risks of hospital admissions (an indicator for morbidity) for different subtypes of cardiovascular disease (CVD) remain unclear. Therefore, this study aimed to evaluate the associations between short‐term exposure to O3 and the risks of hospital admissions for all‐cause CVD, arrhythmia, atrial fibrillation, cardiac diseases, heart failure, ischemic heart disease, myocardial infarction (MI), and stroke.

Methods

Four electronic databases, including PubMed, Web of Science, Scopus, and Embase, were searched for articles published up to December 21, 2023. Epidemiological studies reporting the associations between short‐term exposure to O3 and the risks of hospital admissions for CVDs were included on the basis of stringent inclusion and exclusion criteria. The random‐effect model was applied to estimate pooled relative risk and 95% CIs. To identify potential effect modifiers, subgroup and meta‐regression analyses were also performed. A total of 111 articles with >65 million participants were included in the meta‐analysis. For a 10 μg/m3 increase in short‐term exposure to O3, the relative risks of hospital admissions for MI and stroke were 1.0084 (95% CI, 1.0019–1.0151) and 1.0023 [95% confidence interval (CI), 1.0012–1.0034], respectively. Subgroup and meta‐regression analyses revealed that study area and national economic status could influence the impact of O3 on different subtypes of CVD.This meta‐analysis provides compelling evidence for the adverse effects of short‐term exposure to ambient O3 pollution on the risks of hospital admissions for MI and stroke

Ozone exposure may contribute to reduced oxygen levels and arterial stiffness

Your competent? doctor should have monitoring in your hospital and give you EXACT INSTRUCTIONS on how to monitor at home. You really think your doctor is capable of that?

Ozone exposure occurs in the air when harmful ground-level ozone forms through chemical reactions between pollutants like nitrogen oxides (NOx) and volatile organic compounds (VOCs) emitted from sources like vehicles, factories, and certain consumer products, primarily in the presence of sunlight and warm temperatures; this process is most prevalent on hot, sunny days, leading to increased ozone levels in the air we breathe. 
 Ozone exposure may contribute to reduced oxygen levels and arterial stiffness

Ozone (O3) exposure may reduce the availability of oxygen in the body, resulting in arterial stiffening due to the body's natural response to create more red blood cells and hemoglobin, according to a study published today in JACC, the flagship journal of the American College of Cardiology.

Researchers found that even brief exposure to elevated ozone levels reduced blood oxygen saturation, triggered hypoxia-related biomarkers, and increased arterial stiffness, highlighting the novel connection between ozone exposure and arterial stiffness, demonstrated through comprehensive biomarker analysis in a high-altitude setting. This study uniquely isolates ozone's effects from other pollutants, providing a critical step forward in understanding its independent role in cardiovascular injury."

Dr. Harlan Krumholz, MD, SM, Editor-in-Chief of JACC

Ozone pollution is becoming a worldwide health issue. Recent studies have linked O3 exposure with an increased risk of cardiovascular diseases (CVDs), including ischemic heart disease, stroke, heart failure, and atherosclerosis. Hypoxia, or the deficiency of oxygen in the body, is recognized as a pivotal factor in O3-associated CVDs.

Source:

American College of Cardiology

Journal reference:

Hua, Q., et al. (2025) Associations of Short-Term Ozone Exposure With Hypoxia and Arterial Stiffness. Journal of the American College of Cardiology. doi.org/10.1016/j.jacc.2024.11.044.