But we have f*cking idiots in the US government that refuse to do anything useful like allow scientists to propose medical interventions.
http://onlinelibrary.wiley.com/doi/10.1111/bph.13186/abstract
Author Information
- 1Department of Physiology, School of Medicine, and Trinity College Institute of Neuroscience, University of Dublin, Trinity College, Dublin 2, Ireland
- 2Department of Anatomy and Neuroscience, Western Gateway Building, University College Cork, Cork, Ireland
*
Correspondence: Eric J. Downer, Department of Anatomy and Neuroscience,
Western Gateway Building, University College Cork, Cork, Ireland. Phone
number: 353-21-4205481; Email: edowner@ucc.ie.
- Abstract
Abstract
The
processes underpinning post-developmental neurogenesis in the mammalian
brain continue to be defined. Such processes involve the proliferation
of neural stem cells (NSCs) and neural progenitor cells (NPCs), neuronal
migration, differentiation and integration into a network of functional
synapses within the brain. Both intrinsic (cell signalling cascades)
and extrinsic (neurotrophins, neurotransmitters, cytokines, hormones)
signalling molecules are intimately associated with adult neurogenesis
and largely dictate the proliferative activity and differentiation
capacity of neural cells. Cannabinoids are a unique class of chemical
compounds incorporating plant-derived cannabinoids (the active
components of Cannabis sativa), the endogenous cannabinoids and
synthetic cannabinoid ligands, and these compounds are becoming
increasingly recognized for their roles in neural developmental
processes. Indeed, cannabinoids have clear modulatory roles in adult
neurogenesis, likely through activation of both CB1 and CB2
receptors. In recent years a large body of literature has deciphered
the signalling networks involved in cannabinoid-mediated regulation of
neurogenesis. This timely review summarises the evidence that the
cannabinoid system is intricately associated with neuronal
differentiation and maturation of NPCs, and highlights
intrinsic/extrinsic signalling mechanisms that are cannabinoid targets.
Overall these findings identify the central role of the cannabinoid
system in adult neurogenesis in the hippocampus and the lateral
ventricles, and hence provide insight into the processes underlying
post-developmental neurogenesis in the mammalian brain.
