Neuroprotective Agents: An Overview on the General Modes of Action

You'll have to ask your doctor which of these agents are being investigated by the researchers they are involved with. No involvement with researchers by your doctor should be a fireable offense.

 

Neuroprotective Agents: An Overview on the General Modes of Action

 

Pituitary adenylate cyclase-activating polypeptide (PACAP)

HGF hepatocyte growth factor

Trophic factors:
              BDNF

              NGF

              neurotrophin-3

              neurotrophin-4

              CNTF

              GDNF

apolipoprotein E(apoE) Containing Lipoproteins

prothymosin α (PTMA)

 

Changes in Serum Growth Factors in Stroke Rehabilitation Patients and Their Relation to Hemiparesis Improvement

Your doctor could use this but this doesn't explain why the effects occur or how to increase/decrease those effects.  Someone will need to translate this into a stroke protocol.
http://www.strokejournal.org/article/S1052-3057%2814%2900041-X/abstract

• Hideto Okazaki, MD, PhD
,
• Hidehiko Beppu, PhD
,
• Kenmei Mizutani, PhD
,
• Sayaka Okamoto, MD, PhD
,
• Shigeru Sonoda, MD, PhD

Received 31 October 2013; received in revised form 9 January 2014; accepted 16 January 2014. published online 25 April 2014.
Corrected Proof

• Abstract
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Predicting recovery from hemiparesis after stroke is important for rehabilitation. A few recent studies reported that the levels of some growth factors shortly after stroke were positively correlated with the clinical outcomes during the chronic phase. The aim of this study was to examine the relationships between the serum levels of growth factors (vascular endothelial growth factor [VEGF], insulin-like growth factor-I [IGF-I], and hepatocyte growth factor [HGF]) and improvement in hemiparesis in stroke patients who received rehabilitation in a postacute rehabilitation hospital. Subjects were 32 stroke patients (cerebral infarction: 21 and intracerebral hemorrhage [ICH]: 11). We measured serum levels of VEGF, IGF-I, and HGF and 5 items of the Stroke Impairment Assessment Set (SIAS) for hemiparesis on admission and at discharge. Age-matched healthy subjects (n = 15) served as controls. Serum levels of VEGF and HGF in cerebral infarct patients on admission were higher than those in control subjects, and the serum levels of IGF-I in stroke patients were lower than those in controls. The level of HGF in ICH patients on admission was negatively correlated with gains in SIAS, and higher outliers in HGF concentration were correlated with lower gains in SIAS. Focusing on the extremely high levels of these factors may be a predictor of the low recovery from hemiparesis after stroke.

Key Words: Growth factor, stroke, hemiparesis, rehabilitation

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