5 Foods with More Resveratrol Than a Glass of Red Wine, According to Dietitians

 Ask your competent? doctor if supplements can provide the same benefits as food or wine.  Doesn't know the answer, I'd be questioning the competence level of your stroke medical 'professionals'!

You can check out why your doctor should be prescribing resveratrol in these.

• resveratrol (60 posts to January 2012)

• resveratrol analogues (1 post to November 2017)

• resveratrol preconditioning (2 posts to July 2015)

5 Foods with More Resveratrol Than a Glass of Red Wine, According to Dietitians

These surprising foods provide a serious boost of antioxidants without the risk of a hangover

Reviewed by Dietitian Kelli McGrane, M.S., RD

Getty Images. EatingWell design.

Key Points

    Resveratrol is an antioxidant that’s been linked with benefits for blood pressure, diabetes and weight management.

    Several foods, including grapes, walnuts and blueberries, are a good source of resveratrol.

    For additional nutrients, it’s best to consume resveratrol through foods rather than wine.

Red wine is often touted for its heart-healthy benefits, which is largely thanks to its high concentration of resveratrol—a polyphenol with potent antioxidant properties. “Studies suggest [resveratrol] may be helpful in lowering blood pressure, promoting weight loss and improving blood sugar levels by boosting insulin production and enhancing insulin’s effectiveness,” says Anne Danahy, MS, RDN. 

However, you don’t have to drink red wine to reap the benefits of resveratrol. There are several food sources of this potent antioxidant, including nuts and some dark blue or red fruits. “They might not all match red wine gram for gram, but they come packed with antioxidants, fiber and way more nutritional perks—minus the hangover,” says Ghida Arnaout, RD. Here are five foods to buy during your next grocery store run to boost your resveratrol intake.

1. Grapes

“Grapes and red wine are among the highest sources of resveratrol,” says Danahy. Specifically, resveratrol is found in high concentrations in the skin of grapes, which is why white and rosé wines contain far less resveratrol than their red wine counterparts. One hundred grams of red wine provides anywhere from 320 to 1535 micrograms (mcg) of resveratrol, while grapes contain 150 to 781 mcg per 100 grams., However, Danahy emphasizes that the amount of resveratrol can vary in foods (including grapes) depending on multiple factors including growing conditions, time of harvest and plant variety. We love adding grapes to chicken salad or enjoying them as a snack with cheese and crackers.

2. Walnuts

One of the most surprising sources of resveratrol is walnuts. These heart-healthy nuts are a top source of this antioxidant with a similar amount of resveratrol per 100 grams that’s found in red wine. “Besides resveratrol, walnuts are also notable for having high levels of anti-inflammatory omega-3 fats, along with vitamin E, other polyphenols and prebiotic fiber,” says Danahy. You can enjoy walnuts in a trail mix, on top of oatmeal or other hot cereal or blended into a sauce. 

3. Blueberries

Grapes aren’t the only fruit with resveratrol. Blueberries are another top source of the antioxidant, though the amount varies significantly depending on growing conditions, variety and processing. And while not as concentrated in resveratrol as grapes or red wine, blueberries are considered a good source of the antioxidant. They also offer a host of other important nutrients for heart health, including 3.5 grams of fiber per cup. They also contain potassium, vitamin C, vitamin K and several other essential vitamins and minerals. Blueberries are incredibly versatile, working well in smoothies, hot or baked oatmeal, baked goods, jams, sauces and salads. They’re also delicious on their own or as part of a cheese plate. 

4. Cranberries

Fresh cranberries aren’t as readily available as other berries, so you may need to venture into the frozen food aisle to stock up on this nutrient-dense fruit. Cranberries are not only rich in antioxidants, including resveratrol, but they also contain a variety of other health-promoting nutrients, like vitamin C and fiber., Like blueberries, the concentration of resveratrol in cranberries can vary significantly depending on growing conditions, variety and processing. Try cranberries in a smoothie, cooked down into a sauce or dried in a trail mix. You can also add cranberries to a dip for a crowd-pleasing appetizer.

