Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex

Increased BDNF signaling and synaptogenesis sound wonderful for stroke recovery.  WHOM THE HELL  is going to do followup research on those two items in humans? I want exact names. Since we have NO STROKE LEADERSHIP, nothing will occur. You are fucking screwed as a stroke survivor.  You can't do this on your own, that would be practicing medicine without a license. 

Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex

• Amanda J. Sales,
• Manoela V. Fogaça,
• Ariandra G. Sartim,
• Vitor S. Pereira,
• Gregers Wegener,
• Francisco S. Guimarães &
• Sâmia R. L. Joca 

Molecular Neurobiology volume 56, pages1070–1081(2019)Cite this article

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Abstract

Currently available antidepressants have a substantial time lag to induce therapeutic response and a relatively low efficacy. The development of drugs that addresses these limitations is critical to improving public health. Cannabidiol (CBD), a non-psychotomimetic component of Cannabis sativa, is a promising compound since it shows large-spectrum therapeutic potential in preclinical models and humans. However, its antidepressant properties have not been completely investigated. Therefore, the aims of this study were to investigate in male rodents (i) whether CBD could induce rapid and sustained antidepressant-like effects after a single administration and (ii) whether such effects could be related to changes in synaptic proteins/function. Results showed that a single dose of CBD dose-dependently induced antidepressant-like effect (7–30 mg/kg) in Swiss mice submitted to the forced swim test (FST), 30 min (acute) or 7 days (sustained) following treatment. Similar effects were observed in the Flinders Sensitive and Flinders Resistant Line (FSL/FRL) rats and the learned helplessness (LH) paradigm using Wistar rats. The acute antidepressant effects (30 min) were associated with increased expression of synaptophysin and PSD95 in the medial prefrontal cortex (mPFC) and elevated BDNF levels in both mPFC and hippocampus (HPC). CBD also increased spine density in the mPFC after 30 min, but not 7 days later. Intracerebroventricular injection of the TrkB antagonist, K252a (0.05 nmol/μL), or the mTOR inhibitor, rapamycin (1 nmol/μL), abolished the behavioral effects of CBD. These results indicate that CBD induces fast and sustained antidepressant-like effect in distinct animal models relevant for depression. These effects may be related to rapid changes in synaptic plasticity in the mPFC through activation of the BDNF-TrkB signaling pathway. The data support a promising therapeutic profile for CBD as a new fast-acting antidepressant drug.

Cross-education plus mirror therapy as a post-stroke rehabilitation intervention: A case study

Just when the hell is a stroke protocol going to be written up on mirror therapy? Or should stroke survivors do this on their own because their doctors are fucking incompetent? I can't comprehend how mirror therapy would work on the lower limb. I need it since spasticity is making my walking all screwed up.

• 13 reasons for mirror-box therapy (2)

• mirror box (9)

• mirror therapy (54)

 Don't listen to me, that would just lead you down the dangerous path of practicing medicine without a license.

Cross-education plus mirror therapy as a post-stroke rehabilitation intervention: A case study 

Article type: Case Report

Authors: Simpson, D.^{a; *} | Ehrensberger, M.^a | Broderick, P.^a | Horgan, F.^b | Blake, C.^c | Roberts, D.^a | Monaghan, K.^a

Affiliations: [a] Clinical Health & Nutrition Centre (CHANCE), School of Science, Institute of Technology, Ballinode, Sligo, Ireland | [b] RCSI Royal College of Surgeons in Ireland, Dublin, Ireland | [c] University College Dublin, Dublin, Ireland

Correspondence: [*] Corresponding author: Daniel Simpson, Clinical Health & Nutrition Centre (CHANCE), School of Science, Institute of Technology, Ash Lane, Ballinode, Sligo, Ireland. Tel.: +353 0 870531507; E-mail: daniel.simpson@mail.itsligo.ie.

Abstract:  

BACKGROUND:A large proportion of patients with chronic stroke have permanent lower limb functional disability leading to reduced levels of independent mobility. Individually, both cross-education of strength and mirror therapy have been shown to improve aspects of lower limb functioning post-stroke. 

OBJECTIVES:This case report examined whether the novel combination of both therapies could be a feasible intervention leading to improvements in lower limb impairments and functional ability for a post-stroke individual. 

METHODS:The participant was a 66-year-old male and was six months’ post-stroke. Due to hemiparesis and spasticity he had lower limb motor impairment. The participant engaged in a combination of cross-education strength training plus mirror therapy three days per week for four weeks. Outcome measures included Maximal Voluntary Contraction, Modified Ashworth Scale, 10 Metre Walk Test, Timed Up and Go and London Handicap Scale. Intervention adherence, adverse effects and subjective feedback were also recorded. 

