Progress in research on the role of clinical nutrition in treating traumatic brain injury affecting the neurovascular unit

WHOM is going to do the similar research on this for stroke AND writeup a stroke protocol on it? With NO stroke leadership or strategy, NOTHING WILL BE DONE!

Progress in research on the role of clinical nutrition in treating traumatic brain injury affecting the neurovascular unit

Jin-Qing Lai, Xiang-Rong Chen, Shu Lin, Chun-Nuan Chen, Xuan-Xuan Zheng

Nutrition Reviews, nuac099, https://doi.org/10.1093/nutrit/nuac099

Published:

21 November 2022

• Cite
• Permissions Icon Permissions
• Share

Abstract

The neurovascular unit (NVU) is composed of neurons, glial cells, and blood vessels. NVU dysfunction involves the processes of neuroinflammation, and microcirculatory disturbances, as well as neuronal injury after traumatic brain injury (TBI). Traditional anti-inflammatory drugs have limited efficacy in improving the prognosis of TBI. Thus, treatments that target NVU dysfunction may provide a breakthrough. A large number of clinical studies have shown that the nutritional status of patients with TBI was closely related to their conditions and prognoses. Nutrient complexes and complementary therapies for the treatment of TBI are therefore being implemented in many preclinical studies. Importantly, the mechanism of action for this treatment may be related to repair of NVU dysfunction by ensuring adequate omega-3 fatty acids, curcumin, resveratrol, apigenin, vitamins, and minerals. These nutritional supplements hold promise for translation to clinical therapy. In addition, dietary habits also play an important role in the rehabilitation of TBI. Poor dietary habits may worsen the pathology and prognosis of TBI. Adjusting dietary habits, especially with a ketogenic diet, may improve outcomes in patients with TBI. This article discusses the impact of clinical nutrition on NVU dysfunction after TBI, focusing on nutritional complexes and dietary habits.

Recent Advances in Clinical Nutrition in Stroke Rehabilitation

Something useful might be in here if your doctor can read between the lines. Assuming your doctor reads research at all. 

Recent Advances in Clinical Nutrition in Stroke Rehabilitation

by

Yoshihiro Yoshimura

Center for Sarcopenia and Malnutrition Research, Kumamoto Rehabilitation Hospital, 760 Magate, Kikuyo-Town, Kikuchi-County, Kumamoto 869-1106, Japan

Nutrients 2022, 14(6), 1130; https://doi.org/10.3390/nu14061130

Received: 14 February 2022 / Revised: 25 February 2022 / Accepted: 28 February 2022 / Published: 8 March 2022

(This article belongs to the Special Issue Recent Advances in Clinical Nutrition in Stroke Rehabilitation)

Download PDF Citation Export

Stroke is a common cause of death and disability worldwide. Malnutrition is prevalent in stroke rehabilitation patients, and has serious negative effects on outcomes. In addition, there is growing interest in new concepts related to malnutrition, such as sarcopenia, frailty, cachexia, chronic inflammation, dysphagia, and oral problems, all of which contribute to a poor prognosis. Therefore, it is necessary to assess nutritional status early and, if needed, provide appropriate nutritional intervention to improve patient outcomes. A multidisciplinary approach is strongly recommended in this setting; as such, high-quality clinical evidence regarding clinical nutrition in stroke rehabilitation is needed.

This Special Issue updates our knowledge of clinical nutrition for stroke patients and includes interesting studies on topics including nutrition and weight management in the early stages of stroke, the relationship between frailty and improved physical function, weight gain by providing stored energy, physical activity and diet quality, L-carnitine and cognitive level, and the prediction of stroke prognosis using temporal muscles.

Aggressive nutritional management at the early stages of stroke onset may be effective in improving prognosis. In a retrospective cohort study, Sato et al. showed that high-energy nutritional intake during the first week post-stroke was associated with high rates of discharge from the hospital to home [1]. Additionally, Kishimoto et al. showed that weight maintenance or gain in post-stroke patients during the early phases of convalescence rehabilitation is independently associated with improvements in physical function [2]. Furthermore, Yoshimura et al. conducted a retrospective cohort study of underweight patients aged ≥70 years with a body mass index of less than 20.0 kg/m² undergoing convalescent rehabilitation after stroke. The study found that providing stored energy contributed to weight gain and increased skeletal muscle mass [3], and that it took approximately 9600 kcal of energy to gain 1 kg of body weight in underweight patients. These findings emphasize the importance of not only exercise therapy [4] and correction of polypharmacy [5], but also of aggressive nutritional support at the early stages to improve prognosis post-stroke.

Physical activity is also important in the rehabilitation of stroke patients. Nguyen et al. showed that physical activity and diet quality significantly modified the negative impacts of comorbidity on disability in stroke patients [6]. Comorbidities in stroke patients are strongly associated with poor prognosis, death, increased levels of disability, and worse functional outcomes post-stroke. Therefore, it is important to assess comorbidities early and increase physical activity and diet quality for appropriate treatment and rehabilitation. Furthermore, Nozoe et al. showed that pre-stroke frailty was associated with declines in physical function several months post-stroke [7]. These findings indicate that preventing frailty reduces functional disability, and that maintaining high physical function is associated with a better post-stroke quality of life.

Another interesting finding is that L-carnitine may serve a neuroprotective role against white matter microstructural damage and cognitive impairment in hemodialysis patients, according to Ueno et al. [8]. Long-term administration of carnitine may ameliorate damage to white matter microstructure by suppressing neuroinflammation and improving the executive function and attention associated with the protection of several candidate fiber tracts. Long-term administration of carnitine may be a novel treatment for vascular dementia. However, as this study is based on hemodialysis patients, further studies are needed to validate the neuroprotective effects of L-carnitine in post-stroke patients.

Katsuki et al. outlined reports on temporal muscle thickness (TMT) and stroke. TMT is associated with nutritional status and risk of sarcopenia after stroke. It is also a useful prognostic marker for dysphagia in patients with subarachnoid and cerebral hemorrhage. In recent years, there has been a rapid increase in the number of reports on TMT and stroke, as TMT is considered one of the most important clinical factors [9]. Sarcopenia and malnutrition are frequently observed in stroke patients and are associated with impaired rehabilitation outcomes. Instruments such as bioelectrical impedance analysis and dual energy X-ray absorptiometry are required to evaluate skeletal muscle mass in diagnosing sarcopenia. However, if TMT can be quantified simply by echo, it may be widely applied in daily stroke rehabilitation clinical practice.

The current Special Issue presents recent advances in clinical nutrition in stroke rehabilitation, highlighting the importance of nutritional management and physical activity in improving functional outcomes after stroke. The advances shown are of great interest from a clinical perspective, with a growing number of stroke patients around the world, and may act as the basis for future research.