So rather than working on coming up with solutions for every stroke patient we have our medical staff working to improve results for those who have smaller strokes. Lazy irresponsible bastards. This would require staffed MRIs in all stroke hospitals. Managers should be tackling the hard problems not just tweaking the existing recommendations. But we have
NO leaders in stroke so we shouldn't complain when they do worthless things.
http://www.medpagetoday.com/Cardiology/Strokes/54471?
Picks patients more likely to do well -- and more of them, study suggests
MRI "compares favorably" with CT for selection of ischemic stroke
patients for endovascular thrombectomy when combined with clinical
characteristics, an observational study suggested.
A favorable outcome, with modified Rankin Scale (mRS) score of 2 or less at 90 days, occurred in
52.5% of patients determined likely to benefit by the MRI and clinical criteria, compared with 25.0% of patients determined uncertain to benefit by the same criteria but who were treated anyway (
P=0.02).
The MRI-based determination was the only factor to remain
significantly associated with outcome on multivariable logistic
regression,
Thabele M. Leslie-Mazwi, MD, of Massachusetts General Hospital in Boston, and colleagues found.
Even among those who actually achieved successful reperfusion, the
MRI-based determination still
selected a group more likely to do well:
74.1% (20 of 27) in the "likely to benefit" group versus 33.3% (eight of
24) "uncertain to benefit" patients had a favorable outcome (
P=0.004).
"Patients prospectively classified as likely to benefit based on
diffusion MRI and clinical criteria (including age and time from onset)
have a likelihood of favorable outcome after successful thrombectomy
similar to that found in recent trials," the authors concluded.
The difference was "that MRI use in a clinical setting produced a
higher treated to screened ratio," they wrote in the paper online in
JAMA Neurology.
The ratio of treated to screened patients was one to three in their
single-center prospective cohort of 72 patients with middle cerebral
artery or terminal internal carotid artery ischemic stroke who got
thrombectomy from 2012 through 2014.
By comparison, "the most selective recent trials"
EXTEND-IA and SWIFT PRIME had ratios of one in 13 and one in 7.5,
respectively, Leslie-Mazwi noted in an email to
MedPage Today. "These findings may point to a better way of identifying which severe stroke patients will benefit from invasive treatments."
The exact imaging criteria required for entry have varied across the
spate of recent positive trials with mechanical clot busters.
EXTEND-IA used perfusion CT imaging to measure salvageable brain as
an indication of "likely to benefit." SWIFT PRIME required perfusion
imaging by CT or MR angiography, while ESCAPE used noncontrast CT and CT
angiography with MRI discouraged as too time consuming.
No clear mandate has emerged for one over the other, and experts have
noted that MR CLEAN showed a benefit of thrombectomy over medical
treatment alone with little in the way of imaging required to confirm
small core infarct.
However,
patient selection appears key
to the magnitude of benefit, with trials that did require CT selection
showing about double the advantage over medical treatment as MR CLEAN
and REVASCAT.
Leslie-Mazwi's group labeled those as likely to benefit
as age under 80, with a time from stroke onset or last seen well to
groin puncture of less than 6 hours, and a premorbid baseline mRS score
of 1o or less, as well as more than 12 months of life expectancy, and a
diffusion-weighted imaging stroke volume less than 70 mL.
Patients somewhat outside of those criteria -- 80 and older, with a
6 to 8 hour time from onset, premorbid mRS score of 2 to 3, 6 to 12
months' life expectancy, or a lesion volume of 70 to 100 mL -- were
considered uncertain to benefit.
"We should rigorously investigate the limits of this therapy," Leslie-Mazwi told
MedPage Today.
"Imaging selection is part of that rigorous evaluation. We will see
attempts being made to understand better who can be treated late, and
who can be treated with stroke in the posterior circulation, populations
where many questions remain. We think MRI will be essential in defining
those parameters."
Meanwhile,
centers must commit to speed
not just in whatever imaging strategy they choose, but also in priming
the interventional team, using bundled kits for material, and every
other strategy that can shave precious minutes off the time to
reperfusion, SWIFT PRIME primary investigator
Jeffrey Saver, MD, of the University of California Los Angeles, told
MedPage Today in an earlier interview on
best practices.