Free Radicals and Stroke

 You'll have to ask you competent? doctor to get this book; 'Role of Free Radicals in Pathology' and use it to get you recovered.

Free Radicals and Stroke

Curcumin Can Activate the Nrf2/HO-1 Signaling Pathway and Scavenge Free Radicals in Spinal Cord Injury Treatment

 Will this do the same for stroke? WHOM do we ask to do the followup? Specific names only. With NO LEADERSHIP AND NO STRATEGY NOTHING WILL BE DONE. Nothing on dosage or delivery method so you can't even guess how to accomplish this. Don't do this until 50 years from now when your doctor will have a prescription ready.

Curcumin Can Activate the Nrf2/HO-1 Signaling Pathway and Scavenge Free Radicals in Spinal Cord Injury Treatment

Wenlong Jin, Benson O. A. Botchway, MD, Xuehong Liu

First Published May 13, 2021 Review Article Find in PubMed 

https://doi.org/10.1177/15459683211011232

Article information

Abstract

Spinal cord injury (SCI) is a devastating event that often leads to permanent neurological deficits. Evidence from emerging studies has implicated oxygen-derived free radicals and high-energy oxidants as mediators of secondary SCI. Therefore, targeting these mediators using antioxidants could be beneficial for the disease. Several signaling pathways, such as the nuclear factor erythroid-2-related factor 2/heme oxygenase 1 (Nrf2/HO-1), have been associated with the regulation of some pathophysiological features of SCI. Curcumin is a plant medicinal agent whose diverse pharmacological properties have been extensively investigated and reported, notably its ability to curtail inflammatory damage by inhibiting the nuclear factor-κ-light-chain-enhancer of activated B cells. In this review, we analyze the role of curcumin in activating Nrf2/HO-1 and scavenging free radicals to repair SCI. With its minimal side effects, curcumin could be a potential therapy for SCI treatment.

Keywords

curcumin, Nrf2/HO-1 signaling pathway, antioxidant, spinal cord injury

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WHOM is going to research this for stroke and figure out how to get it across the blood brain barrier? Specific names only.

Curcumin Can Activate the Nrf2/HO-1 Signaling Pathway and Scavenge Free Radicals in Spinal Cord Injury Treatment

Wenlong Jin, Benson O. A. Botchway, MD, Xuehong Liu

First Published May 13, 2021 Review Article 

https://doi.org/10.1177/15459683211011232

Article information

Abstract

Spinal cord injury (SCI) is a devastating event that often leads to permanent neurological deficits. Evidence from emerging studies has implicated oxygen-derived free radicals and high-energy oxidants as mediators of secondary SCI. Therefore, targeting these mediators using antioxidants could be beneficial for the disease. Several signaling pathways, such as the nuclear factor erythroid-2-related factor 2/heme oxygenase 1 (Nrf2/HO-1), have been associated with the regulation of some pathophysiological features of SCI. Curcumin is a plant medicinal agent whose diverse pharmacological properties have been extensively investigated and reported, notably its ability to curtail inflammatory damage by inhibiting the nuclear factor-κ-light-chain-enhancer of activated B cells. In this review, we analyze the role of curcumin in activating Nrf2/HO-1 and scavenging free radicals to repair SCI. With its minimal side effects, curcumin could be a potential therapy for SCI treatment.

Keywords curcumin, Nrf2/HO-1 signaling pathway, antioxidant, spinal cord injury

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New research into health benefits of coffee

But why are you reading this from me? Go ask your damned doctor. And this doesn't even mention my two main reasons for using it. 1. Helps me handle my stroke fatigue. 2.  Coffee May Lower Your Risk of Dementia

http://www.rdmag.com/news/2015/05/new-research-health-benefits-coffee?et_cid=4547254&et_rid=648870051&location=top

New research has brought us closer to being able to understand the health benefits of coffee.
Monash Univ. researchers, in collaboration with Italian coffee roasting company Illycaffè, have conducted the most comprehensive study to date on how free radicals and antioxidants behave during every stage of the coffee brewing process, from intact bean to coffee brew.
The team observed the behavior of free radicals—unstable molecules that seek electrons for stability and are known to cause cellular and DNA damage in the human body—in the coffee brewing process. For the first time, they discovered that under certain conditions coffee can act as an antioxidant, a compound found in foods that helps stabilize free radicals.
The findings, published in PLOS ONE, will lead to a deeper understanding of the brewing process, as well as the potential health benefits of coffee.
Chief Chemist of Illycaffè, Dr. Luciano Navarini, approached Monash physicist Dr. Gordon Troup, School of Physics and Astronomy, and his team in 2012 to conduct the research using state-of-the-art EPR (Electron Paramagnetic Resonance) Spectroscopy.
“Dr. Troup was one of the first scientists to discover free radicals in coffee in 1988 and so it made sense for Illycaffè—a world-leading coffee roasting company actively involved in coffee research—to collaborate with Dr. Troup and his team on this significant piece of research into free radical and antioxidant behavior in coffee,” Dr. Navarini said.
“The most important aim of this research was to better understand the development of stable free radicals during the roasting process and the possible influence exerted by developed radicals on the well-documented coffee antioxidant properties. We also wanted to evidence possible coffee constituents as a source of antioxidant activity.”
Dr. Troup worked with a team of researchers including Monash alumnus Dr. Simon Drew from the Univ. of Melbourne, who carried out the spectroscopy at the Univ. of Melbourne.
“Our research studied both the Arabica coffee bean itself and what happens to its stable free radical and antioxidant properties during the brewing process,” Dr. Troup said.
“The findings provide a better understanding of the potential health benefits of coffee, as well as a deeper knowledge of the roasting process—ultimately leading to the highest quality cup of coffee.”

Drug found to reduce damage caused by heart attack and stroke

But, but, have they accounted for the fact that mouse inflammation is not the same as human inflammation? 

Drug found to reduce damage caused by heart attack and stroke

Research has found that a new drug can reduce the damage that heart attacks and strokes cause to the body.
Scientists at the Medical Research Council Mitochondrial Biology Unit inside Cambridge University found that a drug known as MitoSNO could repair tissue that has been starved of oxygen when running tests on mice.
After a heart attack, tissue can be damaged when blood flow is suddenly restored after a period without air.
Researchers believe MitoSNO has the power to turn off harmful molecules known as free radicals, which are produced during this process.
"MitoSNO effectively flicks a switch in the mitochondria, slowing down reactivation during those critical first minutes when blood flow returns and protecting the heart tissue from further damage," Dr Mike Murphy, who led the study, said.
He added that trials will need to be conducted on humans before anything conclusive can be stated, but if successful the drugs could be used in other areas of treatment.