5. Peanuts

    The humble peanut is an unexpected source of resveratrol in the diet. Like other foods, the amount varies depending on growing conditions and processing. Peanuts also contribute protein, fiber and heart-healthy monounsaturated fats., Try peanuts in a trail mix or roasted with extra spices.

What to Know About Red Wine Consumption

Resveratrol offers health benefits, but red wine may not be the best choice to up your intake. “While red wine does contain some beneficial compounds like resveratrol, the health risks of alcohol often outweigh the potential perks, especially when it’s not consumed in strict moderation,” says Arnaout. Plus, the health benefits of resveratrol are typically seen when consumed in levels that are difficult to get from food or drinks alone. As Danahy points out, research suggests you need to consume about 1 gram (1,000 mg) per day to get a significant health benefit—an amount that’s virtually impossible to get through foods and beverages. According to one study, you’d need to consume 4.2 liters of red wine daily to reach this amount.

Ask your competent? doctor how you are supposed to get the necessary resveratrol.

 To get to the research level that mice had in research; 

According to researchers, this amount of resveratrol equated to the amount found in approximately 1,000 bottles of red wine. (Is that a daily dose of 1000 bottles of wine?)

The role of resveratrol in neurogenesis: a systematic review

 Ask your doctor how you are supposed to get the necessary resveratrol.

 To get to the the research level that mice had in research; 

According to researchers, this amount of resveratrol equated to the amount found in approximately 1,000 bottles of red wine. (Is that a daily dose of 1000 bottles of wine?)

You can check out why your doctor should be prescribing resveratrol in these.

• resveratrol (60 posts to January 2012)

• resveratrol analogues (1 post to November 2017)

• resveratrol preconditioning (2 posts to July 2015)

The role of resveratrol in neurogenesis: a systematic review

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Nutrition Reviews, nuae025, https://doi.org/10.1093/nutrit/nuae025

Published:

20 March 2024

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Abstract

Context

Resveratrol (RV) is a natural compound found in grapes, wine, berries, and peanuts and has potential health benefits—namely, neurogenesis improvement. Neurogenesis, which is the process through which new neurons or nerve cells are generated in the brain, occurs in the subventricular zone and hippocampus and is influenced by various factors. RV has been shown to increase neural stem cell proliferation and survival, improving cognitive function in hippocampus-dependent tasks. Thus, to provide a convergent and unbiased conclusion of the available evidence on the correlation between the RV and neurogenesis, a systematic review needs to be undertaken meticulously and with appropriate attention.

Objective

This study aimed to systematically review any potential connection between the RV and neurogenesis in animal models.

Data Sources and Extraction

Based on the particular selection criteria, 8 original animal studies that investigated the relationship between RV and neurogenesis were included. Studies written in English and published in peer-reviewed journals with no restrictions on the starting date of publication on August 17, 2023, were searched in the Google Scholar and PubMed databases. Furthermore, data were extracted and analyzed independently by 2 researchers and then reviewed by a third researcher, and discrepancies were resolved by consensus. This project followed PRISMA reporting standards.

Data Analysis

In the studies analyzed in this review, there is a definite correlation between RV and neurogenesis, meaning that RV intake, irrespective of the mechanisms thereof, can boost neurogenesis in both the subventricular zone and hippocampus.

Conclusion

This finding, albeit with some limitations, provides a plausible indication of RV’s beneficial function in neurogenesis. Indeed, RV intake may result in neurogenesis benefits—namely, cognitive function, mood regulation, stress resilience, and neuroprotection, potentially preventing cognitive decline.

Resveratrol Neuroprotection in Stroke and Traumatic CNS injury

Nothing here even remotely should be followed because potential is not close to being proven. And there is this problem from earlier research. According to researchers, this amount of resveratrol equated to the amount found in approximately 1,000 bottles of red wine. (Is that a daily dose of 1000 bottles of wine?)

Resveratrol Neuroprotection in Stroke and Traumatic CNS injury

Neurochem Int. Author manuscript; available in PMC 2016 Oct 1.

Published in final edited form as:

Neurochem Int. 2015 Oct; 89: 75–82.

