Relationship between relevant inflammatory markers and short-term functional outcomes of acute ischemic stroke treated with mechanical thrombectomy: a retrospective cohort study

 Predicting failure to recover DOES NOTHING FOR SURVIVORS! You're fired!

Relationship between relevant inflammatory markers and short-term functional outcomes of acute ischemic stroke treated with mechanical thrombectomy: a retrospective cohort study

• 

  Jin-Cheng Liu 1,2†

• J

  Jie Wen 2†

• S

  Shi-Xiong Peng 2

• H

  Hao Ren 2

• Y

  Yiran Liu 2

• C

  Cui Zhou 2

• 

  Xiao Hu 1

• 

  Qi Li 1*

• 1. Department of Neurology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China

• 2. Department of Neurology, Xiangyang Hospital of Traditional Chinese Medicine, Xiangyang, Hubei, China

Abstract

Background and purpose: 

Perioperative inflammatory markers are considered critical factors influencing long-term postoperative survival. This study evaluated the neutrophil-to-high-density lipoprotein ratio (NHR), neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammatory response index (SII), and systemic inflammatory response index (SIRI) in relation to functional outcomes in patients with acute ischemic stroke who underwent mechanical thrombectomy (MT). Our objective is to determine the prognostic value of inflammatory composite indices for 90-day functional outcomes in patients with acute ischemic stroke undergoing mechanical thrombectomy and to develop a multivariable prediction model integrating these indices for individualized outcome risk stratification.

Method: 

A total of 112 patients who underwent MT were enrolled between April 2021 and December 2023. Blood tests were performed at admission. Logistic regression analysis was used to evaluate the relationship between NHR, NLR, PLR, LMR, SII, SIRI and poor functional outcomes at 3 months (mRS Score 3–6). Receiver operating characteristic (ROC) curve analysis was conducted to assess the ability of NHR, NLR, PLR, LMR, SII, and SIRI to predict 90-day functional outcomes.

Results: 

A total of 54 patients (48%) had poor functional outcomes at 3 months. The median stroke onset to admission time was [6.7] hours (IQR, [3.45]–[8.05]) for poor functional outcome and [9.0] hours (IQR, [7.45]–[14.15]) for good functional outcome. Mean age of the study cohort was 67.5 years, and 64.3% were male. Multivariate logistic regression analysis revealed that NHR (odds ratio [OR], 1.150; 95% confidence interval [CI] 1.002–1.320, p = 0.046) was an independent predictor for poor functional outcome after adjusting for other clinical and imaging parameters.

Conclusion: 

NHR was independently associated with poor functional outcomes at 3 months in patients with acute ischemic stroke who underwent MT. These findings need to be confirmed in larger samples.(The research you should be doing is PREVNTING THAT POOR FUNCTIONAL OUTCOME! And you're so blitheringly stupid you can't figure that out?

Neutrophil Counts as Promising Marker for Predicting In-Hospital Mortality in Aneurysmal Subarachnoid Hemorrhage

Where is the research that prevents this increased mortality and infections? As is this research is useless. 

Neutrophil Counts as Promising Marker for Predicting In-Hospital Mortality in Aneurysmal Subarachnoid Hemorrhage

Yu Zhang

,

Linjie Li

,

Lu Jia

,

Tiangui Li

,

Yuanyuan Di

,

Peng Wang

,

Haidong Deng

,

Huaqian Fan

,

Ying Li

,

Xin Cheng

,

Younian Chen

,

Xing Wang

,

Weelic Chong

,

Yang Hai

,

Chao You

,

Yongzhong Cheng

,

Fang Fang

Originally published25 Jun 2021https://doi.org/10.1161/STROKEAHA.120.034024Stroke. 2021;52:3266–3275

Abstract

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Background and Purpose:

Systemic inflammation is recognized as a hallmark of stroke. We aimed to evaluate the prognostic value of various inflammatory factors using blood at admission in patients with aneurysmal subarachnoid hemorrhage.

Methods:

In a multicenter observational study of patients with aneurysmal subarachnoid hemorrhage, the counts of neutrophil, platelet, and lymphocyte were collected on admission. Patients were stratified based on neutrophil counts with propensity score matching to minimize confounding. We calculated the adjusted odds ratios with 95% CIs for the primary outcome of in-hospital mortality and hospital-acquired infections.

Results:

A total of 6041 patients were included in this study and 344(5.7%) of them died in hospital. Propensity score matching analyses indicated that compared with the lower neutrophil counts, higher neutrophil counts were associated with increased risk of in-hospital mortality (odds ratio, 1.53 [95% CI, 1.14–2.06]), hospital-acquired infections (odds ratio, 1.61 [95% CI, 1.38–1.79]), and delayed neurological ischemic deficits (odds ratio, 1.52 [95% CI, 1.09–1.97]). Moreover, out of all the inflammatory factors studied, neutrophil counts demonstrated the highest correlation with in-hospital mortality and hospital-acquired infections.

Conclusions:

Among patients with aneurysmal subarachnoid hemorrhage, high neutrophil counts at admission were associated with increased mortality and hospital-acquired infections. The neutrophil count is a simple, useful marker with prognostic value in patients with aneurysmal subarachnoid hemorrhage.