Clinical neurorestorative progress in traumatic brain injury

Which of these therapies mentioned can also be used in stroke? Does your doctor know anything about this?
http://www.dovepress.com/articles.php?article_id=20957

Authors Huang H, Chen L, Huang H
Published Date March 2015 Volume 2015:3 Pages 57—62
DOI http://dx.doi.org/10.2147/JN.S74486
Received 30 September 2014, Accepted 26 November 2014, Published 20 March 2015
Approved for publication by Prof. Dr. Hari Shanker Sharma

Huiling Huang,¹ Lin Chen,^2,3 Hongyun Huang<sup>4–6

1</sup>Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, Tianjin Neurosurgical Institute, Tianjin, People's Republic of China; ²Medical Center, Tsinghua University, Beijing, People's Republic of China; ³Tsinghua University Yuquan Hospital, Beijing, People's Republic of China; ⁴General Hospital of Chinese people's Armed Police Forces, ⁵Beijing Rehabilitation Hospital of Capital Medical University, Beijing, People's Republic of China; ⁶Beijing Hongtianji Neuroscience Academy, Beijing, People's Republic of China

Abstract: Traumatic brain injury (TBI) is a leading cause of death and disability from trauma to the central nervous system. Besides the surgical interventions and symptomatic management, the conventional therapies for TBI and its sequelae are still limited. Recently emerging evidence suggests that some neurorestorative treatments appear to have a potential therapeutic role for TBI and improving the patient's quality of life. The current clinical neurorestorative strategies available in TBI include pharmacological treatments (recombinant human interleukin-1 receptor antagonist, amantadine, lithium, and valproate), the neuromodulation treatments (repetitive transcranial magnetic stimulation, transcranial direct current stimulation, and low-level laser therapy), cell transplantation (bone marrow stromal cells and umbilical cord stromal cells), and combined neurorehabilitation. In this review, we summarize the recent clinical neurorestorative progress in the management of neurodegeneration as well as cognitive and motor deficits after TBI; indeed further clinical trials are required to provide more robust evidence.

Researchers propose novel new treatment of stroke and other neurological diseases - Thymosin beta-4

What is your doctor doing to start up a clinical trial with this? Does your doctor not have any goals and objectives to improve stroke rehab through research? If not, call your hospital president and ask why they are so incompetent that they don't set useable goals for their doctors to help their patients. 

Researchers propose novel new treatment of stroke and other neurological diseases - Thymosin beta-4

Medicine should reconsider how it treats stroke and other neurological disorders, focusing on the intrinsic abilities of the brain and nervous system to heal themselves rather than the "modest" benefits of clot-busting drugs and other neuroprotective treatments.

Michael Chopp, Ph,D., internationally renowned stroke researcher and scientific director of the Neuroscience Institute at Henry Ford Hospital, and Zhenggang Zhang,M.D., Ph.D., senior scientist at Henry Ford's Department of Neurology, make their case for the change in treatment strategy in an editorial published online in Expert Opinion on Biological Therapy.
The co-authors argue that pharmacologically enhancing the brain's own restorative abilities could benefit not only stroke patients, but those suffering other neurological damage or disease including traumatic brain injury (TBI), multiple sclerosis (MS) and peripheral neuropathy - nerve damage that afflicts the elderly, chemotherapy patients and especially diabetics.
Central to their proposal is a new pharmacological agent developed by Dr. Chopp and his colleagues, a synthetic version of a peptide that occurs naturally in humans and other mammals called Thymosin beta-4.
"Pioneering animal studies at Henry Ford have shown Thymosin beta-4 is highly effective for the treatment of neurological diseases in part by increasing the formation of protective myelin around nerve fibers in the central and peripheral nervous systems," says Dr. Chopp.
In their editorial, the authors first detail the limited effectiveness of current standard drug therapy, using tissue plasminogen activator (tPA), more commonly known as a "clot buster," to treat neurological disease.
Offering stroke as an example, they cite research showing that only about 5 percent of patients receive tPA, and of those only about 30 percent show significant improvements.
Similar conditions exist for nerve injury after TBI, MS and peripheral neuropathy, the authors write, and for those patients "there is a paucity of therapeutic options."
Among tPA's limitations is that it must be administered within a very short time after stroke to prevent "cascades" of irreversible cell damage.
In contrast, "restorative therapies" such as dosing with Thymosin beta-4 "may be applied well after the onset of injury or the onset of clinical symptoms for degenerative diseases" including stroke and others.
Says Dr. Chopp: "Rather than focusing on destroying clots or other lesions leading to nerve damage, restorative therapies are designed to 'remodel' or rebuild the nervous system by stimulating self-healing processes that already exist in the brain, spinal cord and the peripheral nerves connected to them."
"It is therefore time to reconsider how we think about treating neural injury and disease," the authors contend.