NMN improves high-fat-diet-induced myocardial damage of aging mice through Sirt3/PINK1/Parkin signaling pathway

 Didn't your competent? doctor prescribe NMN years ago? NO? So fucking incompetence reigned and your doctor is still employed?

Editorial: Inflammation in ischemic stroke and novel therapeutic strategies for stroke treatment November 2022 

The latest here:

NMN improves high-fat-diet-induced myocardial damage of aging mice through Sirt3/PINK1/Parkin signaling pathway

Author links open overlay panel, , , , , , , 

https://doi.org/10.1016/j.tjnut.2026.101435Get rights and content

Abstract

Background

Long-term high-fat diet (HFD) consumption is associated with the development of metabolic cardiomyopathy and contributes to accelerated cardiac aging. Nicotinamide mononucleotide (NMN), a key NAD+ precursor, has shown promise in ameliorating age-related cardiac decline, but its mechanisms are not fully understood.

Methods

14-month-old male C57BL/6J mice were divided into three groups: normal-diet (ND) group, high-fat diet (HFD) group and HFD+NMN group. NMN was added to their drinking water at a dose of 400 mg/kg for 7 months. Cardiac tissues were collected and analyzed using hematoxylin and eosin (H&E) and Masson's trichrome staining, Western blotting, Quantitative Real-Time PCR, and immunohistochemistry. In vitro, H9c2 cardiomyocytes were exposed to palmitic acid (PA) to establish a lipotoxicity model, and the effects of NMN on cell viability and autophagy flux were assessed via MTT assay and mRFP-GFP-LC3 adenoviral transfection.

Results

Compared to HFD group, NMN treatment significantly reduced the heart index, ameliorated myocardial fibrosis, and decreased the expression levels of senescence-associated secretory phenotype (SASP) markers (Serpine1, MMP3, CXCL-1, CXCL-10, P16; P<0.05), as well as senescence markers (P21 and β-gal; P<0.01), pro-inflammatory cytokines (IL-1β and TNF-α; P<0.05) and apoptotic indicators (Bax/Bcl-2 ratio, cleaved caspase-3; P<0.01). Conversely, NMN treatment upregulated the levels of anti-inflammatory factor IL-10 (P<0.01) in the cardiac tissue. Furthermore, NMN treatment increased protein levels of Sirt3, PINK1 and Parkin (P<0.01), and enhanced autophagy-lysosomal markers including LC3-II/LC3-I ratio and TFEB (P<0.05), alongside decreased p62 level (P<0.01) in cardiac tissue. In H9c2 cardiomyocytes, NMN treatment significantly attenuated PA-induced cytotoxicity (P<0.01) and enhanced PA-induced the impaired autophagy flux. Notably, these protective effects were abolished by co-treatment with 3-TYP, a selective Sirt3 inhibitor.

Conclusion

NMN alleviates HFD-induced myocardial damage of aging mice by activating the Sirt3/PINK1/Parkin signaling pathway, enhancing autophagy-lysosomal function. These findings indicate that NMN is a promising therapeutic candidate for the treatment of metabolic cardiomyopathy.

Cardiac complications after stroke: protocol for a systematic review and meta-analysis

When this review is done your doctor will need to update the cardiac post-stroke protocol. My doctors never even suggested testing my cardiac arteries, I had to set that up completely on my own. 

Cardiac complications after stroke: protocol for a systematic review and meta-analysis

1. Guidelle Héloïse Kenmogne-Domning1,
2. Joseph Kamtchum-Tatuene

23,

4

,

Christophe Maxime Fokoua-Dongmo5,

Joseline Guetsop Zafack

6,

Jean Jacques Noubiap7

Author affiliations

Abstract

Introduction Stroke is the second most common cause of death after ischaemic heart diseases and the third leading cause of disability worldwide. The contribution of cardiac complications to the mortality of patients with stroke is variable across studies, ranging from 12.5% to 22.7%. Many of these cardiac complications are preventable, and early recognition and adequate management guided by appropriate up-to-date knowledge of their relative incidence and fatality can help to improve patients’ outcomes. This systematic review aims to summarise the available data on the burden of cardiac complications after stroke.

Methods and analysis

This review will include all cross-sectional, case–control and cohort studies and clinical trials published between 1 January 1950 and 31 December 2017, involving adults and/or children, and reporting on the prevalence, the incidence and/or the mortality of cardiac complications after stroke. Two reviewers will independently screen titles and abstracts of records retrieved from PubMed, Excerpta Medica Database, ISI Web of Science and the Cumulative Index to Nursing and Allied Health Literature for eligibility, and then assess the risk of bias and quality of reporting to select the studies which will be included. All authors will contribute to the retrieval of full texts of eligible records and data extraction. Heterogeneity across studies will be evaluated by the χ² test on Cochran’s Q statistic. Study-specific estimates of the prevalence, incidence and mortality of cardiac complications after stroke across studies will be pooled through random-effect or fixed-effect meta-analysis depending on the source of the heterogeneity, after stabilising the variance of individual studies using the Freeman-Tukey double arcsine transformation. Visual analysis of funnel plots and Egger’s test will be done to detect small-study effect.

Ethics and dissemination This review and meta-analysis will be based on published data and will therefore not require a specific ethical clearance. The results will be published in peer-reviewed journals.

PROSPERO registration number CRD42018082551.

