2 Plant Extracts That Reverse Alzheimer’s Disease

This readable article explains this much better.

 But if you want the research behind it. Remember you can't do this on your own, it is not clinically proven yet. And since I'm not medically trained, don't listen to me.

You can't do this on your own, no human clinical research to back it up and no amounts or protocol to follow. 

Be very careful with green tea extract:

Herbal supplements linked to at least six Australian organ transplants since 2011, data shows  March 2016 

The research behind this:

Combined treatment with the phenolics (−)-epigallocatechin-3-gallate and ferulic acid improves cognition and reduces Alzheimer-like pathology in mice

The readable article here:

2 Plant Extracts That Reverse Alzheimer’s Disease

The extracts work by preventing the build up of sticky amyloid beta in the brain.

Compounds found in carrots and green tea have been shown to reverse Alzheimer’s, research finds.

The plant-based treatment was able to completely restore the memories of mice in the study.

Epigallocatechin-3-gallate (EGCG) is a compound found in green tea.

Meanwhile, ferulic acid is found in rice, tomatoes, carrots, oats and wheat.

For the study, mice genetically programmed to develop the disease were given plant-based supplements for three months.

Although mouse studies often do not translate into humans, the findings are still promising, said Professor Terrence Town, study co-author:

“You don’t have to wait 10 to 12 years for a designer drug to make it to market; you can make these dietary changes today.

I find that very encouraging.”

For the research, 32 mice with Alzheimer’s symptoms were randomly assigned to different diets.

Four groups were fed with different combinations of EGCG and ferulic acid.

The dosages were 30 mg per kilogram of body weight.

This amount could easily be consumed by a human as part of a healthy diet or in the form of supplements.

The mice were given a range of tests of their memory and learning.

These are the mouse-equivalent of tests given to assess dementia in humans.

Professor Town explained the results:

“After three months, combination treatment completely restored working memory and the Alzheimer’s mice performed just as well as the healthy comparison mice.”

The group of mice that did best were those that were given both compounds together.

The two compounds appear to work by preventing the build up of sticky amyloid beta in the brain.

These are the clumps of protein seen in the brains of people with Alzheimer’s.

The compounds also reduced neuroinflammation and oxidative stress.

About the author

Psychologist, Jeremy Dean, PhD is the founder and author of PsyBlog. He holds a doctorate in psychology from University College London and two other advanced degrees in psychology.

He has been writing about scientific research on PsyBlog since 2004. He is also the author of the book “Making Habits, Breaking Habits” (Da Capo, 2003) and several ebooks:

• Accept Yourself: How to feel a profound sense of warmth and self-compassion
• The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic
• Spark: 17 Steps That Will Boost Your Motivation For Anything
• Activate: How To Find Joy Again By Changing What You Do

→ Dr Dean’s bio, Twitter, Facebook and how to contact him.

The study was published in the Journal of Biological Chemistry (Mori et al., 2019).

 

Diet reverses Alzheimer’s-like symptoms in mice

You can't do this on your own, no human clinical research to back it up and no amounts or protocol to follow. 

Be very careful with green tea extract:

Herbal supplements linked to at least six Australian organ transplants since 2011, data shows  March 2016

Diet reverses Alzheimer’s-like symptoms in mice

• Download PDF Copy

Reviewed by Alina Shrourou, BScMar 7 2019

A diet containing compounds found in green tea and carrots reversed Alzheimer's-like symptoms in mice genetically programmed to develop the disease, USC researchers say.
Researchers emphasize that the study, recently published in the Journal of Biological Chemistry, was in mice, and many mouse discoveries never translate into human treatments. Nevertheless, the findings lend credence to the idea that certain readily available, plant-based supplements might offer protection against dementia in humans.
"You don't have to wait 10 to 12 years for a designer drug to make it to market; you can make these dietary changes today," said senior author Terrence Town, a professor of physiology and neuroscience at the Keck School of Medicine of USC's Zilkha Neurogenetic Institute. "I find that very encouraging."
What's more, the study supports the idea that combination therapy, rather than a single magic bullet, may offer the best approach to treating the 5.7 million Americans living with Alzheimer's. Combination treatment is already the standard of care for diseases such as cancer, HIV infection and rheumatoid arthritis.
For this study, the researchers took a look at two compounds: EGCG, or epigallocatechin-3-gallate, a key ingredient in green tea, and FA, or ferulic acid, which is found in carrots, tomatoes, rice, wheat and oats.
The researchers randomly assigned 32 mice with Alzheimer's-like symptoms to one of four groups with an equal number of males and females. For comparison, each group also contained an equal number of healthy mice. For three months, the mice consumed a combination of EGCG and FA, or EGCG or FA only, or a placebo. The dosage was 30 mg per kilogram of body weight--a dosage well-tolerated by humans and easily consumed as part of a healthy, plant-based diet or in the form supplements.

Related Stories

• Dementia caregivers design robots for alleviating stress and increasing joyful moments
• New mathematical algorithm objectively classifies shapes of neurons in the brain
• Females on ketogenic diet fail to show metabolic benefits in animal model

Before and after the three-month special diet, scientists ran the mice through a battery of neuropsychological tests that are roughly analogous to the thinking and memory tests that assess dementia in humans. Of particular note was a maze in the shape of a Y, which tests a mouse's spatial working memory--a skill that humans use to find their way out of a building.
Healthy mice instinctively explore each arm of the Y maze, looking for food or a route to escape and entering the three arms in sequence more often than by chance alone. Impaired mice can't do this as well as their mentally healthy counterparts.
"After three months, combination treatment completely restored working memory and the Alzheimer's mice performed just as well as the healthy comparison mice," Town said.
How did it work? Town says one mechanism appeared to be the substances' ability to prevent amyloid precursor proteins from breaking up into the smaller proteins called amyloid beta that gum up Alzheimer patients' brains. In addition, the compounds appeared to reduce neuroinflammation and oxidative stress in the brain--key aspects of Alzheimer's pathology in humans.
Town said he and his lab will continue exploring combination treatment, with a focus on plant-derived substances that inhibit production of the sticky amyloid beta plaques.​

Source:

https://news.usc.edu/154890/alzheimers-like-symptoms-in-mice-reversed-with-special-diet/