A look at the fight against chronic fatigue syndrome

Is there ANYTHING in here that would help us with stroke fatigue? Whom do I go to to get that simple question answered?
http://scopeblog.stanford.edu/2016/07/26/a-look-at-the-fight-against-chronic-fatigue-syndrome/

Coenzyme Q10 and NADH supplementation for Chronic Fatigue Syndrome continued

Ask your doctor if this might help your fatigue, not to be undertaken without a doctor. How else is your doctor treating your fatigue? If at all?
http://questioning-answers.blogspot.com/2015/08/coenzyme-q10-and-nadh-supplementation-chronic-fatigue-syndrome.html

Does oral Coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in Chronic Fatigue Syndrome?

Is CFS close enough to stroke fatigue to possibly be able to use the same interventions? Tell your doctor to find out. Do not self-prescribe. 

Does oral Coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in Chronic Fatigue Syndrome? 

Dr. JESUS CASTRO-MARRERO, Ph.D.

Vall de Hebron Univ Hospital Research Institute, CFS Research Unit,

PASSEIG DE VALL DE HEBRON, 119-129

,

PASSEIG DE VALL DE HEBRON, 119-129

, BARCELONA, Barcelona, Spain,

08035

, 934893000 (EXT. 4927), 932746708; jesus.castro@vhir.org

Prof. Mario D. Cordero

Research Laboratory, Dental School, Universidad de Sevilla, Sevilla, Spain,

C/Avicena s/n

, Sevilla, Spain,

41009

, +34 954 481120, +34 954 486784; mdcormor@us.es

Dr. Maria Jose jesus.castro@vhir.org Segundo

Vitae Natural Nutrition, SL, Research and Development (R&D), BARCELONA, Sant Cugat del Vallès, Spain; msegundo@vitae.es

Naia Saez-Francas

Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Departamento de Psiquiatría y Medicina Legal, BARCELONA, BARCELONA, Spain; nasaez2@gmail.com

Dr. Natalia Calvo

Vall d'Hebron University Hospital, Departamento de Psiquiatría y Medicina Legal, BARCELONA, BARCELONA, Spain; nacalvo@vhebron.net

Dr. Lourdes Román-Malo

Dental School University of Sevilla, Research Laboratory, SEVILLA, SEVILLA, Spain; lvrmalo@gmail.com

Luisa Aliste

Vall d'Hebron University Hospital, CFS Clinical Unit, BARCELONA, BARCELONA, Spain; luisa_a_s@yahoo.es

Prof. Tomas Fernandez de Sevilla

Vall d'Hebron University Hospital, CFS Clinical Unit, BARCELONA, BARCELONA, Spain; 10653tfd@comb.cat

Dr. Jose Alegre-Martin

Vall d'Hebron University Hospital, CFS Clinical Unit, BARCELONA, BARCELONA, Spain; jalegre@vhebron.net

Accepted: November 03 2014
Received: November 03 2014

ABSTRACT

Chronic Fatigue Syndrome (CFS) is a chronic and extremely debilitating illness characterized by prolonged fatigue and multiple symptoms with unknown cause, diagnostic test, or universally effective treatment. Inflammation, oxidative stress, mitochondrial dysfunction, and CoQ10 deficiency have been well documented in CFS. We conducted an 8-weeks randomized, double-blind, placebo-controlled trial to evaluate the benefits of oral CoQ10 (200 mg/day) plus NADH (20 mg/day) supplementation on fatigue and biochemical parameters in 73 Spanish CFS patients. This study was registered in ClinicalTrials.gov (NCT02063126). A significant improvement of fatigue showing a reduction in FIS total score (p< 0.05) was reported in treated group vs. placebo. In addition, a recovery of the biochemical parameters was also reported. NAD+/NADH (p< 0.001), CoQ10 (p< 0.05), ATP (p< 0.05) and citrate synthase (p< 0.05) were significantly higher and lipoperoxides (p< 0.05) were significantly lower in blood mononuclear cells (BMCs) of the treated group. These observations lead to the hypothesis that the oral CoQ10 plus NADH supplementation could confers potential therapeutic benefits on fatigue and biochemical parameters in CFS. Larger sample trials are warranted to confirm these findings.

Patient Advocates Work Better if They Speak FDA's Language

So whenever we do get a drug that might help stop the neuronal cascade of death or help neurogenesis, neuroplasticity or our fatigue, remember this and marshal your scientific reasoning appropriately. Our stroke associations won't do anything like this, that would require someone doing some hard work and analysis. So who is going to look at this drug for stroke fatigue?  Maybe an off-label use question for your doctor?
http://www.medpagetoday.com/InOtherWords/36767
Selected paragraphs here, rest at the link.
Patient advocates of the rare disorder chronic fatigue syndrome (CFS) filed up to the podium during the public hearing portion of an FDA advisory committee meeting last month on a drug for the condition.
Here is where all those patient advocates failed: They based their pleas to the FDA on emotion rather than scientific data. 

They told stories about how much a treatment was needed for CFS and offered anecdotes on how rintatolimod helped them regain some small amount of normalcy in their life. 

Patients spoke about how CFS causes them to sleep their lives away and how the drug offers a sense of hope for a patient community struggling for help. 

But the FDA doesn't base its decisions on emotion. It approves drugs whose benefits outweigh the risks, and rintatolimod had questionable evidence for both. 

Those 30-some patient advocates didn't seem to care or understand that fact.