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

http://dx.doi.org/10.1136/bmjopen-2017-021416

Saunas Promote Good Heart Health, Says Study

You'll have to make the assumption that this would also promote good brain health so go ask your doctor that simple question. When is your hospital getting a sauna? Not to be done on your own, way too dangerous.
https://www.biosciencetechnology.com/news/2018/01/saunas-promote-good-heart-health-says-study?

Over the past couple of years, scientists at the University of Eastern Finland have shown that sauna bathing is associated with a variety of health benefits. Using an experimental setting this time, the research group now investigated the physiological mechanisms through which the heat exposure of sauna may influence a person’s health. Their latest study with 100 test subjects shows that taking a sauna bath of 30 minutes reduces blood pressure and increases vascular compliance, while also increasing heart rate similarly to medium-intensity exercise.
Previously, the research group has published findings from a population-based study indicating that regular sauna bathing is associated with a reduced risk of coronary diseases and sudden cardiac death, hypertension and Alzheimer’s disease and dementia. Frequent sauna bathing has also been associated with a reduced disk of respiratory diseases and lower CRP levels.
The experimental study carried out in the Sauna and Cardiovascular Health project provides new insight into changes that take place in the human body during and after having a sauna. The study analyzed the effects of a 30-minute sauna bath in 100 test subjects. In particular, the objective was to analyze the role of vascular compliance and reduced blood pressure in the health benefits caused by sauna bathing.
Vascular compliance was measured from the carotid and femoral artery before sauna, immediately after sauna, and after 30 minutes of recovery. These vascular compliance measurements carried out in the experimental study constitute a new assessment method in a sauna setting.
Immediately after 30 minutes of sauna bathing, test subjects’ mean systolic blood pressure reduced from 137 mmHg to 130 mmHg, and their diastolic blood pressure from 82 mmHg to 75 mmHg. Furthermore, their systolic blood pressure remained lower even after 30 minutes of sauna bathing. Test subjects’ mean carotid-femoral pulse wave velocity, which is an indicator of vascular compliance, was 9.8 m/s before sauna, decreasing to 8.6 m/s immediately after. During sauna bathing, test subjects’ heart rate increased similarly to medium-intensity exercise, and their body temperature rose by approximately 2°C. The findings shed light on the physiological mechanisms through which health benefits, which have been observed at the population level and are caused by the heat exposure of sauna, may develop.
The findings on the effects of sauna bathing on the human body were published in the Journal of Human Hypertension, and the findings relating to the carotid-femoral pulse wave velocity measurements were published in the European Journal of Preventive Cardiology. The study was funded by the Finnish Funding Agency for Innovation, Tekes, and it was carried out by Professor Jari Laukkanen’s research group at the University of Eastern Finland. The project partners were Harvia Ltd., Velha Ltd., Pihlajalinna, Fintravel Ltd. and the Finnish Sauna Culture Association. The test subjects were 100 clients of the Pihlajalinna health care service provider. Their background information was collected by extensive surveys and interviews, and their physical health was measured by a clinical exercise test. The study was carried out in experimental saunas provided by the sauna stove and sauna heater manufacturer Harvia Ltd. The experimental sauna setting was a careful simulation of the way people in Finland take a sauna in their own homes.
Research indicates that regular physical exercise and a healthy lifestyle promote cardiac health and prevent disease, but not all of the risk and protective factors are yet known. The benefits of regular sauna bathing on cardiac health observed in the population-based study can, according to this experimental study, be explained by the fact that sauna bathing reduces blood pressure and increases vascular compliance. However, further research data from experimental settings relating to the physiological mechanisms of sauna bathing that promote cardiac health is still needed.
Source: University of Eastern Finland

Study Reveals Yet Another Reason Red Wine Is Good For Your Health

Not that I need a reason other than my new social connections and laughter. Don't follow me, nothing I do is clinically proven, except I'm having the time of my life. You can have your doctor criticize the study because it approves of alcohol. 

Study Reveals Yet Another Reason Red Wine Is Good For Your Health

A glass of red wine a day might indeed keep the doctor away — at least that could be the case for those suffering from type 2 diabetes, according to a new study. It suggests red wine in moderation helps patients manage cholesterol and improves cardiac health.
READ: Here's What's REALLY Causing Your Wine Headaches
Researchers set out to discover the effects of moderate alcohol consumption on people with well-controlled type 2 diabetes, who generally have a higher risk of cardiovascular disease and lower levels of HDL cholesterol, which is good for the heart, reports Time. The 224 alcohol-abstaining participants with a low risk for alcohol abuse, aged 40 to 75, were then assigned a beverage — mineral water, dry white wine or dry red wine — and told to drink 5 ounces with a meal each night for two years, while also following a Mediterranean diet.
At the end of the study, there were no major differences in blood pressure and liver function among the three groups, reports Medical News Today. However, red wine drinkers were the only ones to see decreased cardiometabolic risks. They also saw a significant boost in HDL cholesterol and lower cholesterol overall, while all wine drinkers reported improved sleep, reports CBS News.
Though the alcohol appeared to aid glycemic control in white wine drinkers, the differences between the red wine and white wine groups suggest alcohol wasn't responsible for all the benefits. The red wine had seven times higher levels of total phenols than the white wine, and "it's the phenols, it's the resveratrol, it's the tannins" in the red wine that effect these benefits, says an expert.
READ: An Understandable Guide to Common Wine Terms
Genetic differences also affected glycemic control, meaning certain people are more likely to benefit from drinking wine. (Just watch out for arsenic.)