Brain Adapts to Neuron Loss Through Rapid Rewiring

 Ask your competent? doctor EXACTLY HOW TO ENGAGE THIS post stroke!

This is what your doctor is up against, I'd suggest charging your hospital $1000 a dead neuron, that might get them to solve stroke, nothing else gets them off their asses!

 In each  untreated minute,

1.9 million neurons die

14 billion synapses die

12 km (7.5 miles) of myelinated fibers die

brain ages 3.6 years each hour without treatment

If Pedro Bach-y-Rita can recover you can solve most stroke problems.

Pedro Bach-y-Rita had a stroke in 1958, it destroyed a large portion of his brain stem and yet over the last 7 years of his life he recovered most of his faculties.  We have the methods he used, your doctor should be able to modify them to help you. If you have a competent doctor!

Brainstem stroke recovery How Pedro recovered in here.

And negative Nellie here, don't listen to her, she knows nothing!

Brain can't rewire itself: A new study on brain damage and recovery

The latest here:

Brain Adapts to Neuron Loss Through Rapid Rewiring

Summary: New research shows that the brain’s cortex can rapidly reorganize itself after losing neurons, allowing other nerve cells to take over lost functions. Scientists studied neural networks in the auditory cortex and found that although sound-processing patterns were briefly disrupted, the brain formed nearly identical patterns within days.

Neurons previously uninvolved in processing stimuli stepped in to compensate for the loss. This adaptive mechanism could help explain how the brain maintains function during aging or in diseases like Alzheimer’s and Parkinson’s.

Key Facts:

• Rapid Reorganization: Neural networks re-establish activity patterns just days after neuron loss.
• Functional Compensation: Unused neurons can adapt to take over the roles of lost cells.
• Clinical Implication: May explain brain resilience in aging and neurodegenerative conditions.

Source: Johannes Gutenberg University Mainz

How the brain largely maintains its function when neurons are lost—this is what researchers at the University Medical Center Mainz, the Frankfurt Institute for Advanced Studies (FIAS) and Hebrew University (Jerusalem) have deciphered.

They show that neuronal networks in the cerebral cortex reorganize within a short period of time, with other nerve cells taking over the tasks of the lost neurons.

Nerve cells (neurons) are the most important building blocks of the brain. Credit: Neuroscience News

These findings could form the basis for future research into natural aging processes and neurodegenerative diseases such as Alzheimer’s or Parkinson’s.

The study is published in the journal Nature Neuroscience.

Nerve cells (neurons) are the most important building blocks of the brain.

They form the basis for all mental and physical functions such as thinking, feeling, movement, and perception. In the course of life, nerve cells in the brain can be lost for various reasons: They die off due to age-related processes, are damaged by toxins such as alcohol, or neurodegenerative diseases such as Alzheimer’s and Parkinson’s lead to a more rapid progressive loss of neurons.

While most body organs regularly replace old or damaged cells with new ones in order to maintain their organ function, new neurons only form in certain regions of the brain. In the cerebral cortex, which is responsible for complex thought processes and perception, the ability to form new neurons is very limited in adulthood.

“Nevertheless, clinical studies have shown that cortical brain function is often surprisingly resistant to the loss of neurons that occurs in the course of aging or neurodegenerative diseases,” explains Simon Rumpel, head of the Systems Neurophysiology research group at the Institute of Physiology at the University Medical Center Mainz.

Until now, it was not known how the brain can compensate for the loss of nerve cells and maintain its function. To find this out, the research team used an animal model to investigate the neuronal networks in the auditory cortex, which is responsible for processing acoustic stimuli.

The perception of sounds is based on activity patterns that are triggered in the brain by acoustic stimuli. These patterns are very complex. Ph.D. student Bastian Eppler and Senior Fellow Matthias Kaschube at FIAS contributed significantly to the analysis of these data and the interpretation of the results with their expertise.

The researchers found that the activity patterns initially destabilize when the loss of a few specific nerve cells is deliberately induced. This indicates that the neuronal network responsible for sound perception is in a delicate balance.

After just a few days, very similar activity patterns form again. The nerve cells that were not previously activated by the acoustic stimuli now acquire the ability to take the place of the lost neurons.

“We assume that this newly discovered neuronal mechanism plays an important role in the loss of nerve cells in natural aging processes as well as in neurodegenerative diseases,” says Rumpel. Future research efforts could aim to support this neuronal reorganization.

About this neuroscience research news

Author: Simon Rumpel
Source: Johannes Gutenberg University Mainz
Contact: Simon Rumpel – Johannes Gutenberg University Mainz
Image: The image is credited to Neuroscience News

Original Research: Open access.
“Homeostasis of a representational map in the neocortex” by Simon Rumpel et al. Nature Neuroscience

Brain can't rewire itself: A new study on brain damage and recovery

 Well, I disagree.