RESULTS:Maximal Voluntary Contraction increased in both limbs. Improvements were also seen in the Modified Ashworth Scale, 10 Metre Walk Test and Timed Up and Go. Improvements in function were reflected in a positive increase in self-perceived participation scores. The intervention was well received and no adverse effects were noted for the participant. 

DISCUSSION:The positive outcomes from this new combination therapy for this participant are encouraging and indicate the potential benefit of mirror therapy as an adjunct to cross-education training for improving lower limb strength, spasticity and motor function post-stroke.

Keywords: Stroke rehabilitation, hemiparesis, cross-education, mirror therapy

DOI: 10.3233/PPR-180125

Journal: Physiotherapy Practice and Research, vol. 40, no. 1, pp. 51-57, 2019

Published: 07 February 2019

Price: EUR 27.50

Doing This Activity 1 Hour a Week Lowers Heart Attack/Stroke Risk by 40-70 Percent - Strength training

You'll need your doctor to set up the correct protocol. You can't do this on your own, way too dangerous, practicing medicine without a license. 

Doing This Activity 1 Hour a Week Lowers Heart Attack/Stroke Risk by 40-70 Percent - Strength training

Yanghui Liu; Duck-chul Lee; Yehua Li; Weicheng Zhu; Riquan Zhang; Xuemei Sui; Carl J. Lavie; Steven N. Blair

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Abstract

PurposeResistance exercise (RE) can improve many cardiovascular disease (CVD) risk factors, but specific data on the effects on CVD events and mortality are lacking. We investigated the associations of RE with CVD and all-cause mortality, and further examined the mediation effect of body mass index between RE and CVD outcomes.
MethodsWe included 12,591 participants (mean age 47 years) who received at least two clinical examinations 1987-2006. RE was assessed by a self-reported medical history questionnaire.
ResultsDuring a mean follow-up of 5.4 and 10.5 years, 205 total CVD events (morbidity and mortality combined) and 276 all-cause deaths occurred, respectively. Compared with no RE, weekly RE frequencies of one, two, three times or total amount of 1-59 minutes were associated with approximately 40-70% decreased risk of total CVD events, independent of aerobic exercise (AE) (all p-values <0.05). However, there was no significant risk reduction for higher weekly RE of more than four times or ≥60 minutes. Similar results were observed for CVD morbidity and all-cause mortality. In the stratified analyses by AE, weekly RE of one time or 1-59 minutes was associated with lower risks of total CVD events and CVD morbidity regardless of meeting the AE guidelines. Our mediation analysis showed that RE was associated with the risk of total CVD events in two ways: RE had a direct U-shape association with CVD risk (p-value for quadratic trend <0.001) and RE indirectly lowered CVD risk by decreasing BMI.
ConclusionEven one time or less than one hour/week of RE, independent of AE, is associated with reduced risks of CVD and all-cause mortality. BMI mediates the association of RE with total CVD events.

This Is What Comedy Does to Your Brain

Does your doctor know anything about this? And prescribe you comedy movies and CDs and comedy theaters? Or are you going to have to self-treat yourself in violation of practicing medicine without a license as compared to your doctor practicing medicine without knowledge? Your choice, violate the law and possibly get better or do nothing.

This Is What Comedy Does to Your Brain

Comedy can lift your spirits and make the world seem a little more tolerable when times are tough. But what’s the physical and psychological science behind how comedy affects us?

We asked Scott Weems, Ph.D., cognitive neuroscientist and author or “Ha!: The Science of When We Laugh and Why,” and Caleb Warren, assistant professor of marketing at the University of Arizona and assistant professor at the Humor Research Lab, for their insights on some of the serious ways funny business can impact our bodies and minds.

1. Comedy is actually good for your body.

2. Comedy is also good for your mental well-being — most of the time.

3. Funny people can seem — or really be — depressed.

4. We think something’s funny when it’s so wrong it feels so right.

5. This may be because the brain processes comedy like a conflict.

Details at link.

 

Eating away at cognitive decline: MIND diet may slow brain from aging by 7.5 years

To counteract your cognitive decline from your stroke your doctor better have this diet stroke protocol ready for you. But I bet it won't happen and you can't do anything about it because you can't prescribe your own foods. That would be practicing medicine without a license. 

Eating away at cognitive decline: MIND diet may slow brain from aging by 7.5 years

What is the Unauthorized Practice of Medicine?

I'm just trying to make sure no one ever accuses me. Most of our doctors are obviously not  doing medicine, they are just practicing for the real game to come. 

What is the Unauthorized Practice of Medicine? 

I think I would fall under this line.
Helping save a persons life falls under the Good Samaritan act and you are covered from lawsuits in most cases.
I do wonder about doing that in a hospital with a doctor standing by doing nothing. Can you get charged for practicing medicine on yourself?