Your doctor will do just as well with this as with the young blood rejuvenation. And EXACTLY WHAT DID YOUR DOCTOR DO WITH YOUNG BLOOD? NOTHING? Good, you can expect nothing to ever get from research to an intervention. If you have no hope, then you will never be disappointed.
Young Blood Revitalizes the Aging Brain June 2014
The latest here:
Age-related impairments reversed in animal model
ScienceDaily Top Science|July 7, 2020
Frailty
and immune decline are two main features of old age. Researchers from
the University of Bern and the University Hospital Bern now demonstrate
in an animal model that these two age-related impairments can be halted
and even partially reversed using a novel cell-based therapeutic
approach.
Elderly people are more prone to
infectious diseases as the function of their immune system continuously
declines with progression of age. This becomes especially apparent
during seasonal influenza outbreaks or the occurrence of other viral
diseases such as COVID-19. As the efficacy of vaccination in the elderly
is strongly reduced, this age group is particularly vulnerable to such
infectious pathogens and often shows the highest mortality rate. In
addition to the age-related immune decline aged individuals are commonly
affected by frailty that negatively impacts quality-of-life. Even
though the average life-expectancy for humans continuous to rise, living
longer is often associated with age-related health issues.
Important role of belly fat in aging processes identified
Researchers
from the Department for BioMedical Reserarch (DBMR) and the Institute
of Pathology at the University of Bern as well as the University
Hospital Bern (Inselspital) have set out to identify new approaches to
improve health-span in a fast-growing aging population. For many years
scientists speculated that chronic low-grade inflammation accelerates
aging processes and the development of age-related disorders. An
international team of researchers under Bernese guidance has now
demonstrated that visceral adipose tissue, known as belly fat, crucially
contributes to the development of chronic low-grade inflammation.
Scientist around Dr. Mario Noti, formerly at the Institute of Pathology
of the University of Bern and Dr. Alexander Eggel from the Department
for BioMedical Research (DBMR) of the Universität of Bern reported that
certain immune cells in the belly fat play and an essential role in
regulating chronic low-grade inflammation and downstream aging
processes. They could show, that these immune cells may be used to
reverse such processes. The findings of this study have been published
in the scientific journal Nature Metabolism and were further highlighted by a News and Views editorial article.
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Belly fat as a source of chronic inflammation
The
team around Dr. Noti and Dr. Eggel could demonstrated that a certain
kind of immune cells, known as eosinophils, which are predominantly
found in the blood circulation, are also present in belly fat of both
humans and mice. Although classically known to provide protection from
parasite infection and to promote allergic airway disease, eosinophils
located in belly fat are responsible to maintain local immune
homeostasis. With increasing age the frequency of eosinophils in belly
fat declines, while the number of pro-inflammatory macrophages
increases. Owing to this immune cell dysbalance, belly fat turns into a
source of pro-inflammatory mediators accumulating systemically in old
age.
Eosinophil cell therapy promotes rejuvenation
In
a next step, the researchers investigated the possibility to reverse
age-related impairments by restoring the immune cell balance in visceral
adipose tissue. "In different experimental approaches, we were able to
show that transfers of eosinophils from young mice into aged recipients
resolved not only local but also systemic low-grade inflammation," says
Dr. Eggel. "In these experiments, we observed that transferred
eosinophils were selectively homing into adipose tissue," adds Dr. Noti.
This approach had a rejuvenating effect on the aged organism. As a
consequence, aged animals showed significant improvements in physical
fitness as assessed by endurance and grip strength tests. Moreover, the
therapy had a rejuvenating effect on the immune system manifesting in
improved vaccination responses of aged mice.
Translating findings into clinics
"Our
results indicate that the biological processes of aging and the
associated functional impairments are more plastic than previously
assumed," states Dr. Noti. Importantly, the observed age-related changes
in adipose immune cell distribution in mice were also confirmed in
humans. "A future direction of our research will be to now leverage the
gained knowledge for the establishment of targeted therapeutic
approaches to promote and sustain healthy aging in humans," says Dr.
Eggel.
This study has been supported by the
VELUX STIFTUNG, the FONDATION ACTERIA, and funds of the FreeNovation and
medical-biological science research programs of Novartis.
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