Extremely low frequency electromagnetic fields promote cognitive function and hippocampal neurogenesis of rats with cerebral ischemia

 

You'll have to ask your doctor if anything was done with the earlier ones or if any followup is being done with the latest. 

Effect of acute extremely low frequency electromagnetic field exposure on the antioxidant status and lipid levels in rat brain April 2012

The potential of transcranial magnetotherapy in color and rhythm therapy in the rehabilitation of ischemic stroke October 2010 

The latest here:

Extremely low frequency electromagnetic fields promote cognitive function and hippocampal neurogenesis of rats with cerebral ischemia

Qiang Gao¹ , Aaron Leung PhD ², Yong-Hong Yang³, Benson Wui-Man Lau⁴, Qian Wang⁵, Ling-Yi Liao⁶, Yun-Juan Xie⁶, Cheng-Qi He^5
1 Department of Rehabilitation Medicine, West China Hospital of Sichuan University; Institute of Disaster Management and Reconstruction, Sichuan University–The Hong Kong Polytechnic University, Chengdu, Sichuan Province; Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China
² Institute of Disaster Management and Reconstruction, Sichuan University–The Hong Kong Polytechnic University, Chengdu, Sichuan Province; Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China
³ Department of Rehabilitation Medicine, West China Hospital of Sichuan University; Institute of Disaster Management and Reconstruction, Sichuan University–The Hong Kong Polytechnic University, Chengdu, Sichuan Province; Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China
⁴ Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China
⁵ Department of Rehabilitation Medicine, West China Hospital of Sichuan University; Institute of Disaster Management and Reconstruction, Sichuan University–The Hong Kong Polytechnic University, Chengdu, Sichuan Province, China
⁶ Department of Rehabilitation Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China

Date of Submission	25-Nov-2019
Date of Decision	25-Nov-2019
Date of Acceptance	25-Aug-2020
Date of Web Publication	12-Dec-2020

Correspondence Address:
Aaron Leung
Institute of Disaster Management and Reconstruction, Sichuan University–The Hong Kong Polytechnic University, Chengdu, Sichuan Province; Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region
China
Cheng-Qi He
Department of Rehabilitation Medicine, West China Hospital of Sichuan University; Institute of Disaster Management and Reconstruction, Sichuan University–The Hong Kong Polytechnic University, Chengdu, Sichuan Province
China
Source of Support: This work was supported by the National Natural Science Foundation of China, No. 81201513 (to QG), Conflict of Interest: None

DOI: 10.4103/1673-5374.301020

Abstract

Extremely low frequency electromagnetic fields (ELF-EMF) can improve the learning and memory impairment of rats with Alzheimer’s disease, however, its effect on cerebral ischemia remains poorly understood. In this study, we established rat models of middle cerebral artery occlusion/reperfusion. One day after modeling, a group of rats were treated with ELF-EMF (50 Hz, 1 mT) for 2 hours daily on 28 successive days. Our results showed that rats treated with ELF-EMF required shorter swimming distances and latencies in the Morris water maze test than those of untreated rats. The number of times the platform was crossed and the time spent in the target quadrant were greater than those of untreated rats. The number of BrdU⁺/NeuN⁺ cells, representing newly born neurons, in the hippocampal subgranular zone increased more in the treated than in untreated rats. Up-regulation in the expressions of Notch1, Hes1, and Hes5 proteins, which are the key factors of the Notch signaling pathway, was greatest in the treated rats. These findings suggest that ELF-EMF can enhance hippocampal neurogenesis of rats with cerebral ischemia, possibly by affecting the Notch signaling pathway. The study was approved by the Institutional Ethics Committee of Sichuan University, China (approval No. 2019255A) on March 5, 2019.

Keywords: cerebral ischemia; cognitive function; electromagnetic fields; hippocampus; neurogenesis; plasticity; repair; signaling pathway; stroke; rat

How to cite this article: Gao Q, Leung A, Yang YH, Lau BW, Wang Q, Liao LY, Xie YJ, He CQ. Extremely low frequency electromagnetic fields promote cognitive function and hippocampal neurogenesis of rats with cerebral ischemia. Neural Regen Res 2021;16:1252-7

 

Intensification of the neuroplasticity process using an Extremely Low Frequency Electromagnetic Field in post-stroke patients

You'll have to ask your doctor if anything was done with the earlier ones or if any followup is being done with the latest. 8 years and is your stroke hospital still incompetent?

Extremely low frequency electromagnetic field reduces oxidative stress during the rehabilitation of post-acute stroke patients July 2018

Effect of acute extremely low frequency electromagnetic field exposure on the antioxidant status and lipid levels in rat brain April 2012

The potential of transcranial magnetotherapy in color and rhythm therapy in the rehabilitation of ischemic stroke October 2010

 The latest here:

Intensification of the neuroplasticity process using an Extremely Low Frequency Electromagnetic Field in post-stroke patients 

Natalia Cichoń^1*, Michal Bijak¹, Piotr Czarny², Elzbieta Miller², Ewelina Synowiec¹, Tomasz Sliwinski¹ and Joanna Saluk¹

• ¹University of Łódź, Poland
• ²Medical University of Lodz, Poland

Background: Neuroplasticity ensures the improvement of functional status in patients after stroke. The aim of this study was to evaluate the effect of extremely low frequency electromagnetic field therapy (ELF-EMF) on brain plasticity in the rehabilitation of patients after stroke.
Methods: 48 patients were divided into two groups. In the study group, the patients additionally underwent ELF-EMF therapy. In order to determine the level of neuroplasticity, we measured the plasma level of the brain-derived neurotrophic factor, the vascular-endothelial growth factor, as well as brain-derived neurotrophic factor (BDNF) mRNA expression. Additionally, we determined the molecule levels for hepatocyte growth factor, stem cell factor, stromal cell-derived factor 1α, nerve growth factor β, and leukaemia inhibitory factor, using 5plex cytokine panel in plasma. We assessed functional recovery using Barthel Index, Mini-Mental State Examination, Geriatric Depression Scale, National Institutes of Health Stroke Scale, and modified Rankin Scale.
Results: We observed that ELF-EMF significantly increased growth factors and cytokine levels involved in neuroplasticity, as well as promoted an enhancement of functional recovery in post-stroke patients. Additionally, we presented evidence that these effects could be related to enhancement of gene expression on the mRNA level. Moreover, a change of BDNF plasma level was positively correlated with Barthel Index, MMSE, and negatively correlated with GDS.
Conclusion: Extremely Low Frequency Electromagnetic Field therapy improves effectiveness of rehabilitation of post-stroke patients by improving neuroplasticity processes.

Extremely low frequency electromagnetic field or magnetotherapy for stroke

You'll have to ask your doctor if anything was done with the earlier ones or if any followup is being done with the latest. 

Extremely low frequency electromagnetic field reduces oxidative stress during the rehabilitation of post-acute stroke patients July 2018

Effect of acute extremely low frequency electromagnetic field exposure on the antioxidant status and lipid levels in rat brain April 2012

The potential of transcranial magnetotherapy in color and rhythm therapy in the rehabilitation of ischemic stroke October 2010