Published online 2015 Aug 12. doi: 10.1016/j.neuint.2015.08.009

PMCID: PMC4587342

NIHMSID: NIHMS719784

PMID: 26277384

Mary Lopez, Robert J Dempsey, and Raghu Vemuganti

Author information Copyright and License information Disclaimer

The publisher's final edited version of this article is available at Neurochem Int

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Abstract

Resveratrol, a stilbene formed in many plants in response to various stressors, elicits multiple beneficial effects in vertebrates. Particularly, resveratrol was shown to have therapeutic properties in cancer, atherosclerosis and neurodegeneration. Resveratrol-induced benefits are modulated by multiple synergistic pathways that control oxidative stress, inflammation and cell death. Despite the lack of a definitive mechanism, both in vivo and in vitro studies suggest that resveratrol can induce a neuroprotective state when administered acutely or prior to experimental injury to the CNS. In this review, we discuss the neuroprotective potential of resveratrol in stroke, traumatic brain injury and spinal cord injury, with a focus on the molecular pathways responsible for this protection.

Keywords: Polyphenols, Neuroprotection, Ischemia, CNS injury, Oxidative stress, Inflammation

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1. Introduction

Resveratrol is a naturally occurring stilbene-class of polyphenol produced in the skins of many edible plants as a response to fungal infection (Siemann and Creasy, 1992; Takaoka, 1940). Resveratrol is widely known for its anti-oxidant properties, and has been implicated in the putative anti-atherosclerotic effects of red wine. The neuroprotective benefits of resveratrol were known since it was shown to ameliorate kainate-induced excitotoxicity (Virgili and Contestabile, 2000). Subsequently, resveratrol has been shown to improve histopathological and behavioral outcomes after various types of acute CNS injuries including stroke (Girbovan et al., 2012; Huang et al., 2001; Karalis et al., 2011), traumatic brain injury (TBI) (Singleton et al., 2010; Sonmez et al., 2007), subarachnoid hemorrhage (SAH) (Shao et al., 2014) and spinal cord injury (SCI) (Ates et al., 2006; Kaplan et al., 2005).

The exact mechanism of resveratrol-induced neuroprotection is not clear (Morris-Blanco et al., 2014; Park et al., 2012; Tang, 2010), but many of its beneficial effects were thought to be promoted by activation of silent mating type information regulation 2 homolog 1 (SIRT1) (Borra et al., 2005), AMP-activated kinase (AMPK) (Dasgupta and Milbrandt, 2007) and nuclear factor (erythroid derived 2)-like 2 (Nrf2) (Chen et al., 2005; Ungvari et al., 2010). SIRT1 is a nicotinamide adenine dinucleotide (NAD⁺)-dependent deacetylase that acts on histone and non-histone targets to improve lifespan and promote a pro-survival environment in the CNS (Wood et al., 2004; Yang et al., 2013). AMPK senses increases in endogenous adenosine levels, specifically AMP or ADP, and compensates by enhancing ATP production. AMPK has been shown to activate acetyl-coA carboxylase and SIRT1, while suppressing the mammalian target of rapamycin complex (mTORC), resulting in an overall improvement in metabolism and increased lifespan (Baur et al., 2006; Spasić et al., 2009). Nrf2 is a transcription factor that is responsible for binding antioxidant response elements (ARE) in the promoters of genes like superoxide dismutase (SOD), heme oxygenase 1 (HO-1), catalase and many other phase II defense enzymes, inducing their expression (Chen et al., 2005; Kansanen et al., 2013; Zhang et al., 2013).

The secondary brain damage and neuronal death after an acute CNS insult like stroke are synergistically mediated by many pathophysiologic mechanisms that include oxidative stress, inflammation, ionic imbalance and apoptosis. Treatment with resveratrol is shown to prevent or slow-down many of these pathological changes and its neuroprotective actions seem to be mediated by many putative effectors and targets (Fig. 1). The goal of this review is to discuss the major mechanisms that are thought to mediate resveratrol-induced neuroprotection.

