Incidence and Association of Reperfusion Therapies With Poststroke Seizures

 SO WHAT THE FUCK IS THE SOLUTION TO PREVENT THOSE SEIZURES? You are supposed to solve problems, not just lazily describe them.

Earlier research says this:

Following stroke, 3–6% of patients develop acute symptomatic seizures within the first 7 days

 

Post-injury epilepsy (PIE) is a devastating, unpreventable consequence of traumatic brain injury (TBI) and stroke, which develops in 10 to 40 percent of survivors months, or even years later 

 

seizures occur in about 10% of stroke patients.  

Just maybe you want your doctor to try these solutions.

Cannabidiol May Reduce Seizures by Half in Hard-to-treat Epilepsy

Or maybe the nasal spray referred to in here:

Preventing Seizure-Caused Damage to the Brain

The answers are out there, does your doctor know about them? 

Mozart may reduce seizure frequency in people with epilepsy

 

A dietary supplement dampens the brain hyperexcitability seen in seizures or epilepsy

 

The latest here: 

Incidence and Association of Reperfusion Therapies With Poststroke Seizures

A Systematic Review and Meta-Analysis

Alain Lekoubou

,

Jonah Fox

,

Paddy Ssentongo

Originally published10 Aug 2020https://doi.org/10.1161/STROKEAHA.119.028899Stroke. 2020;51:2715–2723

Abstract

Background and Purpose:

We performed a systematic review and meta-analysis to assess the incidence and risk of seizures following acute stroke reperfusion therapy (intravenous thrombolysis [IVT] with r-tPA [recombinant tissue-type plasminogen activator], mechanical thrombectomy or both).

Methods:

We searched major databases (MEDLINE, SCOPUS, and Cochrane Library) for articles published between 1995 and October 28, 2019. The primary outcome was the overall and treatment specific pooled incidence of poststroke seizures (PSS) following acute reperfusion therapy. We also computed the pooled incidence of early poststroke seizures and late poststroke seizures separately for all studies. We derived the risk of PSS associated with IVT in the pooled cohort of patients who received only IVT. The small number of studies (<3) that reported on the risk of PSS associated with mechanical thrombectomy alone or in combination with IVT did not allow us to compute an estimate of the risk of seizures associated with this therapy.

Results:

We identified 13 753 patients with stroke, of which 592 had seizures. The pooled incidence of PSS was 5.9 % (95% CI, 4.2%–8.2%). PSS incidence rates among patients with stroke treated with IVT, mechanical thrombectomy, and both were respectively 6.1% (95% CI, 3.6%–10.2%), 5.9% (95% CI, 4.1%–8.4%), and 5.8 % (95% CI, 3.0%–10.9%). The incidence of late PSS was 6.7% (95% CI, 4.01%–11.02%) and that of early PSS was 3.14% (95% CI, 2.05%–4.76%). The pooled odds ratio for the association between IVT and PSS was 1.24 (95% CI, 0.75–2.05).

Conclusions:

The findings of this meta-analysis suggest that about one in 15 ischemic stroke patients treated with IVT, mechanical thrombectomy, or both develop seizures independently of the specific reperfusion treatment that they received.

Footnotes

For Sources of Funding and Disclosures, see page 2722.

The Data Supplement is available with this article at https://www.ahajournals.org/doi/suppl/10.1161/STROKEAHA.119.028899.

Correspondence to: Alain Lekoubou, MD, MSc, Department of Neurology, Penn State University, 30 Hope Dr, Hershey, PA, 17033. Email alekouboulooti@pennstatehealth.psu.edu