If Pedro Bach-y-Rita can recover you can solve most stroke problems.

Pedro Bach-y-Rita had a stroke in 1958, it destroyed a large portion of his brain stem and yet over the last 7 years of his life he recovered most of his faculties.  We have the methods he used, your doctor should be able to modify them to help you. If you have a competent doctor!

Brainstem stroke recovery How Pedro recovered in here.

Brain can't rewire itself: A new study on brain damage and recovery

05.12.2023 00:30

Updated: 13.05.2024 21:21

Contrary to pretty popular belief, specialists think that the previously injured brain cannot completely rewire itself in response to brain injury.

The concept that it can repurpose regions for new functions, such as using the visual cortex for echolocation in people who can't see, is considered flawed.

The brain, instead of creating entirely new functions, is believed to improve or modify existing abilities.

How it was discovered

Studies supporting brain rewiring, like those on amputations or blindness, are challenged by the researchers.

One study suggested that when a finger is amputated, the brain rewires itself to process signals from other neighboring fingers.

Photo:Pixabay

However, a new experiment discovered that existing signals were already present before amputation.

The brain's adaptation to injury is seen as a slow learning process rather than a quick, miraculous rewiring.

Why it's important to know

The specialists highlight how important it is to understand the true nature and limits of brain plasticity for realistic expectations in patient treatment.

While stories of blind navigation and stroke recovery are acknowledged, the emphasis is on persistent effort, repetition, and training, not magical brain resource reassignment.

The specialists claim that recognizing the hard work behind recovery stories helps tailor rehabilitation strategies accordingly.

The 10 Fundamentals Of Rewiring Your Brain

http://www.thebestbrainpossible.com/the-10-fundamentals-of-rewiring-your-brain/

1. Change is mostly limited to  those situations in which the brain is in the mood for it. – If you are alert, on the ball, engaged, motivated, ready for action, the brain releases the neurochemicals necessary to enable brain change. When disengaged, inattentive, distracted, or doing something without thinking that requires no real effort, your neuroplastic switches are “off.”
2. The harder you try, the more you’re motivated, the more alert you are, and the better (or worse)  the potential outcome, the bigger the brain change. – If you’re intensely focused on the task and really trying to master something for an important reason, the change experienced will be greater.
3. What actually changes in the brain are the strengths of the connections of neurons that are engaged together, moment by moment, in time. The more something is practised, the more connections are changed and made to include all elements of the experience (sensory info, movement, cognitive patterns). You can think of it like a “master controller” being formed for that particular behavior which allows it to be performed with remarkable facility and reliability over time.
4. Learning-driven changes in connections increase cell-to cell cooperation which is crucial for increasing reliability. Merzenich explains this by asking you to imagine the sound of a football stadium full of fans all clapping at random versus the same people clapping in unison. He explains, “The more powerfully coordinated your [nerve cell] teams are, the more powerful and more reliable their behavioral productions.”
5. The brain also strengthens its connections between teams of neurons representing separate moments of successive things that reliably occur in serial time. This allows your brain to predict what happens next and have a continuous “associative flow.” Without this ability, your stream of consciousness would be reduced to “a series of separate, stagnating puddles,” explains Merzenich.
6. Initial changes are temporary. Your brain first records the change, then determines whether it should make the change permanent or not. It only becomes permanent if your brain judges the experience to be fascinating or novel enough or if the behavioral outcome is important, good or bad.
7. The brain is changed by internal mental rehearsal in the same ways and involving precisely the same processes that control changes achieved through interactions with the external world. According to Merzenich, “You don’t have to move an inch to drive positive plastic change in your brain. Your internal representations of things recalled from memory work just fine for progressive brain plasticity-based learning.”
8. Memory guides and controls most learning. As you learn a new skill, your brain takes note of and remembers the good attempts, while discarding the not-so-good trys. Then, it recalls the last good pass, makes incremental adjustments, and progressively improves. (If this is true then our therapists shouldn't be so insistent upon us doing things exactly correct.)
9. Every movement of learning provides a moment of opportunity for the brain to stabilize – and reduce the disruptive power of – potentially interfering backgrounds or “noise.” Each time your brain strengthens a connection to advance your mastery of a skill, it also weakens other connections of neurons that weren’t used at that precise moment. This negative plastic brain change erases some of the irrelevant or interfering activity in the brain.
10. Brain plasticity is a two-way street; it is just as easy to generate negative changes as it is positive ones. You have a “use it or lose it” brain. It’s almost as easy to drive changes that impair memory and physical and mental abilities as it is to improve these things. Merzenich says that older people are absolute masters at encouraging plastic brain change in the wrong direction.

More details at link.