Fig. 1

Resveratrol induces a neuroprotective state via several disparate pathways. The exact mechanism of resveratrol-mediated neuroprotection is not yet understood, but the downstream anti-oxidative, anti-inflammatory and anti-apoptotic effectors have been well documented. This diagram illustrates the factors responsible for inducing a pro-survival state after resveratrol treatment in the CNS. Note that some effectors, particularly SIRT1 and AMPK can be activated or inhibited by more than one pathway. Arrows with a point indicate activation, while arrows with a flat tip indicate inhibition. White arrows indicate activation/inhibition via an indirect or poorly understood mechanism. Green = role in inflammation. Pink = role in oxidative stress. Blue = role in apoptosis. White = transcription factor or pathway intermediary.

More  at link.

Red wine molecule may slow Alzheimer's symptoms, study finds

Just what the fuck is your doctors protocol to prevent dementia/Alzheimers? You have a decent chance of getting it. Does your doctor even know about this research? Or is your doctor waiting until resveratrol tomatoes come along so alcohol doesn't have to be prescribed? That answer tells you if you should fire that doctor or not.

Your chances of getting dementia.

1. A documented 33% dementia chance post-stroke from an Australian study?   May 2012.

2. Then this study came out and seems to have a range from 17-66%. December 2013.

3. A 20% chance in this research.   July 2013.

4. Dementia Risk Doubled in Patients Following Stroke September 2018 

5. Parkinson’s Disease May Have Link to Stroke March 2017

 Red wine molecule may slow Alzheimer's symptoms, study finds

A molecule found in red wine may be the key to slowing the progression of Alzheimer’s, new findings presented Wednesday suggest.
Resveratrol, a compound found in red wine, red grapes, raspberries, and chocolate, appears to repair “leaky” blood-brain barriers, which allow blood from the body to enter the brain. This repair slowed the advancement of cognitive problems in Alzheimer’s patients, according to a study from Georgetown University Medical Center.
The brains of patients with Alzheimer’s are often further damaged by nervous tissue inflammation, which is associated with neuron degradation and cognitive decline. This inflammation is partially caused by the secretion of harmful immune molecules from the body into the brain through a permeable blood-brain barrier.

More on this...

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Study authors found that resveratrol appears to restore the integrity of the blood-brain barrier, keeping the harmful immune molecules out of the brain.
“These findings suggest that resveratrol imposes a kind of crowd control at the border of the brain. The agent seems to shut out unwanted immune molecules that can exacerbate brain inflammation and kill neurons,” study author Dr. Charbel Moussa, scientific and clinical research director of the Georgetown Medical Center Translational Neurotherapeutics Program, said in the news release. “These are very exciting findings because it shows that resveratrol engages the brain in a measurable way, and that the immune response to Alzheimer’s disease comes, in part, from outside the brain.”
The results, presented at the Alzheimer’s Association International Conference in Toronto,  built off of a study from Georgetown Medical Center on resveratrol in individuals with mild to moderate Alzheimer’s, published last year in Neurology.
The new aspects of the study examined the cerebrospinal fluid of 38 individuals with Alzheimer’s. Half of the participants were given a placebo, and the other half were treated daily with resveratrol for a year. According to researchers, this amount of resveratrol equated to the amount found in approximately 1,000 bottles of red wine. (Is that a daily dose of 1000 bottles of wine?)
Researchers saw a 50 percent reduction in the levels of a molecule known as matrix metalloproteinase-9 (MMP-9) in the cerebrospinal fluid. High levels of MMP-9 result in the breakdown of the blood-brain barrier and the leakage of harmful immune molecules through it. Low levels of MMP-9, researchers assert, maintain the barrier more effectively.
“These new findings are exciting because they increase our understanding of how resveratrol may be clinically beneficial to individuals with Alzheimer’s disease,” lead researcher R. Scott Turner, director of Georgetown Medical Center’s Memory Disorders Program and co-director of the Translational Neurotherapeutics Program, said in the news release. “In particular, they point to the important role of inflammation in the disease, and the potent anti-inflammatory effects of resveratrol.”
Researchers noted that resveratrol should be further tested in clinical settings; however, they do not see the molecule itself becoming a complete treatment for Alzheimer’s. Instead, Turner said, researchers hope to combine the molecule with a separate agent that can target specific Alzheimer’s-causing proteins in the brain.